DE60016415D1 - Genetisches versuchssystem - Google Patents

Genetisches versuchssystem

Info

Publication number
DE60016415D1
DE60016415D1 DE60016415T DE60016415T DE60016415D1 DE 60016415 D1 DE60016415 D1 DE 60016415D1 DE 60016415 T DE60016415 T DE 60016415T DE 60016415 T DE60016415 T DE 60016415T DE 60016415 D1 DE60016415 D1 DE 60016415D1
Authority
DE
Germany
Prior art keywords
samples
reagents
glass slide
openings
slide member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60016415T
Other languages
English (en)
Other versions
DE60016415T2 (de
Inventor
D Juncosa
Rene Bongard
Johannes Dapprich
Richard Scribner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Cellmark Inc
Original Assignee
Orchid Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Biosciences Inc filed Critical Orchid Biosciences Inc
Application granted granted Critical
Publication of DE60016415D1 publication Critical patent/DE60016415D1/de
Publication of DE60016415T2 publication Critical patent/DE60016415T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
DE60016415T 1999-05-27 2000-05-11 Genetisches versuchssystem Expired - Fee Related DE60016415T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US321170 1999-05-27
US09/321,170 US6225109B1 (en) 1999-05-27 1999-05-27 Genetic analysis device
PCT/US2000/013100 WO2000073766A1 (en) 1999-05-27 2000-05-11 Genetic assay system

Publications (2)

Publication Number Publication Date
DE60016415D1 true DE60016415D1 (de) 2005-01-05
DE60016415T2 DE60016415T2 (de) 2005-05-19

Family

ID=23249497

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60016415T Expired - Fee Related DE60016415T2 (de) 1999-05-27 2000-05-11 Genetisches versuchssystem

Country Status (8)

Country Link
US (2) US6225109B1 (de)
EP (1) EP1196755B1 (de)
JP (1) JP2003501620A (de)
AT (1) ATE284027T1 (de)
AU (1) AU777018B2 (de)
CA (1) CA2374928A1 (de)
DE (1) DE60016415T2 (de)
WO (1) WO2000073766A1 (de)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6270730B1 (en) 1998-06-16 2001-08-07 Northwest Engineering Inc. Multi-well rotary synthesizer
US6585939B1 (en) * 1999-02-26 2003-07-01 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7115423B1 (en) * 1999-10-22 2006-10-03 Agilent Technologies, Inc. Fluidic structures within an array package
US6982147B2 (en) * 2000-01-24 2006-01-03 Ingeneus Corporation Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
US20030170659A1 (en) * 2000-01-24 2003-09-11 Ingeneus Corporation Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding
US7371563B2 (en) * 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US6803205B2 (en) * 2000-11-08 2004-10-12 Surface Logix, Inc. Methods of measuring enzyme activity using peelable and resealable devices
US7351575B2 (en) * 2000-11-08 2008-04-01 Surface Logix, Inc. Methods for processing biological materials using peelable and resealable devices
US6967074B2 (en) * 2000-11-08 2005-11-22 Surface Logix, Inc. Methods of detecting immobilized biomolecules
US7001740B2 (en) * 2000-11-08 2006-02-21 Surface Logix, Inc. Methods of arraying biological materials using peelable and resealable devices
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7776571B2 (en) * 2000-12-12 2010-08-17 Autogenomics, Inc. Multi-substrate biochip unit
JP4797196B2 (ja) 2001-02-14 2011-10-19 株式会社 フューエンス マイクロチップ
EP1372848A4 (de) * 2001-03-09 2006-08-09 Biomicro Systems Inc Verfahren und system zur mikrofluiden zusammenwirkung mit arrays
JP2004523243A (ja) * 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
EP2169383A1 (de) * 2001-06-15 2010-03-31 Bayer Technology Services GmbH Körper für Durchflussküvetten und deren Verwendung
CA2495021A1 (en) * 2001-08-06 2003-07-03 Vanderbilt University System and methods for measuring at least one metabolic rate of a plurality of cells
US6682702B2 (en) 2001-08-24 2004-01-27 Agilent Technologies, Inc. Apparatus and method for simultaneously conducting multiple chemical reactions
US7118910B2 (en) * 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same
JP4566509B2 (ja) * 2001-12-28 2010-10-20 株式会社エンプラス プラスチックプレート及びプラスチックプレート組立体
US6773677B2 (en) * 2002-01-09 2004-08-10 Caliper Life Sciences, Inc. Slide cassette for fluidic injection
US7736594B1 (en) * 2002-01-22 2010-06-15 Grace Bio-Labs, Inc. Reaction surface array diagnostic apparatus
US7731909B1 (en) * 2002-01-22 2010-06-08 Grace Bio-Labs, Inc. Reaction surface array diagnostic apparatus
EP1499706A4 (de) 2002-04-01 2010-11-03 Fluidigm Corp Mikrofluidische partikelanalysesysteme
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003087410A1 (en) * 2002-04-11 2003-10-23 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
US20030235521A1 (en) * 2002-06-21 2003-12-25 Shea Laurence R. Array assay devices and methods of using the same
US7220573B2 (en) * 2002-06-21 2007-05-22 Agilent Technologies, Inc. Array assay devices and methods of using the same
AU2003277853A1 (en) * 2002-06-24 2004-01-06 Fluidigm Corporation Recirculating fluidic network and methods for using the same
US7442342B2 (en) * 2002-06-26 2008-10-28 Ge Healthcare Bio-Sciences Ab Biochip holder and method of collecting fluid
US7745203B2 (en) * 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
JP4057967B2 (ja) * 2002-07-31 2008-03-05 株式会社東芝 塩基配列自動解析装置
US7202398B2 (en) * 2002-08-16 2007-04-10 E. I. Du Pont De Nemours And Company Chalcone isomerase
CA2500283A1 (en) 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
AU2003287568A1 (en) * 2002-11-08 2004-06-03 Irm, Llc Systems and methods of sorting samples
US20040248287A1 (en) * 2003-03-28 2004-12-09 Qianjin Hu Multi-array systems and methods of use thereof
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
JP2007502435A (ja) * 2003-05-30 2007-02-08 アプレラ コーポレイション ハイブリダイゼーションおよびｓｐｒ検出のための装置および方法
US20060246573A1 (en) * 2003-07-04 2006-11-02 Kubota Corporation Bio-chip
US20050026299A1 (en) * 2003-07-31 2005-02-03 Arindam Bhattacharjee Chemical arrays on a common carrier
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005052578A1 (ja) * 2003-11-28 2005-06-09 Olympus Corporation 生体関連物質の検査装置とその反応ステージ
KR100695123B1 (ko) 2003-12-03 2007-03-14 삼성전자주식회사 Ｔｍ에 따라 기판상에 고정화된 프로브 폴리뉴클레오티드군을 2이상 포함하는 폴리뉴클레오티드 어레이 및 그를이용하는 표적 핵산 검출 방법
US20050135974A1 (en) * 2003-12-18 2005-06-23 Harvey Michael A. Device for preparing multiple assay samples using multiple array surfaces
WO2005073408A2 (en) * 2004-01-23 2005-08-11 Pyxis Genomics, Inc. Small segments of dna determine animal identity and source
EP1716254B1 (de) 2004-02-19 2010-04-07 Helicos Biosciences Corporation Verfahren zur analyse von polynukleotidsequenzen
US8034306B1 (en) * 2004-02-20 2011-10-11 Grace Bio-Labs, Inc. Reaction surface array diagnostic apparatus including a flexible microtitre plate
DE102004022483B4 (de) * 2004-05-07 2006-05-04 P.A.L.M. Microlaser Technologies Ag Halter für eine Aufnahmevorrichtung zum Aufnehmen von biologischen Objekten
JP4627455B2 (ja) * 2004-05-18 2011-02-09 三菱レイヨン株式会社 Ｄｎａマイクロアレイ処理装置
US20050277122A1 (en) * 2004-06-14 2005-12-15 Fredrick Joseph P Devices and methods for contacting fluid with a chemical array
JP2006153785A (ja) * 2004-12-01 2006-06-15 Hitachi Ltd 溶液攪拌装置及び分析システム
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
TW200722524A (en) * 2005-12-13 2007-06-16 Zen U Biotechnology Co Ltd The device of determining the activity value of nattokinase
US7815868B1 (en) * 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US20090186775A1 (en) * 2008-01-15 2009-07-23 Empire Genomics, Llc Organization Method and device for dual array hybridization karyotype analysis
US20090286692A1 (en) * 2008-04-15 2009-11-19 Wainwright Norman R Cartridge and Method for Sample Analysis
DE102008025992B4 (de) * 2008-05-30 2011-01-27 Siemens Healthcare Diagnostics Gmbh Titerplatte und Verfahren zur Detektion eines Analyten
CN101368206B (zh) * 2008-07-16 2012-08-22 深圳华因康基因科技有限公司 测序反应小室、基因测序反应台及基因测序设备
US20100036110A1 (en) * 2008-08-08 2010-02-11 Xiaoliang Sunney Xie Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
US20100227327A1 (en) * 2008-08-08 2010-09-09 Xiaoliang Sunney Xie Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides
KR101578153B1 (ko) * 2008-08-26 2015-12-17 삼성전자주식회사 슬라이드 반응 장치
DE102008053270A1 (de) 2008-10-27 2010-05-12 Medizinische Hochschule Hannover Vorrichtung und Verfahren zur Analyse von Zellen
KR20100090955A (ko) * 2009-02-09 2010-08-18 삼성전자주식회사 혼성화 챔버 및 이를 이용한 혼성화 방법
US20120135876A1 (en) 2010-11-01 2012-05-31 Nanolnk, Inc. High-throughput assay methods and articles
TW201234011A (en) 2010-11-01 2012-08-16 Nanoink Inc High-throughput slide processing apparatus
CN110220876B (zh) * 2011-01-10 2022-04-26 伊鲁米那股份有限公司 用于生物或化学分析的样品的成像方法
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2012122379A2 (en) * 2011-03-08 2012-09-13 Colorado State University Research Foundation Microfluidic cytochemical staining system
SG10201510189WA (en) 2011-10-19 2016-01-28 Nugen Technologies Inc Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
EP3578697B1 (de) 2012-01-26 2024-03-06 Tecan Genomics, Inc. Zusammensetzungen und verfahren zur gezielten nukleinsäuresequenzanreicherung und hocheffizienten erzeugung einer bibliothek
JP6181751B2 (ja) 2012-06-18 2017-08-16 ニューゲン テクノロジーズ， インコーポレイテッド 望まれない核酸配列のネガティブ選択のための組成物および方法
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
GB2519255B (en) 2013-02-01 2016-01-06 Univ California Methods for genome assembly and haplotype phasing
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
EP2971130A4 (de) 2013-03-15 2016-10-05 Nugen Technologies Inc Sequentielle sequenzierung
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
US9546399B2 (en) 2013-11-13 2017-01-17 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
AU2014362322B2 (en) 2013-12-11 2021-05-27 The Regents For Of The University Of California Methods for labeling DNA fragments to recontruct physical linkage and phase
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
US10526641B2 (en) 2014-08-01 2020-01-07 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
EP3177740B1 (de) 2014-08-06 2021-01-13 Nugen Technologies, Inc. Digitale messungen von gezielter sequenzierung
CN107533590B (zh) 2015-02-17 2021-10-26 多弗泰尔基因组学有限责任公司 核酸序列装配
GB2554572B (en) 2015-03-26 2021-06-23 Dovetail Genomics Llc Physical linkage preservation in DNA storage
US10384207B2 (en) 2015-07-21 2019-08-20 Neuro Probe Incorporated Assay apparatus and methods
EP3365445B1 (de) 2015-10-19 2023-05-31 Dovetail Genomics, LLC Verfahren für genomassemblierung, haplotyp-phasing und zielunabhängigen nukleinsäurenachweis
KR20180116377A (ko) 2016-02-23 2018-10-24 더브테일 제노믹스 엘엘씨 게놈 어셈블리를 위한 페이징된 판독 세트의 생성 및 반수체형 페이징
KR102412442B1 (ko) 2016-05-13 2022-06-22 더브테일 제노믹스 엘엘씨 보존된 샘플로부터의 장범위 링키지 정보의 회수
US11083907B2 (en) 2016-08-01 2021-08-10 Neuropair, Inc. Superparamagnetic particle scaffold for regenerating damaged neural tissue
US10190155B2 (en) 2016-10-14 2019-01-29 Nugen Technologies, Inc. Molecular tag attachment and transfer
US11602751B2 (en) 2017-03-31 2023-03-14 Forward Biotech, Inc. Liquid evaluation
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
EP3746566A1 (de) 2018-01-31 2020-12-09 Dovetail Genomics, LLC Probenvorbereitung zur wiederherstellung der dna-verknüpfung
DE202019005610U1 (de) 2018-12-07 2021-06-10 Element Biosciences, Inc. Durchflusszellenvorrichtung und ihre Verwendung
US11408032B2 (en) 2020-01-17 2022-08-09 Element Biosciences, Inc. Tube lens design for improved depth-of-field
US11198121B1 (en) 2020-06-10 2021-12-14 Element Biosciences, Inc. Flow cell systems and devices
EP4263784A1 (de) * 2020-12-15 2023-10-25 Colgate-Palmolive Company Mikrofluidische vorrichtung zum testen von biomaterialien enthaltenden wässrigen proben

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753776A (en) * 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US6176962B1 (en) * 1990-02-28 2001-01-23 Aclara Biosciences, Inc. Methods for fabricating enclosed microchannel structures
EP0624059A4 (en) * 1991-11-22 1994-12-21 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis.
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
JP2763468B2 (ja) * 1992-12-25 1998-06-11 株式会社日立製作所 光散乱を用いた液体内の粒子分類装置
EP0695941B1 (de) * 1994-06-08 2002-07-31 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
GB9506312D0 (en) 1995-03-28 1995-05-17 Medical Res Council Improvements in or relating to sample processing
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
JP3748571B2 (ja) * 1996-11-18 2006-02-22 ノバルティス アクチエンゲゼルシャフト 測定装置及びその使用方法
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US6322683B1 (en) * 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6225109B1 (en) * 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
DE10014204C2 (de) * 2000-03-22 2002-08-14 Max Planck Gesellschaft Mikrohybridisierungskammer

Also Published As

Publication number Publication date
EP1196755A1 (de) 2002-04-17
AU5010400A (en) 2000-12-18
CA2374928A1 (en) 2000-12-07
AU777018B2 (en) 2004-09-30
DE60016415T2 (de) 2005-05-19
WO2000073766A1 (en) 2000-12-07
US6225109B1 (en) 2001-05-01
ATE284027T1 (de) 2004-12-15
US20010051113A1 (en) 2001-12-13
EP1196755A4 (de) 2002-08-14
JP2003501620A (ja) 2003-01-14
US6720143B2 (en) 2004-04-13
EP1196755B1 (de) 2004-12-01

Similar Documents

Publication Publication Date Title
DE60016415D1 (de) Genetisches versuchssystem
WO2002035260A3 (en) Light detection device
WO2003100012A3 (en) Microarrays and method for running hybridization reaction for multiple samples on a single microarray
DE60042262D1 (en) Biochip
KR930010192A (ko) 에이치엘에이(hla) 제i형 디엠에이(dna) 타이핑 방법 및 시약
DK0804731T4 (da) Fremgangsmåde og apparat til fremstilling af microarrays af biologiske prøver
ATE416375T1 (de) Mikrofluidische analysesysteme und -verfahren mit extrem hohem durchsatz
WO2004099378A3 (en) Automated laboratory for high-throughput biological assays and rna interference
ATE336591T1 (de) Nachweisverfahren für kurze sequenzvarianten
CA2362117A1 (en) A system for cell-based screening
DE69738941D1 (de) Hochdurchsatz-screening-testsystem mittels mikrofluidischer vorrichtungen
CA2258489A1 (en) High-throughput screening assay systems in microscale fluidic devices
CA2348132A1 (en) A system for cell-based screening
EP1188482A3 (de) Vorrichtung und Verfahren zur Durchführung von Versuchen
EP1391242A3 (de) Mikrosäulenbasierte Anordnung zur Hochdurchsatzanalyse
WO2000017643A8 (en) A system for cell-based screening
EP1350851A4 (de) Verfahren zum nachweis von polymorphismus in dna unter verwendung der massenspektroskopie
NZ504112A (en) Continuous format high throughput screening for testing compound for biological activity
WO2003057873A1 (fr) Plaque de plastique et ensemble plaque de plastique
WO2007047149A3 (en) Susceptibility-matched multi-well sample holders for high-throughput screening by magnetic analysis
DE69917636D1 (en) Polymerasesignalversuch
WO2001026029A3 (en) Method and system for providing genotype clinical information over a computer network
EP0382261A3 (de) DNS-Sonden gegen VNTR-Orte
WO2002024959A3 (en) Multiple reporter read-out for bioassays
WO2004011668A3 (en) Methods and apparatus for screening and detecting multiple genetic mutations

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee