DE60035799T2 - Ionische wässrige lösungen und deren verwendungen insbesondere in der ophtalmologie - Google Patents
Ionische wässrige lösungen und deren verwendungen insbesondere in der ophtalmologie Download PDFInfo
- Publication number
- DE60035799T2 DE60035799T2 DE60035799T DE60035799T DE60035799T2 DE 60035799 T2 DE60035799 T2 DE 60035799T2 DE 60035799 T DE60035799 T DE 60035799T DE 60035799 T DE60035799 T DE 60035799T DE 60035799 T2 DE60035799 T2 DE 60035799T2
- Authority
- DE
- Germany
- Prior art keywords
- seawater
- eye
- aqueous
- aqueous ionic
- hand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007864 aqueous solution Substances 0.000 title 1
- 239000013535 sea water Substances 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000000243 solution Substances 0.000 claims description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 235000002639 sodium chloride Nutrition 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 238000011033 desalting Methods 0.000 claims description 2
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims 2
- 238000004140 cleaning Methods 0.000 abstract description 2
- 238000005259 measurement Methods 0.000 description 11
- 239000011575 calcium Substances 0.000 description 7
- 239000011777 magnesium Substances 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- 239000000460 chlorine Substances 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 210000000795 conjunctiva Anatomy 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 206010015946 Eye irritation Diseases 0.000 description 4
- 210000004087 cornea Anatomy 0.000 description 4
- 231100000013 eye irritation Toxicity 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 231100000635 Draize test Toxicity 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000909 electrodialysis Methods 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 229940012356 eye drops Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000012088 reference solution Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 101100116570 Caenorhabditis elegans cup-2 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000006069 Corneal Opacity Diseases 0.000 description 1
- 101100116572 Drosophila melanogaster Der-1 gene Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 229930183419 Irisone Natural products 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Natural products OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- UZFLPKAIBPNNCA-BQYQJAHWSA-N alpha-ionone Chemical compound CC(=O)\C=C\C1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-BQYQJAHWSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 231100000269 corneal opacity Toxicity 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000008596 edematous infiltration Effects 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 125000001477 organic nitrogen group Chemical group 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
- A61K35/08—Mineral waters; Sea water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9916814A FR2803205B1 (fr) | 1999-12-31 | 1999-12-31 | Solutions ioniques aqueuses et leurs utilisations notamment en ophtalmologie |
| FR9916814 | 1999-12-31 | ||
| PCT/FR2000/003709 WO2001049304A2 (fr) | 1999-12-31 | 2000-12-28 | Solutions ioniques aqueuses et leurs utilisations notamment en ophtalmologie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60035799D1 DE60035799D1 (de) | 2007-09-13 |
| DE60035799T2 true DE60035799T2 (de) | 2008-04-30 |
Family
ID=9554118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60035799T Expired - Lifetime DE60035799T2 (de) | 1999-12-31 | 2000-12-28 | Ionische wässrige lösungen und deren verwendungen insbesondere in der ophtalmologie |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20030152645A1 (enExample) |
| EP (1) | EP1242098B1 (enExample) |
| JP (1) | JP2003519190A (enExample) |
| AT (1) | ATE368468T1 (enExample) |
| AU (1) | AU3029501A (enExample) |
| CA (1) | CA2396045C (enExample) |
| DE (1) | DE60035799T2 (enExample) |
| FR (1) | FR2803205B1 (enExample) |
| PT (1) | PT1242098E (enExample) |
| WO (1) | WO2001049304A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843029B1 (fr) * | 2002-08-02 | 2006-05-26 | Goemar Lab Sa | Solution de rincage pour lentilles de contact |
| ITMI20022353A1 (it) * | 2002-11-06 | 2004-05-07 | Farmaceutici S R L | Composizione di un preparato per gli occhi con attivita' antiallergica, antibatterica e disarrossante. |
| FR2872046B1 (fr) * | 2004-06-28 | 2006-09-15 | Pascal Hemmery | Compostion a base d'eau de mer, son procede de preparation, son utilisation pour l'hygiene de l'appareil genital feminin et dispositif pour son utilisation |
| FR2905267B1 (fr) * | 2006-09-05 | 2012-02-17 | Yslab | Solution a ionisation controlee a base d'eau de mer, destine a l'ophtalmologie. |
| FR2915389B1 (fr) * | 2007-04-26 | 2012-12-21 | De La Mer Laboratoire | Utilisation de solutions ioniques isoosmotiques a base d'eau de mer pour la fabrication de dispositifs medicaux pour la prevention des complications du rhume courant |
| FR2971713B1 (fr) | 2011-02-18 | 2019-03-29 | Laboratoire De La Mer | Solution ionique aqueuse contenant de l'eau de mer et au moins un compose originellement non miscible a l'eau de mer. |
| FR3005264B1 (fr) * | 2013-05-03 | 2015-05-15 | Ys Lab | Solution marine enrichie en zinc et en potassium |
| CN103340901A (zh) * | 2013-07-17 | 2013-10-09 | 银川高新区广煜科技有限公司 | 纯天然成分的眼药水及其制备和使用方法 |
| IT201600078342A1 (it) * | 2016-07-26 | 2018-01-26 | Farm S R L C U S | Processo per la ristrutturazione idroionica delle acque termali e marine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4581226A (en) * | 1983-04-07 | 1986-04-08 | Dillon Richard S | Method of treating sensitive animal tissue with a specially processed seawater solution |
| FR2735980B1 (fr) * | 1995-06-30 | 1997-09-12 | Sun Trading Ltd | Nouvelles preparations pour l'otologie et leur procede de preparation |
| FR2778562B1 (fr) * | 1998-05-14 | 2000-08-04 | Sephra | Composition pharmaceutique, hygienique et/ou cosmetique contenant de l'eau de mer et de l'arginine |
| FR2780284B1 (fr) * | 1998-06-29 | 2001-10-05 | Goemar Lab Sa | Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments cerumenolytiques a base de ces solutions |
| FR2780285B1 (fr) * | 1998-06-29 | 2001-10-05 | Goemar Lab Sa | Utilisation de solutions salines isoosmotiques, leur procede de preparation et medicaments anti-inflammatoires a base de ces solutions |
-
1999
- 1999-12-31 FR FR9916814A patent/FR2803205B1/fr not_active Expired - Fee Related
-
2000
- 2000-12-28 WO PCT/FR2000/003709 patent/WO2001049304A2/fr not_active Ceased
- 2000-12-28 JP JP2001549672A patent/JP2003519190A/ja active Pending
- 2000-12-28 US US10/169,284 patent/US20030152645A1/en not_active Abandoned
- 2000-12-28 AU AU30295/01A patent/AU3029501A/en not_active Abandoned
- 2000-12-28 CA CA2396045A patent/CA2396045C/fr not_active Expired - Fee Related
- 2000-12-28 DE DE60035799T patent/DE60035799T2/de not_active Expired - Lifetime
- 2000-12-28 EP EP00990830A patent/EP1242098B1/fr not_active Expired - Lifetime
- 2000-12-28 PT PT00990830T patent/PT1242098E/pt unknown
- 2000-12-28 AT AT00990830T patent/ATE368468T1/de not_active IP Right Cessation
-
2005
- 2005-05-23 US US11/135,113 patent/US7700077B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7700077B2 (en) | 2010-04-20 |
| AU3029501A (en) | 2001-07-16 |
| ATE368468T1 (de) | 2007-08-15 |
| FR2803205A1 (fr) | 2001-07-06 |
| FR2803205B1 (fr) | 2002-10-18 |
| DE60035799D1 (de) | 2007-09-13 |
| JP2003519190A (ja) | 2003-06-17 |
| CA2396045A1 (fr) | 2001-07-12 |
| EP1242098B1 (fr) | 2007-08-01 |
| CA2396045C (fr) | 2010-09-21 |
| PT1242098E (pt) | 2007-10-31 |
| US20030152645A1 (en) | 2003-08-14 |
| WO2001049304A2 (fr) | 2001-07-12 |
| EP1242098A2 (fr) | 2002-09-25 |
| WO2001049304A3 (fr) | 2002-05-23 |
| US20060003025A1 (en) | 2006-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LABORATOIRE DE LA MER, SAINT-MALO, FR |