DE60106882D1 - Verfahren zur herstellung von 9-deoxo- 8a-aza-(8a-alkyl)-homoerythromycine a derivate von 9-deoxo-9(z) - hydroxyiminoerythromycine a - Google Patents

Verfahren zur herstellung von 9-deoxo- 8a-aza-(8a-alkyl)-homoerythromycine a derivate von 9-deoxo-9(z) - hydroxyiminoerythromycine a

Info

Publication number
DE60106882D1
DE60106882D1 DE60106882T DE60106882T DE60106882D1 DE 60106882 D1 DE60106882 D1 DE 60106882D1 DE 60106882 T DE60106882 T DE 60106882T DE 60106882 T DE60106882 T DE 60106882T DE 60106882 D1 DE60106882 D1 DE 60106882D1
Authority
DE
Germany
Prior art keywords
deoxo
hydroxyiminoerythromycine
homoerythromycine
aza
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106882T
Other languages
English (en)
Other versions
DE60106882T2 (de
Inventor
Patrick Leon
Frederic Lhermitte
Gilles Oddon
Denis Pauze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health France SAS
Original Assignee
Merial SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial SAS filed Critical Merial SAS
Application granted granted Critical
Publication of DE60106882D1 publication Critical patent/DE60106882D1/de
Publication of DE60106882T2 publication Critical patent/DE60106882T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE60106882T 2000-03-24 2001-03-23 Verfahren zur herstellung von 9-deoxy-8a-aza-(8a-alkyl)-8a-homoerythromycin a derivaten aus 9-deoxy-9(z)-hydroxyiminoerythromycin a Expired - Lifetime DE60106882T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0003807A FR2806724B1 (fr) 2000-03-24 2000-03-24 Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
FR0003807 2000-03-24
PCT/FR2001/000897 WO2001072763A1 (fr) 2000-03-24 2001-03-23 Procede pour la preparation de derives 9-deoxo-8a-aza-(8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9(z)-hydroxyiminoerythromycine a

Publications (2)

Publication Number Publication Date
DE60106882D1 true DE60106882D1 (de) 2004-12-09
DE60106882T2 DE60106882T2 (de) 2005-12-01

Family

ID=8848497

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106882T Expired - Lifetime DE60106882T2 (de) 2000-03-24 2001-03-23 Verfahren zur herstellung von 9-deoxy-8a-aza-(8a-alkyl)-8a-homoerythromycin a derivaten aus 9-deoxy-9(z)-hydroxyiminoerythromycin a

Country Status (17)

Country Link
EP (1) EP1265908B1 (de)
JP (1) JP4975933B2 (de)
CN (1) CN1174992C (de)
AR (1) AR027706A1 (de)
AT (1) ATE281463T1 (de)
AU (2) AU2001246636C1 (de)
BR (1) BRPI0109413B8 (de)
CA (1) CA2399634C (de)
DE (1) DE60106882T2 (de)
DK (1) DK1265908T3 (de)
ES (1) ES2232609T3 (de)
FR (1) FR2806724B1 (de)
NZ (1) NZ520878A (de)
PL (1) PL206683B1 (de)
PT (1) PT1265908E (de)
WO (1) WO2001072763A1 (de)
ZA (1) ZA200207443B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314218B2 (en) * 2008-10-24 2012-11-20 Merial Limited Method of synthesizing macrolide compounds
CN103833807B (zh) * 2012-11-21 2016-12-07 洛阳惠中兽药有限公司 一种加米霉素中间体的制备方法
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105849094B (zh) * 2013-12-26 2018-04-10 住友化学株式会社 卤素取代苯酞的制造方法
CN109970827A (zh) * 2017-12-27 2019-07-05 洛阳惠中兽药有限公司 加米霉素中间体化合物i的晶型及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
EP0503932B1 (de) * 1991-03-15 1998-12-02 Merck & Co. Inc. 9-Deoxo-9(Z)-hydroxyiminoerythromycin A und O-Derivate hiervon
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
EP0508795A1 (de) * 1991-04-10 1992-10-14 Merck & Co. Inc. 8A-Aza-8A-homoerythromycin Cyclischiminoethere
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
EP0515141A1 (de) * 1991-05-20 1992-11-25 Merck & Co. Inc. Verfahren zur Herstellung von 8A-aza-8A-homoerythromycin cyclische Lactam
EP0549040A1 (de) * 1991-12-20 1993-06-30 Merck & Co. Inc. Verfahren zur Herstellung von 4"-Derivaten von 9-Deoxo-8a-Aza-8a-Alkyl-8a-Homoerythromycin A
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide

Also Published As

Publication number Publication date
BRPI0109413B1 (pt) 2015-08-04
FR2806724A1 (fr) 2001-09-28
AU4663601A (en) 2001-10-08
AU2001246636C1 (en) 2006-02-23
PL206683B1 (pl) 2010-09-30
BRPI0109413B8 (pt) 2021-05-25
DE60106882T2 (de) 2005-12-01
ZA200207443B (en) 2003-10-17
JP4975933B2 (ja) 2012-07-11
ATE281463T1 (de) 2004-11-15
PT1265908E (pt) 2005-03-31
DK1265908T3 (da) 2005-03-14
FR2806724B1 (fr) 2003-12-05
BR0109413A (pt) 2002-12-10
CN1425022A (zh) 2003-06-18
NZ520878A (en) 2004-05-28
ES2232609T3 (es) 2005-06-01
WO2001072763A1 (fr) 2001-10-04
EP1265908A1 (de) 2002-12-18
PL361225A1 (en) 2004-09-20
AR027706A1 (es) 2003-04-09
AU2001246636B2 (en) 2005-04-21
JP2003528882A (ja) 2003-09-30
CN1174992C (zh) 2004-11-10
CA2399634C (en) 2011-05-24
CA2399634A1 (en) 2001-10-04
EP1265908B1 (de) 2004-11-03

Similar Documents

Publication Publication Date Title
ATE386736T1 (de) Verfahren zur herstellung von benzimidazol-2-yl - chinolinonderivaten
DE60102784D1 (de) Verfahren zur herstellung von alkylaromaten
DE60221399D1 (de) Verfahren zur herstellung von mitteldistillaten
ATE403641T1 (de) Verfahren zur herstellung von o- desmethylvenlafaxin
ATE325098T1 (de) Verfahren zur herstellung von 3- hydroxypicolinsäure-derivaten
AT7110U9 (de) Verfahren zur herstellung von amlodipinmaleat
DE60230908D1 (de) Verfahren zur herstellung von polyarylenethern
ATE331804T1 (de) Verfahren zur herstellung von ansamitocin
ATE316518T1 (de) Verfahren zur herstellung von (r)-2-alkyl-3- phenyl-1-propanolen
DE50102444D1 (de) Verfahren zur herstellung von isocyanatoorganosilanen
ATE441662T1 (de) Verfahren zur herstellung von echinocandinderivaten
ATE287870T1 (de) Verfahren zur herstellung von phenethylamin- derivaten
DE50111560D1 (de) Verfahren zur herstellung von guerbetalkoholen
DE60103173D1 (de) Verfahren zur herstellung von 3-amino-2-chlor-4-methylpyridin
DE50200870D1 (de) Verfahren zur herstellung von hydroxyalkylpolysiloxanen
DE60105991D1 (de) Verfahren zur herstellung von 6-aminocapronamid
DE50204977D1 (de) Verfahren zur herstellung von polykondensaten
DE60106760D1 (de) Verfahren zur herstellung von chinolinderivaten
ATE281463T1 (de) Verfahren zur herstellung von 9-deoxo- 8a-aza-(8a-alkyl)-homoerythromycine a derivate von 9-deoxo- 9(z) - hydroxyiminoerythromycine a
ATE238316T1 (de) Verfahren zur herstellung von phosphonomethylglycin
ATE325810T1 (de) Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden
ATE271046T1 (de) Verfahren zur herstellung benzo-annelierter heterocyclen
DE69928784D1 (de) Verfahren zur herstellung von oxazolidin-2-on-derivaten
ATE233238T1 (de) Verfahren zur herstellung von 3-acyl-indolen
ATE327995T1 (de) Verfahren zur herstellung von camptothectin

Legal Events

Date Code Title Description
8364 No opposition during term of opposition