DE540573T1 - Bestimmung von freiem und komplexiertem prostat-spezifisches antigen. - Google Patents

Bestimmung von freiem und komplexiertem prostat-spezifisches antigen.

Info

Publication number
DE540573T1
DE540573T1 DE0540573T DE91913019T DE540573T1 DE 540573 T1 DE540573 T1 DE 540573T1 DE 0540573 T DE0540573 T DE 0540573T DE 91913019 T DE91913019 T DE 91913019T DE 540573 T1 DE540573 T1 DE 540573T1
Authority
DE
Germany
Prior art keywords
psa
free
complex
antiging
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0540573T
Other languages
English (en)
Inventor
Hans Lilja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20380033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE540573(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of DE540573T1 publication Critical patent/DE540573T1/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
DE0540573T 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostat-spezifisches antigen. Pending DE540573T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002480A SE9002480D0 (sv) 1990-07-23 1990-07-23 Assay of free and complexed prostate-specific antigen
PCT/FI1991/000223 WO1992001936A1 (en) 1990-07-23 1991-07-22 Assay of free and complexed prostate-specific antigen (psa)

Publications (1)

Publication Number Publication Date
DE540573T1 true DE540573T1 (de) 1995-09-28

Family

ID=20380033

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69117292T Expired - Lifetime DE69117292T3 (de) 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostata-spezifischem antigen
DE0540573T Pending DE540573T1 (de) 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostat-spezifisches antigen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69117292T Expired - Lifetime DE69117292T3 (de) 1990-07-23 1991-07-22 Bestimmung von freiem und komplexiertem prostata-spezifischem antigen

Country Status (10)

Country Link
US (4) US5501983A (de)
EP (1) EP0540573B2 (de)
JP (1) JP2669566B2 (de)
AT (1) ATE134448T1 (de)
DE (2) DE69117292T3 (de)
DK (1) DK0540573T4 (de)
ES (1) ES2070107T5 (de)
GR (1) GR3019888T3 (de)
SE (1) SE9002480D0 (de)
WO (1) WO1992001936A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965379A (en) * 1991-07-19 1999-10-12 Cytimmune Sciences Inc. Method for measuring endogenous cytokines
GB9309966D0 (en) * 1993-05-14 1993-06-30 Nordion Int Inc Detection of prostrate-specific antigen in breast tumors
GB9314623D0 (en) * 1993-07-14 1993-08-25 Nordion Int Inc Localization and therapy with agents directed against prostate specific antigen in breast cancer
EP0635575A1 (de) 1993-07-22 1995-01-25 Wallac Oy Monoklonale Antikörper gegen Epitope in freiem uber nicht in Alpha-1-antichymotrypsin komplexiertem Prostata spezifisches Antigen
EP0652014A1 (de) * 1993-11-10 1995-05-10 National Institute Of Immunology Behandlung von Prostatahypertrophie
US5599677A (en) * 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
GB9415489D0 (en) * 1994-08-01 1994-09-21 Nordion Int Inc Detection of prostate-specific antigen in amniotic fluid
EP0725139A3 (de) * 1995-02-03 1997-11-26 Bayer Corporation Rekombinantes prostat-spezifisches Antigen und seiner Verwendung als Immunoassay-Kalibrator
US5698402A (en) * 1995-02-23 1997-12-16 Dianon Systems, Inc. Methods for diagnosing benign prostatic hyperplasia
US5614372A (en) * 1995-02-24 1997-03-25 Lilja; Hans Early detection of prostate cancer (CAP) by employing prostate specific antigen (PSA) and human glandular kallikrein (hGK-1)
US5654161A (en) * 1995-05-12 1997-08-05 Chiron Diagnostics Corporation Method for diagnosing prostate cancer
US5807978A (en) * 1995-06-07 1998-09-15 Kokolus; William J. Immunogenic peptides of prostate specific antigen
US5800347A (en) * 1995-11-03 1998-09-01 The General Hospital Corporation ROC method for early detection of disease
EP0957749A2 (de) * 1995-09-12 1999-11-24 The General Hospital Corporation Verfahren zur früherkennung des eierstockrebs
US5710007A (en) * 1995-09-29 1998-01-20 Luderer; Albert A. Methods for diagnosing prostatic adenocarcinoma
EP0855910A4 (de) * 1995-10-18 2000-07-05 Merck & Co Inc Verwendbare konjugate zur behandlung der gutartigen prostatehyperplasie
EP0789032A2 (de) * 1996-02-01 1997-08-13 Bayer Corporation Verfahren zur Herstellung eines monoklonalen Antikörpers, der zu einer equimolären Responz gegen eine freie und komplexierte Analyseprobe in einem monoklonalen/polyklonalen Sandwichimmuntest
US6143509A (en) * 1996-02-06 2000-11-07 Abbott Laboratories Prostate specific antigen peptides and uses thereof
US6811995B1 (en) 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
AU775537B2 (en) * 1996-04-26 2004-08-05 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
AU2681997A (en) * 1996-04-26 1997-11-19 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
AU4086397A (en) * 1996-09-06 1998-03-26 Centocor Inc. Monoclonal antibodies specific for prostate specific antigen and methods of detecting prostate specific antigen
DE19641560A1 (de) * 1996-10-09 1998-04-16 Boehringer Mannheim Gmbh Monoklonale Antikörper gegen einen Komplex aus humanem ACT und einer Serinprotease
US6107103A (en) * 1996-10-15 2000-08-22 Procyon Bropharma Inc. Assay for PSP94 protein
US6177404B1 (en) 1996-10-15 2001-01-23 Merck & Co., Inc. Conjugates useful in the treatment of benign prostatic hyperplasia
US5840501A (en) * 1996-10-25 1998-11-24 Bayer Corporation Determination of cPSA
IL121659A (en) * 1996-10-25 2000-07-16 Bayer Ag Method for determining CPSA in a blood sample
US5856182A (en) * 1996-11-18 1999-01-05 Beckman Coulter, Inc. Monoclonal antibodies specific for the PSA-ACT complex
US6548260B1 (en) 1997-01-21 2003-04-15 Bayer Corporation Detection of PSA-α2-macroglobulin complex in a biological fluid
US6309816B1 (en) * 1997-04-16 2001-10-30 Horus Therapeutics, Inc. Methods for diagnosing cancer by measuring creatine kinase
DE19717436C2 (de) * 1997-04-25 2001-02-15 Biomac Gmbh Verfahren zur exakten Bestimmung von Prostata-spezifischem Antigen in Körperflüssigkeiten
US7288636B2 (en) * 1997-04-30 2007-10-30 Hybritech Incorporated Forms of prostate specific antigens and methods for their detection
