MX2007014297A - Derivados de purina y su uso para el tratamiento de enfermedades autoinmunes. - Google Patents

Derivados de purina y su uso para el tratamiento de enfermedades autoinmunes.

Info

Publication number
MX2007014297A
MX2007014297A MX2007014297A MX2007014297A MX2007014297A MX 2007014297 A MX2007014297 A MX 2007014297A MX 2007014297 A MX2007014297 A MX 2007014297A MX 2007014297 A MX2007014297 A MX 2007014297A MX 2007014297 A MX2007014297 A MX 2007014297A
Authority
MX
Mexico
Prior art keywords
sub
treatment
autoimmune diseases
purine derivatives
formula
Prior art date
Application number
MX2007014297A
Other languages
English (en)
Inventor
Boulos Zacharie
Christopher Penney
Daniel Fortin
Nicole Wilb
Original Assignee
Prometic Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometic Biosciences Inc filed Critical Prometic Biosciences Inc
Publication of MX2007014297A publication Critical patent/MX2007014297A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos utiles en el tratamiento de enfermedad autoinmune se describen mediante la siguiente formula general (I): (ver formula) donde R1, R3 = NH2, F, Cl, grupo alcoxi de C1-C4 o fenoxi, pero R1 no es necesariamente igual a R3; y R2 = H, F, Cl, NH2, o NH-R-XH; donde R = -(CH2)p- p= 2-4 = Formula (II), Formula (III) = Formula (IV) q = 0-3 X= CH2, NH, O o S.
MX2007014297A 2005-05-16 2006-05-15 Derivados de purina y su uso para el tratamiento de enfermedades autoinmunes. MX2007014297A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68114105P 2005-05-16 2005-05-16
PCT/CA2006/000783 WO2006136005A1 (en) 2005-05-16 2006-05-15 Purine derivatives and their use for treatment of autoimmune diseases

Publications (1)

Publication Number Publication Date
MX2007014297A true MX2007014297A (es) 2008-04-21

Family

ID=37570052

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014297A MX2007014297A (es) 2005-05-16 2006-05-15 Derivados de purina y su uso para el tratamiento de enfermedades autoinmunes.

Country Status (8)

Country Link
US (1) US8080555B2 (es)
EP (1) EP1881987B1 (es)
JP (1) JP5108752B2 (es)
AU (1) AU2006261527B2 (es)
BR (1) BRPI0610824A8 (es)
CA (1) CA2608314C (es)
MX (1) MX2007014297A (es)
WO (1) WO2006136005A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1556129A4 (en) * 2002-10-15 2011-02-09 Irm Llc COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS
WO2012142029A2 (en) * 2011-04-10 2012-10-18 Florida A&M University Serms for the treatment of estrogen receptor-mediated disorders
CN103288682B (zh) * 2012-02-25 2016-06-22 浙江华海药业股份有限公司 一种简便的纯化(4-氨基苯基)氨基甲酸叔丁酯的方法
JP6258922B2 (ja) 2012-04-25 2018-01-10 アメリカ合衆国 制御性ｂ細胞の製造及び使用方法
JP2022536859A (ja) 2019-06-18 2022-08-19 アメリカ合衆国 Ｉｎｔｅｒｌｅｕｋｉｎ－２７産生ｂ細胞及びその使用
EP4274887A1 (en) 2021-01-11 2023-11-15 The United States of America, as represented by the Secretary, Department of Health and Human Services Exosomes comprising il-35 or il-27 and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6790958B2 (en) * 1996-08-02 2004-09-14 Robert T. Lum Purine inhibitors of cyclin dependent kinase 2 & IKBA
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
GEP20033092B (en) * 1999-02-01 2003-10-27 Cv Therapeutics Inc Us Purine Inhibitors of Cyclin Dependent Kinase 2 and Ik-Aa
IL150061A0 (en) * 1999-12-17 2002-12-01 Ariad Pharma Inc Purine derivatives
IL150060A0 (en) * 1999-12-17 2002-12-01 Ariad Pharma Inc Novel purines
JP2003531111A (ja) * 1999-12-17 2003-10-21 アライアッド・ファーマシューティカルズ・インコーポレーテッド プロトンポンプインヒビター
JP2005512972A (ja) 2001-10-12 2005-05-12 アイアールエム エルエルシー キナーゼ阻害剤足場およびそれらの調製方法
CA2463507A1 (en) 2001-10-12 2003-04-17 Sheng Ding Methods for the synthesis of substituted purines
US20060009642A1 (en) 2001-10-12 2006-01-12 Irm Llc, A Delaware Limited Liability Company Methods for the synthesis of substituted purines
US6949644B2 (en) 2001-10-12 2005-09-27 Irm Llc Methods for the synthesis of substituted purines
AU2004264419B2 (en) * 2003-08-15 2009-01-15 Irm Llc 6-substituted anilino purines as RTK inhibitors
AP2006003517A0 (en) * 2003-09-25 2006-02-28 Janssen Pharmaceutica Nv Hiv replication purine derivatives.
EP1720877A4 (en) * 2004-03-02 2009-11-04 Neurogen Corp ANALOGUES OF PURINS ARYL SUBSTITUTION

Also Published As

Publication number Publication date
CA2608314A1 (en) 2006-12-28
JP2008540583A (ja) 2008-11-20
JP5108752B2 (ja) 2012-12-26
CA2608314C (en) 2015-10-27
EP1881987A1 (en) 2008-01-30
US8080555B2 (en) 2011-12-20
WO2006136005A1 (en) 2006-12-28
BRPI0610824A2 (pt) 2010-07-27
EP1881987A4 (en) 2014-08-13
BRPI0610824A8 (pt) 2017-04-04
US20090042768A1 (en) 2009-02-12
EP1881987B1 (en) 2016-10-19
AU2006261527A1 (en) 2006-12-28
AU2006261527B2 (en) 2012-11-22

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