DE60041491D1 - Erkennung, lokalisierung und zielen von internen stellen in vivo mit optischen kontrastmitteln - Google Patents

Erkennung, lokalisierung und zielen von internen stellen in vivo mit optischen kontrastmitteln

Info

Publication number
DE60041491D1
DE60041491D1 DE60041491T DE60041491T DE60041491D1 DE 60041491 D1 DE60041491 D1 DE 60041491D1 DE 60041491 T DE60041491 T DE 60041491T DE 60041491 T DE60041491 T DE 60041491T DE 60041491 D1 DE60041491 D1 DE 60041491D1
Authority
DE
Germany
Prior art keywords
contrast
optical contrast
localization
objectives
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041491T
Other languages
English (en)
Inventor
David A Benaron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spectros Corp
Original Assignee
Spectros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23182660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60041491(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Spectros Corp filed Critical Spectros Corp
Application granted granted Critical
Publication of DE60041491D1 publication Critical patent/DE60041491D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4375—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the male reproductive system
    • A61B5/4381—Prostate evaluation or disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/849—Manufacture, treatment, or detection of nanostructure with scanning probe
    • Y10S977/86—Scanning probe structure
    • Y10S977/868—Scanning probe structure with optical means
    • Y10S977/869—Optical microscope
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
DE60041491T 1999-05-05 2000-03-28 Erkennung, lokalisierung und zielen von internen stellen in vivo mit optischen kontrastmitteln Expired - Lifetime DE60041491D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/305,855 US6167297A (en) 1999-05-05 1999-05-05 Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
PCT/US2000/008151 WO2000068665A1 (en) 1999-05-05 2000-03-28 Detecting, localizing, and targeting internal sites in vivo using optical contrast agents

Publications (1)

Publication Number Publication Date
DE60041491D1 true DE60041491D1 (de) 2009-03-19

Family

ID=23182660

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041491T Expired - Lifetime DE60041491D1 (de) 1999-05-05 2000-03-28 Erkennung, lokalisierung und zielen von internen stellen in vivo mit optischen kontrastmitteln

Country Status (7)

Country Link
US (2) US6167297A (de)
EP (2) EP2048504A1 (de)
JP (2) JP4340392B2 (de)
AT (1) ATE422048T1 (de)
AU (1) AU3926900A (de)
DE (1) DE60041491D1 (de)
WO (1) WO2000068665A1 (de)

