DE60017359T2 - Glutathioneanaloge enthaltende therapeutische zusammensetzungen - Google Patents

Glutathioneanaloge enthaltende therapeutische zusammensetzungen Download PDF

Info

Publication number
DE60017359T2
DE60017359T2 DE60017359T DE60017359T DE60017359T2 DE 60017359 T2 DE60017359 T2 DE 60017359T2 DE 60017359 T DE60017359 T DE 60017359T DE 60017359 T DE60017359 T DE 60017359T DE 60017359 T2 DE60017359 T2 DE 60017359T2
Authority
DE
Germany
Prior art keywords
compound
lipid
lipid formulation
weight
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017359T
Other languages
German (de)
English (en)
Other versions
DE60017359D1 (de
Inventor
Thomas Redelmeier
M. Lawrence KAUVAR
T. Robert LUM
H. Matthew LYTTLE
W. Robert MACSATA
R. Steven SCHOW
O. Hugo VILLAR
R. Michael KOZLOWSKI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telik Inc filed Critical Telik Inc
Application granted granted Critical
Publication of DE60017359D1 publication Critical patent/DE60017359D1/de
Publication of DE60017359T2 publication Critical patent/DE60017359T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60017359T 1999-01-27 2000-01-27 Glutathioneanaloge enthaltende therapeutische zusammensetzungen Expired - Lifetime DE60017359T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23853099A 1999-01-27 1999-01-27
US238530 1999-01-27
PCT/US2000/002297 WO2000044366A2 (en) 1999-01-27 2000-01-27 Therapeutic compositions containing glutathione analogs

Publications (2)

Publication Number Publication Date
DE60017359D1 DE60017359D1 (de) 2005-02-17
DE60017359T2 true DE60017359T2 (de) 2005-12-01

Family

ID=22898312

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017359T Expired - Lifetime DE60017359T2 (de) 1999-01-27 2000-01-27 Glutathioneanaloge enthaltende therapeutische zusammensetzungen

Country Status (12)

Country Link
EP (1) EP1143992B1 (OSRAM)
JP (2) JP2002535359A (OSRAM)
KR (1) KR100750842B1 (OSRAM)
CN (1) CN1185008C (OSRAM)
AT (1) ATE286741T1 (OSRAM)
AU (1) AU778340B2 (OSRAM)
CA (1) CA2360795C (OSRAM)
DE (1) DE60017359T2 (OSRAM)
ES (1) ES2231159T3 (OSRAM)
HK (1) HK1043310B (OSRAM)
PT (1) PT1143992E (OSRAM)
WO (1) WO2000044366A2 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69925824D1 (de) 1998-04-16 2005-07-21 Teijin Ltd Glutathionderivate und dazugehörige dosisformen
US7029695B2 (en) 2001-07-10 2006-04-18 Telik, Inc. Therapeutic compositions containing glutathione analogs
DE602006003064D1 (en) 2005-01-06 2008-11-20 Telik Inc Tripeptid- und tetrapeptid-thioether
CN101434645B (zh) * 2008-12-24 2013-01-16 中国农业大学 一种合成寡肽及其用途
JP2015500809A (ja) * 2011-12-02 2015-01-08 テリク， インコーポレイテッド 非晶質エザチオスタット非溶媒和物
CN108863888B (zh) * 2018-07-18 2021-10-12 吉尔生化（上海）有限公司 一种(s)-1-(叔丁氧羰基)-5-氧吡咯烷-2-羧酸乙酯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786336A (en) * 1991-04-29 1998-07-28 Terrapin Technologies, Inc. Target-selective protocols based on mimics
JP3118869B2 (ja) * 1991-05-14 2000-12-18 ウェルファイド株式会社 プロスタグランジン類含有脂肪小体組成物
CA2087902C (en) * 1992-02-05 2006-10-17 Narendra Raghunathji Desai Liposome compositions of porphyrin photosensitizers
JP3383704B2 (ja) * 1993-04-02 2003-03-04 わかもと製薬株式会社 安定なリポソーム水分散液
EP0721328A4 (en) * 1993-09-27 1997-09-17 Smithkline Beecham Corp CAMPTOTHECIN FORMULATIONS
JP2891883B2 (ja) * 1993-11-05 1999-05-17 学校法人近畿大学 抗白内障医薬組成物
DK0831877T3 (da) * 1995-06-07 2005-02-14 Telik Inc Metabolske virkninger af visse glutathionanaloge

Also Published As

Publication number Publication date
ES2231159T3 (es) 2005-05-16
CA2360795C (en) 2010-03-23
AU778340B2 (en) 2004-12-02
WO2000044366A3 (en) 2000-12-21
CN1185008C (zh) 2005-01-19
HK1043310A1 (en) 2002-09-13
JP2007326877A (ja) 2007-12-20
HK1043310B (zh) 2005-10-07
KR20010101775A (ko) 2001-11-14
JP2002535359A (ja) 2002-10-22
DE60017359D1 (de) 2005-02-17
EP1143992B1 (en) 2005-01-12
AU2976700A (en) 2000-08-18
WO2000044366A2 (en) 2000-08-03
EP1143992A2 (en) 2001-10-17
ATE286741T1 (de) 2005-01-15
PT1143992E (pt) 2005-05-31
CN1342084A (zh) 2002-03-27
CA2360795A1 (en) 2000-08-03
KR100750842B1 (ko) 2007-08-22

Similar Documents

Publication Publication Date Title
DE69506867T2 (de) Stabilisierte und unter sterilen bedingungen filtrierbare nanopartikel
DE69425773T2 (de) Stabile wässrige liposomenhaltige Dispersionen
DE69632408T2 (de) Stabilisierte und steril filtrierbare nanopartikel
US7029695B2 (en) Therapeutic compositions containing glutathione analogs
DE60115045T2 (de) Verbesserte liposomale camptothecine und deren verwendungen
EP0730860B1 (de) Mischmicellen
DE4430593C2 (de) Verfahren zur Herstellung von Liposomal verkapseltem Taxol
EP0178624B1 (de) Liposomen aus synthetischen Lipiden
EP1477166B1 (de) Verwendung von Riluzole kombiniert mit geeigneten Hilfs-und Zusatzstoffen zur Behandlung von Krankheiten, die durch eine Hyperproliferation von Keratinozyten gekennzeichnet sind, insbesondere Neurodermitis und Psoriasis
DE69825137T2 (de) Liposomale Erythropoietin-Dispersion
HUT74423A (en) Pharmaceutical basic compositions
EP0733358A2 (de) Intravenös applizierbare Nanosuspensionen
JP2009507049A (ja) リン脂質のポリエチレングリコール誘導体に包み込まれたビンカアルカロイド系制癌剤のナノミセル製剤
DE69633722T2 (de) Stoffwechseleffekt von bestimmten glutation analogen
DE2921852A1 (de) Lipide senkendes mittel
JP2007326877A (ja) グルタチオン類縁体を含有する治療用組成物
AT397460B (de) Verfahren zur herstellung eines pharmazeutischen trockenpräparates enthaltend ein diclofenac-salz
JP2003516348A (ja) がん治療のための細胞増殖抑制剤及び電子受容体を含有する医薬製剤
EP0451103B1 (de) Parenteral applizierbare Liposomenformulierung aus synthetischen Lipiden
DE69300945T2 (de) Fettstoffwechsel verbessernde Zusammensetzung.
EP0611303B1 (de) Carboplatin oder Lobaplatin ENTHALTENDE ZUBEREITUNGEN ZUR ANTITUMORTHERAPIE UND/ODER STIMULIERUNG DES HÄMATOPOETISCHEN SYSTEMS
JPS58208229A (ja) 抗腫瘍剤
JPS58208223A (ja) 抗腫瘍剤
JPS58208225A (ja) 抗腫瘍剤
JPS58206521A (ja) 抗腫瘍剤

Legal Events

Date Code Title Description
8364 No opposition during term of opposition