DE60008354D1 - Substituierte Metallphthalocyaninen, ihre Herstellung und Verwendung - Google Patents

Substituierte Metallphthalocyaninen, ihre Herstellung und Verwendung

Info

Publication number
DE60008354D1
DE60008354D1 DE60008354T DE60008354T DE60008354D1 DE 60008354 D1 DE60008354 D1 DE 60008354D1 DE 60008354 T DE60008354 T DE 60008354T DE 60008354 T DE60008354 T DE 60008354T DE 60008354 D1 DE60008354 D1 DE 60008354D1
Authority
DE
Germany
Prior art keywords
preparation
substituted metal
metal phthalocyanines
blood
phthalocyanines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60008354T
Other languages
English (en)
Other versions
DE60008354T2 (de
Inventor
Gabrio Roncucci
Lia Fantetti
Filippis Maria Paola De
Donata Dei
Giulio Jori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molteni and C SpA
Original Assignee
Molteni and C SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molteni and C SpA filed Critical Molteni and C SpA
Application granted granted Critical
Publication of DE60008354D1 publication Critical patent/DE60008354D1/de
Publication of DE60008354T2 publication Critical patent/DE60008354T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C07C255/51—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings containing at least two cyano groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60008354T 2000-06-15 2000-06-15 Substituierte Metallphthalocyaninen, ihre Herstellung und Verwendung Expired - Lifetime DE60008354T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00112654A EP1164135B1 (de) 2000-06-15 2000-06-15 Substituierte Metallphthalocyaninen, ihre Herstellung und Verwendung

Publications (2)

Publication Number Publication Date
DE60008354D1 true DE60008354D1 (de) 2004-03-25
DE60008354T2 DE60008354T2 (de) 2004-12-09

Family

ID=8168978

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60008354T Expired - Lifetime DE60008354T2 (de) 2000-06-15 2000-06-15 Substituierte Metallphthalocyaninen, ihre Herstellung und Verwendung

Country Status (13)

Country Link
US (2) US7144879B2 (de)
EP (1) EP1164135B1 (de)
JP (1) JP5137282B2 (de)
AT (1) ATE259814T1 (de)
AU (2) AU7246301A (de)
CA (1) CA2412750C (de)
DE (1) DE60008354T2 (de)
DK (1) DK1164135T3 (de)
ES (1) ES2215522T3 (de)
IL (2) IL153447A0 (de)
PT (1) PT1164135E (de)
WO (1) WO2001096343A1 (de)
ZA (1) ZA200300381B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1381611T3 (da) * 2001-03-21 2005-10-24 Molteni & C Metalsubstituerede ikke-centrosymmetriske phthalocyaninanaloger, fremstilling heraf og anvendelse i fotodynamisk terapi samt in vivo diagnostik
PT1444236E (pt) 2001-10-29 2007-11-08 Molteni & C Separação de regioisómeros de ftalocianinas metálicas
SI1356813T1 (sl) 2002-04-25 2006-02-28 Molteni & C Protibakterijske sestave, vsebujoce analogone kovinskega ftalocianina
ITFI20020200A1 (it) 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
ITFI20050092A1 (it) * 2005-05-05 2006-11-06 Molteni & C Derivati ftalocianinici, processo per la loro preparazione, composizioni farmaceutiche che li contengono e loro uso
ITFI20050093A1 (it) * 2005-05-05 2006-11-06 Molteni & C Processo per la preparazione di cloruri di derivati ftalocianinici comprendenti almeno un gruppo ammonio quaternario
WO2007000473A1 (en) * 2005-06-29 2007-01-04 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Use of phthalocyanine derivates for the non-photodynamic treatment of diseases
EP1904109B1 (de) 2005-06-29 2013-04-03 L. MOLTENI & C. dei Fratelli Alitti Società' di Esercizio S.p.A. Selbststerilisierende produkte
CN101212987B (zh) * 2005-06-29 2011-02-02 阿利提兄弟有限公司L.莫太尼公司 自杀菌产品
WO2008056433A1 (fr) * 2006-11-08 2008-05-15 Nihon University Dérivé de phtalocyanine polyamidoamine dendritique
WO2010116423A1 (ja) * 2009-04-09 2010-10-14 パナソニック株式会社 テロメラーゼ反応阻害方法
JP4510929B1 (ja) * 2009-04-09 2010-07-28 パナソニック株式会社 テロメラーゼ反応阻害方法およびそれに用いられるテロメラーゼ反応阻害剤
ITFI20110166A1 (it) 2011-08-05 2013-02-06 Molteni & C Nuovi fotosensibilizzanti ad uso terapeutico.
CN102499924B (zh) * 2011-11-23 2013-07-24 中国医学科学院生物医学工程研究所 二乙撑三胺五乙酸或乙二胺四乙酸或胺三乙酸修饰卟啉的用途
CN104003994A (zh) * 2014-06-03 2014-08-27 南京师范大学 一种阳离子酞菁及其制备和应用
CN106554356B (zh) * 2016-10-25 2017-11-10 深圳市声光动力生物医药科技有限公司 1,4‑二取代酞菁锌配合物及其制备方法和在医药上的应用
FI127163B (en) * 2016-11-17 2017-12-29 Tty-Säätiö photosensitiser
US11498903B2 (en) 2017-08-17 2022-11-15 Bristol-Myers Squibb Company 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
CN108658995B (zh) * 2018-05-29 2020-05-05 南京师范大学 一种二硫联吡啶修饰锌酞菁及其制备方法和应用
KR102357352B1 (ko) * 2020-01-06 2022-01-28 이화여자대학교 산학협력단 화합물, 상기 화합물을 포함하는 조성물, 상기 화합물을 이용하여 박테리아 세균을 비활성화 또는 사멸시키는 방법
CN111072679B (zh) * 2020-01-16 2022-07-01 福州大学 一种非周边季铵基修饰锌酞菁及其制备方法和应用
CN112028901B (zh) * 2020-10-16 2021-06-01 福州大学 十六铵基修饰的酞菁及其制备方法与作为光动力药物的应用
CN113731310B (zh) * 2021-10-15 2024-01-19 西能化工科技(上海)有限公司 超大粒径的中空可膨胀微球及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1351928A1 (ru) * 1986-06-18 1987-11-15 Институт Биологической И Медицинской Химии Амн Ссср Способ получени производных 1,2,3,4-тетрагидрохинолина
JPH07324170A (ja) * 1993-09-14 1995-12-12 Hiroyoshi Shirai フタロシアニン化合物および製造方法、ニトロ置換フタロシアニン化合物、アミノ置換フタロシアニン化合物、フタロシアニン含有重合体および製造方法、触媒、ならびに光記録媒体
IT1294325B1 (it) * 1997-08-14 1999-03-24 Molteni L E C Dei Fratelli Ali Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici

Also Published As

Publication number Publication date
ES2215522T3 (es) 2004-10-16
JP2004503555A (ja) 2004-02-05
IL153447A0 (en) 2003-07-06
US7749991B2 (en) 2010-07-06
AU7246301A (en) 2001-12-24
US7144879B2 (en) 2006-12-05
DE60008354T2 (de) 2004-12-09
CA2412750A1 (en) 2001-12-20
ZA200300381B (en) 2004-04-15
DK1164135T3 (da) 2004-06-21
EP1164135B1 (de) 2004-02-18
EP1164135A1 (de) 2001-12-19
IL153447A (en) 2009-06-15
CA2412750C (en) 2011-03-29
WO2001096343A1 (en) 2001-12-20
US20030170178A1 (en) 2003-09-11
US20070066513A1 (en) 2007-03-22
PT1164135E (pt) 2004-06-30
JP5137282B2 (ja) 2013-02-06
ATE259814T1 (de) 2004-03-15
AU2001272463B2 (en) 2005-12-22

Similar Documents

Publication Publication Date Title
DE60008354D1 (de) Substituierte Metallphthalocyaninen, ihre Herstellung und Verwendung
CY1107963T1 (el) Μεσο-υποκαθιστοyμενες πορφυρiνες
DK0906758T3 (da) Zink-phthalocyaniner og tilsvarende konjugater, deres frembingelse og anvendelse i fotodynamisk terapi og som diagnostiske midler
DE60003863D1 (de) Dioxocyclopentylhydroxamsäure
ATE442142T1 (de) Fredericamycin-derivate als arzneimittel zur tumorbehandlung
IL158032A (en) Metal substituted non centrosymmetrical phthalocyanine analogues, their preparation and use in photodynamic therapy and in vivo diagnostics
ECSP066311A (es) Derivados de la piperazina y su uso como agentes terapéuticos
DE60324155D1 (de) Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen
AU2002331313A1 (en) Use of l-polynucleotides and derivatives thereof for in vivo imaging
MXPA04007443A (es) Nuevos compuestos de porfirina-platino solubles en agua con alta selectividad tumoral y su uso para el tratamiento de enfermedades tumorales benignas y malignas.
EA200600316A1 (ru) ПРОИЗВОДНЫЕ 3-НИТРОПИРАЗОЛО[1,5-a]ПИРИМИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИСПОЛЬЗУЕМЫЕ В НЕМ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ЛЕКАРСТВЕННОЕ СРЕДСТВО (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С МОДУЛЯЦИЕЙ РЕЦЕПТОРА ГАМК(ВАРИАНТЫ)
EA200200883A1 (ru) Производные пирано[2,3-с]имидазо[1,2-а]пиридина для лечения заболеваний желудочно-кишечного тракта
EA200200853A1 (ru) Применение 2-метилтиазолидин-3,3-дикарбоновой кислоты (2-мтдк) и/или ее физиологически совместимых солей для лечения и/или предупреждения рака
TW200504051A (en) Novel acridine derivatives and their use as medicaments
DE60206599D1 (de) Biotin-derivate und ihre konjugaten mit chelatierungsmitteln
AU2001292698A1 (en) Hexahydropyrazino `1'2' : 1, 6!- pyrido `3, 4-b! indole-1, 4-dione derivatives for the treatment of cardiovascular disorders and erectile disfunction
GB0309440D0 (en) Quinolone derivatives
BR9902049A (pt) Derivados 9a,11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina.
ATE480522T1 (de) 9-alkylamino-1-nitroacridin-derivate

Legal Events

Date Code Title Description
8364 No opposition during term of opposition