AR027706A1 - Procedimiento para la preparacion de derivados de 9-deoxo-8a-aza-(8a-alquil)8a-heomoeritromicina a partir de 9-deoxo-9(z)-hidroxii-minoeritromicina a - Google Patents

Procedimiento para la preparacion de derivados de 9-deoxo-8a-aza-(8a-alquil)8a-heomoeritromicina a partir de 9-deoxo-9(z)-hidroxii-minoeritromicina a

Info

Publication number
AR027706A1
AR027706A1 ARP010101371A ARP010101371A AR027706A1 AR 027706 A1 AR027706 A1 AR 027706A1 AR P010101371 A ARP010101371 A AR P010101371A AR P010101371 A ARP010101371 A AR P010101371A AR 027706 A1 AR027706 A1 AR 027706A1
Authority
AR
Argentina
Prior art keywords
deoxo
aza
preparation
derivatives
minoeritromycin
Prior art date
Application number
ARP010101371A
Other languages
English (en)
Original Assignee
Merial Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Sas filed Critical Merial Sas
Publication of AR027706A1 publication Critical patent/AR027706A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un procedimiento para la preparacion de 9-deoxo-8a-aza-8a-homoeritromicina A formula 1. Y de sus derivados 8a-alquilados a partir de 9-deoxo-9(Z)-hidroxiiminoeritromicina A por vía de transposicion estereoespecífica de Beckmann en un medio de reaccio n que utiliza piridina como solvente principal, y queconduce a intermediarios imitados que no éstan aislados de dicho medio y que están directamente implicados en una etapa de reduccion con la ayuda de unacantidad suficiente de bohohidruro, luego de la extraccion de la piridina, por un hidrocarburo miscible en esta y en el cual dichos imidatos son insolubles. Elcompuesto V puede ser directamente N-alquilado en posicion -8a, con la ayuda de un aldehído, sin estar aislado del medio de reduccion.
ARP010101371A 2000-03-24 2001-03-23 Procedimiento para la preparacion de derivados de 9-deoxo-8a-aza-(8a-alquil)8a-heomoeritromicina a partir de 9-deoxo-9(z)-hidroxii-minoeritromicina a AR027706A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0003807A FR2806724B1 (fr) 2000-03-24 2000-03-24 Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a

Publications (1)

Publication Number Publication Date
AR027706A1 true AR027706A1 (es) 2003-04-09

Family

ID=8848497

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101371A AR027706A1 (es) 2000-03-24 2001-03-23 Procedimiento para la preparacion de derivados de 9-deoxo-8a-aza-(8a-alquil)8a-heomoeritromicina a partir de 9-deoxo-9(z)-hidroxii-minoeritromicina a

Country Status (17)

Country Link
EP (1) EP1265908B1 (es)
JP (1) JP4975933B2 (es)
CN (1) CN1174992C (es)
AR (1) AR027706A1 (es)
AT (1) ATE281463T1 (es)
AU (2) AU4663601A (es)
BR (1) BRPI0109413B8 (es)
CA (1) CA2399634C (es)
DE (1) DE60106882T2 (es)
DK (1) DK1265908T3 (es)
ES (1) ES2232609T3 (es)
FR (1) FR2806724B1 (es)
NZ (1) NZ520878A (es)
PL (1) PL206683B1 (es)
PT (1) PT1265908E (es)
WO (1) WO2001072763A1 (es)
ZA (1) ZA200207443B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314218B2 (en) * 2008-10-24 2012-11-20 Merial Limited Method of synthesizing macrolide compounds
CN103833807B (zh) * 2012-11-21 2016-12-07 洛阳惠中兽药有限公司 一种加米霉素中间体的制备方法
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
KR102233327B1 (ko) * 2013-12-26 2021-03-26 스미또모 가가꾸 가부시끼가이샤 할로겐 치환 프탈리드의 제조 방법
CN109970827A (zh) * 2017-12-27 2019-07-05 洛阳惠中兽药有限公司 加米霉素中间体化合物i的晶型及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69227713D1 (de) * 1991-03-15 1999-01-14 Merck & Co Inc 9-Deoxo-9(Z)-hydroxyiminoerythromycin A und O-Derivate hiervon
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065674A1 (en) * 1991-04-10 1992-10-11 Robert R. Wilkening 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives
CA2068951A1 (en) * 1991-05-20 1992-11-21 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic lactams
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide

Also Published As

Publication number Publication date
PL361225A1 (en) 2004-09-20
EP1265908B1 (fr) 2004-11-03
DE60106882D1 (de) 2004-12-09
JP2003528882A (ja) 2003-09-30
BR0109413A (pt) 2002-12-10
WO2001072763A1 (fr) 2001-10-04
DK1265908T3 (da) 2005-03-14
AU2001246636B2 (en) 2005-04-21
FR2806724A1 (fr) 2001-09-28
ATE281463T1 (de) 2004-11-15
ZA200207443B (en) 2003-10-17
BRPI0109413B1 (pt) 2015-08-04
PT1265908E (pt) 2005-03-31
EP1265908A1 (fr) 2002-12-18
FR2806724B1 (fr) 2003-12-05
ES2232609T3 (es) 2005-06-01
CN1425022A (zh) 2003-06-18
NZ520878A (en) 2004-05-28
AU2001246636C1 (en) 2006-02-23
BRPI0109413B8 (pt) 2021-05-25
JP4975933B2 (ja) 2012-07-11
AU4663601A (en) 2001-10-08
PL206683B1 (pl) 2010-09-30
CA2399634A1 (en) 2001-10-04
DE60106882T2 (de) 2005-12-01
CN1174992C (zh) 2004-11-10
CA2399634C (en) 2011-05-24

Similar Documents

Publication Publication Date Title
CA2452474C (en) Nucleotide compositions comprising photocleavable markers and methods of preparation thereof
ES2422204T3 (es) Novedosos derivados de imidazolidin-2-ona como moduladores selectivos de receptor de andrógenos (SARMS)
BR0207746A (pt) Método para a sìntese de 2',3'-didesoxi-2',3'-didesidronucleosìdeo
EP1152008A3 (en) Fluorescent nucleotides containing a cyanine, merocyanine or styryl dye for the detection of nucleic acid
PT1326851E (pt) Dipeptidos substituidos como secretagogues da hormona do crescimento
AR005010A1 (es) Metodo para convertir metanol a olefinas
GT200200069A (es) Derivados de mercaptoacetilamida, procedimiento para su preparacion y su uso
ECSP066271A (es) Un método para la preparación de mirtazapina enantioméricamente pura
AR027706A1 (es) Procedimiento para la preparacion de derivados de 9-deoxo-8a-aza-(8a-alquil)8a-heomoeritromicina a partir de 9-deoxo-9(z)-hidroxii-minoeritromicina a
BRPI0512081A (pt) azaporfirinas substituìdas como rótulos de fluorescência
AR018802A1 (es) Procedimiento de preparacion de un oxirano
AR048040A1 (es) Metodo de purificacion de mesotriona
ATE359294T1 (de) Toxinrezeptoren aus zonula occludens
CY1109259T1 (el) Παρασκευη συμπλοκων του λευκοχρυσου(ιι)
PE20040991A1 (es) Separacion de intermediarios para la preparacion de escitalopram
AR026076A1 (es) Un metodo para producir una preparacion de liposomas mediante secado al vacio
ATE223499T1 (de) Von kreisförmiger matrize abhängige kettenreaktion
AR049566A1 (es) Procedimiento para preparar diisopropil((1-(hidroximetil)-ciclopropil)oxi)metilfosfonato
DE60333353D1 (de) Verfahren zur wiedergewinnung von secoisolariciresinol diglycosid aus entfetteten flachs-saatgut
ECSP077384A (es) Compuestos tricíclicos que contienen heteroátomos
DE60131176D1 (de) Fluoreszierende verbindungen
WO2020206114A1 (en) Sequencing by synthesis with energy transfer dye pairs
BR0116918A (pt) Preparação de warfarin sódico a partir do ácido de warfarin
DE60102014D1 (de) Synthese von cyaninfarbstoffen an fester phase
ES2164305T3 (es) Procedimiento para purificar 1,1,1-tris(4-hidroxifenil)alcanos.

Legal Events

Date Code Title Description
FG Grant, registration