CA2359404A1 - Phenanthridine-n-oxides with pde-iv inhibiting activity - Google Patents

Phenanthridine-n-oxides with pde-iv inhibiting activity Download PDF

Info

Publication number
CA2359404A1
CA2359404A1 CA002359404A CA2359404A CA2359404A1 CA 2359404 A1 CA2359404 A1 CA 2359404A1 CA 002359404 A CA002359404 A CA 002359404A CA 2359404 A CA2359404 A CA 2359404A CA 2359404 A1 CA2359404 A1 CA 2359404A1
Authority
CA
Canada
Prior art keywords
alkoxy
hydrogen
alkyl
compounds
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002359404A
Other languages
English (en)
French (fr)
Inventor
Beate Gutterer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2359404A1 publication Critical patent/CA2359404A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA002359404A 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity Abandoned CA2359404A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100707.1 1999-01-15
EP99100707 1999-01-15
PCT/EP2000/000150 WO2000042017A1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
CA2359404A1 true CA2359404A1 (en) 2000-07-20

Family

ID=8237354

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002359404A Abandoned CA2359404A1 (en) 1999-01-15 2000-01-12 Phenanthridine-n-oxides with pde-iv inhibiting activity

Country Status (12)

Country Link
US (1) US6538005B2 (https=)
EP (1) EP1147087B1 (https=)
JP (1) JP2002534505A (https=)
AT (1) ATE295352T1 (https=)
AU (1) AU2107700A (https=)
CA (1) CA2359404A1 (https=)
DE (1) DE60020079T2 (https=)
DK (1) DK1147087T3 (https=)
ES (1) ES2242594T3 (https=)
PT (1) PT1147087E (https=)
SI (1) SI1147087T1 (https=)
WO (1) WO2000042017A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200501553T2 (tr) * 1999-01-15 2005-06-21 Altana Pharma Ag PDE-IV inhibe edici aktivitesi olan fenilfenantridinler
WO2001051470A1 (en) 2000-01-11 2001-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides
ES2236288T3 (es) 2000-07-14 2005-07-16 Altana Pharma Ag 6-heteroarilfenantridinas.
WO2002006239A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Phenanthridine n-oxides
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
PL2589599T4 (pl) 2004-03-03 2015-06-30 Takeda Gmbh Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
EP1725534A1 (en) * 2004-03-10 2006-11-29 Altana Pharma AG Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
EP1791847A2 (en) 2004-09-08 2007-06-06 Altana Pharma AG Novel 3-thia-10-aza-phenanthrene derivatives
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
CA2599368A1 (en) * 2005-03-09 2006-09-14 Nycomed Gmbh Amido-substituted 6-phenylphenanthridines
ES2460897T3 (es) 2007-10-04 2014-05-14 F. Hoffmann-La Roche Ag Derivados de ciclopropil aril amida y usos de los mismos
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
BR9707233A (pt) 1996-01-31 1999-07-20 Byk Gulden Lomberg Chem Fab Fenantridinas
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
SI0889886T1 (en) * 1996-03-26 2003-02-28 Altana Pharma Ag Novel phenanthridines substituted in the 6 position
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
PL189641B1 (pl) 1996-11-11 2005-09-30 Altana Pharma Ag Benzonaftyrydyny, środki farmaceutyczne je zawierające oraz zastosowanie benzonaftyrydyn
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
SI0968211T1 (en) 1997-03-07 2004-02-29 Altana Pharma Ag Tetrazole derivatives
ES2193539T3 (es) * 1997-06-03 2003-11-01 Altana Pharma Ag Benzonaftiridinas.
PT998460E (pt) 1997-07-25 2004-07-30 Altana Pharma Ag Novos derivados de tetrazole
JP2001510827A (ja) * 1997-07-25 2001-08-07 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 置換６−フェニルフェナントリジン
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
EP1147087A1 (en) 2001-10-24
DE60020079T2 (de) 2006-01-19
ES2242594T3 (es) 2005-11-16
WO2000042017A1 (en) 2000-07-20
JP2002534505A (ja) 2002-10-15
DE60020079D1 (de) 2005-06-16
PT1147087E (pt) 2005-09-30
ATE295352T1 (de) 2005-05-15
AU2107700A (en) 2000-08-01
SI1147087T1 (en) 2005-10-31
US20020183350A1 (en) 2002-12-05
EP1147087B1 (en) 2005-05-11
DK1147087T3 (da) 2005-09-05
US6538005B2 (en) 2003-03-25

Similar Documents

Publication Publication Date Title
EP1000035B1 (en) Substituted 6-phenylphenanthridines
CA2359440C (en) Phenylphenanthridines with pde-iv inhibiting activity
EP0998460B1 (en) Novel tetrazole derivatives
US6127378A (en) Phenanthridines substituted in the 6 position
US6534518B1 (en) Polysubstituted 6-phenylphenanthridines with PDE-IV inhibiting activity
EP1147103B1 (en) Phenantrhridine-n-oxides with pde-iv inhibiting activity
EP1147087B1 (en) Phenanthridine-n-oxides with pde-iv inhibiting activity
EP1000034B1 (en) Substituted 6-alkylphenanthridines
US6479505B1 (en) 6-arylphenanthridines with PDE-IV inhibiting activity
WO2002005616A1 (en) Novel 6-phenylphenanthridines
EP1250325B1 (en) Phenanthridine-n-oxides
WO2002006238A1 (en) Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines
WO2002006239A1 (en) Phenanthridine n-oxides

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued