TWI340140B - N-[3-(3-substituted-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-sulfonamides and compositions and methods related thereto - Google Patents

N-[3-(3-substituted-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-sulfonamides and compositions and methods related thereto

Info

Publication number
TWI340140B
TWI340140B TW093121113A TW93121113A TWI340140B TW I340140 B TWI340140 B TW I340140B TW 093121113 A TW093121113 A TW 093121113A TW 93121113 A TW93121113 A TW 93121113A TW I340140 B TWI340140 B TW I340140B
Authority
TW
Taiwan
Prior art keywords
pyrazolo
sulfonamides
pyrimidin
phenyl
substituted
Prior art date
Application number
TW093121113A
Other languages
English (en)
Other versions
TW200510422A (en
Inventor
Luis Anglada
Albert Palomer
Marta Princep
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of TW200510422A publication Critical patent/TW200510422A/zh
Application granted granted Critical
Publication of TWI340140B publication Critical patent/TWI340140B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW093121113A 2003-07-24 2004-07-15 N-[3-(3-substituted-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-sulfonamides and compositions and methods related thereto TWI340140B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301746A ES2222813B1 (es) 2003-07-24 2003-07-24 N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
ES200401697A ES2245894B1 (es) 2003-07-24 2004-07-12 Mejoras en el objeto de la patente de invencion n.p200301746 que se refiere a "n-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados".

Publications (2)

Publication Number Publication Date
TW200510422A TW200510422A (en) 2005-03-16
TWI340140B true TWI340140B (en) 2011-04-11

Family

ID=34137682

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093121113A TWI340140B (en) 2003-07-24 2004-07-15 N-[3-(3-substituted-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-sulfonamides and compositions and methods related thereto

Country Status (30)

Country Link
US (1) US7947688B2 (zh)
EP (1) EP1648897B1 (zh)
JP (1) JP2006528608A (zh)
KR (1) KR100840450B1 (zh)
CN (1) CN100393721C (zh)
AR (1) AR047017A1 (zh)
AT (1) ATE417048T1 (zh)
AU (1) AU2004263278B2 (zh)
BR (1) BRPI0412826A (zh)
CA (1) CA2532437C (zh)
CL (1) CL2004001814A1 (zh)
DE (1) DE602004018320D1 (zh)
DK (1) DK1648897T3 (zh)
EA (1) EA009519B1 (zh)
ES (2) ES2222813B1 (zh)
HK (1) HK1083844A1 (zh)
HR (1) HRP20060009A2 (zh)
IL (1) IL173252A0 (zh)
MA (1) MA27944A1 (zh)
MX (1) MXPA06000754A (zh)
NO (1) NO20060580L (zh)
NZ (1) NZ544349A (zh)
PA (1) PA8607501A1 (zh)
PE (1) PE20050254A1 (zh)
PL (1) PL1648897T3 (zh)
PT (1) PT1648897E (zh)
TW (1) TWI340140B (zh)
UA (1) UA81959C2 (zh)
UY (1) UY28440A1 (zh)
WO (1) WO2005014597A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084835A1 (en) * 2005-02-10 2006-08-17 Ferrer Internacional, S. A. N-(3-(imidazo [1,5-a]pyrimidin-4-yl)phenyl]-sulfonamides and n-[3-(imidazo[1,5-a]pyrimidin-4-yl)-phenyl]-carboxamides and their use as gabaa receptor modulators
EP1736475A1 (en) * 2005-06-21 2006-12-27 Ferrer Internacional, S.A. Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates
AU2007227557A1 (en) * 2006-03-17 2007-09-27 Wyeth Pyrazolo[1,5-a]pyrimidine derivatives and methods of use thereof
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
EP1884516A1 (en) 2006-08-04 2008-02-06 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions
EP1956021A1 (en) 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
EP1921079A1 (en) * 2006-11-08 2008-05-14 Ferrer Internacional, S.A. Amorphous form of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
ES2427972T3 (es) * 2009-01-13 2013-11-05 Interquim, S.A. Procedimiento para la preparación de la N-[5-(3-dimetilamino-acriloil)-2-fluoro-fenil]-N-metil-acetamida
US9371307B2 (en) 2011-09-12 2016-06-21 The Johns Hopkins University Serine protease inhibitors
CN102807569B (zh) * 2012-08-21 2015-02-25 四川大学 一种镇静催眠的化合物及其制备方法和用途
MY182036A (en) * 2013-02-21 2021-01-18 Sunshine Lake Pharma Co Ltd Heteroaromatic compounds as pi3 kinase modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
DE19975048I2 (de) * 1985-05-13 2001-06-13 American Cyanamid Co 7-(3-Disubstituierte Amino)phenyl pyrazolo 1,5-a -pyrimidine
EP0264773A1 (en) * 1986-10-16 1988-04-27 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
US5538977A (en) * 1995-03-17 1996-07-23 American Cyanamid Company 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
CA2369557A1 (en) * 1999-04-02 2000-10-12 Neurogen Corporation Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of gabaa receptors
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

Also Published As

Publication number Publication date
AR047017A1 (es) 2006-01-04
NZ544349A (en) 2009-05-31
EP1648897B1 (en) 2008-12-10
CN100393721C (zh) 2008-06-11
DE602004018320D1 (de) 2009-01-22
CA2532437C (en) 2010-01-26
ATE417048T1 (de) 2008-12-15
ES2222813B1 (es) 2005-12-16
ES2245894B1 (es) 2006-12-01
JP2006528608A (ja) 2006-12-21
WO2005014597A1 (en) 2005-02-17
US7947688B2 (en) 2011-05-24
CL2004001814A1 (es) 2005-06-03
CA2532437A1 (en) 2005-02-17
AU2004263278B2 (en) 2009-03-12
TW200510422A (en) 2005-03-16
HRP20060009A2 (en) 2006-08-31
PE20050254A1 (es) 2005-04-11
US20060270690A1 (en) 2006-11-30
DK1648897T3 (da) 2009-04-06
MA27944A1 (fr) 2006-06-01
CN1829719A (zh) 2006-09-06
IL173252A0 (en) 2006-06-11
UA81959C2 (en) 2008-02-25
KR20060030908A (ko) 2006-04-11
KR100840450B1 (ko) 2008-06-20
AU2004263278A1 (en) 2005-02-17
HK1083844A1 (en) 2006-07-14
BRPI0412826A (pt) 2006-09-26
ES2222813A1 (es) 2005-02-01
EA200600316A1 (ru) 2006-06-30
EA009519B1 (ru) 2008-02-28
UY28440A1 (es) 2004-11-08
PA8607501A1 (es) 2005-09-28
MXPA06000754A (es) 2006-03-30
EP1648897A1 (en) 2006-04-26
PL1648897T3 (pl) 2009-07-31
ES2245894A1 (es) 2006-01-16
NO20060580L (no) 2006-02-03
PT1648897E (pt) 2009-03-17

Similar Documents

Publication Publication Date Title
HK1083844A1 (en) N-[3-(3-substituted-pyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-sulfonamides, and compositions, and methods related thereto
HK1090639A1 (en) Immunosuppressant compounds and compositions
HK1087929A1 (zh) 免疫抑制劑化合物和組合物
EP1644367A4 (en) IMMUNE REPRESENTING COMPOUNDS AND COMPOSITIONS
AUPR815201A0 (en) Session mobility using digital items
EP1644009A4 (en) COMPOSITIONS AND METHOD FOR INCREASING TELOMERASE ACTIVITY
IL175300A0 (en) Indirubin-type compounds, compositions, and methods for their use
EP1477070A4 (en) GREASE COMPOSITION
HK1099302A1 (en) Pyrazolo and imidazo-pyrimidine derivatives
IL165925A0 (en) Phenyl benzamides
HK1103631A1 (en) Compositions including different types of transfer factor, methods for making the compositions, and methods of treatment using the compositions
AU2003252324A1 (en) Fat composition
AU2003278392A1 (en) 5- (substituted phenyl) -thiadiazolidine-3-ones and their use as ptp1b
IL163657A0 (en) Ophthalmic composition comprising ascomycin
IL160076A0 (en) Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
EP1675834A4 (en) COMPOUNDS, COMPOSITIONS AND METHODS
EP1594849A4 (en) COMPOUNDS, COMPOSITIONS, AND METHODS
EP1620092A4 (en) COMPOUNDS, COMPOSITIONS AND METHODS
GB0218332D0 (en) Preparation of type pneumocytes
EP1706111A4 (en) COMPOUNDS, COMPOSITIONS AND METHODS
PL373738A1 (en) Immunosuppressant compounds, methods and uses related thereto
HUP0400325A3 (en) Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
EP1622883A4 (en) COMPOUNDS, COMPOSITIONS AND METHODS
AU2002332244A8 (en) Demelanizing agents, beautifying agents, demelanizing compositions and beautifying compositions
GB0313025D0 (en) Rossette fresh

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees