EA200600316A1 - ПРОИЗВОДНЫЕ 3-НИТРОПИРАЗОЛО[1,5-a]ПИРИМИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИСПОЛЬЗУЕМЫЕ В НЕМ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ЛЕКАРСТВЕННОЕ СРЕДСТВО (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С МОДУЛЯЦИЕЙ РЕЦЕПТОРА ГАМК(ВАРИАНТЫ) - Google Patents

ПРОИЗВОДНЫЕ 3-НИТРОПИРАЗОЛО[1,5-a]ПИРИМИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИСПОЛЬЗУЕМЫЕ В НЕМ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ЛЕКАРСТВЕННОЕ СРЕДСТВО (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С МОДУЛЯЦИЕЙ РЕЦЕПТОРА ГАМК(ВАРИАНТЫ)

Info

Publication number
EA200600316A1
EA200600316A1 EA200600316A EA200600316A EA200600316A1 EA 200600316 A1 EA200600316 A1 EA 200600316A1 EA 200600316 A EA200600316 A EA 200600316A EA 200600316 A EA200600316 A EA 200600316A EA 200600316 A1 EA200600316 A1 EA 200600316A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gaba
receptor
derivatives
compounds
gabara
Prior art date
Application number
EA200600316A
Other languages
English (en)
Other versions
EA009519B1 (ru
Inventor
Луис Англада
Антонио Гугльетта
Альберт Паломер
Марта Принсеп
Original Assignee
Феррер Интернасионал, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Феррер Интернасионал, С.А. filed Critical Феррер Интернасионал, С.А.
Publication of EA200600316A1 publication Critical patent/EA200600316A1/ru
Publication of EA009519B1 publication Critical patent/EA009519B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Настоящее изобретение относится к соединениям формулы (I)где R, Rи Rимеют значения, как описано в формуле изобретения. Соединения проявляют специфическую аффинность к рецептору ГАМКи, следовательно, их можно использовать для лечения и профилактики заболеваний, связанных с модуляцией рецепторов α-ГАМКили α-ГАМК.
EA200600316A 2003-07-24 2004-07-22 ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-а]ПИРИМИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИСПОЛЬЗУЕМЫЕ В НЕМ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ЛЕКАРСТВЕННОЕ СРЕДСТВО (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С МОДУЛЯЦИЕЙ РЕЦЕПТОРА ГАМК(ВАРИАНТЫ) EA009519B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200301746A ES2222813B1 (es) 2003-07-24 2003-07-24 N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
ES200401697A ES2245894B1 (es) 2003-07-24 2004-07-12 Mejoras en el objeto de la patente de invencion n.p200301746 que se refiere a "n-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados".
PCT/EP2004/008208 WO2005014597A1 (en) 2003-07-24 2004-07-22 N-[3-(3-SUBSTITUTED-PYRAZOLO[1,5-a]PYRIMIDIN-7-YL)PHENYL]-SULFONAMIDES, AND COMPOSITIONS, AND METHODS RELATED THERETO

Publications (2)

Publication Number Publication Date
EA200600316A1 true EA200600316A1 (ru) 2006-06-30
EA009519B1 EA009519B1 (ru) 2008-02-28

Family

ID=34137682

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600316A EA009519B1 (ru) 2003-07-24 2004-07-22 ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-а]ПИРИМИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИСПОЛЬЗУЕМЫЕ В НЕМ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), ЛЕКАРСТВЕННОЕ СРЕДСТВО (ВАРИАНТЫ) И СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С МОДУЛЯЦИЕЙ РЕЦЕПТОРА ГАМК(ВАРИАНТЫ)

Country Status (30)

