DE60021286D1 - Verfahren zur herstellung von pyrazolo[1,5-b]pyridazin-derivaten - Google Patents

Verfahren zur herstellung von pyrazolo[1,5-b]pyridazin-derivaten

Info

Publication number
DE60021286D1
DE60021286D1 DE60021286T DE60021286T DE60021286D1 DE 60021286 D1 DE60021286 D1 DE 60021286D1 DE 60021286 T DE60021286 T DE 60021286T DE 60021286 T DE60021286 T DE 60021286T DE 60021286 D1 DE60021286 D1 DE 60021286D1
Authority
DE
Germany
Prior art keywords
6alkyl
6alkoxy
nsc1
fluorine atoms
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60021286T
Other languages
English (en)
Other versions
DE60021286T2 (de
Inventor
Neil Mathews
Richard A Ward
J Whitehead
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE60021286D1 publication Critical patent/DE60021286D1/de
Publication of DE60021286T2 publication Critical patent/DE60021286T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
DE60021286T 1999-12-22 2000-12-20 Verfahren zur herstellung von pyrazolo[1,5-b]pyridazin-derivaten Expired - Fee Related DE60021286T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9930358 1999-12-22
GBGB9930358.8A GB9930358D0 (en) 1999-12-22 1999-12-22 Process for the preparation of chemical compounds
PCT/EP2000/013001 WO2001046194A2 (en) 1999-12-22 2000-12-20 Process for the preparation of pyrazolo[1,5-b]pyridazine derivatives

Publications (2)

Publication Number Publication Date
DE60021286D1 true DE60021286D1 (de) 2005-08-18
DE60021286T2 DE60021286T2 (de) 2005-12-29

Family

ID=10866856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60021286T Expired - Fee Related DE60021286T2 (de) 1999-12-22 2000-12-20 Verfahren zur herstellung von pyrazolo[1,5-b]pyridazin-derivaten

Country Status (22)

Country Link
US (1) US6803463B2 (de)
EP (1) EP1242424B1 (de)
JP (1) JP2003518121A (de)
KR (1) KR20020062362A (de)
CN (1) CN1197864C (de)
AT (1) ATE299506T1 (de)
AU (1) AU776777B2 (de)
BR (1) BR0016549A (de)
CA (1) CA2395569A1 (de)
CZ (1) CZ20022178A3 (de)
DE (1) DE60021286T2 (de)
ES (1) ES2243343T3 (de)
GB (1) GB9930358D0 (de)
HK (1) HK1047586B (de)
HU (1) HUP0203407A3 (de)
IL (1) IL150274A0 (de)
MX (1) MXPA02006132A (de)
NO (1) NO323412B1 (de)
NZ (1) NZ519691A (de)
PL (1) PL356141A1 (de)
WO (1) WO2001046194A2 (de)
ZA (1) ZA200204911B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0021494D0 (en) * 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
GB0112802D0 (en) * 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112810D0 (en) * 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
ES2263058T3 (es) 2002-08-19 2006-12-01 Glaxo Group Limited Derivados de pirimidina como inhibidores selectivos de cox-2.
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
GB0227443D0 (en) * 2002-11-25 2002-12-31 Glaxo Group Ltd Pyrimidine derivatives
GB0229808D0 (en) * 2002-12-20 2003-01-29 Glaxo Group Ltd Novel compositions
US7145762B2 (en) * 2003-02-11 2006-12-05 Taser International, Inc. Systems and methods for immobilizing using plural energy stores
GB0319037D0 (en) * 2003-08-13 2003-09-17 Glaxo Group Ltd 7-Azaindole Derivatives
DE102006040754B3 (de) * 2006-08-31 2008-03-27 Knorr-Bremse Systeme für Nutzfahrzeuge GmbH Scheibenbremse, insbesondere für ein Nutzfahrzeug

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58134094A (ja) * 1982-02-02 1983-08-10 Mitsubishi Paper Mills Ltd ３―ホルミル―ピラゾロ〔１，５―ｂ〕ピリダジン類
US5002941A (en) 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4925849A (en) 1987-06-15 1990-05-15 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutically useful pyrazolopyridines
US5155114A (en) 1989-01-23 1992-10-13 Fujisawa Pharmaceutical Company, Ltd. Method of treatment using pyrazolopyridine compound
GB8901423D0 (en) 1989-01-23 1989-03-15 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
AU6355190A (en) 1989-06-13 1991-01-17 Smithkline Beecham Corporation Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
AU622330B2 (en) 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
AU8205991A (en) 1990-06-12 1992-01-07 Smithkline Beecham Corporation Inhibition of 5-lipoxygenase and cyclooxygenase pathway mediated diseases
GB9015764D0 (en) 1990-07-18 1990-09-05 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
US5300478A (en) 1993-01-28 1994-04-05 Zeneca Limited Substituted fused pyrazolo compounds
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5552422A (en) 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
NZ304886A (en) 1995-04-04 1998-11-25 Glaxo Group Ltd Imidazo [1,2a] pyridine derivatives, preparation and pharmaceutical compositions thereof
EP0833622B8 (de) 1995-06-12 2005-10-12 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
CA2224563A1 (en) 1995-06-12 1996-12-27 G.D. Searle & Co. Combination of a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist for the treatment of inflammations
AU744997B2 (en) 1997-09-05 2002-03-07 Glaxo Group Limited 2,3-diaryl-pyrazolo(1,5-B)pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors
ATE261444T1 (de) * 1999-02-27 2004-03-15 Glaxo Group Ltd Pyrazolopyridine
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
GB9930358D0 (en) 2000-02-09
NO20023041D0 (no) 2002-06-21
ZA200204911B (en) 2004-02-13
ES2243343T3 (es) 2005-12-01
WO2001046194A2 (en) 2001-06-28
HUP0203407A2 (hu) 2003-01-28
PL356141A1 (en) 2004-06-14
CN1413215A (zh) 2003-04-23
WO2001046194A3 (en) 2002-05-30
DE60021286T2 (de) 2005-12-29
HK1047586B (zh) 2005-12-16
US6803463B2 (en) 2004-10-12
NO20023041L (no) 2002-08-16
CA2395569A1 (en) 2001-06-28
EP1242424A2 (de) 2002-09-25
NZ519691A (en) 2004-06-25
HUP0203407A3 (en) 2004-12-28
CZ20022178A3 (cs) 2003-02-12
CN1197864C (zh) 2005-04-20
HK1047586A1 (en) 2003-02-28
KR20020062362A (ko) 2002-07-25
EP1242424B1 (de) 2005-07-13
US20030078267A1 (en) 2003-04-24
IL150274A0 (en) 2002-12-01
AU2675101A (en) 2001-07-03
ATE299506T1 (de) 2005-07-15
BR0016549A (pt) 2002-09-17
MXPA02006132A (es) 2002-12-05
JP2003518121A (ja) 2003-06-03
NO323412B1 (no) 2007-04-30
AU776777B2 (en) 2004-09-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee