DE60104690T2 - Anilin-disulfid-derivate zur behandlung allergischer erkrankungen - Google Patents

Anilin-disulfid-derivate zur behandlung allergischer erkrankungen Download PDF

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Publication number
DE60104690T2
DE60104690T2 DE2001604690 DE60104690T DE60104690T2 DE 60104690 T2 DE60104690 T2 DE 60104690T2 DE 2001604690 DE2001604690 DE 2001604690 DE 60104690 T DE60104690 T DE 60104690T DE 60104690 T2 DE60104690 T2 DE 60104690T2
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DE
Germany
Prior art keywords
alkyl
substituted
amount
disulfide derivative
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE2001604690
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German (de)
English (en)
Other versions
DE60104690D1 (de
Inventor
R. Mark HELLBERG
Zixia Feng
T. Steven MILLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
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Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of DE60104690D1 publication Critical patent/DE60104690D1/de
Application granted granted Critical
Publication of DE60104690T2 publication Critical patent/DE60104690T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE2001604690 2000-05-19 2001-04-25 Anilin-disulfid-derivate zur behandlung allergischer erkrankungen Expired - Fee Related DE60104690T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20574600P 2000-05-19 2000-05-19
US205746P 2000-05-19
PCT/US2001/013242 WO2001090059A1 (en) 2000-05-19 2001-04-25 Aniline disulfide derivatives for treating allergic diseases

Publications (2)

Publication Number Publication Date
DE60104690D1 DE60104690D1 (de) 2004-09-09
DE60104690T2 true DE60104690T2 (de) 2005-01-13

Family

ID=22763478

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2001604690 Expired - Fee Related DE60104690T2 (de) 2000-05-19 2001-04-25 Anilin-disulfid-derivate zur behandlung allergischer erkrankungen

Country Status (19)

Country Link
US (2) US6372802B2 (enExample)
EP (1) EP1289945B1 (enExample)
JP (1) JP2003534317A (enExample)
KR (1) KR20020093982A (enExample)
CN (1) CN1173697C (enExample)
AR (1) AR028565A1 (enExample)
AT (1) ATE272619T1 (enExample)
AU (2) AU2001257227B2 (enExample)
BR (1) BR0110845A (enExample)
CA (1) CA2408145A1 (enExample)
DE (1) DE60104690T2 (enExample)
DK (1) DK1289945T3 (enExample)
ES (1) ES2222370T3 (enExample)
MX (1) MXPA02011480A (enExample)
PL (1) PL365459A1 (enExample)
PT (1) PT1289945E (enExample)
TR (1) TR200402299T4 (enExample)
WO (1) WO2001090059A1 (enExample)
ZA (1) ZA200208839B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045668A2 (en) * 1999-12-20 2001-06-28 Schering Corporation Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine
SK287105B6 (sk) * 1999-12-20 2009-12-07 Schering Corporation Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním
UA82323C2 (uk) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань
WO2006076027A2 (en) * 2004-05-17 2006-07-20 Cambrios Technology Corp. Biofabrication of transistors including field effect transistors
KR20070024618A (ko) * 2004-06-28 2007-03-02 알콘, 인코퍼레이티드 알레르기성 질환 치료용 국소 제제
US20130304180A1 (en) * 2012-05-09 2013-11-14 Michael L. Green Catheter having dual balloon hydraulic actuator
US11058444B2 (en) 2017-12-11 2021-07-13 Covidien Lp Electrically enhanced retrieval of material from vessel lumens

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1232787A (enExample) 1967-08-08 1971-05-19
US3663616A (en) 1969-10-13 1972-05-16 Sherwin Williams Co Bis(2-carbamylphenyl)disulfides
EP0062827B1 (en) 1978-06-16 1986-07-23 Kyowa Hakko Kogyo Co., Ltd Novel benzamide derivatives
JPS59205356A (ja) * 1983-05-10 1984-11-20 Teikoku Hormone Mfg Co Ltd ジスルフアニルベンゼン酢酸誘導体
US4923892A (en) 1985-08-17 1990-05-08 Burroughs Wellcome Co. Tricyclic aromatic compounds
GB8520662D0 (en) 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds
JPS6310784A (ja) 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
GB9020933D0 (en) 1990-09-26 1990-11-07 Ici Plc Compound,preparation and use
US5859017A (en) 1994-04-01 1999-01-12 Cell Therapeutics, Inc. Method for inhibiting mast cell and basophil activation
US5734081A (en) 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
US5463122A (en) 1994-08-05 1995-10-31 Warner-Lambert Company Arylthio compounds
US6001555A (en) 1994-09-23 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein
JPH08253454A (ja) * 1994-12-26 1996-10-01 Nisshin Flour Milling Co Ltd ジフェニルジスルフィド化合物
JPH095926A (ja) 1995-04-18 1997-01-10 Fuji Photo Film Co Ltd 熱現像感光材料
US5641805A (en) 1995-06-06 1997-06-24 Alcon Laboratories, Inc. Topical ophthalmic formulations for treating allergic eye diseases
WO1997038693A1 (en) 1996-04-18 1997-10-23 Alcon Laboratories, Inc. Calcium channel blockers as human conjunctival mast cell degranulation inhibitors for treating ocular allergic conditions
JP2894445B2 (ja) * 1997-02-12 1999-05-24 日本たばこ産業株式会社 Ｃｅｔｐ活性阻害剤として有効な化合物
JP3940201B2 (ja) 1997-05-20 2007-07-04 大塚製薬株式会社 ３，３’−ジチオジベンゾヒドロキサム酸
JP3702382B2 (ja) * 1997-10-22 2005-10-05 参天製薬株式会社 ＮＦ−κＢ活性化阻害剤
AU5567501A (en) * 2000-05-19 2001-12-03 Alcon Universal Ltd Disulfide derivatives useful for treating allergic diseases
AU5380701A (en) * 2000-05-19 2001-12-03 Alcon Universal Ltd Compositions containing a benzamide disulfide derivative for treating allergic diseases
JP2002193796A (ja) * 2000-12-27 2002-07-10 Ajinomoto Co Inc 炎症因子活性化抑制剤、その用途及びそのために使用可能な新規ポリスルフィド誘導体

Also Published As

Publication number Publication date
PL365459A1 (en) 2005-01-10
ZA200208839B (en) 2004-02-03
DK1289945T3 (da) 2004-11-01
AU5722701A (en) 2001-12-03
ES2222370T3 (es) 2005-02-01
US6452052B1 (en) 2002-09-17
ATE272619T1 (de) 2004-08-15
US20020115658A1 (en) 2002-08-22
CA2408145A1 (en) 2001-11-29
WO2001090059A1 (en) 2001-11-29
JP2003534317A (ja) 2003-11-18
DE60104690D1 (de) 2004-09-09
MXPA02011480A (es) 2003-06-06
AR028565A1 (es) 2003-05-14
KR20020093982A (ko) 2002-12-16
CN1429208A (zh) 2003-07-09
EP1289945B1 (en) 2004-08-04
AU2001257227B2 (en) 2005-04-07
TR200402299T4 (tr) 2004-12-21
US6372802B2 (en) 2002-04-16
PT1289945E (pt) 2004-10-29
US20020013311A1 (en) 2002-01-31
HK1050677A1 (en) 2003-07-04
EP1289945A1 (en) 2003-03-12
CN1173697C (zh) 2004-11-03
BR0110845A (pt) 2003-02-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee