DE60034139T2 - Pharmazeutisch-aktive isoindolin-derivate - Google Patents

Pharmazeutisch-aktive isoindolin-derivate Download PDF

Info

Publication number
DE60034139T2
DE60034139T2 DE60034139T DE60034139T DE60034139T2 DE 60034139 T2 DE60034139 T2 DE 60034139T2 DE 60034139 T DE60034139 T DE 60034139T DE 60034139 T DE60034139 T DE 60034139T DE 60034139 T2 DE60034139 T2 DE 60034139T2
Authority
DE
Germany
Prior art keywords
ethoxy
methoxyphenyl
carbon atoms
mixture
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034139T
Other languages
German (de)
English (en)
Other versions
DE60034139D1 (de
Inventor
Hon-Wah Neshanic Station MAN
George Bridgewater MULLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of DE60034139D1 publication Critical patent/DE60034139D1/de
Publication of DE60034139T2 publication Critical patent/DE60034139T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60034139T 1999-11-12 2000-11-09 Pharmazeutisch-aktive isoindolin-derivate Expired - Lifetime DE60034139T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US590344 1996-01-19
US16516899P 1999-11-12 1999-11-12
US165168P 1999-11-12
US59034400A 2000-06-08 2000-06-08
US09/708,199 US6667316B1 (en) 1999-11-12 2000-11-08 Pharmaceutically active isoindoline derivatives
US708199 2000-11-08
PCT/US2000/030770 WO2001034606A1 (en) 1999-11-12 2000-11-09 Pharmaceutically active isoindoline derivatives

Publications (2)

Publication Number Publication Date
DE60034139D1 DE60034139D1 (de) 2007-05-10
DE60034139T2 true DE60034139T2 (de) 2007-12-06

Family

ID=27389110

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034139T Expired - Lifetime DE60034139T2 (de) 1999-11-12 2000-11-09 Pharmazeutisch-aktive isoindolin-derivate

Country Status (19)

Country Link
US (1) US6667316B1 (enExample)
EP (4) EP1698334B1 (enExample)
JP (1) JP5116201B2 (enExample)
CN (1) CN1325497C (enExample)
AT (4) ATE506058T1 (enExample)
AU (2) AU782409B2 (enExample)
CA (1) CA2392081C (enExample)
CY (2) CY1107610T1 (enExample)
DE (1) DE60034139T2 (enExample)
DK (2) DK2263669T3 (enExample)
ES (4) ES2363933T3 (enExample)
FI (1) FI119931B (enExample)
HK (1) HK1049158A1 (enExample)
MX (1) MXPA02004793A (enExample)
NO (2) NO323633B1 (enExample)
NZ (1) NZ519459A (enExample)
PT (2) PT2263669E (enExample)
SI (1) SI1228071T1 (enExample)
WO (1) WO2001034606A1 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429221B1 (en) 1994-12-30 2002-08-06 Celgene Corporation Substituted imides
US6518281B2 (en) * 1995-08-29 2003-02-11 Celgene Corporation Immunotherapeutic agents
ATE418536T1 (de) * 1996-08-12 2009-01-15 Celgene Corp Neue immunotherapeutische mittel und deren verwendung in der reduzierung von cytokinenspiegel
US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
US7491634B2 (en) * 2006-04-28 2009-02-17 Asm International N.V. Methods for forming roughened surfaces and applications thereof
WO2002086078A2 (en) 2001-04-23 2002-10-31 University Of Virginia Patent Foundation Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic agents
ATE428419T1 (de) * 2001-08-06 2009-05-15 Childrens Medical Center Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
NZ570777A (en) * 2002-05-17 2009-04-30 Celgene Corp Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
BR0315316A (pt) 2002-10-15 2005-08-16 Celgene Corp Métodos de tratar, prevenir ou controlar uma sìndrome mielodisplásica, e de reduzir ou evitar um efeito adverso associado com a administração de um segundo ingrediente ativo em um paciente sofrendo de uma sìndrome mielodisplásica, composição farmacêutica, forma de dosagem unitária, e, kit
US20050203142A1 (en) * 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US20040087558A1 (en) 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
EP1567148A4 (en) * 2002-10-31 2010-09-15 Celgene Corp METHOD OF USE AND COMPOSITIONS WITH SELECTIVE CYTOKINE INHIBITORS FOR THE TREATMENT AND SUPPLEMENT OF MACULAR DEGENERATION
US7776907B2 (en) 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
US7354948B2 (en) 2002-11-06 2008-04-08 Celgene Corporation Methods for treatment of chronic uveitis using cyclopropyl-n-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
BR0316002A (pt) * 2002-11-06 2005-09-13 Celgene Corp Métodos de tratar ou prevenir e controlar uma doença mieloproliferativa, de reduzir ou evitar de um efeito adverso associado com a administração de um segundo agente ativo em um paciente sofrendo de uma doença mieloproliferativa e de aumentar a eficácia terapêutica de um tratamento de doença mieloproliferativa, composição farmacêutica e kit
AU2003294311B8 (en) * 2002-11-18 2008-06-05 Celgene Corporation Method of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
CN1738614A (zh) * 2002-11-18 2006-02-22 细胞基因公司 包含(－)－3－(3,4－二甲氧基－苯基)－3－(1－氧代－1,3－二氢－异吲哚－2－基)－丙酰胺的组合物及其使用方法
CA2511843C (en) * 2002-12-30 2012-04-24 Celgene Corporation Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses
US20040175382A1 (en) * 2003-03-06 2004-09-09 Schafer Peter H. Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
CN1780616B (zh) * 2003-03-06 2010-05-12 细胞基因公司 治疗中枢神经系统疾病的选择性细胞因子抑制药物
NZ542671A (en) 2003-03-12 2008-12-24 Celgene Corp 7-Amido-isoindolyl compounds and their pharmaceutical uses
CN100427465C (zh) * 2003-03-12 2008-10-22 细胞基因公司 N-烷基-异羟肟酸-异吲哚基化合物及其药物用途
CA2518513C (en) * 2003-03-12 2014-05-20 Celgene Corporation N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
US7320992B2 (en) * 2003-08-25 2008-01-22 Amgen Inc. Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
JP2007524656A (ja) * 2003-10-23 2007-08-30 セルジーン・コーポレーション 疼痛を治療、改変および管理するための選択的サイトカイン阻害薬を含む組成物ならびにその使用方法
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
CA2563207A1 (en) * 2004-04-14 2005-11-24 Celgene Corporation Use of selective cytokine inhibitory drugs in myelodysplastic syndromes
KR20070007945A (ko) * 2004-04-23 2007-01-16 셀진 코포레이션 폐 고혈압증의 치료 및 관리를 위한 ｐｄｅ4 조절인자의사용 방법 및 그를 포함하는 조성물
US20080267905A1 (en) * 2004-05-05 2008-10-30 Celgene Corporation Methods and Compositions Using Selective Cytokine Inhibitory Drugs for Treatment and Management of Cancers and Other Diseases
WO2005112917A1 (en) * 2004-05-05 2005-12-01 Celgene Corporation Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases
WO2006004191A1 (en) * 2004-07-05 2006-01-12 Astellas Pharma Inc. Pyrrolopyridazine derivatives which inhibit pde iv and tnf alfa
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US20070190070A1 (en) * 2004-09-03 2007-08-16 Zeldis Jerome B Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
BRPI0514857A (pt) * 2004-09-03 2008-05-06 Celgene Corp composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central
AU2005302523A1 (en) * 2004-10-28 2006-05-11 Celgene Corporation Methods and compositions using PDE4 modulators for treatment and management of central nervous system injury
BRPI0519030A2 (pt) * 2004-12-13 2008-12-23 Celgene Corp mÉtodos de tratamento, prevenÇço, ou controle de inflamaÇço das vias aÉreas e de uma doenÇa ou distérbio das vias aÉreas ou pulmonar, e, composiÇço farmacÊutica
US20070155791A1 (en) * 2005-12-29 2007-07-05 Zeldis Jerome B Methods for treating cutaneous lupus using aminoisoindoline compounds
MX2010010334A (es) * 2008-03-24 2010-10-08 Celgene Corp Tratamiento de psoriasis o artritis psoriatica utilizando ciclopropil-n-{2-{(1s)-1-(3-etoxi-4-metoxifenil)-2-(metilsulfonil )etil]-3-oxoisoindolina-4-il}carboxamida.
WO2010039538A2 (en) * 2008-09-23 2010-04-08 Georgetown University Flavivirus inhibitors and methods for their use
EP2344479B1 (en) * 2008-09-23 2015-04-08 Georgetown University 1,2-benzisothiazolinone and isoindolinone derivatives
KR20110116049A (ko) 2009-02-10 2011-10-24 셀진 코포레이션 결핵의 치료, 예방 및 관리를 위한 ｐｄｅ4 조절제를 포함하는 조성물 및 사용 방법
MX2011012122A (es) * 2009-05-14 2012-02-28 Tianjin Hemay Bio Tech Co Ltd Derivados de tiofeno.
SI2443089T1 (sl) 2009-06-18 2014-07-31 Concert Pharmaceuticals, Inc. Devterirani derivati izoindolin-1,3-diona kot inhibitorji pde4 in tnf-alfa
PH12012500669A1 (en) * 2009-10-09 2018-02-07 Celgene Corp Processes for the preparation of 2-(1-phenylethyl) isoindolin-1-one compounds
PH12012501237A1 (en) * 2009-12-22 2012-11-26 Celgene Corp (methylsulfonyl) ethyl benzene isoindoline derivatives and their therapeutic uses
MX341050B (es) 2010-04-07 2016-08-05 Celgene Corp * Metodos para tratar infeccion viral respiratoria.
AU2011268450B2 (en) 2010-06-15 2015-07-16 Amgen (Europe) GmbH Biomarkers for the treatment of psoriasis
WO2012096859A2 (en) * 2011-01-10 2012-07-19 Celgene Corporation Oral dosage forms of cyclopropanecarboxylic acid {2-[(1s)-1-(3-ethoxy-4-methoxy-phenyl]-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1h-isoindol-4-yl}-amide
CN103402980B (zh) * 2011-01-10 2016-06-29 细胞基因公司 作为pde4和/或细胞因子抑制剂的苯乙基砜异吲哚啉衍生物
WO2012097116A2 (en) 2011-01-14 2012-07-19 Celgene Corporation Isotopologues of isoindole derivatives
EP2683376B1 (en) 2011-03-07 2018-11-28 Celgene Corporation Methods for treating diseases using isoindoline compounds
US9428472B2 (en) 2011-08-16 2016-08-30 Georgetown University Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives
ES2803524T3 (es) * 2011-09-14 2021-01-27 Amgen Europe Gmbh Formulaciones de {2-[(1S)-1-(3-etoxi-4-metoxi-fenil)-2-metanosulfonil-etil]-3-oxo-2,3-dihidro-1H-isoindol-4-il}-amida del ácido ciclopropanocarboxílico
US8981117B2 (en) 2012-09-14 2015-03-17 Celgene Corporation Processes for the preparation of isoindole compounds and isotopologues thereof
EP3142663A1 (en) 2014-05-16 2017-03-22 Celgene Corporation Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators
JP6687550B2 (ja) 2014-06-23 2020-04-22 セルジーン コーポレイション 肝疾患又は肝機能異常を治療するためのアプレミラスト
WO2016146990A1 (en) * 2015-03-19 2016-09-22 Cipla Limited Improved process for the preparation of apremilast
US10682336B2 (en) 2015-10-21 2020-06-16 Amgen Inc. PDE4 modulators for treating and preventing immune reconstitution inflammatory syndrome (IRIS)
HU231259B1 (hu) 2016-02-04 2022-06-28 Egyt Gyogyszervegyeszeti Gyar Eljárás pomalidomide elõállítására
CA3034785C (en) * 2016-08-22 2022-11-15 Shijiazhuang Sagacity New Drug Development Co., Ltd. Pde4 inhibitor
CN107698484B (zh) * 2017-11-13 2020-05-19 广东中科药物研究有限公司 一种来那度胺的衍生物的制备方法与应用
WO2019142124A1 (en) 2018-01-17 2019-07-25 Cadila Healthcare Limited Pharmaceutical compositions for treatment of vitiligo
WO2019201255A1 (zh) 2018-04-17 2019-10-24 天津合美医药科技有限公司 异吲哚衍生物
WO2020020101A1 (zh) * 2018-07-22 2020-01-30 上海星叶医药科技有限公司 苯并异硒唑酮胺类化合物及其制备方法和用途
CN110003084B (zh) * 2019-03-15 2022-08-02 华南师范大学 一种同时具有力致发光和聚集诱导发光特性的有机圆偏振发光材料及其制备方法与应用
CN111170925B (zh) * 2020-01-09 2023-01-17 常州大学 作为pde2/4双重抑制剂的邻苯二甲酰亚胺类化合物及其制备方法
WO2022132603A1 (en) * 2020-12-14 2022-06-23 Biotheryx, Inc. Pde4 degraders, pharmaceutical compositions, and therapeutic applications
KR20230157439A (ko) * 2021-03-15 2023-11-16 선전 포워드 파머수티컬즈 코 엘티디 에스트로겐 수용체 조절제
CN114790164B (zh) * 2021-08-13 2022-12-27 苏州璞正医药有限公司 一种取代的异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途
CN116354857B (zh) * 2023-03-01 2025-01-21 中国人民解放军海军军医大学 一种β-氨基砜及其衍生物的制备方法
WO2025103426A1 (zh) * 2023-11-14 2025-05-22 赣州和美药业股份有限公司 白塞综合征的治疗
WO2025103430A1 (zh) * 2023-11-14 2025-05-22 天津合美医药科技有限公司 干燥综合征的预防或治疗

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173652A (en) 1976-12-18 1979-11-06 Akzona Incorporated Pharmaceutical hydroxamic acid compositions and uses thereof
SE434638B (sv) 1980-06-06 1984-08-06 Lekemedelsfabriken Medica Ab Nya terapeutiska verdefulla taurinderivat och deras framstellning
US4820828A (en) 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
US5605914A (en) 1993-07-02 1997-02-25 Celgene Corporation Imides
US5698579A (en) 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
US6429221B1 (en) * 1994-12-30 2002-08-06 Celgene Corporation Substituted imides
US5801195A (en) 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
US5703098A (en) * 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
JP3131225B2 (ja) 1995-07-26 2001-01-31 ファイザー・インコーポレーテッド Ｎ−（アロイル）グリシンヒドロキサム酸誘導体および関連化合物
US5728845A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic nitriles
US5728844A (en) 1995-08-29 1998-03-17 Celgene Corporation Immunotherapeutic agents
US5658940A (en) 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
AU1529897A (en) 1996-01-02 1997-07-28 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds
EP0968182B1 (en) * 1996-08-07 2004-05-06 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity
ATE418536T1 (de) 1996-08-12 2009-01-15 Celgene Corp Neue immunotherapeutische mittel und deren verwendung in der reduzierung von cytokinenspiegel
NZ502379A (en) * 1997-07-31 2002-10-25 Celgene Corp Substituted alkanohydroxamic acids and use in pharmaceuticals for reducing TNF-alpha levels
US6020358A (en) 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels

Also Published As

Publication number Publication date
CN1420889A (zh) 2003-05-28
HK1053467A1 (en) 2003-10-24
NO336210B1 (no) 2015-06-15
ES2363933T3 (es) 2011-08-19
CA2392081C (en) 2010-01-05
DK1228071T3 (da) 2007-08-06
EP1228071B1 (en) 2007-03-28
NO20071490L (no) 2002-07-08
ATE544451T1 (de) 2012-02-15
AU2005202964A1 (en) 2005-08-11
JP2004500346A (ja) 2004-01-08
PT1228071E (pt) 2007-05-31
NZ519459A (en) 2003-11-28
DE60034139D1 (de) 2007-05-10
AU2005202964B2 (en) 2007-11-22
AU782409B2 (en) 2005-07-28
NO323633B1 (no) 2007-06-18
EP1228071A1 (en) 2002-08-07
EP2255801A1 (en) 2010-12-01
EP1228071A4 (en) 2002-12-04
ATE544452T1 (de) 2012-02-15
EP1698334B1 (en) 2011-04-20
CY1112707T1 (el) 2016-02-10
FI20020892A0 (fi) 2002-05-10
NO20022223L (no) 2002-07-08
DK2263669T3 (da) 2012-04-23
ATE357913T1 (de) 2007-04-15
US6667316B1 (en) 2003-12-23
SI1228071T1 (sl) 2007-08-31
FI20020892L (fi) 2002-06-20
EP2255801B1 (en) 2012-02-08
ATE506058T1 (de) 2011-05-15
AU1478001A (en) 2001-06-06
FI119931B (fi) 2009-05-15
WO2001034606A1 (en) 2001-05-17
CA2392081A1 (en) 2001-05-17
MXPA02004793A (es) 2003-10-14
EP2263669A1 (en) 2010-12-22
CY1107610T1 (el) 2013-03-13
JP5116201B2 (ja) 2013-01-09
ES2282147T3 (es) 2007-10-16
ES2380574T3 (es) 2012-05-16
ES2381174T3 (es) 2012-05-23
EP1228071B8 (en) 2012-02-29
NO20022223D0 (no) 2002-05-08
HK1049158A1 (zh) 2003-05-02
EP2263669B1 (en) 2012-02-08
EP1698334A1 (en) 2006-09-06
PT2263669E (pt) 2012-04-23
CN1325497C (zh) 2007-07-11

Similar Documents

Publication Publication Date Title
DE60034139T2 (de) Pharmazeutisch-aktive isoindolin-derivate
DE60126324T2 (de) Pharmazeutisch wirksame isoindolinderivate
USRE45685E1 (en) Pharmaceutically active isoindoline derivatives
FI121708B (fi) Substituoidut 1,3,4-oksadiatsolit
DE69434645T2 (de) Aminen als Inhibitoren von TNF alpha
DE69522961T2 (de) Immunotherapeutische arylamide
DE69925819T2 (de) 2-(2,6-dioxopiperidin-3-yl)isoindolin derivate, deren herstellung und deren verwendung als inhibitoren von entzündungszytokinen
SK27298A3 (en) Nitrile compounds as inhibitors of tumor necrosis factor alpha, pharmaceutical composition containing the mentioned compounds and their use
DE69520750T2 (de) IMMUNOTHERAPEUTISCHE IMIDE/AMIDE UND IHRE VERWENDUNG ZUR VERMINDERUNG DES TNFalpha-SPIEGELS
KR100590449B1 (ko) 제약학적으로 활성인 이소인돌린 유도체
DE69834668T2 (de) Substituierte 2-(2,6-dioxo-3-fluoropiperidine-3-yl)-isoindoline und ihre Verwendung zum reduzieren des TNF-alpha spiegels
HK1095274A1 (en) Pharmaceutically active isoindoline derivatives
HK1095274B (en) Pharmaceutically active isoindoline derivatives
HK1053467B (en) Pharmaceutically active isoindoline derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R083 Amendment of/additions to inventor(s)

Ref document number: 1228071

Country of ref document: EP