DE60044365D1 - Loid-ablagerung - Google Patents
Loid-ablagerungInfo
- Publication number
- DE60044365D1 DE60044365D1 DE60044365T DE60044365T DE60044365D1 DE 60044365 D1 DE60044365 D1 DE 60044365D1 DE 60044365 T DE60044365 T DE 60044365T DE 60044365 T DE60044365 T DE 60044365T DE 60044365 D1 DE60044365 D1 DE 60044365D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- compositions
- iapp
- deposits
- amyloid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 abstract 4
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 abstract 4
- 230000003941 amyloidogenesis Effects 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 206010002022 amyloidosis Diseases 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000004153 islets of langerhan Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13554599P | 1999-05-24 | 1999-05-24 | |
US14312399P | 1999-07-09 | 1999-07-09 | |
US09/576,677 US6562836B1 (en) | 1999-05-24 | 2000-05-23 | Methods and compounds for inhibiting amyloid deposits |
PCT/CA2000/000607 WO2000071101A2 (en) | 1999-05-24 | 2000-05-24 | Methods and compounds for inhibiting amyloid deposits |
Publications (1)
Publication Number | Publication Date |
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DE60044365D1 true DE60044365D1 (de) | 2010-06-17 |
Family
ID=27384726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60044365T Expired - Lifetime DE60044365D1 (de) | 1999-05-24 | 2000-05-24 | Loid-ablagerung |
Country Status (13)
Country | Link |
---|---|
US (3) | US6562836B1 (de) |
EP (1) | EP1227803B1 (de) |
JP (1) | JP2003500350A (de) |
CN (1) | CN100435785C (de) |
AT (1) | ATE466571T1 (de) |
AU (1) | AU4905000A (de) |
CA (2) | CA2684016A1 (de) |
DE (1) | DE60044365D1 (de) |
HK (1) | HK1050133A1 (de) |
IL (3) | IL146681A0 (de) |
MX (1) | MXPA01011989A (de) |
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2000
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- 2000-05-24 IL IL14668100A patent/IL146681A0/xx active IP Right Grant
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- 2000-05-24 DE DE60044365T patent/DE60044365D1/de not_active Expired - Lifetime
- 2000-05-24 EP EP00930923A patent/EP1227803B1/de not_active Expired - Lifetime
- 2000-05-24 CA CA002373093A patent/CA2373093C/en not_active Expired - Fee Related
- 2000-05-24 WO PCT/CA2000/000607 patent/WO2000071101A2/en active Application Filing
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US6562836B1 (en) | 2003-05-13 |
US7786174B2 (en) | 2010-08-31 |
US20040248876A1 (en) | 2004-12-09 |
ATE466571T1 (de) | 2010-05-15 |
EP1227803B1 (de) | 2010-05-05 |
WO2000071101A3 (en) | 2001-12-06 |
IL146681A0 (en) | 2002-07-25 |
NZ552354A (en) | 2008-04-30 |
MXPA01011989A (es) | 2002-05-06 |
NZ541238A (en) | 2007-02-23 |
CN100435785C (zh) | 2008-11-26 |
IL146681A (en) | 2007-12-03 |
IL180523A0 (en) | 2009-02-11 |
HK1050133A1 (zh) | 2003-06-13 |
CA2373093A1 (en) | 2000-11-30 |
EP1227803A2 (de) | 2002-08-07 |
US20080227767A1 (en) | 2008-09-18 |
CN1377260A (zh) | 2002-10-30 |
CA2684016A1 (en) | 2000-11-30 |
JP2003500350A (ja) | 2003-01-07 |
AU4905000A (en) | 2000-12-12 |
US7393875B2 (en) | 2008-07-01 |
NZ566739A (en) | 2009-10-30 |
WO2000071101A2 (en) | 2000-11-30 |
CA2373093C (en) | 2010-01-19 |
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