DE60100473T2 - Verwendung von neurotoxinen in medikamenten zur behandlung von thyroidstörungen - Google Patents
Verwendung von neurotoxinen in medikamenten zur behandlung von thyroidstörungen Download PDFInfo
- Publication number
- DE60100473T2 DE60100473T2 DE60100473T DE60100473T DE60100473T2 DE 60100473 T2 DE60100473 T2 DE 60100473T2 DE 60100473 T DE60100473 T DE 60100473T DE 60100473 T DE60100473 T DE 60100473T DE 60100473 T2 DE60100473 T2 DE 60100473T2
- Authority
- DE
- Germany
- Prior art keywords
- thyroid
- botulinum toxin
- neurotoxin
- type
- botulinum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002581 neurotoxin Substances 0.000 title claims description 100
- 231100000618 neurotoxin Toxicity 0.000 title claims description 99
- 208000024799 Thyroid disease Diseases 0.000 title claims description 46
- 239000003814 drug Substances 0.000 title claims description 38
- 210000001685 thyroid gland Anatomy 0.000 claims description 177
- 108030001720 Bontoxilysin Proteins 0.000 claims description 169
- 229940053031 botulinum toxin Drugs 0.000 claims description 151
- 101710138657 Neurotoxin Proteins 0.000 claims description 86
- 206010020850 Hyperthyroidism Diseases 0.000 claims description 37
- 229940079593 drug Drugs 0.000 claims description 25
- 210000000331 sympathetic ganglia Anatomy 0.000 claims description 17
- 210000003771 C cell Anatomy 0.000 claims description 13
- 241000193403 Clostridium Species 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 description 60
- 238000011282 treatment Methods 0.000 description 48
- 239000005495 thyroid hormone Substances 0.000 description 43
- 229940036555 thyroid hormone Drugs 0.000 description 43
- 208000003532 hypothyroidism Diseases 0.000 description 42
- 238000000034 method Methods 0.000 description 41
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 39
- 230000002989 hypothyroidism Effects 0.000 description 37
- 108700012359 toxins Proteins 0.000 description 36
- 101710117542 Botulinum neurotoxin type A Proteins 0.000 description 34
- 229940089093 botox Drugs 0.000 description 34
- 210000003205 muscle Anatomy 0.000 description 33
- 230000028327 secretion Effects 0.000 description 33
- 231100000765 toxin Toxicity 0.000 description 33
- 239000003053 toxin Substances 0.000 description 32
- 230000000694 effects Effects 0.000 description 30
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 29
- 238000002360 preparation method Methods 0.000 description 29
- 229940094657 botulinum toxin type a Drugs 0.000 description 26
- 208000021510 thyroid gland disease Diseases 0.000 description 26
- 210000001519 tissue Anatomy 0.000 description 25
- 230000001713 cholinergic effect Effects 0.000 description 24
- 210000002569 neuron Anatomy 0.000 description 22
- 230000002889 sympathetic effect Effects 0.000 description 19
- 208000024891 symptom Diseases 0.000 description 18
- 238000002347 injection Methods 0.000 description 17
- 239000007924 injection Substances 0.000 description 17
- 208000023328 Basedow disease Diseases 0.000 description 16
- 208000015023 Graves' disease Diseases 0.000 description 14
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 13
- 229960004373 acetylcholine Drugs 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 13
- 230000003325 follicular Effects 0.000 description 11
- 108010074523 rimabotulinumtoxinB Proteins 0.000 description 11
- 239000007927 intramuscular injection Substances 0.000 description 10
- 238000010255 intramuscular injection Methods 0.000 description 10
- 230000001734 parasympathetic effect Effects 0.000 description 10
- 230000001225 therapeutic effect Effects 0.000 description 10
- 238000002560 therapeutic procedure Methods 0.000 description 10
- 241000193155 Clostridium botulinum Species 0.000 description 9
- 241000282414 Homo sapiens Species 0.000 description 9
- 210000000609 ganglia Anatomy 0.000 description 9
- 210000002820 sympathetic nervous system Anatomy 0.000 description 9
- 230000009471 action Effects 0.000 description 8
- 210000001367 artery Anatomy 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- 238000002271 resection Methods 0.000 description 8
- 230000003248 secreting effect Effects 0.000 description 8
- 238000001356 surgical procedure Methods 0.000 description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 7
- 102000055006 Calcitonin Human genes 0.000 description 7
- 108060001064 Calcitonin Proteins 0.000 description 7
- 208000003098 Ganglion Cysts Diseases 0.000 description 7
- 208000037147 Hypercalcaemia Diseases 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 208000005400 Synovial Cyst Diseases 0.000 description 7
- 229960004015 calcitonin Drugs 0.000 description 7
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 7
- 210000002932 cholinergic neuron Anatomy 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 230000000148 hypercalcaemia Effects 0.000 description 7
- 210000005036 nerve Anatomy 0.000 description 7
- 230000001537 neural effect Effects 0.000 description 7
- 210000002990 parathyroid gland Anatomy 0.000 description 7
- 102000005962 receptors Human genes 0.000 description 7
- 108020003175 receptors Proteins 0.000 description 7
- 230000004936 stimulating effect Effects 0.000 description 7
- 206010018498 Goitre Diseases 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 206010033799 Paralysis Diseases 0.000 description 6
- 229940043671 antithyroid preparations Drugs 0.000 description 6
- 210000003195 fascia Anatomy 0.000 description 6
- 210000004907 gland Anatomy 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 230000030214 innervation Effects 0.000 description 6
- 229910052740 iodine Inorganic materials 0.000 description 6
- 239000011630 iodine Substances 0.000 description 6
- 210000000867 larynx Anatomy 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 208000013038 Hypocalcemia Diseases 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 5
- KNAHARQHSZJURB-UHFFFAOYSA-N Propylthiouracile Chemical compound CCCC1=CC(=O)NC(=S)N1 KNAHARQHSZJURB-UHFFFAOYSA-N 0.000 description 5
- 150000001413 amino acids Chemical group 0.000 description 5
- 239000003200 antithyroid agent Substances 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 238000002591 computed tomography Methods 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 230000000705 hypocalcaemia Effects 0.000 description 5
- PMRYVIKBURPHAH-UHFFFAOYSA-N methimazole Chemical compound CN1C=CNC1=S PMRYVIKBURPHAH-UHFFFAOYSA-N 0.000 description 5
- 239000002858 neurotransmitter agent Substances 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 230000002093 peripheral effect Effects 0.000 description 5
- 229960002662 propylthiouracil Drugs 0.000 description 5
- 230000002797 proteolythic effect Effects 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 230000009885 systemic effect Effects 0.000 description 5
- 210000003437 trachea Anatomy 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 4
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 108010079650 abobotulinumtoxinA Proteins 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 108010069038 botulinum toxin type F Proteins 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 230000002498 deadly effect Effects 0.000 description 4
- 230000002638 denervation Effects 0.000 description 4
- 229940098753 dysport Drugs 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 208000030915 hypercalcemia disease Diseases 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 4
- XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical compound [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 description 4
- 210000004126 nerve fiber Anatomy 0.000 description 4
- 210000000653 nervous system Anatomy 0.000 description 4
- 210000000715 neuromuscular junction Anatomy 0.000 description 4
- 229960002748 norepinephrine Drugs 0.000 description 4
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 4
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 4
- 230000000849 parathyroid Effects 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229960002178 thiamazole Drugs 0.000 description 4
- 208000005057 thyrotoxicosis Diseases 0.000 description 4
- 229940034208 thyroxine Drugs 0.000 description 4
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000003508 Botulism Diseases 0.000 description 3
- 208000003164 Diplopia Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 3
- 208000019695 Migraine disease Diseases 0.000 description 3
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 description 3
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 description 3
- 208000010428 Muscle Weakness Diseases 0.000 description 3
- 206010028372 Muscular weakness Diseases 0.000 description 3
- 108090000445 Parathyroid hormone Proteins 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 102000011923 Thyrotropin Human genes 0.000 description 3