Families Citing this family (281)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6378809B1 (en) 1997-10-10 2002-04-30 Space Systems AFT deployable thermal radiators for spacecraft
US6607829B1 (en) 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
ATE468068T1 (de) 1998-07-04 2010-06-15 Whitland Res Ltd Unblutige messung von analyten aus blut
EP0979635A2 (de) 1998-08-12 2000-02-16 Origin Medsystems, Inc. Gewebedissektor
JP4488259B2 (ja) * 1999-09-13 2010-06-23 オリンパス株式会社 量子ドット観察装置
US6915154B1 (en) * 1999-09-24 2005-07-05 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
US20050182434A1 (en) * 2000-08-11 2005-08-18 National Research Council Of Canada Method and apparatus for performing intra-operative angiography
CA2286447C (en) * 1999-10-15 2009-01-06 Vittorio Accomazzi Perspective with shear warp
US6553356B1 (en) * 1999-12-23 2003-04-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Multi-view computer-assisted diagnosis
JP2003530544A (ja) * 2000-01-04 2003-10-14 アイメトリクス インコーポレイティッド 血管内画像処理検出器
US6494363B1 (en) * 2000-01-13 2002-12-17 Ncr Corporation Self-service terminal
AU769396B2 (en) * 2000-03-31 2004-01-22 Lic Automation Limited Method and apparatus for detecting mastitis by using visible light and/or near infrared light
US6869430B2 (en) 2000-03-31 2005-03-22 Rita Medical Systems, Inc. Tissue biopsy and treatment apparatus and method
JP2001299676A (ja) * 2000-04-25 2001-10-30 Fuji Photo Film Co Ltd センチネルリンパ節検出方法および検出システム
AU2001253654A1 (en) * 2000-04-27 2001-11-12 Medtronic, Inc. Vibration sensitive ablation apparatus and method
US6748259B1 (en) * 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US7826889B2 (en) * 2000-08-21 2010-11-02 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8489176B1 (en) 2000-08-21 2013-07-16 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8909325B2 (en) 2000-08-21 2014-12-09 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8036731B2 (en) * 2001-01-22 2011-10-11 Spectrum Dynamics Llc Ingestible pill for diagnosing a gastrointestinal tract
WO2004042546A1 (en) * 2002-11-04 2004-05-21 V-Target Technologies Ltd. Apparatus and methods for imaging and attenuation correction
US8565860B2 (en) 2000-08-21 2013-10-22 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system
JP2002095663A (ja) * 2000-09-26 2002-04-02 Fuji Photo Film Co Ltd センチネルリンパ節光断層画像取得方法および装置
US6558313B1 (en) 2000-11-17 2003-05-06 Embro Corporation Vein harvesting system and method
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
GB0031566D0 (en) * 2000-12-22 2001-02-07 Mets Ometrix Methods for spectral analysis and their applications
AU2002243602A1 (en) * 2001-01-19 2002-07-30 U.S. Army Medical Research And Materiel Command A method and apparatus for generating two-dimensional images of cervical tissue from three-dimensional hyperspectral cubes
IL157007A0 (en) * 2001-01-22 2004-02-08 Target Technologies Ltd V Ingestible device
EP1390077B1 (de) 2001-05-02 2014-07-16 Purdue Research Foundation Behandlung und diagnose vom makrophagen-vermittelter erkrankung
US7403812B2 (en) 2001-05-17 2008-07-22 Xenogen Corporation Method and apparatus for determining target depth, brightness and size within a body region
AU2002327180A1 (en) * 2001-06-04 2003-01-21 The General Hospital Corporation Detection and therapy of vulnerable plaque with photodynamic compounds
JP4842509B2 (ja) * 2001-06-19 2011-12-21 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 侵襲性カテーテルの配置用の光学的案内システム
US7992573B2 (en) * 2001-06-19 2011-08-09 The Trustees Of The University Of Pennsylvania Optically guided system for precise placement of a medical catheter in a patient
US6965793B2 (en) * 2001-06-28 2005-11-15 Chemimage Corporation Method for Raman chemical imaging of endogenous chemicals to reveal tissue lesion boundaries in tissue
US8078268B2 (en) 2001-06-28 2011-12-13 Chemimage Corporation System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery
US20050203578A1 (en) * 2001-08-15 2005-09-15 Weiner Michael L. Process and apparatus for treating biological organisms
US20030045798A1 (en) * 2001-09-04 2003-03-06 Richard Hular Multisensor probe for tissue identification
US6939310B2 (en) 2001-10-10 2005-09-06 Lifescan, Inc. Devices for physiological fluid sampling and methods of using the same
DE10151670A1 (de) * 2001-10-19 2003-05-08 Siemens Ag Bildgebungsverfahren und Bildgebungsvorrichtung, insbesondere für die Kleintierbildgebung
US7505811B2 (en) 2001-11-19 2009-03-17 Dune Medical Devices Ltd. Method and apparatus for examining tissue for predefined target cells, particularly cancerous cells, and a probe useful in such method and apparatus
US8116845B2 (en) 2005-08-04 2012-02-14 Dune Medical Devices Ltd. Tissue-characterization probe with effective sensor-to-tissue contact
US8721565B2 (en) 2005-08-04 2014-05-13 Dune Medical Devices Ltd. Device for forming an effective sensor-to-tissue contact
US8019411B2 (en) 2002-01-04 2011-09-13 Dune Medical Devices Ltd. Probes, systems, and methods for examining tissue according to the dielectric properties thereof
US8032211B2 (en) 2002-01-04 2011-10-04 Dune Medical Devices Ltd. Probes, systems, and methods for examining tissue according to the dielectric properties thereof
WO2005089065A2 (en) 2004-03-23 2005-09-29 Dune Medical Devices Ltd. Clean margin assessment tool
US7809425B2 (en) 2003-07-24 2010-10-05 Dune Medical Devices Ltd. Method and apparatus for examining a substance, particularly tissue, to characterize its type
US8043602B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8043603B2 (en) * 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
JP4381820B2 (ja) * 2002-03-11 2009-12-09 ポーリスツィン、ジャヌス・ビー 生体組織検査用マイクロ抽出装置
US9870907B2 (en) 2002-03-11 2018-01-16 Jp Scientific Limited Probe for extraction of molecules of interest from a sample
US8598325B2 (en) 2002-03-11 2013-12-03 Janusz B. Pawliszyn Solid-phase microextraction coatings and methods for their preparation
US20090026122A1 (en) 2002-03-11 2009-01-29 Janusz Biocompatible solid-phase microextraction coatings and methods for their preparation
US9733234B2 (en) 2002-03-11 2017-08-15 Jp Scientific Limited Probe for extraction of molecules of interest from a sample
US7232689B2 (en) 2002-03-11 2007-06-19 Pawliszyn Janusz B Calibration procedure for investigating biological systems
US8620410B2 (en) * 2002-03-12 2013-12-31 Beth Israel Deaconess Medical Center Multi-channel medical imaging system
ES2406697T3 (es) * 2002-03-12 2013-06-07 Beth Israel Deaconess Medical Center Sistema de obtención de imágenes médicas
US9155544B2 (en) * 2002-03-20 2015-10-13 P Tech, Llc Robotic systems and methods
US8131332B2 (en) * 2002-04-04 2012-03-06 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites
US20080009689A1 (en) * 2002-04-09 2008-01-10 Benaron David A Difference-weighted somatic spectroscopy
US20070015981A1 (en) * 2003-08-29 2007-01-18 Benaron David A Device and methods for the detection of locally-weighted tissue ischemia
US7031772B2 (en) * 2002-04-29 2006-04-18 Medtronic, Inc. Method and apparatus for rate responsive adjustments in an implantable medical device
WO2003097125A2 (en) * 2002-05-17 2003-11-27 Case Western Reserve University Double contrast technique for mri-guided vascular interventions
US20040077951A1 (en) * 2002-07-05 2004-04-22 Wei-Chiang Lin Apparatus and methods of detection of radiation injury using optical spectroscopy
US20040101088A1 (en) * 2002-11-27 2004-05-27 Sabol John Michael Methods and apparatus for discriminating multiple contrast agents
GB0228960D0 (en) * 2002-12-11 2003-01-15 Mirada Solutions Ltd Improvements in or relating to processing systems
US7623908B2 (en) 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
US7181266B2 (en) * 2003-03-04 2007-02-20 Massachusetts Institute Of Technology Materials and methods for near-infrared and infrared lymph node mapping
DE10315574A1 (de) * 2003-04-05 2004-10-28 ETH Zürich Vorrichtung zur Bestimmung des Blutflusses in einem Organ
US20040236231A1 (en) * 2003-05-23 2004-11-25 Embro Corporation Light catheter for illuminating tissue structures
CA2527196C (en) * 2003-05-30 2012-10-16 Purdue Research Foundation Diagnostic method for atherosclerosis
DE502004003658D1 (de) * 2003-05-30 2007-06-14 Siemens Ag Gerät zum Erfassen wenigstens einer Substanz in einem Stoffwechselprozess eines Lebewesens
US7217410B2 (en) * 2003-06-17 2007-05-15 The Board Of Trustees Of The Universtiy Of Illinois Surface modified protein microparticles
US7198777B2 (en) * 2003-06-17 2007-04-03 The Board Of Trustees Of The University Of Illinois Optical contrast agents for optically modifying incident radiation
US8473035B2 (en) * 2003-09-15 2013-06-25 Beth Israel Deaconess Medical Center Medical imaging systems
WO2005032342A2 (en) * 2003-09-30 2005-04-14 Vanderbilt University Methods and apparatus for optical spectroscopic detection of cell and tissue death
US7651506B2 (en) * 2003-10-02 2010-01-26 University Of Florida Research Foundation, Inc. Frameless stereotactic guidance of medical procedures
US20050107694A1 (en) * 2003-11-17 2005-05-19 Jansen Floribertus H. Method and system for ultrasonic tagging of fluorescence
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
US7968851B2 (en) 2004-01-13 2011-06-28 Spectrum Dynamics Llc Dynamic spect camera
WO2006051531A2 (en) 2004-11-09 2006-05-18 Spectrum Dynamics Llc Radioimaging
WO2007010537A2 (en) * 2005-07-19 2007-01-25 Spectrum Dynamics Llc Reconstruction stabilizer and active vision
WO2006075333A2 (en) * 2005-01-13 2006-07-20 Spectrum Dynamics Llc Multi-dimensional image reconstruction and analysis for expert-system diagnosis
US9470801B2 (en) 2004-01-13 2016-10-18 Spectrum Dynamics Llc Gating with anatomically varying durations
WO2005067383A2 (en) 2004-01-13 2005-07-28 Spectrum Dynamics Llc Multi-dimensional image reconstruction
US8586932B2 (en) 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
WO2008010227A2 (en) 2006-07-19 2008-01-24 Spectrum Dynamics Llc Imaging protocols
US8571881B2 (en) 2004-11-09 2013-10-29 Spectrum Dynamics, Llc Radiopharmaceutical dispensing, administration, and imaging
US9750425B2 (en) * 2004-03-23 2017-09-05 Dune Medical Devices Ltd. Graphical user interfaces (GUI), methods and apparatus for data presentation
US7904145B2 (en) 2004-03-23 2011-03-08 Dune Medical Devices Ltd. Clean margin assessment tool
DE102004014712B4 (de) * 2004-03-25 2007-05-24 Siemens Ag Verfahren zur Freigabe oder Sperrung eines Betriebsmodus eines medizinischen Diagnosegeräts
US20050220714A1 (en) * 2004-04-01 2005-10-06 Susan Kauzlarich Agents for use in magnetic resonance and optical imaging
EP1766550A2 (de) * 2004-06-01 2007-03-28 Spectrum Dynamics LLC Verfahren zur ansichtsauswahl für messungen radioaktiver emission
EP1778957A4 (de) * 2004-06-01 2015-12-23 Biosensors Int Group Ltd Optimierung der messung radioaktiver strahlung an besonderen körperstrukturen
WO2006042233A1 (en) * 2004-10-08 2006-04-20 The Cleveland Clinic Foundation Medical imaging using quantum dots
US20080039715A1 (en) * 2004-11-04 2008-02-14 Wilson David F Three-dimensional optical guidance for catheter placement
US9943274B2 (en) 2004-11-09 2018-04-17 Spectrum Dynamics Medical Limited Radioimaging using low dose isotope
US9316743B2 (en) 2004-11-09 2016-04-19 Biosensors International Group, Ltd. System and method for radioactive emission measurement
US8615405B2 (en) 2004-11-09 2013-12-24 Biosensors International Group, Ltd. Imaging system customization using data from radiopharmaceutical-associated data carrier
US8423125B2 (en) * 2004-11-09 2013-04-16 Spectrum Dynamics Llc Radioimaging
US7854705B2 (en) * 2004-12-16 2010-12-21 Olga Pawluczyk Ex vivo verification of biopsy tissue samples
WO2006071754A2 (en) * 2004-12-23 2006-07-06 Purdue Research Foundation Positron emission tomography imaging method
US20080015569A1 (en) 2005-02-02 2008-01-17 Voyage Medical, Inc. Methods and apparatus for treatment of atrial fibrillation
US10064540B2 (en) 2005-02-02 2018-09-04 Intuitive Surgical Operations, Inc. Visualization apparatus for transseptal access
US11478152B2 (en) 2005-02-02 2022-10-25 Intuitive Surgical Operations, Inc. Electrophysiology mapping and visualization system
US8137333B2 (en) 2005-10-25 2012-03-20 Voyage Medical, Inc. Delivery of biological compounds to ischemic and/or infarcted tissue
US7860556B2 (en) * 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue imaging and extraction systems
US8078266B2 (en) 2005-10-25 2011-12-13 Voyage Medical, Inc. Flow reduction hood systems
US7860555B2 (en) * 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue visualization and manipulation system
US8934962B2 (en) 2005-02-02 2015-01-13 Intuitive Surgical Operations, Inc. Electrophysiology mapping and visualization system
US8050746B2 (en) 2005-02-02 2011-11-01 Voyage Medical, Inc. Tissue visualization device and method variations
US7930016B1 (en) 2005-02-02 2011-04-19 Voyage Medical, Inc. Tissue closure system
US9510732B2 (en) 2005-10-25 2016-12-06 Intuitive Surgical Operations, Inc. Methods and apparatus for efficient purging
US7918787B2 (en) 2005-02-02 2011-04-05 Voyage Medical, Inc. Tissue visualization and manipulation systems
US7586618B2 (en) * 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
CN101991415B (zh) 2005-03-29 2013-04-10 沙丘医疗设备有限公司 用于组织表征的电磁传感器
US20070064987A1 (en) * 2005-04-04 2007-03-22 Esham Matthew P System for processing imaging device data and associated imaging report information
US7725169B2 (en) 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
US20060239921A1 (en) 2005-04-26 2006-10-26 Novadaq Technologies Inc. Real time vascular imaging during solid organ transplant
WO2006119166A2 (en) * 2005-04-29 2006-11-09 The Regents Of The University Of Colorado Multi-excitation diagnostic systems and methods for classification of tissue
EP2289452A3 (de) * 2005-06-06 2015-12-30 Intuitive Surgical Operations, Inc. Laparoskopisches Ultraschall-Robotersystem für chirurgische Zwecke
US11259870B2 (en) 2005-06-06 2022-03-01 Intuitive Surgical Operations, Inc. Interactive user interfaces for minimally invasive telesurgical systems
EP1904183B1 (de) 2005-07-05 2014-10-15 Purdue Research Foundation Pharmazeutische Zusammensetzung zur Behandlung von Arthrose
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
EP1909853B1 (de) 2005-07-19 2015-03-18 Biosensors International Group, Ltd. Bildgebungsprotokolle
US20070025917A1 (en) * 2005-07-26 2007-02-01 General Electric Company Optical imaging based on locally activated bioluminescence
US7813778B2 (en) * 2005-07-29 2010-10-12 Spectros Corporation Implantable tissue ischemia sensor
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US20070073160A1 (en) 2005-09-13 2007-03-29 Children's Medical Center Corporation Light-guided transluminal catheter
US8954134B2 (en) * 2005-09-13 2015-02-10 Children's Medical Center Corporation Light-guided transluminal catheter
CA2824033A1 (en) * 2005-09-13 2007-03-22 Edwards Lifesciences Corporation Continuous spectroscopic measurement of total hemoglobin
EP1940473A2 (de) 2005-09-23 2008-07-09 Purdue Research Foundation Verfahren und vorrichtung für die multiphotonen-in-vivo-durchflusszytometrie
US8221310B2 (en) 2005-10-25 2012-07-17 Voyage Medical, Inc. Tissue visualization device and method variations
EP1948008A2 (de) * 2005-11-10 2008-07-30 Philips Intellectual Property & Standards GmbH Absorptions- und streukarten-rekonstruktion für die optische fluoreszenztomographie
DE102005056066B3 (de) * 2005-11-24 2007-06-28 Siemens Ag Einrichtung für die Röntgen-Brachytherapie mit einer in das Innere eines Körpers einführbaren Sonde
EP1966984A2 (de) 2005-12-28 2008-09-10 Starhome GmbH Spätes umleiten zu lokalem sprachnachrichten-system von anrufen zu roamenden benutzern
US7787129B2 (en) * 2006-01-31 2010-08-31 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US8105239B2 (en) 2006-02-06 2012-01-31 Maui Imaging, Inc. Method and apparatus to visualize the coronary arteries using ultrasound
CN1895184B (zh) * 2006-03-07 2010-04-07 赵世光 自动荧光检测系统
US8894974B2 (en) 2006-05-11 2014-11-25 Spectrum Dynamics Llc Radiopharmaceuticals for diagnosis and therapy
US9770230B2 (en) 2006-06-01 2017-09-26 Maquet Cardiovascular Llc Endoscopic vessel harvesting system components
WO2007143200A2 (en) 2006-06-02 2007-12-13 Futrell J William Systems and methods for illuminating materials
US9055906B2 (en) 2006-06-14 2015-06-16 Intuitive Surgical Operations, Inc. In-vivo visualization systems
US10796390B2 (en) * 2006-07-03 2020-10-06 3M Innovative Properties Company System and method for medical coding of vascular interventional radiology procedures
US20080050316A1 (en) * 2006-08-24 2008-02-28 Baylor College Of Medicine Molecular imaging of epithelial cells in lymph
US20080064954A1 (en) * 2006-08-24 2008-03-13 Baylor College Of Medicine Method of measuring propulsion in lymphatic structures
US20080097476A1 (en) 2006-09-01 2008-04-24 Voyage Medical, Inc. Precision control systems for tissue visualization and manipulation assemblies
US10004388B2 (en) 2006-09-01 2018-06-26 Intuitive Surgical Operations, Inc. Coronary sinus cannulation
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
US20090315402A1 (en) * 2006-10-04 2009-12-24 The Tokyo Electric Power Company, Incorporated Ac-dc conversion device
US10335131B2 (en) 2006-10-23 2019-07-02 Intuitive Surgical Operations, Inc. Methods for preventing tissue migration
WO2008051639A2 (en) 2006-10-25 2008-05-02 Maui Imaging, Inc. Method and apparatus to produce ultrasonic images using multiple apertures
US8685752B2 (en) 2006-11-03 2014-04-01 Purdue Research Foundation Ex vivo flow cytometry method and device
US8610075B2 (en) 2006-11-13 2013-12-17 Biosensors International Group Ltd. Radioimaging applications of and novel formulations of teboroxime
US20080183036A1 (en) 2006-12-18 2008-07-31 Voyage Medical, Inc. Systems and methods for unobstructed visualization and ablation
US9275451B2 (en) 2006-12-20 2016-03-01 Biosensors International Group, Ltd. Method, a system, and an apparatus for using and processing multidimensional data
US8131350B2 (en) 2006-12-21 2012-03-06 Voyage Medical, Inc. Stabilization of visualization catheters
US9226648B2 (en) 2006-12-21 2016-01-05 Intuitive Surgical Operations, Inc. Off-axis visualization systems
EP2567711A3 (de) 2007-02-07 2013-05-01 Purdue Research Foundation Bildgebungsverfahren für Positronenemissionstomographie
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8147423B2 (en) * 2007-03-01 2012-04-03 Dune Medical Devices, Ltd. Tissue-characterization system and method
JP2010524651A (ja) 2007-04-27 2010-07-22 ボエッジ メディカル， インコーポレイテッド 複雑な形状の操縦可能な組織可視化および操作カテーテル
US20110060232A1 (en) * 2007-05-04 2011-03-10 The General Hospital Corporation Retinal flow cytometry
US8657805B2 (en) 2007-05-08 2014-02-25 Intuitive Surgical Operations, Inc. Complex shape steerable tissue visualization and manipulation catheter
EP3025636B1 (de) 2007-05-11 2017-11-01 Intuitive Surgical Operations, Inc. Visuelle elektrodenablationssysteme
CA2688308A1 (en) * 2007-05-25 2008-12-04 Purdue Research Foundation Method of imaging localized infections
US8579897B2 (en) 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8235985B2 (en) 2007-08-31 2012-08-07 Voyage Medical, Inc. Visualization and ablation system variations
US9788813B2 (en) 2010-10-13 2017-10-17 Maui Imaging, Inc. Multiple aperture probe internal apparatus and cable assemblies
US9282945B2 (en) * 2009-04-14 2016-03-15 Maui Imaging, Inc. Calibration of ultrasound probes
CA2702298A1 (en) * 2007-10-11 2009-04-16 Tufts University Systems, devices, and methods employing fiber optic shape tracking
WO2009050667A1 (en) * 2007-10-18 2009-04-23 Koninklijke Philips Electronics N.V. Tumor demarcation using targeted fluorescent probe and photonic needle
US8521253B2 (en) 2007-10-29 2013-08-27 Spectrum Dynamics Llc Prostate imaging
US20090112059A1 (en) 2007-10-31 2009-04-30 Nobis Rudolph H Apparatus and methods for closing a gastrotomy
WO2009083846A2 (en) * 2007-12-20 2009-07-09 Koninklijke Philips Electronics N.V. Optical coupling medium
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
ES2671710T3 (es) 2008-05-02 2018-06-08 Novadaq Technologies ULC Métodos para la producción y uso de eritrocitos cargados con sustancias para la observación y el tratamiento de la hemodinámica microvascular
ES2699376T3 (es) 2008-05-05 2019-02-11 Massachusetts Gen Hospital Métodos para usar sustratos enzimáticos marcados con bodipy
ES2715633T3 (es) * 2008-05-20 2019-06-05 Univ Health Network Dispositivo y método para formación de imágenes y supervisión por fluorescencia
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8906035B2 (en) 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
US9101735B2 (en) 2008-07-07 2015-08-11 Intuitive Surgical Operations, Inc. Catheter control systems
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
JP5666446B2 (ja) * 2008-08-08 2015-02-12 マウイ イマギング，インコーポレーテッド マルチアパーチャ方式の医用超音波技術を用いた画像形成方法及びアドオンシステムの同期方法
WO2010022079A1 (en) * 2008-08-18 2010-02-25 Board Of Regents, The University Of Texas System System and methods for diagnosis of epithelial lesions
CN101380226A (zh) * 2008-09-27 2009-03-11 同济大学 标记前哨淋巴结的有机蓝染料与荧光成像的组合技术
US20110196231A1 (en) * 2008-09-29 2011-08-11 Raghavan Rajagopalan Fused Ring Thiophene Dyes for Imaging and Therapy
CA2738035A1 (en) * 2008-09-29 2010-04-01 Mallinckrodt Inc. Dithienopyrrole dyes for imaging and therapy
EP2350205A2 (de) * 2008-09-29 2011-08-03 Mallinckrodt Inc. Dithienofuranfarbstoffe für bildgebung und therapie
US20110200525A1 (en) * 2008-10-09 2011-08-18 Patz Jr Edward F Vhh antibody fragments for use in the detection and treatment of cancer
US8333012B2 (en) 2008-10-10 2012-12-18 Voyage Medical, Inc. Method of forming electrode placement and connection systems
US8894643B2 (en) 2008-10-10 2014-11-25 Intuitive Surgical Operations, Inc. Integral electrode placement and connection systems
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US8361066B2 (en) 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
RU2526929C2 (ru) * 2009-01-23 2014-08-27 Конинклейке Филипс Электроникс Н.В. Оптическое исследовательское устройство, выполненное с возможностью, по меньшей мере, частичного помещения в мутную среду
DE102009006025A1 (de) * 2009-01-23 2010-07-29 Bundesrepublik Deutschland, vertr.d.d. Bundesministerium für Wirtschaft und Technologie, d.vertr.d.d. Präsidenten der Physikalisch-Technischen Bundesanstalt Verfahren und Vorrichtung zur Darstellung eines Karzinoms mit Hilfe eines fluoreszierenden Farbstoffes
US9339221B1 (en) 2009-03-24 2016-05-17 Vioptix, Inc. Diagnosing intestinal ischemia based on oxygen saturation measurements
US9737213B1 (en) * 2009-03-24 2017-08-22 Vioptix, Inc. Using an oximeter probe to detect intestinal ischemia
EP2416839B1 (de) 2009-04-07 2020-03-11 Dignity Health Elektrisches gebärmutterstimulationssystem und verfahren
EP2419022B1 (de) * 2009-04-14 2019-11-06 Maui Imaging, Inc. Ausrichtungsvorrichtung für ultraschall-array mit mehreren aperturen
EP2248462B1 (de) * 2009-05-06 2016-04-20 Brainlab AG Verfahren zur Darstellung von Bilddaten eines Patientenkörperteils
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
WO2010132554A2 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Diaza heterocyclic compounds for phototherapy
US8731655B2 (en) 2009-05-12 2014-05-20 Mallinckrodt Llc Compounds containing acyclic N-N bonds for phototherapy
US9114226B1 (en) 2009-07-08 2015-08-25 Vioptix, Inc. Devices and monitoring systems for locating a blood vessel
US8338788B2 (en) 2009-07-29 2012-12-25 Spectrum Dynamics Llc Method and system of optimized volumetric imaging
EP2461733A1 (de) * 2009-08-07 2012-06-13 Dignity Health Vorrichtung und verfahren zur untersuchung und bewertung der gebärmutter, der fetalen membranen und des fruchtwassers
WO2011031955A2 (en) 2009-09-11 2011-03-17 Mallinckrodt Inc. Optical monitoring of leukemia
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8608652B2 (en) 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
WO2011060113A1 (en) 2009-11-11 2011-05-19 Mallinckrodt Inc. Sulfenamide compounds for phototherapy
JP6275382B2 (ja) * 2009-12-15 2018-02-07 エモリー ユニバーシティ 診断又は治療処置においてリアルタイム解剖学的指針を提供するシステム及び方法
WO2011084571A2 (en) 2009-12-16 2011-07-14 Mallinckrodt Inc. Azide derivatives for phototherapy
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
WO2011092617A1 (en) * 2010-01-27 2011-08-04 Koninklijke Philips Electronics N.V. Lymph node detection system
US9005198B2 (en) 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8694071B2 (en) 2010-02-12 2014-04-08 Intuitive Surgical Operations, Inc. Image stabilization techniques and methods
EP2536339B1 (de) 2010-02-18 2024-05-15 Maui Imaging, Inc. Punktquellenübertragung und schallgeschwindigkeitskorrektur mittels ultraschallbildgebung mit mehreren blenden
US8792951B1 (en) 2010-02-23 2014-07-29 Vioptix, Inc. Bone oxygenation measurement
US9814522B2 (en) 2010-04-06 2017-11-14 Intuitive Surgical Operations, Inc. Apparatus and methods for ablation efficacy
US9668714B2 (en) 2010-04-14 2017-06-06 Maui Imaging, Inc. Systems and methods for improving ultrasound image quality by applying weighting factors
US8904871B2 (en) * 2010-07-23 2014-12-09 Board Of Regents, The University Of Texas System Temperature dependent photoacoustic imaging
KR101906838B1 (ko) 2010-10-13 2018-10-11 마우이 이미징, 인코포레이티드 오목한 초음파 트랜스듀서들 및 3d 어레이들
US8839672B2 (en) * 2010-10-19 2014-09-23 Board Of Regents, The University Of Texas System Combined ultrasound and photoacoustic imaging of metal objects
US9872983B2 (en) 2010-10-27 2018-01-23 Dignity Health Uterine electrical stimulation system and method
CA2816073C (en) 2010-10-27 2018-12-18 Dignity Health Uterine electrical stimulation system and method
US20120116155A1 (en) * 2010-11-04 2012-05-10 Ethicon Endo-Surgery, Inc. Light-based, transcutaneous video signal transmission
WO2012065163A2 (en) 2010-11-12 2012-05-18 Emory University Additional systems and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure
US10092291B2 (en) 2011-01-25 2018-10-09 Ethicon Endo-Surgery, Inc. Surgical instrument with selectively rigidizable features
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
US9417240B2 (en) 2011-05-27 2016-08-16 Drexel University Capped and conjugated quantum dots
EP2785253B1 (de) 2011-12-01 2023-11-15 Maui Imaging, Inc. Bewegungserfassung unter verwendung von ping-basiertem doppler-ultraschall mit mehreren aperturen
JP2015503404A (ja) 2011-12-29 2015-02-02 マウイ イマギング，インコーポレーテッド 任意経路のｍモード超音波イメージング
EP2797508A2 (de) * 2011-12-30 2014-11-05 Koninklijke Philips N.V. System und verfahren zur navigation mithilfe des pa-effekts in der us-bildgebung
CN104135937B (zh) 2012-02-21 2017-03-29 毛伊图像公司 使用多孔超声确定材料刚度
US9155473B2 (en) 2012-03-21 2015-10-13 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus for skin autofluorescence
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
WO2013177061A1 (en) 2012-05-21 2013-11-28 The Regents Of The University Of Colorado, A Body Corporate Three-dimensional mapping and therapy of prostate cancer
US9814448B2 (en) 2012-05-21 2017-11-14 Precision Biopsy, Inc. Three-dimensional optical imaging and therapy of prostate cancer
WO2013190391A2 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
US10314649B2 (en) 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
EP2837322B1 (de) * 2012-08-07 2017-07-12 Olympus Corporation Abtastendoskopvorrichtung
WO2014026185A1 (en) 2012-08-10 2014-02-13 Maui Imaging, Inc. Calibration of multiple aperture ultrasound probes
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
CN104582582B (zh) 2012-08-21 2017-12-15 毛伊图像公司 超声成像系统存储器架构
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
US9510806B2 (en) 2013-03-13 2016-12-06 Maui Imaging, Inc. Alignment of ultrasound transducer arrays and multiple aperture probe assembly
EP2829222B1 (de) 2013-07-24 2020-05-27 Cook Medical Technologies LLC Lokalisierungsvorrichtung
US9883848B2 (en) 2013-09-13 2018-02-06 Maui Imaging, Inc. Ultrasound imaging using apparent point-source transmit transducer
ES2830392T3 (es) 2014-07-23 2021-06-03 Ohio State Innovation Foundation Métodos y composiciones relacionados con fragmentos de anticuerpo que se unen a la glicoproteína 72 asociada a tumores (TAG-72)
ES2894912T3 (es) 2014-07-24 2022-02-16 Univ Health Network Recopilación y análisis de datos con fines de diagnóstico
US10401493B2 (en) 2014-08-18 2019-09-03 Maui Imaging, Inc. Network-based ultrasound imaging system
CN107209118B (zh) 2014-09-29 2021-05-28 史赛克欧洲运营有限公司 在自体荧光存在下生物材料中目标荧光团的成像
EP3915467A1 (de) 2014-10-09 2021-12-01 Novadaq Technologies ULC Quantifizierung der absoluten blutströmung in gewebe mittels fluoreszenzvermittelter photoplethysmographie
EP3262605A1 (de) * 2015-02-26 2018-01-03 Brainlab AG Anpassung von bilddatensätzen an ein aktualisiertes atlasbasiertes referenzsystem
WO2016166176A1 (en) 2015-04-17 2016-10-20 Koninklijke Philips N.V. Tissue inspection system with optical fibers and continuous calibration
EP3393355A1 (de) * 2015-12-21 2018-10-31 Erasmus University Medical Center Rotterdam Optische sonde zur messung einer gewebeprobe
CN113729764A (zh) 2016-01-27 2021-12-03 毛伊图像公司 具有稀疏阵列探测器的超声成像
US10545077B2 (en) 2016-03-02 2020-01-28 Jp Scientific Limited Solid phase microextraction coating
JP6803400B2 (ja) 2016-05-10 2020-12-23 ジェイ・ピィ・サイエンティフィック・リミテッドＪｐ Ｓｃｉｅｎｔｉｆｉｃ Ｌｉｍｉｔｅｄ 固相マイクロ抽出装置上に吸着された分析物を脱着および検出するためのシステムおよび方法
AU2016423159A1 (en) * 2016-09-15 2019-03-07 Avent, Inc. System and method for in situ visualization of nerves using targeted fluorescent molecules
WO2018145193A1 (en) 2017-02-10 2018-08-16 Novadaq Technologies ULC Open-field handheld fluorescence imaging systems and methods
US11642172B2 (en) * 2019-03-05 2023-05-09 Biosense Webster (Israel) Ltd. Showing catheter in brain
US11730831B2 (en) 2019-03-26 2023-08-22 Sicreations, Llc Imaging agents and methods of using the same
WO2020243585A1 (en) 2019-05-29 2020-12-03 Sicreations, Llc Methods for preserving a subject and using imaging contrast agents
CN114729888A (zh) * 2019-12-27 2022-07-08 阿西耶斯医疗有限责任公司 用于医疗设备的实时荧光检测系统
KR102444393B1 (ko) 2020-09-25 2022-09-20 주식회사 올리브헬스케어 유방암 진단 시스템
CN113219828B (zh) * 2021-04-22 2022-07-05 中国电子科技集团公司第二十九研究所 一种多通道模拟光模块增益一致性的控制方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483472A (en) 1983-03-01 1984-11-20 Gerber Scientific Inc. Apparatus and method for indexing sheet material
US4932412A (en) * 1986-12-18 1990-06-12 Immunomedics, Inc. Intraoperative and endoscopic tumor detection and therapy
US4805623A (en) * 1987-09-04 1989-02-21 Vander Corporation Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment
US5851527A (en) * 1988-04-18 1998-12-22 Immunomedics, Inc. Method for antibody targeting of therapeutic agents
US5137355A (en) 1988-06-08 1992-08-11 The Research Foundation Of State University Of New York Method of imaging a random medium
US5596987A (en) 1988-11-02 1997-01-28 Noninvasive Technology, Inc. Optical coupler for in vivo examination of biological tissue
US5555885A (en) * 1988-12-21 1996-09-17 Non-Invasive Technology, Inc. Examination of breast tissue using time-resolved spectroscopy
JP2950928B2 (ja) * 1990-07-19 1999-09-20 三井化学株式会社 標識化抗体
US5699798A (en) * 1990-08-10 1997-12-23 University Of Washington Method for optically imaging solid tumor tissue
US5303026A (en) * 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
US5280788A (en) * 1991-02-26 1994-01-25 Massachusetts Institute Of Technology Devices and methods for optical diagnosis of tissue
EP0505918B1 (de) * 1991-03-25 1996-12-04 Hoeft, Andreas, Prof. Dr. med. Vorrichtung und Verfahren zur Ermittlung des Herzzeitvolumens
US5203339A (en) 1991-06-28 1993-04-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Health And Human Services Method and apparatus for imaging a physical parameter in turbid media using diffuse waves
WO1993018797A1 (en) * 1992-03-25 1993-09-30 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US5536248A (en) * 1992-05-11 1996-07-16 Arrow Precision Products, Inc. Method and apparatus for electrosurgically obtaining access to the biliary tree and placing a stent therein
US5853370A (en) * 1996-09-13 1998-12-29 Non-Invasive Technology, Inc. Optical system and method for non-invasive imaging of biological tissue
US5698397A (en) * 1995-06-07 1997-12-16 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
ATE151615T1 (de) * 1992-11-18 1997-05-15 Spectrascience Inc Diagnosebildgerät
JPH06207939A (ja) * 1992-12-21 1994-07-26 Wako Pure Chem Ind Ltd リポソーム膜溶解方法及びそれを利用した抗原又は抗体の定量方法
US5413108A (en) * 1993-04-21 1995-05-09 The Research Foundation Of City College Of New York Method and apparatus for mapping a tissue sample for and distinguishing different regions thereof based on luminescence measurements of cancer-indicative native fluorophor
US5820558A (en) * 1994-12-02 1998-10-13 Non-Invasive Technology, Inc. Optical techniques for examination of biological tissue
JPH07134126A (ja) * 1993-06-22 1995-05-23 Nippon Oil & Fats Co Ltd トリオキサン誘導体標識抗体・抗原および免疫測定方法
US5596992A (en) * 1993-06-30 1997-01-28 Sandia Corporation Multivariate classification of infrared spectra of cell and tissue samples
US5349954A (en) * 1993-07-23 1994-09-27 General Electric Company Tumor tissue characterization apparatus and method
DE4330460C2 (de) * 1993-09-08 1996-05-23 Siemens Ag Vorrichtung zur Untersuchung von Gewebe mit Licht unterschiedlicher Wellenlängen
ZA948393B (en) * 1993-11-01 1995-06-26 Polartechnics Ltd Method and apparatus for tissue type recognition
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent
US5782770A (en) * 1994-05-12 1998-07-21 Science Applications International Corporation Hyperspectral imaging methods and apparatus for non-invasive diagnosis of tissue for cancer
JPH0875737A (ja) * 1994-09-06 1996-03-22 Fuji Yakuhin Kogyo Kk ヒト前立腺特異抗原とヒトプロテインｃインヒビターとの複合体の測定方法および同測定用キット
DE69627477T2 (de) * 1995-01-03 2004-03-18 Non-Invasive Technology, Inc. Optische koppelvorrichtung zur in-vivo untersuchung von biologischen geweben
JP3669752B2 (ja) * 1995-01-30 2005-07-13 第一化学薬品株式会社 診断用マーカー
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5773292A (en) * 1995-06-05 1998-06-30 Cornell University Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood
US5678550A (en) * 1995-08-11 1997-10-21 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Apparatus and method for in situ detection of areas of cardiac electrical activity
US5865754A (en) * 1995-08-24 1999-02-02 Purdue Research Foundation Office Of Technology Transfer Fluorescence imaging system and method
US5857463A (en) * 1995-10-13 1999-01-12 Neoprobe Corporation Remotely controlled apparatus and system for tracking and locating a source of photoemissions
US5782764A (en) * 1995-11-07 1998-07-21 Iti Medical Technologies, Inc. Fiber composite invasive medical instruments and methods for use in interventional imaging procedures
US5647368A (en) * 1996-02-28 1997-07-15 Xillix Technologies Corp. Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract
US5861248A (en) * 1996-03-29 1999-01-19 Urocor, Inc. Biomarkers for detection of prostate cancer
PT907379E (pt) * 1996-04-01 2004-09-30 Epix Medical Inc Agentes de contraste bioactivados para imagiologia de diagnostico
US5672333A (en) * 1996-05-13 1997-09-30 Mallinckrodt Medical, Inc. Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
JP3896176B2 (ja) * 1996-05-21 2007-03-22 浜松ホトニクス株式会社 近赤外線蛍光トレーサーおよび蛍光イメージング方法
DE19640700C2 (de) * 1996-10-02 2002-08-14 Wolf Gmbh Richard Einrichtung zur photodynamischen endoskopischen Diagnose von Tumorgewebe
JP3962122B2 (ja) * 1996-11-20 2007-08-22 オリンパス株式会社 内視鏡装置
JP3713347B2 (ja) * 1996-11-25 2005-11-09 オリンパス株式会社 蛍光内視鏡装置
US5840507A (en) * 1997-03-19 1998-11-24 Oncotech, Inc. Methods for cancer prognosis and diagnosis
US5994071A (en) * 1997-04-04 1999-11-30 Albany Medical College Assessment of prostate cancer
DE69820867T2 (de) * 1997-04-29 2004-11-18 Amersham Health As Lichtbilderzeugungskontrastmitteln
US5846513B1 (en) 1997-07-08 2000-11-28 Carewise Medical Products Corp Tumor localization and removal system using penetratable detection probe and removal instrument
ATE254479T1 (de) * 1997-10-02 2003-12-15 Epix Medical Inc Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung

Also Published As

Publication number Publication date
EP2048504A1 (de) 2009-04-15
JP4340392B2 (ja) 2009-10-07
ATE422048T1 (de) 2009-02-15
US6246901B1 (en) 2001-06-12
JP2009133876A (ja) 2009-06-18
EP1196763B1 (de) 2009-01-28
WO2000068665A1 (en) 2000-11-16
US6167297A (en) 2000-12-26
AU3926900A (en) 2000-11-21
EP1196763A1 (de) 2002-04-17
EP1196763B2 (de) 2012-06-27
JP2002543859A (ja) 2002-12-24

Similar Documents

Publication Publication Date Title
DE60041491D1 (de) Erkennung, lokalisierung und zielen von internen stellen in vivo mit optischen kontrastmitteln
US20070092447A1 (en) Contrast agent for combined modality imaging and methods and systems thereof
DE69614902D1 (de) In organischen Stoffen lösliche, kationische Farbstoffe mit fluorierten Alkylsulfonylgegenionen
DK1178830T3 (da) Cyanin- og indocyaninfarvestof-biokonjugater til biomedicinske anvendelser
ES2177939T3 (es) Construccion de proteina fluorescente en tandem.
PT1228147E (pt) Compostos de imidazoquinolina marcados com corante
DE69632401D1 (de) Neue zielgerichtete mittel zur diagnostischen und therapeutischen verwendung
NO20050873L (no) Blanding for a farge keratinfibre, anvendelse derav samt flerroms fargeinnretning
DK1798288T3 (da) Humane Toll-lignende receptorproteiner, relaterede reagenser og fremgangsmåder
ATE280178T1 (de) Langwellig fluorezierende proteine
ATE254664T1 (de) Renilla luciferase und green fluorescent protein fusionsgene
DK0778842T3 (da) Mammal telomerase
ATE303412T1 (de) Nicht antigen wirkende verzweigte polymerkonjugate
DK1021712T3 (da) Phosphorescerende dendritiske makromolekylære forbindelser til billeddannelse af oxygen i væv
FI884922A (fi) Diagnostinen analyysielementti ja fluoresoiva konjugaatti
ES2090052T3 (es) Anticuerpos monoclonales (mak) contra antigenos asociados a tumores, su preparacion y uso.
DE60109741D1 (de) Verfahren zur vermeidung von fluoreszenzlöschung
WO2000075332A3 (en) USE OF THE REGULATORY SUBUNIT OF THE CAMP DEPENDENT PROTEIN KINASE (PKA) FROM DICTYOSTELIUM FOR cAMP MEASUREMENTS
ES2130703T3 (es) Conjugados de benzodiazepinas y proteinas y su utilizacion para la determinacion inmunologica de benzodiazepinas.
BR9611709A (pt) Intermediários e seu uso para preparação de bis-indolil maleimidas com ponte-n.n.
DE69612350D1 (de) Blaue Dispersionsfarbstoffmischung
Babincova et al. Gene transfer-mediated intracellular photodynamic therapy
PT1274803E (pt) Mistura corante de corantes azo hidrossoluveis reactivos as fibras processo para a sua preparacao e sua utilizacao
ID22944A (id) Turunan-turunan asam phenoksiasetat dan pemakaiannya sebagai herbisida
ID15847A (id) Bahan pewarna asam disazo dan perantara sulfonamida daripadanya.

Legal Events

Date Code Title Description
8363 Opposition against the patent