Country Link
US (1) US7947688B2 (ru)
EP (1) EP1648897B1 (ru)
JP (1) JP2006528608A (ru)
KR (1) KR100840450B1 (ru)
CN (1) CN100393721C (ru)
AR (1) AR047017A1 (ru)
AT (1) ATE417048T1 (ru)
AU (1) AU2004263278B2 (ru)
BR (1) BRPI0412826A (ru)
CA (1) CA2532437C (ru)
CL (1) CL2004001814A1 (ru)
DE (1) DE602004018320D1 (ru)
DK (1) DK1648897T3 (ru)
EA (1) EA009519B1 (ru)
ES (2) ES2222813B1 (ru)
HK (1) HK1083844A1 (ru)
HR (1) HRP20060009A2 (ru)
IL (1) IL173252A0 (ru)
MA (1) MA27944A1 (ru)
MX (1) MXPA06000754A (ru)
NO (1) NO20060580L (ru)
NZ (1) NZ544349A (ru)
PA (1) PA8607501A1 (ru)
PE (1) PE20050254A1 (ru)
PL (1) PL1648897T3 (ru)
PT (1) PT1648897E (ru)
TW (1) TWI340140B (ru)
UA (1) UA81959C2 (ru)
UY (1) UY28440A1 (ru)
WO (1) WO2005014597A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084835A1 (en) * 2005-02-10 2006-08-17 Ferrer Internacional, S. A. N-(3-(imidazo [1,5-a]pyrimidin-4-yl)phenyl]-sulfonamides and n-[3-(imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides and their use as gabaa receptor modulators
EP1736475A1 (en) 2005-06-21 2006-12-27 Ferrer Internacional, S.A. Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates
CA2643968A1 (en) * 2006-03-17 2007-09-27 Wyeth Pyrazolo[1,5-a]pyrimidine derivatives and methods of use thereof
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
EP1884516A1 (en) 2006-08-04 2008-02-06 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions
EP1956021A1 (en) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
EP1921079A1 (en) * 2006-11-08 2008-05-14 Ferrer Internacional, S.A. Amorphous form of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
US8163903B2 (en) * 2009-01-13 2012-04-24 Interquim, S.A. Process for the preparation of N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-acetamide
WO2013039985A2 (en) * 2011-09-12 2013-03-21 The Johns Hopkins University Serine protease inhibitors
CN102807569B (zh) * 2012-08-21 2015-02-25 四川大学 一种镇静催眠的化合物及其制备方法和用途
MY182036A (en) * 2013-02-21 2021-01-18 Sunshine Lake Pharma Co Ltd Heteroaromatic compounds as pi3 kinase modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
DE19975048I2 (de) * 1985-05-13 2001-06-13 American Cyanamid Co 7-(3-Disubstituierte Amino)phenyl pyrazolo 1,5-a -pyrimidine
EP0264773A1 (en) * 1986-10-16 1988-04-27 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
US5538977A (en) * 1995-03-17 1996-07-23 American Cyanamid Company 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
AU4058000A (en) * 1999-04-02 2000-10-23 Neurogen Corporation Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulatorsof gabaa receptors
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

Also Published As

Publication number Publication date
CA2532437A1 (en) 2005-02-17
ES2222813A1 (es) 2005-02-01
CL2004001814A1 (es) 2005-06-03
EP1648897A1 (en) 2006-04-26
AR047017A1 (es) 2006-01-04
UY28440A1 (es) 2004-11-08
KR20060030908A (ko) 2006-04-11
DE602004018320D1 (de) 2009-01-22
CN1829719A (zh) 2006-09-06
US7947688B2 (en) 2011-05-24
JP2006528608A (ja) 2006-12-21
UA81959C2 (en) 2008-02-25
EP1648897B1 (en) 2008-12-10
HRP20060009A2 (en) 2006-08-31
KR100840450B1 (ko) 2008-06-20
AU2004263278A1 (en) 2005-02-17
PL1648897T3 (pl) 2009-07-31
ATE417048T1 (de) 2008-12-15
PE20050254A1 (es) 2005-04-11
US20060270690A1 (en) 2006-11-30
TW200510422A (en) 2005-03-16
MA27944A1 (fr) 2006-06-01
BRPI0412826A (pt) 2006-09-26
ES2245894B1 (es) 2006-12-01
TWI340140B (en) 2011-04-11
NO20060580L (no) 2006-02-03
CA2532437C (en) 2010-01-26
WO2005014597A1 (en) 2005-02-17
ES2245894A1 (es) 2006-01-16
PA8607501A1 (es) 2005-09-28
IL173252A0 (en) 2006-06-11
ES2222813B1 (es) 2005-12-16
PT1648897E (pt) 2009-03-17
AU2004263278B2 (en) 2009-03-12
EA009519B1 (ru) 2008-02-28
NZ544349A (en) 2009-05-31
MXPA06000754A (es) 2006-03-30
DK1648897T3 (da) 2009-04-06
CN100393721C (zh) 2008-06-11
HK1083844A1 (en) 2006-07-14

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU