DE60026509D1 - Chinolinderivate als mek enzym-inhibitoren - Google Patents
Chinolinderivate als mek enzym-inhibitorenInfo
- Publication number
- DE60026509D1 DE60026509D1 DE60026509T DE60026509T DE60026509D1 DE 60026509 D1 DE60026509 D1 DE 60026509D1 DE 60026509 T DE60026509 T DE 60026509T DE 60026509 T DE60026509 T DE 60026509T DE 60026509 D1 DE60026509 D1 DE 60026509D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- ring
- group
- groups
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9910577.7A GB9910577D0 (en) | 1999-05-08 | 1999-05-08 | Chemical compounds |
GB9910577 | 1999-05-08 | ||
PCT/GB2000/001697 WO2000068201A1 (en) | 1999-05-08 | 2000-05-03 | Quinoline derivatives as inhibitors of mek enzymes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60026509D1 true DE60026509D1 (de) | 2006-05-04 |
DE60026509T2 DE60026509T2 (de) | 2006-11-16 |
Family
ID=10852987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60026509T Expired - Fee Related DE60026509T2 (de) | 1999-05-08 | 2000-05-03 | Chinolinderivate als mek enzym-inhibitoren |
Country Status (26)
Country | Link |
---|---|
EP (2) | EP1584619A1 (de) |
JP (1) | JP2002544196A (de) |
KR (1) | KR100667719B1 (de) |
CN (1) | CN1219768C (de) |
AT (1) | ATE319688T1 (de) |
AU (1) | AU772846B2 (de) |
BG (1) | BG106073A (de) |
BR (1) | BR0010391A (de) |
CA (1) | CA2372663A1 (de) |
CZ (1) | CZ20013997A3 (de) |
DE (1) | DE60026509T2 (de) |
DK (1) | DK1178967T3 (de) |
EE (1) | EE200100589A (de) |
ES (1) | ES2258455T3 (de) |
GB (2) | GB9910577D0 (de) |
HU (1) | HUP0201219A3 (de) |
IL (1) | IL146317A0 (de) |
IS (1) | IS6138A (de) |
NO (1) | NO321696B1 (de) |
NZ (1) | NZ514980A (de) |
PL (1) | PL352413A1 (de) |
PT (1) | PT1178967E (de) |
SK (1) | SK16102001A3 (de) |
TR (1) | TR200103186T2 (de) |
WO (1) | WO2000068201A1 (de) |
ZA (1) | ZA200108971B (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU8856201A (en) | 2000-09-01 | 2002-03-13 | Andel Inst Van | Inhibition of mitogen-activated protein kinase (mapk) pathway: a selective therapeutic strategy against melanoma |
WO2002036570A1 (en) | 2000-11-02 | 2002-05-10 | Astrazeneca Ab | 4-substituted quinolines as antitumor agents |
JP2004514718A (ja) * | 2000-11-02 | 2004-05-20 | アストラゼネカ アクチボラグ | 抗癌剤としての置換キノリン類 |
CN100457719C (zh) | 2000-12-29 | 2009-02-04 | 惠氏公司 | 区域选择性制备取代的苯并[g]喹啉-3-腈和苯并[g]喹唑啉的方法 |
WO2002076496A1 (en) * | 2001-03-22 | 2002-10-03 | Van Andel Institute | Anthrax lethal factor inhibits tumor growth and angiogenesis |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
WO2003000705A1 (en) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel quinolines and uses thereof |
ES2272737T3 (es) | 2001-07-16 | 2007-05-01 | Astrazeneca Ab | Derivados de quinolina y su uso como inhibidores de tirosina quinasas. |
RU2309150C2 (ru) * | 2001-11-27 | 2007-10-27 | Уайт Холдингз Корпорейшн | 3-цианохинолины в качестве ингибиторов egf-r и her2 киназ |
WO2003048159A1 (en) * | 2001-12-05 | 2003-06-12 | Astrazeneca Ab | Quinoline derivatives |
WO2003047584A1 (en) * | 2001-12-05 | 2003-06-12 | Astrazeneca Ab | Quinoline derivatives |
WO2003047582A1 (en) * | 2001-12-05 | 2003-06-12 | Astrazeneca Ab | Quinoline derivatives as antitumour agents |
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
ES2335276T3 (es) | 2002-03-13 | 2010-03-24 | Array Biopharma, Inc. | Derivados de bencimidazol alquilado n3 como inhibidores de mek. |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
EA200701302A1 (ru) * | 2002-03-30 | 2007-12-28 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | 4-(n-фениламино)хиназолины/-хинолины в качестве ингибиторов тирозинкиназы |
GB0215823D0 (en) | 2002-07-09 | 2002-08-14 | Astrazeneca Ab | Quinazoline derivatives |
EP1521747B1 (de) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Modulatoren von rezeptor-typ-kinase und anwendungsverfahren |
GB0225579D0 (en) * | 2002-11-02 | 2002-12-11 | Astrazeneca Ab | Chemical compounds |
WO2004069250A1 (en) * | 2003-02-03 | 2004-08-19 | Astrazeneca Ab | 3-cyano-quinoline derivatives as non-receptor tyrosine kinase inhibitors |
WO2004069249A1 (en) * | 2003-02-03 | 2004-08-19 | Astrazeneca Ab | 3-cyano-quinoline derivatives as non-receptor tyrosine kinase inhibitors |
MXPA05012839A (es) * | 2003-05-27 | 2006-05-17 | Pfizer Prod Inc | Quinazolinas y pirido[3,4-d] pirimidinas como inhibidores de receptores tirosina quinasa. |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
ATE532782T1 (de) | 2003-09-26 | 2011-11-15 | Exelixis Inc | C-met-modulatoren und anwendungsverfahren |
MXPA06005657A (es) | 2003-11-19 | 2006-08-23 | Array Biopharma Inc | Inhibidores heterociclicos de mek y metodos para usarlos. |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
RU2006121990A (ru) | 2003-11-21 | 2007-12-27 | Эррэй Биофарма Инк. (Us) | Ингибиторы протеинкиназ акт |
BRPI0520812A2 (pt) | 2004-01-16 | 2009-10-06 | Wyeth Corp | método para preparar um composto de quinolina 4-substituìda, e, composto |
TW200529846A (en) | 2004-02-20 | 2005-09-16 | Wyeth Corp | 3-quinolinecarbonitrile protein kinase inhibitors |
JP5214971B2 (ja) | 2004-10-20 | 2013-06-19 | メルク セローノ ソシエテ アノニム | 3−アリルアミノピペリジン誘導体 |
FR2884516B1 (fr) * | 2005-04-15 | 2007-06-22 | Cerep Sa | Antagonistes npy, preparation et utilisations |
CN101626767A (zh) | 2005-05-18 | 2010-01-13 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
PT1971601E (pt) | 2005-11-15 | 2010-01-26 | Array Biopharma Inc | Derivados de n4-fenil-quinazolina-4-amina e compostos relacionados como inibidores de tirosina quinases receptoras do tipo i erbb para o tratamento de doenças hiperproliferativas |
CA2652328A1 (en) | 2006-05-15 | 2007-11-22 | Takeda Pharmaceutical Company Limited | Prophylactic and therapeutic agent for cancer |
WO2008006039A1 (en) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Dihydrothieno pyrimidines as akt protein kinase inhibitors |
WO2008006025A1 (en) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
MY147628A (en) | 2006-07-06 | 2012-12-31 | Array Biopharma Inc | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
CA2677336A1 (en) | 2007-02-06 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof |
EP2136628B1 (de) * | 2007-03-12 | 2015-07-01 | Bayer Intellectual Property GmbH | Phenoxy-substituierte phenylamidin-derivate und deren verwendung als fungizide |
EP1969932A1 (de) * | 2007-03-12 | 2008-09-17 | Bayer CropScience AG | Phenoxyphenylamidine und deren Verwendung als Fungizide |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
JP5628028B2 (ja) | 2007-07-05 | 2014-11-19 | アレイ バイオファーマ、インコーポレイテッド | Aktプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン |
BRPI0813993A2 (pt) | 2007-07-05 | 2015-06-16 | Array Biopharma Inc | Ciclopentanos de pirimidila como inibidores de proteína quinase akt |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
EA018798B1 (ru) | 2007-11-15 | 2013-10-30 | Кланотек Аб | Производные хинолина и их применение |
JP5539216B2 (ja) | 2007-11-20 | 2014-07-02 | メルク・シャープ・アンド・ドーム・コーポレーション | 非ヌクレオシド系逆転写酵素阻害剤 |
EP2240455B1 (de) | 2008-01-09 | 2012-12-26 | Array Biopharma, Inc. | Hydroxylierte pyrimidyl-cyclopentane als akt-proteinkinasehemmer |
BRPI0906798A2 (pt) | 2008-01-09 | 2015-07-14 | Array Biopharma Inc | Pirimidil ciclopentanos hidroxilados como inibidores de proteína quinase akt |
KR20100111291A (ko) | 2008-02-07 | 2010-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 스피로사이클릭 헤테로사이클, 상기 화합물을 함유하는 약제, 이의 용도 및 이의 제조 방법 |
UA107183C2 (uk) | 2008-08-04 | 2014-12-10 | Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань | |
CA2733153C (en) | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
EP2346818B1 (de) | 2008-11-10 | 2012-12-05 | Bayer Intellectual Property GmbH | Substituierte sulfonamidophenoxybenzamide |
EA019959B1 (ru) | 2009-01-16 | 2014-07-30 | Экселиксис, Инк. | Малатная соль n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее кристаллические формы для лечения рака |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
US20120269803A1 (en) | 2009-10-21 | 2012-10-25 | Bayer Intellectual Property Gmbh | Substituted benzosulphonamides |
EP2491014A1 (de) | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Substituierte halophenoxybenzamidderivate |
US8962606B2 (en) | 2009-10-21 | 2015-02-24 | Bayer Intellectual Property Gmbh | Substituted benzosulphonamides |
CN102753533B (zh) * | 2009-12-11 | 2014-07-30 | 奥蒂福尼疗法有限公司 | 咪唑烷二酮衍生物 |
KR101562347B1 (ko) | 2010-06-09 | 2015-10-22 | 티안진 헤메이 바이오-텍 컴퍼니 리미티드 | 시아노퀴놀린 유도체 |
CN103282351A (zh) | 2010-10-29 | 2013-09-04 | 拜耳知识产权有限责任公司 | 取代的苯氧基吡啶 |
CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
PL2694073T3 (pl) | 2011-04-01 | 2019-06-28 | Genentech, Inc. | Kombinacje inhibitorów AKT i MEK do leczenia nowotworu |
JP6143739B2 (ja) | 2011-04-01 | 2017-06-07 | ジェネンテック, インコーポレイテッド | Akt阻害剤化合物及びベムラフェニブの組み合わせ、及び使用方法 |
CA2836364C (en) | 2011-05-25 | 2021-01-26 | Universite Paris Descartes | Erk inhibitors for use in treating spinal muscular atrophy |
CN103204822B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
WO2015038704A1 (en) | 2013-09-11 | 2015-03-19 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Compositions for preparing cardiomyocytes |
AU2015206603B9 (en) | 2014-01-14 | 2019-07-18 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms |
EP3204516B1 (de) | 2014-10-06 | 2023-04-26 | Dana-Farber Cancer Institute, Inc. | Prädiktive angiopoietin-2-biomarker für anti-immun-checkpoint-reaktion |
MA41866A (fr) | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | Molécules à auto-assemblage pour l'administration ciblée de médicaments |
US11124483B2 (en) * | 2015-09-02 | 2021-09-21 | The Regents Of The University Of California | HER3 ligands and uses thereof |
BR112018006873A2 (pt) | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
WO2019042409A1 (zh) * | 2017-09-01 | 2019-03-07 | 上海医药集团股份有限公司 | 一种含氮杂环化合物、制备方法、中间体、组合物和应用 |
TW202010737A (zh) * | 2018-06-21 | 2020-03-16 | 瑞士商西萊絲蒂亞生物科技股份有限公司 | 胺基二芳基醚的製備方法 |
BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
TW202342018A (zh) | 2022-03-04 | 2023-11-01 | 美商奇奈特生物製藥公司 | Mek激酶抑制劑 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998013350A1 (en) * | 1996-09-25 | 1998-04-02 | Zeneca Limited | Qinoline derivatives inhibiting the effect of growth factors such as vegf |
UA73073C2 (uk) * | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
CA2290506C (en) * | 1997-07-01 | 2005-12-27 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors |
PL201475B1 (pl) * | 1998-09-29 | 2009-04-30 | Wyeth Corp | Podstawione 3-cyjanochinoliny jako inhibitory białkowych kinaz tyrozynowych |
NZ510580A (en) * | 1998-09-29 | 2003-03-28 | American Cyanamid Co | Substituted 3-cyanoquinolines useful as protein tyrosine kinases inhibitors |
-
1999
- 1999-05-08 GB GBGB9910577.7A patent/GB9910577D0/en not_active Ceased
-
2000
- 2000-04-19 GB GBGB0009532.3A patent/GB0009532D0/en not_active Ceased
- 2000-05-03 AU AU45891/00A patent/AU772846B2/en not_active Ceased
- 2000-05-03 EP EP05013587A patent/EP1584619A1/de not_active Withdrawn
- 2000-05-03 AT AT00927491T patent/ATE319688T1/de not_active IP Right Cessation
- 2000-05-03 KR KR1020017014244A patent/KR100667719B1/ko not_active IP Right Cessation
- 2000-05-03 PL PL00352413A patent/PL352413A1/xx not_active Application Discontinuation
- 2000-05-03 CN CNB008099596A patent/CN1219768C/zh not_active Expired - Fee Related
- 2000-05-03 CZ CZ20013997A patent/CZ20013997A3/cs unknown
- 2000-05-03 HU HU0201219A patent/HUP0201219A3/hu unknown
- 2000-05-03 JP JP2000617181A patent/JP2002544196A/ja active Pending
- 2000-05-03 DK DK00927491T patent/DK1178967T3/da active
- 2000-05-03 DE DE60026509T patent/DE60026509T2/de not_active Expired - Fee Related
- 2000-05-03 EP EP00927491A patent/EP1178967B1/de not_active Expired - Lifetime
- 2000-05-03 ES ES00927491T patent/ES2258455T3/es not_active Expired - Lifetime
- 2000-05-03 SK SK1610-2001A patent/SK16102001A3/sk unknown
- 2000-05-03 WO PCT/GB2000/001697 patent/WO2000068201A1/en active IP Right Grant
- 2000-05-03 PT PT00927491T patent/PT1178967E/pt unknown
- 2000-05-03 IL IL14631700A patent/IL146317A0/xx unknown
- 2000-05-03 NZ NZ514980A patent/NZ514980A/en unknown
- 2000-05-03 EE EEP200100589A patent/EE200100589A/xx unknown
- 2000-05-03 CA CA002372663A patent/CA2372663A1/en not_active Abandoned
- 2000-05-03 TR TR2001/03186T patent/TR200103186T2/xx unknown
- 2000-05-03 BR BR0010391-8A patent/BR0010391A/pt not_active Application Discontinuation
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2001
- 2001-10-30 ZA ZA200108971A patent/ZA200108971B/en unknown
- 2001-10-30 IS IS6138A patent/IS6138A/is unknown
- 2001-11-01 BG BG106073A patent/BG106073A/xx unknown
- 2001-11-07 NO NO20015448A patent/NO321696B1/no unknown
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