- 108010061174 Thyrotropin Proteins 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 210000001789 adipocyte Anatomy 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 108700017751 botulinum toxin type C Proteins 0.000 description 3
- 108010069022 botulinum toxin type D Proteins 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 238000002224 dissection Methods 0.000 description 3
- 230000028023 exocytosis Effects 0.000 description 3
- 210000000744 eyelid Anatomy 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 210000004186 follicle cell Anatomy 0.000 description 3
- 230000000762 glandular Effects 0.000 description 3
- 229930195712 glutamate Natural products 0.000 description 3
- 201000003872 goiter Diseases 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000005923 long-lasting effect Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 210000002161 motor neuron Anatomy 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 210000002027 skeletal muscle Anatomy 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 210000000225 synapse Anatomy 0.000 description 3
- 210000000534 thyroid cartilage Anatomy 0.000 description 3
- 210000001364 upper extremity Anatomy 0.000 description 3
- 108060003345 Adrenergic Receptor Proteins 0.000 description 2
- 102000017910 Adrenergic receptor Human genes 0.000 description 2
- 229930003347 Atropine Natural products 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 2
- 241000193171 Clostridium butyricum Species 0.000 description 2
- 241000736355 Euthyroides Species 0.000 description 2
- 206010015997 Eyelid retraction Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 102000003982 Parathyroid hormone Human genes 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108010005730 R-SNARE Proteins Proteins 0.000 description 2
- 208000032023 Signs and Symptoms Diseases 0.000 description 2
- 208000004350 Strabismus Diseases 0.000 description 2
- 102000002215 Synaptobrevin Human genes 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 description 2
- 230000001800 adrenalinergic effect Effects 0.000 description 2
- 210000004079 adrenergic fiber Anatomy 0.000 description 2
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 2
- 229960000396 atropine Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000002876 beta blocker Substances 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 231100001103 botulinum neurotoxin Toxicity 0.000 description 2
- 108010069023 botulinum toxin type E Proteins 0.000 description 2
- 108010069071 botulinum toxin type G Proteins 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000003913 calcium metabolism Effects 0.000 description 2
- 210000001715 carotid artery Anatomy 0.000 description 2
- 230000001364 causal effect Effects 0.000 description 2
- 210000003451 celiac plexus Anatomy 0.000 description 2
- 210000005056 cell body Anatomy 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 210000003109 clavicle Anatomy 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000004190 glucose uptake Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 210000004153 islets of langerhan Anatomy 0.000 description 2
- 210000003801 laryngeal nerve Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000028018 membrane docking Effects 0.000 description 2
- 230000004630 mental health Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000002536 noncholinergic effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 210000004279 orbit Anatomy 0.000 description 2
- 239000000199 parathyroid hormone Substances 0.000 description 2
- 229960001319 parathyroid hormone Drugs 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000003518 presynaptic effect Effects 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 210000003568 synaptosome Anatomy 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 231100001274 therapeutic index Toxicity 0.000 description 2
- 231100000967 thyroidotoxicity Toxicity 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 210000001186 vagus nerve Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 230000003313 weakening effect Effects 0.000 description 2
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 1
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 description 1
- 208000003200 Adenoma Diseases 0.000 description 1
- 206010001233 Adenoma benign Diseases 0.000 description 1
- 201000010000 Agranulocytosis Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- 102100038518 Calcitonin Human genes 0.000 description 1
