DK1147087T3 - Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet - Google Patents
Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitetInfo
- Publication number
- DK1147087T3 DK1147087T3 DK00901089T DK00901089T DK1147087T3 DK 1147087 T3 DK1147087 T3 DK 1147087T3 DK 00901089 T DK00901089 T DK 00901089T DK 00901089 T DK00901089 T DK 00901089T DK 1147087 T3 DK1147087 T3 DK 1147087T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxides
- phenanthridine
- pde
- inhibitory activity
- compounds
- Prior art date
Links
- BSGIEESBTVXEOH-UHFFFAOYSA-N 5-oxidophenanthridin-5-ium Chemical class C1=CC=C2[N+]([O-])=CC3=CC=CC=C3C2=C1 BSGIEESBTVXEOH-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100707 | 1999-01-15 | ||
| EP00901089A EP1147087B1 (en) | 1999-01-15 | 2000-01-12 | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| PCT/EP2000/000150 WO2000042017A1 (en) | 1999-01-15 | 2000-01-12 | Phenanthridine-n-oxides with pde-iv inhibiting activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1147087T3 true DK1147087T3 (da) | 2005-09-05 |
Family
ID=8237354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00901089T DK1147087T3 (da) | 1999-01-15 | 2000-01-12 | Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6538005B2 (https=) |
| EP (1) | EP1147087B1 (https=) |
| JP (1) | JP2002534505A (https=) |
| AT (1) | ATE295352T1 (https=) |
| AU (1) | AU2107700A (https=) |
| CA (1) | CA2359404A1 (https=) |
| DE (1) | DE60020079T2 (https=) |
| DK (1) | DK1147087T3 (https=) |
| ES (1) | ES2242594T3 (https=) |
| PT (1) | PT1147087E (https=) |
| SI (1) | SI1147087T1 (https=) |
| WO (1) | WO2000042017A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200501553T2 (tr) * | 1999-01-15 | 2005-06-21 | Altana Pharma Ag | PDE-IV inhibe edici aktivitesi olan fenilfenantridinler |
| WO2001051470A1 (en) | 2000-01-11 | 2001-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides |
| ES2236288T3 (es) | 2000-07-14 | 2005-07-16 | Altana Pharma Ag | 6-heteroarilfenantridinas. |
| WO2002006239A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Phenanthridine n-oxides |
| ATE353217T1 (de) | 2002-08-29 | 2007-02-15 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
| CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| PL2589599T4 (pl) | 2004-03-03 | 2015-06-30 | Takeda Gmbh | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| EP1725534A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| EP1791847A2 (en) | 2004-09-08 | 2007-06-06 | Altana Pharma AG | Novel 3-thia-10-aza-phenanthrene derivatives |
| PL1856093T3 (pl) | 2005-03-02 | 2010-05-31 | Takeda Gmbh | Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu |
| CA2599368A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
| ES2460897T3 (es) | 2007-10-04 | 2014-05-14 | F. Hoffmann-La Roche Ag | Derivados de ciclopropil aril amida y usos de los mismos |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| US5475003A (en) * | 1994-03-03 | 1995-12-12 | Syntex (U.S.A.) Inc. | 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives |
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
| BR9707233A (pt) | 1996-01-31 | 1999-07-20 | Byk Gulden Lomberg Chem Fab | Fenantridinas |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| SI0889886T1 (en) * | 1996-03-26 | 2003-02-28 | Altana Pharma Ag | Novel phenanthridines substituted in the 6 position |
| GB9622386D0 (en) * | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| PL189641B1 (pl) | 1996-11-11 | 2005-09-30 | Altana Pharma Ag | Benzonaftyrydyny, środki farmaceutyczne je zawierające oraz zastosowanie benzonaftyrydyn |
| GB9626643D0 (en) | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
| SI0968211T1 (en) | 1997-03-07 | 2004-02-29 | Altana Pharma Ag | Tetrazole derivatives |
| ES2193539T3 (es) * | 1997-06-03 | 2003-11-01 | Altana Pharma Ag | Benzonaftiridinas. |
| PT998460E (pt) | 1997-07-25 | 2004-07-30 | Altana Pharma Ag | Novos derivados de tetrazole |
| JP2001510827A (ja) * | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 置換６−フェニルフェナントリジン |
| AU5970199A (en) | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
-
2000
- 2000-01-12 DE DE60020079T patent/DE60020079T2/de not_active Expired - Fee Related
- 2000-01-12 ES ES00901089T patent/ES2242594T3/es not_active Expired - Lifetime
- 2000-01-12 AT AT00901089T patent/ATE295352T1/de not_active IP Right Cessation
- 2000-01-12 PT PT00901089T patent/PT1147087E/pt unknown
- 2000-01-12 JP JP2000593585A patent/JP2002534505A/ja not_active Withdrawn
- 2000-01-12 CA CA002359404A patent/CA2359404A1/en not_active Abandoned
- 2000-01-12 DK DK00901089T patent/DK1147087T3/da active
- 2000-01-12 SI SI200030717T patent/SI1147087T1/xx unknown
- 2000-01-12 EP EP00901089A patent/EP1147087B1/en not_active Expired - Lifetime
- 2000-01-12 WO PCT/EP2000/000150 patent/WO2000042017A1/en not_active Ceased
- 2000-01-12 AU AU21077/00A patent/AU2107700A/en not_active Abandoned
-
2001
- 2001-01-12 US US09/889,142 patent/US6538005B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1147087A1 (en) | 2001-10-24 |
| DE60020079T2 (de) | 2006-01-19 |
| ES2242594T3 (es) | 2005-11-16 |
| WO2000042017A1 (en) | 2000-07-20 |
| JP2002534505A (ja) | 2002-10-15 |
| DE60020079D1 (de) | 2005-06-16 |
| CA2359404A1 (en) | 2000-07-20 |
| PT1147087E (pt) | 2005-09-30 |
| ATE295352T1 (de) | 2005-05-15 |
| AU2107700A (en) | 2000-08-01 |
| SI1147087T1 (en) | 2005-10-31 |
| US20020183350A1 (en) | 2002-12-05 |
| EP1147087B1 (en) | 2005-05-11 |
| US6538005B2 (en) | 2003-03-25 |
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| DE59709437D1 (de) | Neue phenanthridine | |
| PT998460E (pt) | Novos derivados de tetrazole | |
| DK1147087T3 (da) | Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet | |
| AU2904300A (en) | Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity | |
| DK1109810T3 (da) | Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet | |
| DK1147088T3 (da) | 6-arylphenanthridiner med PDE-IV-inhiberende aktivitet |