EP0983509B1 (de) * 1997-05-14 2005-08-17 Biosite Diagnostics Inc. Schnelle bestimmung des verhältnisses von biologischen molekülen
US5994085A (en) * 1997-08-26 1999-11-30 Cantor; Thomas L. Methods and devices for detecting non-complexed prostate specific antigen
US6649420B1 (en) 1997-08-26 2003-11-18 Thomas L. Cantor Methods and devices for detecting no-complexed prostate specific I antigen
US6300088B1 (en) 1997-11-24 2001-10-09 Duke University Method of detecting prostate specific antigen
DE19814915A1 (de) * 1998-04-03 1999-10-07 Roche Diagnostics Gmbh Immunologisches Verfahren zur Bestimmung von PSA
FI981186A (fi) * 1998-05-28 1999-11-29 Stenman Ulf Haakan Uusi immunomääritys ja sen käyttö diagnostiikassa
FI981185A (fi) * 1998-05-28 1999-11-29 Stenman Ulf Haakan Uusi diagnostinen menetelmä
WO2000005376A1 (en) * 1998-07-24 2000-02-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pb 39, a gene dysregulated in prostate cancer, and uses thereof
US7226731B1 (en) 1998-07-24 2007-06-05 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services PB 39, a gene dysregulated in prostate cancer, and uses thereof
DE69934694T2 (de) 1998-08-10 2007-10-04 Agensys, Inc., Santa Monica Bpc-1: ein ausgeschiedenes gehirnspezifisches protein das von prostata- und blasen-krebszellen exprimiert und ausgeschieden wird
CA2370749A1 (en) 1999-04-20 2000-10-26 Target Discovery, Inc. Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
US6423503B1 (en) * 1999-04-30 2002-07-23 Hybritech Incorporated Forms of free prostate-specific antigen (PSA) and their association with prostate tissues from prostate peripheral zone and transition zone
US6893818B1 (en) * 1999-10-28 2005-05-17 Agensys, Inc. Gene upregulated in cancers of the prostate
FR2807438B1 (fr) * 2000-04-10 2004-09-17 Bio Merieux Nouveaux anticorps reconnaissant specifiquement le psa libre inactif, et leurs applications
GB0012718D0 (en) * 2000-05-24 2000-07-19 Angeletti P Ist Richerche Bio Conjugates of aminodrugs
FR2810114B1 (fr) * 2000-06-13 2002-08-23 Bio Merieux Methode, procede, test immunologique et kit de diagnostic d'un adenocarcinome de la prostate ou d'une hypertrophie benigne de la prostate
ATE429643T1 (de) 2000-07-12 2009-05-15 Agensys Inc Neues tumor antigen das für diagnose und therapie von blasen-, eierstock-, lungen- und nierenkrebs verwendet werden kann
DE60107022T2 (de) 2000-07-24 2005-11-24 Health Research Inc. Verfahren zur Detektion von Prostata-spezifischem Membran-Antigen in Serum
US6379550B1 (en) 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
US6984494B2 (en) 2000-08-15 2006-01-10 Genentech, Inc. Analytical method
DK1854809T3 (da) 2000-08-22 2013-01-21 Agensys Inc Nukleinsyre og tilsvarende protein betegnet 158P1D7, der er anvendelig i behandling og påvisning af blærecancer og andre cancere
PT1313850E (pt) 2000-08-28 2008-11-18 Agensys Inc Ácido nucleico e proteína correspondente denominados 85p1b3 úteis no tratamento e na detecção de cancro
US6764825B1 (en) * 2000-10-13 2004-07-20 Tang J. Wang Methods and device for detecting prostate specific antigen (PSA)
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
ES2537074T3 (es) 2001-09-06 2015-06-02 Agensys, Inc. Ácido nucleico y proteína correspondiente denominados STEAP-1 útiles en el tratamiento y la detección de cáncer
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US7534580B2 (en) * 2002-05-01 2009-05-19 Ambrilia Biopharma Inc. PSP94 diagnostic reagents and assays
WO2004016733A2 (en) 2002-08-16 2004-02-26 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
US20040176577A1 (en) * 2002-09-10 2004-09-09 Eva Rojer Immunoassays for specific determination of SCCA isoforms
DK1563100T3 (da) * 2002-11-01 2013-08-05 Iris Int Inc Fortrængningssandwich-immuno-PCR
AU2002352976B2 (en) 2002-11-27 2007-11-08 Agensys, Inc. Nucleic acid corresponding protein entitled 24P4C12 useful in treatment and detection of cancer
CA2860151A1 (en) 2003-02-10 2004-08-26 Agensys, Inc. Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
WO2004094652A2 (en) * 2003-04-22 2004-11-04 Neurobiotex, Inc. Zinc-based screening test and kit for early diagnosis of prostate cancer
PT1629088E (pt) 2003-05-30 2012-04-10 Agensys Inc Variantes de antigénio de células estaminais de próstata (psca) e subsequências das mesmas
WO2005118864A2 (en) 2004-05-28 2005-12-15 Agensys, Inc. Antibodies and related molecules that bind to psca proteins
DE102004027429B4 (de) 2004-06-04 2018-09-13 Siemens Healthcare Diagnostics Gmbh Verfahren zur Anwendung von auf Markerwerten basierenden Dichtekarten bei der Diagnose von Patienten mit Krankheiten insbesondere von Tumoren
CN101137758B (zh) * 2004-11-03 2012-10-10 意力速分子诊断股份有限公司 均相分析物检测
EP2302078B1 (de) * 2004-11-03 2015-07-15 Iris Molecular Diagnostics, Inc. Mikrobläschen zur Konzentration mittels Affinitätstrennung
US8663600B2 (en) * 2005-02-17 2014-03-04 Diaprost Ab Diagnosis of prostate cancer
US20080125582A1 (en) * 2006-10-13 2008-05-29 Bio-Rad Laboratories, Inc. Methods and compositions for stabilizing prostate specific antigen
US20090062624A1 (en) * 2007-04-26 2009-03-05 Thomas Neville Methods and systems of delivering a probability of a medical condition
US8202492B2 (en) 2007-05-04 2012-06-19 Opko Diagnostics, Llc Fluidic connectors and microfluidic systems
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
US8362325B2 (en) 2007-10-03 2013-01-29 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
WO2009105264A1 (en) * 2008-02-21 2009-08-27 Iris International Inc. Method for early determination of recurrence after therapy for prostate cancer
GB2464032A (en) * 2008-05-15 2010-04-07 Soar Biodynamics Ltd Methods and systems for integrated health systems
WO2010075446A1 (en) * 2008-12-23 2010-07-01 Soar Biodynamics, Ltd. Methods and systems for prostate health monitoring
US20100173791A1 (en) 2009-01-05 2010-07-08 Bio-Rad Laboratories, Inc. Process design using mass spectrometry
DE202010018623U1 (de) 2009-02-02 2018-12-07 Opko Diagnostics, Llc Strukturen zur Steuerung der Lichtwechselwirkung mit mikrofluidischen Vorrichtungen
EP2239675A1 (de) 2009-04-07 2010-10-13 BIOCRATES Life Sciences AG Verfahren zur In-vitro-Diagnose einer komplexen Krankheit
CN102346536A (zh) * 2010-07-29 2012-02-08 元太科技工业股份有限公司 省电触控电子书
CN105424936B (zh) 2011-03-28 2018-09-21 积水医疗株式会社 Psa测定方法及其试剂
AU2012328679C1 (en) 2011-10-25 2018-10-25 Memorial Sloan-Kettering Cancer Center Free PSA antibodies as diagnostics, prognostics and therapeutics for prostate cancer
WO2013086499A2 (en) 2011-12-09 2013-06-13 Ceres, Inc. Transgenic plants having altered biomass composition
MY171654A (en) 2012-03-05 2019-10-22 Oy Arctic Partners Ab Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume
SG10201808585TA (en) 2014-03-28 2018-11-29 Opko Diagnostics Llc Compositions and methods related to diagnosis of prostate cancer
HUE055020T2 (hu) 2015-03-27 2021-11-29 Opko Diagnostics Llc Prosztata-antigén szabványok és azok felhasználása
CN108802392A (zh) * 2018-08-29 2018-11-13 上海市东方医院 一种用于诊断前列腺癌的层析试纸条及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042428A4 (de) * 1979-12-28 1982-09-03 Research Corp Gereinigtes menschliches prostat-antigen.
US4446122A (en) * 1979-12-28 1984-05-01 Research Corporation Purified human prostate antigen
US4690890A (en) * 1984-04-04 1987-09-01 Cetus Corporation Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay
IE62580B1 (en) * 1985-03-29 1995-02-08 Hybritech Inc Processes for the stabilization of prostate specific antigen in natural matrices
JPH0690203B2 (ja) * 1985-08-23 1994-11-14 中外製薬株式会社 前立腺特異抗原とα▲下１▼−アンチトリプシン複合体の定量方法
US5599677A (en) * 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides

Also Published As

Publication number Publication date
US20020123616A1 (en) 2002-09-05
ES2070107T3 (es) 1996-04-16
DK0540573T4 (da) 2004-04-05
DE69117292D1 (de) 1996-03-28
EP0540573B1 (de) 1996-02-21
US5501983A (en) 1996-03-26
SE9002480D0 (sv) 1990-07-23
GR3019888T3 (en) 1996-08-31
WO1992001936A1 (en) 1992-02-06
ES2070107T5 (es) 2004-05-16
DE69117292T2 (de) 1996-07-18
DK0540573T3 (da) 1996-04-09
JPH06502719A (ja) 1994-03-24
DE69117292T3 (de) 2004-06-03
US5912158A (en) 1999-06-15
US5939533A (en) 1999-08-17
EP0540573A1 (de) 1993-05-12
ATE134448T1 (de) 1996-03-15
EP0540573B2 (de) 2003-11-19
JP2669566B2 (ja) 1997-10-29
ES2070107T1 (es) 1995-06-01

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