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000193449 Clostridium tetani Species 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 208000027534 Emotional disease Diseases 0.000 description 1
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 102000018711 Facilitative Glucose Transport Proteins Human genes 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 108091052347 Glucose transporter family Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000003807 Graves Disease Diseases 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 229940121799 Hypocalcaemic agent Drugs 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 201000006347 Intellectual Disability Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000008238 Muscle Spasticity Diseases 0.000 description 1
- 206010028665 Myxoedema Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 102100036893 Parathyroid hormone Human genes 0.000 description 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
- 208000014993 Pituitary disease Diseases 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 241000225674 Procerus Species 0.000 description 1
- 101710118538 Protease Proteins 0.000 description 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 108010010469 Qa-SNARE Proteins Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 101000930762 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) Signal recognition particle receptor FtsY Proteins 0.000 description 1
- 102000050389 Syntaxin Human genes 0.000 description 1
- 108010055044 Tetanus Toxin Proteins 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 206010044074 Torticollis Diseases 0.000 description 1
- 206010044242 Toxic nodular goitre Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 101710102828 Vesicle-associated protein Proteins 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 208000005248 Vocal Cord Paralysis Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000003916 acid precipitation Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 210000001943 adrenal medulla Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000003502 anti-nociceptive effect Effects 0.000 description 1
- 230000003208 anti-thyroid effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000002376 aorta thoracic Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- 208000010928 autoimmune thyroid disease Diseases 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 206010005159 blepharospasm Diseases 0.000 description 1
- 230000000744 blepharospasm Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 210000001540 calcitonin secreting cell Anatomy 0.000 description 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 229960001704 carbimazole Drugs 0.000 description 1
- CFOYWRHIYXMDOT-UHFFFAOYSA-N carbimazole Chemical compound CCOC(=O)N1C=CN(C)C1=S CFOYWRHIYXMDOT-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 201000002866 cervical dystonia Diseases 0.000 description 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 1
- 210000003737 chromaffin cell Anatomy 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000003685 cricoid cartilage Anatomy 0.000 description 1
- 238000011461 current therapy Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 210000000172 cytosol Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000007560 devascularization Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 208000029444 double vision Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 210000003372 endocrine gland Anatomy 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000002409 epiglottis Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 208000001936 exophthalmos Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 229960004716 idoxuridine Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229940036571 iodine therapy Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000003447 ipsilateral effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000008095 long lasting therapeutic effect Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 210000001664 manubrium Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 210000000337 motor cortex Anatomy 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- 208000003786 myxedema Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 210000001719 neurosecretory cell Anatomy 0.000 description 1
- 230000000720 neurosecretory effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 208000004235 neutropenia Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 238000002559 palpation Methods 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 210000005037 parasympathetic nerve Anatomy 0.000 description 1
- 210000005034 parasympathetic neuron Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 208000028591 pheochromocytoma Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 208000017402 pituitary gland disease Diseases 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 210000004664 postganglionic parasympathetic fiber Anatomy 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- -1 potassium cations Chemical class 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 231100000654 protein toxin Toxicity 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000002763 pyramidal cell Anatomy 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000003019 respiratory muscle Anatomy 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 210000003270 subclavian artery Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002782 sympathoadrenal effect Effects 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 229940099247 tapazole Drugs 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000000966 temporal muscle Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000009601 thyroid function test Methods 0.000 description 1
- 229940032953 thyroid therapy drug Drugs 0.000 description 1
- 208000013076 thyroid tumor Diseases 0.000 description 1
- 206010043778 thyroiditis Diseases 0.000 description 1
- 229950001470 thyrotrophin Drugs 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- ATCJTYORYKLVIA-SRXJVYAUSA-N vamp regimen Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1.C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C(C45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 ATCJTYORYKLVIA-SRXJVYAUSA-N 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/504,538 US6524580B1 (en) | 2000-02-15 | 2000-02-15 | Method for treating thyroid disorders |
| US504538 | 2000-02-15 | ||
| PCT/US2001/004990 WO2001060396A2 (en) | 2000-02-15 | 2001-02-15 | Method for treating thyroid disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60100473D1 DE60100473D1 (de) | 2003-08-21 |
| DE60100473T2 true DE60100473T2 (de) | 2004-04-15 |
Family
ID=24006701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60100473T Expired - Lifetime DE60100473T2 (de) | 2000-02-15 | 2001-02-15 | Verwendung von neurotoxinen in medikamenten zur behandlung von thyroidstörungen |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US6524580B1 (enExample) |
| EP (1) | EP1253933B1 (enExample) |
| JP (2) | JP2003530320A (enExample) |
| AR (1) | AR027442A1 (enExample) |
| AT (1) | ATE245032T1 (enExample) |
| AU (1) | AU2001238369A1 (enExample) |
| DE (1) | DE60100473T2 (enExample) |
| ES (1) | ES2199209T3 (enExample) |
| TW (1) | TWI283177B (enExample) |
| WO (1) | WO2001060396A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001056594A1 (en) | 2000-02-04 | 2001-08-09 | Unigene Laboratories, Inc. | Nasal calcitonin formulations |
| US6821520B2 (en) * | 2000-02-15 | 2004-11-23 | Allergan, Inc. | Clostridial toxin therapy for Hashimoto's thyroiditis |
| US6773711B2 (en) * | 2000-02-15 | 2004-08-10 | Allergan, Inc. | Botulinum toxin therapy for Hashimoto's thyroiditis |
| US6524580B1 (en) * | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
| US8563257B2 (en) | 2000-03-30 | 2013-10-22 | Diagnostic Hybrids, Inc. | Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity |
| US8293879B2 (en) | 2000-03-30 | 2012-10-23 | Diagnostic Hybrids, Inc. | Methods of using chimeric receptors to identify autoimmune disease |
| JP2004521067A (ja) * | 2000-06-28 | 2004-07-15 | サンダース，イラ | 動物（哺乳動物）における有用な用途を目的とする破傷風毒素の使用方法 |
| US6921538B2 (en) * | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
| US7178059B2 (en) * | 2003-05-07 | 2007-02-13 | Egenera, Inc. | Disaster recovery for processing resources using configurable deployment platform |
| US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| EP1751284A4 (en) * | 2003-12-19 | 2010-01-13 | Wisconsin Alumni Res Found | METHOD AND COMPOSITIONS FOR DETECTING BOTULINUM NEUROTOXINE |
| US7811584B2 (en) * | 2004-06-30 | 2010-10-12 | Allergan, Inc. | Multivalent clostridial toxins |
| US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
| WO2006026780A1 (en) | 2004-09-01 | 2006-03-09 | Allergan, Inc. | Degradable clostridial toxins |
| US8052979B2 (en) | 2005-03-15 | 2011-11-08 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
| US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
| US10052465B2 (en) | 2005-07-22 | 2018-08-21 | The Foundry, Llc | Methods and systems for toxin delivery to the nasal cavity |
| US12433837B2 (en) | 2005-07-22 | 2025-10-07 | The Foundry, Llc | Systems and methods for delivery of a therapeutic agent |
| US7608275B2 (en) | 2005-07-22 | 2009-10-27 | The Foundry, Llc | Systems and methods for delivery of a therapeutic agent |
| US7655243B2 (en) | 2005-07-22 | 2010-02-02 | The Foundry, Llc | Methods and systems for toxin delivery to the nasal cavity |
| US7708699B2 (en) * | 2005-11-18 | 2010-05-04 | Daag International, Inc. | Reflexometry and hormone function |
| US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
| US8470337B2 (en) * | 2008-03-13 | 2013-06-25 | Allergan, Inc. | Therapeutic treatments using botulinum neurotoxin |
| US8088127B2 (en) | 2008-05-09 | 2012-01-03 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| RU2446791C2 (ru) * | 2009-06-18 | 2012-04-10 | Федеральное государственное учреждение "Северо-Западный окружной медицинский центр Минздравсоцразвития" | Способ этаноловой склеротерапии кистозно-трансформированных узлов щитовидной железы |
| CN112089394A (zh) | 2009-10-27 | 2020-12-18 | 努瓦拉公司 | 具有可冷却的能量发射组件的递送装置 |
| US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| EP2498705B1 (en) | 2009-11-11 | 2014-10-15 | Holaira, Inc. | Device for treating tissue and controlling stenosis |
| US9011323B2 (en) * | 2010-10-08 | 2015-04-21 | Invuity, Inc. | Method and apparatus for soft tissue retraction |
| JP6470678B2 (ja) | 2012-04-13 | 2019-02-13 | ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド | ニューロンの開口分泌を阻害する化合物（ｉｉ） |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| US9005628B2 (en) | 2012-10-04 | 2015-04-14 | Dublin City University | Biotherapy for pain |
| US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
| GB201312317D0 (en) | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| US9216210B2 (en) | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
| RU2733493C2 (ru) | 2015-01-09 | 2020-10-02 | Ипсен Байоинновейшн Лимитед | Катионные нейротоксины |
| EP3288626B8 (en) | 2015-04-27 | 2025-12-10 | Tulavi Therapeutics, Inc. | Substances and compositions for use in blocking nerve regeneration |
| GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| GB201607901D0 (en) | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| EP3263710A1 (en) | 2016-07-01 | 2018-01-03 | Ipsen Biopharm Limited | Production of activated clostridial neurotoxins |
| US20210277071A1 (en) | 2016-09-29 | 2021-09-09 | Ipsen Biopharm Limited | Hybrid neurotoxins |
| CN111465352B (zh) | 2018-02-26 | 2024-04-12 | 益普生生物制药有限公司 | 使用超声波引导非细胞毒性蛋白酶的注射 |
| DE102019215585B4 (de) * | 2019-10-10 | 2022-02-17 | KCM Egészségügyi és Tudományos Korlátolt Felelösségü Társaság | Verfahren zur prävention von strahlenschäden in humanen drüsen |
| GB202103372D0 (en) | 2021-03-11 | 2021-04-28 | Ipsen Biopharm Ltd | Modified clostridial neurotoxins |
| AU2022252296A1 (en) | 2021-03-30 | 2023-09-21 | Tulavi Therapeutics, Inc. | Methods and compositions for the ablation of nerves |
| GB202318884D0 (en) | 2023-12-11 | 2024-01-24 | Ipsen Biopharm Ltd | Formulation |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022544A (en) | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
| US5786348A (en) * | 1991-01-08 | 1998-07-28 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
| WO1994006452A1 (en) | 1992-09-21 | 1994-03-31 | The Upjohn Company | Sustained-release protein formulations |
| JPH08503950A (ja) | 1992-12-02 | 1996-04-30 | アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド | 徐放性成長ホルモン含有マイクロスフェア |
| DE69429619T2 (de) * | 1993-06-10 | 2002-09-12 | Allergan, Inc. | Behandlung von neuromusculaeren stoerungen und zustaenden mit botulism serotyp e |
| US5437291A (en) | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| DE69434443T2 (de) * | 1993-12-28 | 2006-05-24 | Allergan, Inc., Irvine | Verwendung der neutrotoxischen Komponente des Botulinum Toxins zur Muskelschmerzbehandlung |
| US5766605A (en) | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| US6007843A (en) | 1995-09-29 | 1999-12-28 | Lam Pharmaceuticals Corp. | Sustained release delivery system |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| ATE314085T1 (de) | 1997-07-15 | 2006-01-15 | Univ Colorado | Verwendung von botulinumtoxin zur behandlung von harninkontinenz |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| US6022554A (en) | 1997-12-15 | 2000-02-08 | American Home Products Corporation | Polymeric microporous film coated subcutaneous implant |
| GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
| US6432723B1 (en) * | 1999-01-22 | 2002-08-13 | Clinical Micro Sensors, Inc. | Biosensors utilizing ligand induced conformation changes |
| US6524580B1 (en) * | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
| US6358513B1 (en) * | 2000-02-15 | 2002-03-19 | Allergan Sales, Inc. | Method for treating Hashimoto's thyroiditis |
| US6328977B1 (en) * | 2000-02-22 | 2001-12-11 | Allergan Sales, Inc. | Method for treating hyperparathyroidism |
| US6432623B1 (en) * | 2001-04-27 | 2002-08-13 | Eastman Kodak Company | Method for processing a photographic element comprising a simultaneously coated protective overcoat |
-
2000
- 2000-02-15 US US09/504,538 patent/US6524580B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,211 patent/US6740321B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,215 patent/US6716427B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,173 patent/US6585970B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,172 patent/US6743424B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,174 patent/US6447785B1/en not_active Expired - Fee Related
-
2001
- 2001-02-14 TW TW090103247A patent/TWI283177B/zh not_active IP Right Cessation
- 2001-02-15 AT AT01910800T patent/ATE245032T1/de not_active IP Right Cessation
- 2001-02-15 AU AU2001238369A patent/AU2001238369A1/en not_active Abandoned
- 2001-02-15 WO PCT/US2001/004990 patent/WO2001060396A2/en not_active Ceased
- 2001-02-15 EP EP01910800A patent/EP1253933B1/en not_active Expired - Lifetime
- 2001-02-15 ES ES01910800T patent/ES2199209T3/es not_active Expired - Lifetime
- 2001-02-15 DE DE60100473T patent/DE60100473T2/de not_active Expired - Lifetime
- 2001-02-15 AR ARP010100698A patent/AR027442A1/es unknown
- 2001-02-15 JP JP2001559492A patent/JP2003530320A/ja active Pending
-
2012
- 2012-06-28 JP JP2012145866A patent/JP2012207030A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001060396A2 (en) | 2001-08-23 |
| US6716427B1 (en) | 2004-04-06 |
| US6743424B1 (en) | 2004-06-01 |
| TWI283177B (en) | 2007-07-01 |
| ATE245032T1 (de) | 2003-08-15 |
| US6585970B1 (en) | 2003-07-01 |
| EP1253933A2 (en) | 2002-11-06 |
| US6740321B1 (en) | 2004-05-25 |
| DE60100473D1 (de) | 2003-08-21 |
| AU2001238369A1 (en) | 2001-08-27 |
| ES2199209T3 (es) | 2004-02-16 |
| JP2003530320A (ja) | 2003-10-14 |
| WO2001060396A3 (en) | 2002-03-14 |
| US6447785B1 (en) | 2002-09-10 |
| US6524580B1 (en) | 2003-02-25 |
| AR027442A1 (es) | 2003-03-26 |
| EP1253933B1 (en) | 2003-07-16 |
| JP2012207030A (ja) | 2012-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60100473T2 (de) | Verwendung von neurotoxinen in medikamenten zur behandlung von thyroidstörungen | |
| DE60007001T2 (de) | Neurotoxine zur behandlung von pankreatischen krankheiten | |
| DE60103770T2 (de) | Botulinumtoxin zur behandlung endokriner erkrankungen | |
| DE60128899T2 (de) | Verwendung eines botulinumtoxins zur herstellung eines arzneimittels zur peripheren behandlung von schmerzen, die nicht mit muskelspasmen oder kopfschmerzen in verbindung stehen | |
| DE602004008329T2 (de) | Botulinustoxin-therapie für hauterkrankungen | |
| DE60310400T2 (de) | Botulinustoxine zur behandlung von priapismus | |
| DE60016794T2 (de) | Intraspinale botulinus-toxin-enthaltende verbindungen zur schmerzbehandlung | |
| US6358513B1 (en) | Method for treating Hashimoto's thyroiditis | |
| DE60102016T2 (de) | Verfahren zur behandlung von beweggungsstörungen | |
| US6350455B1 (en) | Method for treating a catecholamine secretion | |
| DE60306505T2 (de) | Verfahren zur behandlung von brustdrüsenerkrankungen | |
| US20010023243A1 (en) | Method for treating parathyroid disorders | |
| US6773711B2 (en) | Botulinum toxin therapy for Hashimoto's thyroiditis | |
| US6974579B2 (en) | Methods for treating vascular disorders | |
| WO2002009743A1 (en) | Method for treating a neoplasm | |
| JP2020520971A (ja) | ボツリヌス毒素及びヒアルロン酸を含む足部痛疾患の治療用薬学的組成物及びこれを利用した足部痛疾患の治療方法 | |
| CN101027083A (zh) | 梭状芽孢杆菌神经毒素在组织愈合中的用途 | |
| US6821520B2 (en) | Clostridial toxin therapy for Hashimoto's thyroiditis | |
| DE69525728T2 (de) | Verminderung des Fettgewebes durch Verwendung von Kollagenase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |