DE60020079T2 - Phenanthridin-N-oxide mit PDE-IV-hemmender Wirkung - Google Patents

Phenanthridin-N-oxide mit PDE-IV-hemmender Wirkung Download PDF

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Publication number
DE60020079T2
DE60020079T2 DE60020079T DE60020079T DE60020079T2 DE 60020079 T2 DE60020079 T2 DE 60020079T2 DE 60020079 T DE60020079 T DE 60020079T DE 60020079 T DE60020079 T DE 60020079T DE 60020079 T2 DE60020079 T2 DE 60020079T2
Authority
DE
Germany
Prior art keywords
alkoxy
substituted
hydrogen
alkyl
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60020079T
Other languages
German (de)
English (en)
Other versions
DE60020079D1 (de
Inventor
Dieter Flockerzi
Hermann Di Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Gutterer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of DE60020079D1 publication Critical patent/DE60020079D1/de
Publication of DE60020079T2 publication Critical patent/DE60020079T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE60020079T 1999-01-15 2000-01-12 Phenanthridin-N-oxide mit PDE-IV-hemmender Wirkung Expired - Fee Related DE60020079T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100707 1999-01-15
EP99100707 1999-01-15
PCT/EP2000/000150 WO2000042017A1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (2)

Publication Number Publication Date
DE60020079D1 DE60020079D1 (de) 2005-06-16
DE60020079T2 true DE60020079T2 (de) 2006-01-19

Family

ID=8237354

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60020079T Expired - Fee Related DE60020079T2 (de) 1999-01-15 2000-01-12 Phenanthridin-N-oxide mit PDE-IV-hemmender Wirkung

Country Status (12)

Country Link
US (1) US6538005B2 (https=)
EP (1) EP1147087B1 (https=)
JP (1) JP2002534505A (https=)
AT (1) ATE295352T1 (https=)
AU (1) AU2107700A (https=)
CA (1) CA2359404A1 (https=)
DE (1) DE60020079T2 (https=)
DK (1) DK1147087T3 (https=)
ES (1) ES2242594T3 (https=)
PT (1) PT1147087E (https=)
SI (1) SI1147087T1 (https=)
WO (1) WO2000042017A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1650193A3 (en) * 1999-01-15 2006-10-04 ALTANA Pharma AG 6-Phenylphenanthridines with PDE-IV inhibiting activity
CA2396026A1 (en) 2000-01-11 2001-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides
PT1303506E (pt) 2000-07-14 2005-06-30 Altana Pharma Ag 6-heteroarilfenantridinas
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
ES2281658T3 (es) 2002-08-29 2007-10-01 Nycomed Gmbh 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4.
AU2005212857B2 (en) 2004-02-18 2011-04-28 Takeda Gmbh Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors
CN104803974A (zh) 2004-03-03 2015-07-29 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
CA2579000C (en) * 2004-09-08 2013-02-05 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
ES2337083T3 (es) 2005-03-02 2010-04-20 Nycomed Gmbh (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1.
CA2599368A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
MX2010003155A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de ciclopropil aril amida y uso de los mismos.
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
UA48216C2 (uk) 1996-01-31 2002-08-15 Бік Гулден Ломберг Кеміше Фабрік Гмбх Фенантридини та лікарський засіб для лікування захворювань дихальних шляхів
WO1997035854A1 (de) * 1996-03-26 1997-10-02 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue in 6-position substituierte phenanthridine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
EE03829B1 (et) * 1996-11-11 2002-08-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
JP2001514640A (ja) 1997-03-07 2001-09-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規のテトラゾール
CA2291153A1 (en) * 1997-06-03 1998-12-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
DE69822162T2 (de) 1997-07-25 2005-01-27 Altana Pharma Ag Neue tetrazolderivate
JP2001510827A (ja) * 1997-07-25 2001-08-07 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 置換６−フェニルフェナントリジン
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
EP1147087A1 (en) 2001-10-24
ATE295352T1 (de) 2005-05-15
WO2000042017A1 (en) 2000-07-20
ES2242594T3 (es) 2005-11-16
PT1147087E (pt) 2005-09-30
US6538005B2 (en) 2003-03-25
DE60020079D1 (de) 2005-06-16
JP2002534505A (ja) 2002-10-15
CA2359404A1 (en) 2000-07-20
DK1147087T3 (da) 2005-09-05
EP1147087B1 (en) 2005-05-11
SI1147087T1 (en) 2005-10-31
AU2107700A (en) 2000-08-01
US20020183350A1 (en) 2002-12-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NYCOMED GMBH, 78467 KONSTANZ, DE

8339 Ceased/non-payment of the annual fee