DE60036490D1 - Zusammensetzung zur behandlung von prostatakrebs - Google Patents
Zusammensetzung zur behandlung von prostatakrebsInfo
- Publication number
- DE60036490D1 DE60036490D1 DE60036490T DE60036490T DE60036490D1 DE 60036490 D1 DE60036490 D1 DE 60036490D1 DE 60036490 T DE60036490 T DE 60036490T DE 60036490 T DE60036490 T DE 60036490T DE 60036490 D1 DE60036490 D1 DE 60036490D1
- Authority
- DE
- Germany
- Prior art keywords
- prostate cancer
- composition
- treating prostate
- living mammal
- glycosidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010060862 Prostate cancer Diseases 0.000 title abstract 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 3
- -1 for example Proteins 0.000 abstract 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 2
- 102000029816 Collagenase Human genes 0.000 abstract 2
- 108060005980 Collagenase Proteins 0.000 abstract 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 abstract 2
- 102000005744 Glycoside Hydrolases Human genes 0.000 abstract 2
- 229910001424 calcium ion Inorganic materials 0.000 abstract 2
- 229960002424 collagenase Drugs 0.000 abstract 2
- AXMJGXMRGDCRND-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)cyclohexyl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1CCC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)CC1 AXMJGXMRGDCRND-UHFFFAOYSA-N 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- 108010003272 Hyaluronate lyase Proteins 0.000 abstract 1
- 102000009066 Hyaluronoglucosaminidase Human genes 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 108010023197 Streptokinase Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229960002518 gentamicin Drugs 0.000 abstract 1
- 229960002773 hyaluronidase Drugs 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- 229960005202 streptokinase Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US428375 | 1999-10-28 | ||
US09/428,375 US6428785B1 (en) | 1999-10-28 | 1999-10-28 | Method and composition for treating prostate cancer |
PCT/US2000/041562 WO2001034176A1 (en) | 1999-10-28 | 2000-10-25 | A method and composition for treating prostate cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60036490D1 true DE60036490D1 (de) | 2007-10-31 |
DE60036490T2 DE60036490T2 (de) | 2008-06-19 |
Family
ID=23698630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60036490T Expired - Fee Related DE60036490T2 (de) | 1999-10-28 | 2000-10-25 | Zusammensetzung zur behandlung von prostatakrebs |
Country Status (9)
Country | Link |
---|---|
US (2) | US6428785B1 (de) |
EP (1) | EP1242110B1 (de) |
JP (1) | JP2003513931A (de) |
CN (1) | CN1176714C (de) |
AT (1) | ATE373483T1 (de) |
AU (1) | AU2617901A (de) |
CA (1) | CA2389176A1 (de) |
DE (1) | DE60036490T2 (de) |
WO (1) | WO2001034176A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1005654B1 (de) * | 1997-08-01 | 2006-04-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur bestimmung von amyloid-ähnlichen fibrillen oder proteinaggregaten |
ES2424348T3 (es) * | 2002-06-24 | 2013-10-01 | Incept, Llc | Cargas y métodos para desplazar tejidos para mejorar los resultados radiológicos |
US8388951B2 (en) | 2003-07-14 | 2013-03-05 | Cls Therapeutics Limited | Method for treating systemic DNA mutation disease |
US8431123B2 (en) | 2003-07-14 | 2013-04-30 | Cls Therapeutics Limited | Method for treating systemic bacterial, fungal and protozoan infection |
US8710012B2 (en) * | 2003-07-14 | 2014-04-29 | Cls Therapeutics Limited | Method for treating oncological diseases |
WO2005007187A1 (fr) * | 2003-07-14 | 2005-01-27 | Viktor Veniaminovich Tets | Methode de traitement des maladies oncologiques, infectieuses et somatiques, procedes de controle de l'efficacite du traitement, agents et compositions pharmaceutiques associes |
GB2408207A (en) * | 2003-11-24 | 2005-05-25 | Johnson & Johnson Medical Ltd | Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme |
MXPA03011987A (es) * | 2003-12-19 | 2005-06-23 | Osio Sancho Alberto | Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal. |
EP1718759A1 (de) * | 2004-02-19 | 2006-11-08 | Bayer HealthCare AG | Diagnostika und therapeutika für mit kallikrein 3 (klk3) assoziierte krankheiten |
WO2005097149A2 (en) * | 2004-04-09 | 2005-10-20 | Nicholas Piramal India Limited | Herbal extract for renal disorders |
JP2008505853A (ja) * | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
KR20070115580A (ko) | 2005-03-03 | 2007-12-06 | 알러간, 인코포레이티드 | 클로스트리디움 박테리아를 위한 배지 및 클로스트리디움계독소를 얻기 위한 프로세스 |
JP3989936B2 (ja) * | 2005-04-07 | 2007-10-10 | 進 須永 | 抗腫瘍剤及び新規dnアーゼ |
US8916151B2 (en) * | 2005-04-25 | 2014-12-23 | Cls Therapeutics Limited | Method for treating a reduction of fertility |
WO2007079185A2 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
JP2009541333A (ja) * | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 修飾リボヌクレアーゼ |
JP2009543868A (ja) | 2006-07-17 | 2009-12-10 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 癌治療に関する方法および組成物 |
US20080027554A1 (en) * | 2006-07-31 | 2008-01-31 | Talmadge Karen D | Kit and methods of treatment of an intervertebral disc |
ES2369547T3 (es) * | 2006-11-28 | 2011-12-01 | Cls Therapeutics Limited | Procedimiento para el tratamiento de enfermedades humanas asociadas con un contenido elevado del ácido desoxirribonucleico en los espacios extracelulares de los tejidos y preparación médica para llevar a cabo dicho procedimiento. |
ES2441961T3 (es) | 2007-02-15 | 2014-02-07 | Allergan, Inc. | Composiciones de toxina botulínica y métodos |
CN101313926B (zh) * | 2007-05-30 | 2012-12-26 | 中央研究院 | 转录调控物组合物 |
PL2187965T3 (pl) | 2007-08-17 | 2020-05-18 | Purdue Research Foundation | Koniugaty wiążący psma ligand-łącznik i sposoby ich zastosowania |
CA2702043A1 (en) * | 2007-10-08 | 2009-04-16 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapies |
MX339068B (es) | 2008-08-22 | 2016-05-10 | Anthrogenesis Corp | Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias. |
JP2012504423A (ja) | 2008-10-01 | 2012-02-23 | クインテッセンス バイオサイエンシズ,インコーポレーテッド | 治療用リボヌクレアーゼ |
WO2010138918A1 (en) * | 2009-05-29 | 2010-12-02 | Pacira Pharmaceuticals, Inc. | Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent |
EP3583960A1 (de) * | 2009-12-15 | 2019-12-25 | Incept, LLC | Implantate und biologisch abbaubare bezugsmarkierungen |
US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
CN102933221A (zh) | 2010-04-08 | 2013-02-13 | 人类起源公司 | 使用胎盘干细胞治疗结节病 |
WO2012006634A2 (en) * | 2010-07-09 | 2012-01-12 | The Board Of Trustees Of The University Of Illiniois | Prostate specific antigen (psa) peptide therapy |
US8557777B2 (en) | 2010-07-09 | 2013-10-15 | The Board Of Trustees Of The University Of Illinois | Methods for treating cancer using prostate specific antigen and tumor endothelial marker peptides |
WO2012092485A1 (en) | 2010-12-31 | 2012-07-05 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory rna molecules |
EP2672958A1 (de) | 2011-02-08 | 2013-12-18 | Halozyme, Inc. | Zusammensetzung und lipidformulierung eines hyaluronan-abbauenden enzym und seine verwendung zur behandlung von benigner prostatahyperplasie |
DK2714059T3 (en) | 2011-06-01 | 2019-01-21 | Celularity Inc | TREATMENT OF PAIN WHEN USING PLACENT STAM CELLS |
US9943599B2 (en) * | 2011-12-22 | 2018-04-17 | Herlev Hospital | Therapeutic applications of calcium electroporation to effectively induce tumor necrosis |
WO2014026163A2 (en) | 2012-08-10 | 2014-02-13 | Osio Corporation d/b/a Yolia Health | Contact lens use in the treatment of an ophthalmologic condition |
KR20150104092A (ko) | 2012-11-15 | 2015-09-14 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
FI4095130T3 (fi) | 2013-10-18 | 2024-04-25 | Novartis Ag | Prostataspesifisen membraaniantigeenin (psma) leimattuja estäjiä, niiden käyttö kuvantamisaineina ja farmaseuttisia aineita eturauhassyövän hoitoon |
CZ307195B6 (cs) | 2013-11-18 | 2018-03-14 | František Trnka | Farmaceutická kompozice obsahující směs proenzymů a enzymů |
US10183064B2 (en) * | 2014-03-20 | 2019-01-22 | Technion Research & Development Foundation Limited | Delivery system comprising a proteolytic enzyme or effector thereof for use in a method for oral treatment and uses thereof |
US10064681B2 (en) | 2014-04-03 | 2018-09-04 | Corbin Clinical Resources, Llc | Method, system, and device for planning and performing, guided and free-handed transperineal prostate biopsies |
US10743909B2 (en) * | 2014-04-03 | 2020-08-18 | Corbin Clinical Resources, Llc | Transperineal prostate biopsy device, systems, and methods of use |
US10617743B2 (en) | 2014-06-19 | 2020-04-14 | Cls Therapeutics Limited | Method to improve safety and efficacy of anti-cancer therapy |
GB2528304B (en) * | 2014-07-17 | 2020-05-13 | Cambridge Univ Hospitals Nhs Foundation Trust | Perineal prostate biopsy apparatus |
WO2016025922A1 (en) * | 2014-08-14 | 2016-02-18 | Dana-Farber Cancer Institute, Inc. | Coated particles for drug delivery |
CN105477627B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 治疗前列腺癌的组合物及其用途 |
KR101683635B1 (ko) | 2014-12-29 | 2016-12-09 | 가천대학교 산학협력단 | 락테이트 금속염을 포함하는 암 치료용 약학 조성물 |
US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
US11701410B2 (en) | 2015-05-22 | 2023-07-18 | Cls Therapeutics Limited | Extracellular DNA as a therapeutic target in neurodegeneration |
WO2017074257A1 (en) * | 2015-10-26 | 2017-05-04 | Nanyang Technological University | Non-viable derivatives of clostridium sporogenes as anti-cancer therapeutic agents |
CN105255825B (zh) * | 2015-11-16 | 2019-07-19 | 广州赛莱拉干细胞科技股份有限公司 | 一种跟腱来源肌腱干细胞原代分离消化液及分离方法 |
JP2021510539A (ja) | 2018-01-16 | 2021-04-30 | シーエルエス セラピューティクス リミテッドCLS Therapeutics Limited | デオキシリボヌクレアーゼ(DNase)活性を有する酵素の肝臓発現による疾患の処置 |
EP3698806A1 (de) * | 2019-02-19 | 2020-08-26 | Fundacion Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz | Chemisches skalpell |
CN111705051A (zh) * | 2020-07-28 | 2020-09-25 | 金紫晶(南京)生物医药技术有限公司 | 一种复合消化酶及复合消化酶冻干粉 |
CN112941009B (zh) * | 2021-02-22 | 2024-03-01 | 新格元(南京)生物科技有限公司 | 一种ffpe样本预处理液及从ffpe样本中分离单细胞的方法 |
CN115671267A (zh) * | 2021-07-23 | 2023-02-03 | 上海宝济药业有限公司 | 一种皮下抗生素药物组合物 |
Family Cites Families (20)
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US4524065A (en) | 1983-08-04 | 1985-06-18 | Bio-Specifics N.V. | Method for the prevention and treatment of scars with enzymes |
US4645668A (en) | 1983-08-04 | 1987-02-24 | Biospecifics, Nv | Method for the prevention and treatment of scars with enzymes |
US4678668A (en) | 1985-10-28 | 1987-07-07 | Md Associates | Method of reducing soft tissue swelling and pain |
US4978332A (en) | 1987-09-28 | 1990-12-18 | Matrix Pharmaceutical, Inc. | Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas |
US5116615A (en) | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
AU5045690A (en) | 1989-01-27 | 1990-08-24 | Immunolytics, Inc. | Composition and method for treating benign prostatic hypertrophy |
US5051257A (en) | 1989-05-09 | 1991-09-24 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
US5162115A (en) | 1989-05-09 | 1992-11-10 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
US5958406A (en) * | 1994-11-22 | 1999-09-28 | Phairson Medical Inc. | Acne treatment with multifunctional enzyme |
US5422261A (en) | 1993-04-16 | 1995-06-06 | Baxter International Inc. | Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells |
EP0726773A1 (de) | 1993-11-17 | 1996-08-21 | Massachusetts Institute Of Technology | Verfahren zur hemmung der angiogenese mittels heparinase |
EP0766733A4 (de) | 1994-06-24 | 1998-06-10 | Boehringer Mannheim Corp | Gereinigte mischung aus kollagenase und zwei witeren proteasen aus clostridium histolyticum erhaltend |
US5658730A (en) | 1994-12-23 | 1997-08-19 | Ctrc Research Foundation | Methods of human prostate cancer diagnosis |
US5854206A (en) | 1995-08-25 | 1998-12-29 | Corixa Corporation | Compounds and methods for treatment and diagnosis of prostate cancer |
AU7130696A (en) | 1995-09-19 | 1997-04-09 | Schering Aktiengesellschaft | Combination of beta-interferon for the treatment of prostate cancer |
US5783182A (en) | 1996-01-30 | 1998-07-21 | Baylor College Of Medicine | Method for identifying metastatic sequences |
US5780435A (en) | 1995-12-15 | 1998-07-14 | Praecis Pharmaceuticals Incorporated | Methods for treating prostate cancer with LHRH-R antagonists |
US5989888A (en) | 1996-01-24 | 1999-11-23 | Roche Diagnostics Corporation | Purified mixture of collagenase I, collagenase II and two other proteases |
US5716541A (en) | 1996-09-23 | 1998-02-10 | Bayer Corporation | Azeotrope-like compositions of 1,1,1,3,3 pentafluoropropane and tetramethylsilane |
US5830741A (en) | 1996-12-06 | 1998-11-03 | Boehringer Mannheim Corporation | Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease |
-
1999
- 1999-10-28 US US09/428,375 patent/US6428785B1/en not_active Expired - Fee Related
-
2000
- 2000-10-25 AU AU26179/01A patent/AU2617901A/en not_active Abandoned
- 2000-10-25 CA CA002389176A patent/CA2389176A1/en not_active Abandoned
- 2000-10-25 CN CNB008149208A patent/CN1176714C/zh not_active Expired - Fee Related
- 2000-10-25 AT AT00989699T patent/ATE373483T1/de not_active IP Right Cessation
- 2000-10-25 JP JP2001536173A patent/JP2003513931A/ja active Pending
- 2000-10-25 WO PCT/US2000/041562 patent/WO2001034176A1/en active IP Right Grant
- 2000-10-25 DE DE60036490T patent/DE60036490T2/de not_active Expired - Fee Related
- 2000-10-25 EP EP00989699A patent/EP1242110B1/de not_active Expired - Lifetime
-
2002
- 2002-01-22 US US10/055,063 patent/US6913744B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1176714C (zh) | 2004-11-24 |
EP1242110A1 (de) | 2002-09-25 |
US20020061300A1 (en) | 2002-05-23 |
WO2001034176A1 (en) | 2001-05-17 |
CA2389176A1 (en) | 2001-05-17 |
US20020106359A1 (en) | 2002-08-08 |
US6428785B1 (en) | 2002-08-06 |
JP2003513931A (ja) | 2003-04-15 |
DE60036490T2 (de) | 2008-06-19 |
US6913744B2 (en) | 2005-07-05 |
ATE373483T1 (de) | 2007-10-15 |
EP1242110B1 (de) | 2007-09-19 |
CN1384754A (zh) | 2002-12-11 |
AU2617901A (en) | 2001-06-06 |
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