DE60101323T2 - Tricyclische proteinkinasehemmer - Google Patents
Tricyclische proteinkinasehemmer Download PDFInfo
- Publication number
- DE60101323T2 DE60101323T2 DE60101323T DE60101323T DE60101323T2 DE 60101323 T2 DE60101323 T2 DE 60101323T2 DE 60101323 T DE60101323 T DE 60101323T DE 60101323 T DE60101323 T DE 60101323T DE 60101323 T2 DE60101323 T2 DE 60101323T2
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- compound
- neoplasm
- quinoline
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Landscapes
- Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US536919 | 1995-09-29 | ||
| US53691900A | 2000-03-28 | 2000-03-28 | |
| PCT/US2001/010124 WO2001072758A1 (en) | 2000-03-28 | 2001-03-28 | Tricyclic protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60101323D1 DE60101323D1 (de) | 2004-01-08 |
| DE60101323T2 true DE60101323T2 (de) | 2004-05-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| DE60101323T Expired - Lifetime DE60101323T2 (de) | 2000-03-28 | 2001-03-28 | Tricyclische proteinkinasehemmer |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1268487B1 (https=) |
| JP (1) | JP2003528880A (https=) |
| CN (1) | CN100369919C (https=) |
| AR (1) | AR028261A1 (https=) |
| AT (1) | ATE255114T1 (https=) |
| AU (1) | AU2001247882A1 (https=) |
| BR (1) | BR0109598A (https=) |
| CA (1) | CA2404445A1 (https=) |
| DE (1) | DE60101323T2 (https=) |
| MX (1) | MXPA02009440A (https=) |
| WO (1) | WO2001072758A1 (https=) |
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| AU2002352878B2 (en) | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| EP2543376A1 (en) | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| BRPI0610876B8 (pt) | 2005-06-08 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel |
| JP5191391B2 (ja) | 2005-11-01 | 2013-05-08 | ターゲジェン インコーポレーティッド | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| CA2699349C (en) * | 2007-09-14 | 2016-04-19 | Bayer Schering Pharma Aktiengesellschaft | Substituted tricyclic heterocyclic compounds for use as egfr inhibitors |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| AU2009238590A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| ES2598530T3 (es) * | 2010-07-14 | 2017-01-27 | Betta Pharmaceuticals Co., Ltd. | Nuevos derivados heterocíclicos condensados útiles como inhibidores de la tirosina quinasa c-Met |
| EP2975027A1 (en) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| MX363551B (es) | 2011-11-23 | 2019-03-27 | Portola Pharmaceuticals Inc Star | Compuestos derivados de pirazina como inhibidores de cinasa. |
| WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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|---|---|---|---|---|
| FR2712290A1 (fr) * | 1993-11-10 | 1995-05-19 | Pf Medicament | Oxazino-acridines substituées, leur préparation et leur application en thérapeutique. |
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
-
2001
- 2001-03-16 AR ARP010101252A patent/AR028261A1/es unknown
- 2001-03-28 JP JP2001570667A patent/JP2003528880A/ja active Pending
- 2001-03-28 AU AU2001247882A patent/AU2001247882A1/en not_active Abandoned
- 2001-03-28 AT AT01920873T patent/ATE255114T1/de not_active IP Right Cessation
- 2001-03-28 DE DE60101323T patent/DE60101323T2/de not_active Expired - Lifetime
- 2001-03-28 EP EP01920873A patent/EP1268487B1/en not_active Expired - Lifetime
- 2001-03-28 WO PCT/US2001/010124 patent/WO2001072758A1/en not_active Ceased
- 2001-03-28 BR BR0109598-6A patent/BR0109598A/pt not_active Application Discontinuation
- 2001-03-28 MX MXPA02009440A patent/MXPA02009440A/es active IP Right Grant
- 2001-03-28 CN CNB018072011A patent/CN100369919C/zh not_active Expired - Fee Related
- 2001-03-28 CA CA002404445A patent/CA2404445A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001247882A1 (en) | 2001-10-08 |
| EP1268487B1 (en) | 2003-11-26 |
| EP1268487A1 (en) | 2003-01-02 |
| CN1419559A (zh) | 2003-05-21 |
| AR028261A1 (es) | 2003-04-30 |
| ATE255114T1 (de) | 2003-12-15 |
| WO2001072758A1 (en) | 2001-10-04 |
| CN100369919C (zh) | 2008-02-20 |
| DE60101323D1 (de) | 2004-01-08 |
| JP2003528880A (ja) | 2003-09-30 |
| BR0109598A (pt) | 2003-02-04 |
| CA2404445A1 (en) | 2001-10-04 |
| MXPA02009440A (es) | 2003-02-12 |
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| 8364 | No opposition during term of opposition |