AU2001257227B2 - Aniline Disulfide Derivatives for Treating Allergic Diseases - Google Patents
Aniline Disulfide Derivatives for Treating Allergic Diseases Download PDFInfo
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- AU2001257227B2 AU2001257227B2 AU2001257227A AU2001257227A AU2001257227B2 AU 2001257227 B2 AU2001257227 B2 AU 2001257227B2 AU 2001257227 A AU2001257227 A AU 2001257227A AU 2001257227 A AU2001257227 A AU 2001257227A AU 2001257227 B2 AU2001257227 B2 AU 2001257227B2
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- Australia
- Prior art keywords
- alkyl
- substituted
- disulfide derivative
- composition
- alkenyl
- Prior art date
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- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- JCRIVQIOJSSCQD-UHFFFAOYSA-N propylhexedrine Chemical compound CNC(C)CC1CCCCC1 JCRIVQIOJSSCQD-UHFFFAOYSA-N 0.000 description 1
- 229960000786 propylhexedrine Drugs 0.000 description 1
- 229960003908 pseudoephedrine Drugs 0.000 description 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
- 229960001487 rimexolone Drugs 0.000 description 1
- QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229960000337 tetryzoline Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 201000005539 vernal conjunctivitis Diseases 0.000 description 1
- 208000018464 vernal keratoconjunctivitis Diseases 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 229960000833 xylometazoline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20574600P | 2000-05-19 | 2000-05-19 | |
| US60/205,746 | 2000-05-19 | ||
| PCT/US2001/013242 WO2001090059A1 (en) | 2000-05-19 | 2001-04-25 | Aniline disulfide derivatives for treating allergic diseases |
Publications (2)
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|---|---|
| AU2001257227A1 AU2001257227A1 (en) | 2002-02-21 |
| AU2001257227B2 true AU2001257227B2 (en) | 2005-04-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2001257227A Ceased AU2001257227B2 (en) | 2000-05-19 | 2001-04-25 | Aniline Disulfide Derivatives for Treating Allergic Diseases |
| AU5722701A Pending AU5722701A (en) | 2000-05-19 | 2001-04-25 | Aniline disulfide derivatives for treating allergic diseases |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU5722701A Pending AU5722701A (en) | 2000-05-19 | 2001-04-25 | Aniline disulfide derivatives for treating allergic diseases |
Country Status (19)
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|---|---|
| US (2) | US6372802B2 (enExample) |
| EP (1) | EP1289945B1 (enExample) |
| JP (1) | JP2003534317A (enExample) |
| KR (1) | KR20020093982A (enExample) |
| CN (1) | CN1173697C (enExample) |
| AR (1) | AR028565A1 (enExample) |
| AT (1) | ATE272619T1 (enExample) |
| AU (2) | AU2001257227B2 (enExample) |
| BR (1) | BR0110845A (enExample) |
| CA (1) | CA2408145A1 (enExample) |
| DE (1) | DE60104690T2 (enExample) |
| DK (1) | DK1289945T3 (enExample) |
| ES (1) | ES2222370T3 (enExample) |
| MX (1) | MXPA02011480A (enExample) |
| PL (1) | PL365459A1 (enExample) |
| PT (1) | PT1289945E (enExample) |
| TR (1) | TR200402299T4 (enExample) |
| WO (1) | WO2001090059A1 (enExample) |
| ZA (1) | ZA200208839B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001045668A2 (en) * | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
| WO2001045676A2 (en) * | 1999-12-20 | 2001-06-28 | Schering Corporation | Extended release oral dosage composition |
| UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| WO2006076027A2 (en) * | 2004-05-17 | 2006-07-20 | Cambrios Technology Corp. | Biofabrication of transistors including field effect transistors |
| ZA200610350B (en) * | 2004-06-28 | 2008-12-31 | Alcon Inc | Topical formulations for treating allergic diseases |
| US20130304180A1 (en) * | 2012-05-09 | 2013-11-14 | Michael L. Green | Catheter having dual balloon hydraulic actuator |
| US11058444B2 (en) | 2017-12-11 | 2021-07-13 | Covidien Lp | Electrically enhanced retrieval of material from vessel lumens |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705805A (en) * | 1978-06-16 | 1987-11-10 | Koji Yamada | Antithrombotic agent |
| WO1998035937A1 (en) * | 1997-02-12 | 1998-08-20 | Japan Tobacco Inc. | Cetp activity inhibitors |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB1232787A (enExample) | 1967-08-08 | 1971-05-19 | ||
| US3663616A (en) | 1969-10-13 | 1972-05-16 | Sherwin Williams Co | Bis(2-carbamylphenyl)disulfides |
| JPS59205356A (ja) * | 1983-05-10 | 1984-11-20 | Teikoku Hormone Mfg Co Ltd | ジスルフアニルベンゼン酢酸誘導体 |
| GB8520662D0 (en) | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| US4923892A (en) | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| JPS6310784A (ja) | 1986-03-03 | 1988-01-18 | Kyowa Hakko Kogyo Co Ltd | 抗アレルギー剤 |
| GB9020933D0 (en) | 1990-09-26 | 1990-11-07 | Ici Plc | Compound,preparation and use |
| US5859017A (en) | 1994-04-01 | 1999-01-12 | Cell Therapeutics, Inc. | Method for inhibiting mast cell and basophil activation |
| US5734081A (en) | 1994-08-05 | 1998-03-31 | Warner-Lambert Company | Arylthio compounds |
| US5463122A (en) | 1994-08-05 | 1995-10-31 | Warner-Lambert Company | Arylthio compounds |
| US6001555A (en) | 1994-09-23 | 1999-12-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein |
| JPH08253454A (ja) * | 1994-12-26 | 1996-10-01 | Nisshin Flour Milling Co Ltd | ジフェニルジスルフィド化合物 |
| JPH095926A (ja) | 1995-04-18 | 1997-01-10 | Fuji Photo Film Co Ltd | 熱現像感光材料 |
| US5641805A (en) | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
| WO1997038693A1 (en) | 1996-04-18 | 1997-10-23 | Alcon Laboratories, Inc. | Calcium channel blockers as human conjunctival mast cell degranulation inhibitors for treating ocular allergic conditions |
| JP3940201B2 (ja) | 1997-05-20 | 2007-07-04 | 大塚製薬株式会社 | ３，３’−ジチオジベンゾヒドロキサム酸 |
| JP3702382B2 (ja) * | 1997-10-22 | 2005-10-05 | 参天製薬株式会社 | ＮＦ−κＢ活性化阻害剤 |
| DK1282599T3 (da) * | 2000-05-19 | 2006-07-31 | Alcon Inc | Disulfidderivater, der er egnede til behandling af allergiske sygdomme |
| MXPA02011482A (es) * | 2000-05-19 | 2003-06-06 | Alcon Inc | Composiciones que contienen un derivado de disulfuro de benzamida para tratar enfermedades. |
| JP2002193796A (ja) * | 2000-12-27 | 2002-07-10 | Ajinomoto Co Inc | 炎症因子活性化抑制剤、その用途及びそのために使用可能な新規ポリスルフィド誘導体 |
-
2001
- 2001-04-25 ES ES01930719T patent/ES2222370T3/es not_active Expired - Lifetime
- 2001-04-25 PL PL01365459A patent/PL365459A1/xx not_active Application Discontinuation
- 2001-04-25 EP EP01930719A patent/EP1289945B1/en not_active Expired - Lifetime
- 2001-04-25 JP JP2001586248A patent/JP2003534317A/ja active Pending
- 2001-04-25 AU AU2001257227A patent/AU2001257227B2/en not_active Ceased
- 2001-04-25 AT AT01930719T patent/ATE272619T1/de not_active IP Right Cessation
- 2001-04-25 WO PCT/US2001/013242 patent/WO2001090059A1/en not_active Ceased
- 2001-04-25 KR KR1020027014931A patent/KR20020093982A/ko not_active Withdrawn
- 2001-04-25 CN CNB018094759A patent/CN1173697C/zh not_active Expired - Fee Related
- 2001-04-25 AU AU5722701A patent/AU5722701A/xx active Pending
- 2001-04-25 US US09/841,898 patent/US6372802B2/en not_active Expired - Fee Related
- 2001-04-25 PT PT01930719T patent/PT1289945E/pt unknown
- 2001-04-25 CA CA002408145A patent/CA2408145A1/en not_active Abandoned
- 2001-04-25 DK DK01930719T patent/DK1289945T3/da active
- 2001-04-25 TR TR2004/02299T patent/TR200402299T4/xx unknown
- 2001-04-25 MX MXPA02011480A patent/MXPA02011480A/es active IP Right Grant
- 2001-04-25 BR BR0110845-0A patent/BR0110845A/pt not_active IP Right Cessation
- 2001-04-25 DE DE2001604690 patent/DE60104690T2/de not_active Expired - Fee Related
- 2001-05-15 AR ARP010102302A patent/AR028565A1/es not_active Application Discontinuation
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2002
- 2002-01-31 US US10/062,377 patent/US6452052B1/en not_active Expired - Fee Related
- 2002-10-31 ZA ZA200208839A patent/ZA200208839B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705805A (en) * | 1978-06-16 | 1987-11-10 | Koji Yamada | Antithrombotic agent |
| WO1998035937A1 (en) * | 1997-02-12 | 1998-08-20 | Japan Tobacco Inc. | Cetp activity inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| J. H. Sellstedt et al, J. Med Chem., Vol 18, no. 9, 1975, p. 926-933 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1173697C (zh) | 2004-11-03 |
| US20020013311A1 (en) | 2002-01-31 |
| CA2408145A1 (en) | 2001-11-29 |
| US6372802B2 (en) | 2002-04-16 |
| AR028565A1 (es) | 2003-05-14 |
| BR0110845A (pt) | 2003-02-11 |
| KR20020093982A (ko) | 2002-12-16 |
| EP1289945A1 (en) | 2003-03-12 |
| TR200402299T4 (tr) | 2004-12-21 |
| ES2222370T3 (es) | 2005-02-01 |
| HK1050677A1 (en) | 2003-07-04 |
| JP2003534317A (ja) | 2003-11-18 |
| ZA200208839B (en) | 2004-02-03 |
| PL365459A1 (en) | 2005-01-10 |
| WO2001090059A1 (en) | 2001-11-29 |
| DE60104690D1 (de) | 2004-09-09 |
| DE60104690T2 (de) | 2005-01-13 |
| CN1429208A (zh) | 2003-07-09 |
| EP1289945B1 (en) | 2004-08-04 |
| ATE272619T1 (de) | 2004-08-15 |
| US6452052B1 (en) | 2002-09-17 |
| DK1289945T3 (da) | 2004-11-01 |
| US20020115658A1 (en) | 2002-08-22 |
| AU5722701A (en) | 2001-12-03 |
| MXPA02011480A (es) | 2003-06-06 |
| PT1289945E (pt) | 2004-10-29 |
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Legal Events
| Date | Code | Title | Description |
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| TC | Change of applicant's name (sec. 104) |
Owner name: ALCON, INC. Free format text: FORMER NAME: ALCON UNIVERSAL LTD. |
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| FGA | Letters patent sealed or granted (standard patent) |