TWI283177B - New use of neurotoxin for treating thyroid and calcemia disorders - Google Patents
New use of neurotoxin for treating thyroid and calcemia disorders Download PDFInfo
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- TWI283177B TWI283177B TW090103247A TW90103247A TWI283177B TW I283177 B TWI283177 B TW I283177B TW 090103247 A TW090103247 A TW 090103247A TW 90103247 A TW90103247 A TW 90103247A TW I283177 B TWI283177 B TW I283177B
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- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| US09/504,538 US6524580B1 (en) | 2000-02-15 | 2000-02-15 | Method for treating thyroid disorders |
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| ES (1) | ES2199209T3 (enExample) |
| TW (1) | TWI283177B (enExample) |
| WO (1) | WO2001060396A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114746107A (zh) * | 2019-10-10 | 2022-07-12 | 梅尔兹治疗有限公司 | 用于预防人腺体遭受放射损伤的方法 |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001056594A1 (en) | 2000-02-04 | 2001-08-09 | Unigene Laboratories, Inc. | Nasal calcitonin formulations |
| US6821520B2 (en) * | 2000-02-15 | 2004-11-23 | Allergan, Inc. | Clostridial toxin therapy for Hashimoto's thyroiditis |
| US6773711B2 (en) * | 2000-02-15 | 2004-08-10 | Allergan, Inc. | Botulinum toxin therapy for Hashimoto's thyroiditis |
| US6524580B1 (en) * | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
| US8563257B2 (en) | 2000-03-30 | 2013-10-22 | Diagnostic Hybrids, Inc. | Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity |
| US8293879B2 (en) | 2000-03-30 | 2012-10-23 | Diagnostic Hybrids, Inc. | Methods of using chimeric receptors to identify autoimmune disease |
| JP2004521067A (ja) * | 2000-06-28 | 2004-07-15 | サンダース，イラ | 動物（哺乳動物）における有用な用途を目的とする破傷風毒素の使用方法 |
| US6921538B2 (en) * | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
| US7178059B2 (en) * | 2003-05-07 | 2007-02-13 | Egenera, Inc. | Disaster recovery for processing resources using configurable deployment platform |
| US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| EP1751284A4 (en) * | 2003-12-19 | 2010-01-13 | Wisconsin Alumni Res Found | METHOD AND COMPOSITIONS FOR DETECTING BOTULINUM NEUROTOXINE |
| US7811584B2 (en) * | 2004-06-30 | 2010-10-12 | Allergan, Inc. | Multivalent clostridial toxins |
| US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
| WO2006026780A1 (en) | 2004-09-01 | 2006-03-09 | Allergan, Inc. | Degradable clostridial toxins |
| US8052979B2 (en) | 2005-03-15 | 2011-11-08 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
| US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
| US10052465B2 (en) | 2005-07-22 | 2018-08-21 | The Foundry, Llc | Methods and systems for toxin delivery to the nasal cavity |
| US12433837B2 (en) | 2005-07-22 | 2025-10-07 | The Foundry, Llc | Systems and methods for delivery of a therapeutic agent |
| US7608275B2 (en) | 2005-07-22 | 2009-10-27 | The Foundry, Llc | Systems and methods for delivery of a therapeutic agent |
| US7655243B2 (en) | 2005-07-22 | 2010-02-02 | The Foundry, Llc | Methods and systems for toxin delivery to the nasal cavity |
| US7708699B2 (en) * | 2005-11-18 | 2010-05-04 | Daag International, Inc. | Reflexometry and hormone function |
| US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
| US8470337B2 (en) * | 2008-03-13 | 2013-06-25 | Allergan, Inc. | Therapeutic treatments using botulinum neurotoxin |
| US8088127B2 (en) | 2008-05-09 | 2012-01-03 | Innovative Pulmonary Solutions, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
| RU2446791C2 (ru) * | 2009-06-18 | 2012-04-10 | Федеральное государственное учреждение "Северо-Западный окружной медицинский центр Минздравсоцразвития" | Способ этаноловой склеротерапии кистозно-трансформированных узлов щитовидной железы |
| CN112089394A (zh) | 2009-10-27 | 2020-12-18 | 努瓦拉公司 | 具有可冷却的能量发射组件的递送装置 |
| US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
| EP2498705B1 (en) | 2009-11-11 | 2014-10-15 | Holaira, Inc. | Device for treating tissue and controlling stenosis |
| US9011323B2 (en) * | 2010-10-08 | 2015-04-21 | Invuity, Inc. | Method and apparatus for soft tissue retraction |
| JP6470678B2 (ja) | 2012-04-13 | 2019-02-13 | ルブリゾル アドバンスド マテリアルズ， インコーポレイテッド | ニューロンの開口分泌を阻害する化合物（ｉｉ） |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| US9005628B2 (en) | 2012-10-04 | 2015-04-14 | Dublin City University | Biotherapy for pain |
| US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
| GB201312317D0 (en) | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
| US9216210B2 (en) | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
| RU2733493C2 (ru) | 2015-01-09 | 2020-10-02 | Ипсен Байоинновейшн Лимитед | Катионные нейротоксины |
| EP3288626B8 (en) | 2015-04-27 | 2025-12-10 | Tulavi Therapeutics, Inc. | Substances and compositions for use in blocking nerve regeneration |
| GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| GB201607901D0 (en) | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| EP3263710A1 (en) | 2016-07-01 | 2018-01-03 | Ipsen Biopharm Limited | Production of activated clostridial neurotoxins |
| US20210277071A1 (en) | 2016-09-29 | 2021-09-09 | Ipsen Biopharm Limited | Hybrid neurotoxins |
| CN111465352B (zh) | 2018-02-26 | 2024-04-12 | 益普生生物制药有限公司 | 使用超声波引导非细胞毒性蛋白酶的注射 |
| GB202103372D0 (en) | 2021-03-11 | 2021-04-28 | Ipsen Biopharm Ltd | Modified clostridial neurotoxins |
| AU2022252296A1 (en) | 2021-03-30 | 2023-09-21 | Tulavi Therapeutics, Inc. | Methods and compositions for the ablation of nerves |
| GB202318884D0 (en) | 2023-12-11 | 2024-01-24 | Ipsen Biopharm Ltd | Formulation |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022544A (en) | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
| US5786348A (en) * | 1991-01-08 | 1998-07-28 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2 |
| WO1994006452A1 (en) | 1992-09-21 | 1994-03-31 | The Upjohn Company | Sustained-release protein formulations |
| JPH08503950A (ja) | 1992-12-02 | 1996-04-30 | アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド | 徐放性成長ホルモン含有マイクロスフェア |
| DE69429619T2 (de) * | 1993-06-10 | 2002-09-12 | Allergan, Inc. | Behandlung von neuromusculaeren stoerungen und zustaenden mit botulism serotyp e |
| US5437291A (en) | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| DE69434443T2 (de) * | 1993-12-28 | 2006-05-24 | Allergan, Inc., Irvine | Verwendung der neutrotoxischen Komponente des Botulinum Toxins zur Muskelschmerzbehandlung |
| US5766605A (en) | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| US6007843A (en) | 1995-09-29 | 1999-12-28 | Lam Pharmaceuticals Corp. | Sustained release delivery system |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| ATE314085T1 (de) | 1997-07-15 | 2006-01-15 | Univ Colorado | Verwendung von botulinumtoxin zur behandlung von harninkontinenz |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| US6022554A (en) | 1997-12-15 | 2000-02-08 | American Home Products Corporation | Polymeric microporous film coated subcutaneous implant |
| GB9818548D0 (en) | 1998-08-25 | 1998-10-21 | Microbiological Res Authority | Treatment of mucas hypersecretion |
| US6432723B1 (en) * | 1999-01-22 | 2002-08-13 | Clinical Micro Sensors, Inc. | Biosensors utilizing ligand induced conformation changes |
| US6524580B1 (en) * | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
| US6358513B1 (en) * | 2000-02-15 | 2002-03-19 | Allergan Sales, Inc. | Method for treating Hashimoto's thyroiditis |
| US6328977B1 (en) * | 2000-02-22 | 2001-12-11 | Allergan Sales, Inc. | Method for treating hyperparathyroidism |
| US6432623B1 (en) * | 2001-04-27 | 2002-08-13 | Eastman Kodak Company | Method for processing a photographic element comprising a simultaneously coated protective overcoat |
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2000
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- 2000-11-02 US US09/706,211 patent/US6740321B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,215 patent/US6716427B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,173 patent/US6585970B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,172 patent/US6743424B1/en not_active Expired - Fee Related
- 2000-11-02 US US09/706,174 patent/US6447785B1/en not_active Expired - Fee Related
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2001
- 2001-02-14 TW TW090103247A patent/TWI283177B/zh not_active IP Right Cessation
- 2001-02-15 AT AT01910800T patent/ATE245032T1/de not_active IP Right Cessation
- 2001-02-15 AU AU2001238369A patent/AU2001238369A1/en not_active Abandoned
- 2001-02-15 WO PCT/US2001/004990 patent/WO2001060396A2/en not_active Ceased
- 2001-02-15 EP EP01910800A patent/EP1253933B1/en not_active Expired - Lifetime
- 2001-02-15 ES ES01910800T patent/ES2199209T3/es not_active Expired - Lifetime
- 2001-02-15 DE DE60100473T patent/DE60100473T2/de not_active Expired - Lifetime
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- 2001-02-15 JP JP2001559492A patent/JP2003530320A/ja active Pending
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2012
- 2012-06-28 JP JP2012145866A patent/JP2012207030A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114746107A (zh) * | 2019-10-10 | 2022-07-12 | 梅尔兹治疗有限公司 | 用于预防人腺体遭受放射损伤的方法 |
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| WO2001060396A2 (en) | 2001-08-23 |
| US6716427B1 (en) | 2004-04-06 |
| US6743424B1 (en) | 2004-06-01 |
| ATE245032T1 (de) | 2003-08-15 |
| US6585970B1 (en) | 2003-07-01 |
| EP1253933A2 (en) | 2002-11-06 |
| US6740321B1 (en) | 2004-05-25 |
| DE60100473D1 (de) | 2003-08-21 |
| AU2001238369A1 (en) | 2001-08-27 |
| ES2199209T3 (es) | 2004-02-16 |
| JP2003530320A (ja) | 2003-10-14 |
| WO2001060396A3 (en) | 2002-03-14 |
| US6447785B1 (en) | 2002-09-10 |
| US6524580B1 (en) | 2003-02-25 |
| DE60100473T2 (de) | 2004-04-15 |
| AR027442A1 (es) | 2003-03-26 |
| EP1253933B1 (en) | 2003-07-16 |
| JP2012207030A (ja) | 2012-10-25 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |