DE4428874A1 - Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel - Google Patents

Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel

Info

Publication number
DE4428874A1
DE4428874A1 DE4428874A DE4428874A DE4428874A1 DE 4428874 A1 DE4428874 A1 DE 4428874A1 DE 4428874 A DE4428874 A DE 4428874A DE 4428874 A DE4428874 A DE 4428874A DE 4428874 A1 DE4428874 A1 DE 4428874A1
Authority
DE
Germany
Prior art keywords
bis
carboxymethyl
amino
ethyl
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4428874A
Other languages
German (de)
English (en)
Inventor
Werner Krause
Franz-Karl Maier
Michael Bauer
Wolf-Ruediger Press
Gabriele Schuhmann-Giampieri
Johannes Platzek
Heribert Schmitt-Willich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE4428874A priority Critical patent/DE4428874A1/de
Priority to US08/476,117 priority patent/US5695737A/en
Priority to IL11485895A priority patent/IL114858A0/xx
Priority to DK95929815T priority patent/DK0775104T3/da
Priority to PL95318503A priority patent/PL318503A1/xx
Priority to JP8506999A priority patent/JPH10503777A/ja
Priority to DE59505856T priority patent/DE59505856D1/de
Priority to CZ97405A priority patent/CZ40597A3/cs
Priority to EP95929815A priority patent/EP0775104B1/de
Priority to AT95929815T priority patent/ATE179696T1/de
Priority to MX9701080A priority patent/MX9701080A/es
Priority to PCT/EP1995/003142 priority patent/WO1996005167A1/de
Priority to ES95929815T priority patent/ES2134487T3/es
Priority to HU9700370A priority patent/HUT77532A/hu
Priority to KR1019970700944A priority patent/KR970704668A/ko
Priority to AU33433/95A priority patent/AU695878B2/en
Priority to CA002197074A priority patent/CA2197074A1/en
Priority to ZA956650A priority patent/ZA956650B/xx
Priority to SK173-97A priority patent/SK17397A3/sk
Publication of DE4428874A1 publication Critical patent/DE4428874A1/de
Priority to FI970535A priority patent/FI970535A/fi
Priority to NO970602A priority patent/NO970602L/no
Priority to GR990401917T priority patent/GR3030827T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE4428874A 1994-08-08 1994-08-08 Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel Withdrawn DE4428874A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE4428874A DE4428874A1 (de) 1994-08-08 1994-08-08 Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
US08/476,117 US5695737A (en) 1994-08-08 1995-06-07 Dimeric DTPA derivatives, their metal complexes and pharmaceutical agents containing these complexes
IL11485895A IL114858A0 (en) 1994-08-08 1995-08-07 DTPA derivatives metal complexes thereof pharmaceutical and diagnostic agents containing the same and methods for the preparation thereof
PCT/EP1995/003142 WO1996005167A1 (de) 1994-08-08 1995-08-08 Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel
KR1019970700944A KR970704668A (ko) 1994-08-08 1995-08-08 다이머 DTPA 유도체 및 이들의 금속 착물, 이들을 함유하는 약제, 진단 및 치료법에 있어서의 이들의 용도, 및 상기 착물 약제의 제조 방법(Dimer DTPA Derivatives and Their Metal Complexes, Pharmaceuticals Containing the Same, Their Use in Diagnosis and Therapy and Process for Preparing Said Complexes and Pharmaceuticals)
JP8506999A JPH10503777A (ja) 1994-08-08 1995-08-08 ダイマーのｄｔｐａ誘導体及びその金属複合体、これらの複合体を含む医薬剤、それらの診断及び治療における使用並びに前記複合体及び医薬剤を製造するための方法
DE59505856T DE59505856D1 (de) 1994-08-08 1995-08-08 Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel
CZ97405A CZ40597A3 (en) 1994-08-08 1995-08-08 Dimeric derivatives of diethylenetriaminepentaacetic acid and their metal complexes, pharmaceutical compositions containing the complexes, their application for diagnosis and therapy as well as process for preparing such complexes and pharmaceutical preparations
EP95929815A EP0775104B1 (de) 1994-08-08 1995-08-08 Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel
AT95929815T ATE179696T1 (de) 1994-08-08 1995-08-08 Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel
MX9701080A MX9701080A (es) 1994-08-08 1995-08-08 Derivados dtpa dimericos y sus complejos de metal agentes farmaceuticos que contienen estos complejos, su uso en el diagnistico y terapia asi como tambien el proceso para la produccion de complejos y agentes.
DK95929815T DK0775104T3 (da) 1994-08-08 1995-08-08 Dimere DTPA-derivater og deres metalkomplekser, farmaceutiske midler indeholdende disse komplekser, deres anvendelse inden
ES95929815T ES2134487T3 (es) 1994-08-08 1995-08-08 Derivados dimeros de dtpa y sus complejos con metales, agentes farmaceuticos que contienen estos complejos, su utilizacion en el diagnostico y la terapia, asi como procedimientos para la preparacion de los complejos y agentes.
HU9700370A HUT77532A (hu) 1994-08-08 1995-08-08 Dimer DTPA-származékok és fémkomplexeik, az ezeket a komplexeket tartalmazó gyógyszerkészítmények, alkalmazásuk a diagnosztikában és a terápiában, valamint eljárás a komplexek és a gyógyszerkészítmények előállítására
PL95318503A PL318503A1 (en) 1994-08-08 1995-08-08 Dimeric derivatives of dtpa and their metal complexes, pharmaceutic agents containing such complexes, their application in diagnostics and therapy as well as methods of obtaining such complexes and agents
AU33433/95A AU695878B2 (en) 1994-08-08 1995-08-08 Dimeric DTPA derivatives and their metal complexes, pharmaceutical agents containing these complexes, their use in diagnosis and therapy as well as process for the production of complexes and agents
CA002197074A CA2197074A1 (en) 1994-08-08 1995-08-08 Dimer dtpa derivatives and their metal complexes, pharmaceuticals containing the same, their use in diagnosis and therapy and process for preparing said complexes and pharmaceuticals
ZA956650A ZA956650B (en) 1994-08-08 1995-08-08 Dimeric DTPA derivatives their metal complexes and pharmaceutical agents containing these complexes
SK173-97A SK17397A3 (en) 1994-08-08 1995-08-08 Dimer dtpa derivatives and their metal complexes, pharmaceuticals containing the same, their use in diagnosis and therapy and process for preparing said complexes and pharmaceuticals
FI970535A FI970535A (fi) 1994-08-08 1997-02-07 Dimeerisiä DTPA-johdoksia ja niiden metallikomplekseja, kyseisiä komplekseja sisältäviä farmaseuttisia aineita, niiden käyttö diagnostiikassa ja terapiassa sekä menetelmä kyseisten kompleksien ja aineiden valmistamiseksi
NO970602A NO970602L (no) 1994-08-08 1997-02-10 Dimere DTPA-derivater og deres metallkomplekser, farmasöytiske midler inneholdende kompleksene, deres anvendelse ved diagnostikk og terapi, samt fremgangsmåter for fremstilling av kompleksene og midlene
GR990401917T GR3030827T3 (en) 1994-08-08 1999-07-21 Dimer dtpa derivatives and their metal complexes, pharmaceuticals containing the same, their use in diagnosis and therapy and process for preparing said complexes and pharmaceuticals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4428874A DE4428874A1 (de) 1994-08-08 1994-08-08 Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel

Publications (1)

Publication Number Publication Date
DE4428874A1 true DE4428874A1 (de) 1996-02-22

Family

ID=6525715

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4428874A Withdrawn DE4428874A1 (de) 1994-08-08 1994-08-08 Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE59505856T Expired - Fee Related DE59505856D1 (de) 1994-08-08 1995-08-08 Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59505856T Expired - Fee Related DE59505856D1 (de) 1994-08-08 1995-08-08 Dimere dtpa-derivate und deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel, deren verwendung in der diagnostik und therapie sowie verfahren zur herstellung der komplexe und mittel

Country Status (21)

Country Link
US (1) US5695737A (zh-CN)
EP (1) EP0775104B1 (zh-CN)
JP (1) JPH10503777A (zh-CN)
KR (1) KR970704668A (zh-CN)
AT (1) ATE179696T1 (zh-CN)
AU (1) AU695878B2 (zh-CN)
CA (1) CA2197074A1 (zh-CN)
CZ (1) CZ40597A3 (zh-CN)
DE (2) DE4428874A1 (zh-CN)
DK (1) DK0775104T3 (zh-CN)
ES (1) ES2134487T3 (zh-CN)
FI (1) FI970535A (zh-CN)
GR (1) GR3030827T3 (zh-CN)
HU (1) HUT77532A (zh-CN)
IL (1) IL114858A0 (zh-CN)
MX (1) MX9701080A (zh-CN)
NO (1) NO970602L (zh-CN)
PL (1) PL318503A1 (zh-CN)
SK (1) SK17397A3 (zh-CN)
WO (1) WO1996005167A1 (zh-CN)
ZA (1) ZA956650B (zh-CN)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19646762A1 (de) * 1996-11-04 1998-05-07 Schering Ag Verwendung von Metallchelaten als Radiosensitizer

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
CA2309749A1 (en) * 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
AU2002211517A1 (en) 2000-10-04 2002-04-15 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4915933A (en) * 1986-06-26 1990-04-10 The University Of New Mexico Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5482700A (en) * 1987-03-31 1996-01-09 Schering Aktiengesellschaft Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5284647A (en) * 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
DE3827940A1 (de) * 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2652004B1 (fr) * 1989-09-21 1994-10-28 Immunotech Partners Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques.
US5244816A (en) * 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
CA2069886A1 (en) * 1989-10-23 1991-04-24 David Love Multi-site metal chelating agents
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
CA2092434A1 (en) * 1990-09-27 1992-03-28 Wolfgang J. Wrasidlo Chelating agents
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5466439A (en) * 1992-11-12 1995-11-14 Magnetic Research, Inc. Polymeric contrast enhancing agents for magnetic resonance images
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19646762A1 (de) * 1996-11-04 1998-05-07 Schering Ag Verwendung von Metallchelaten als Radiosensitizer
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren

Also Published As

Publication number Publication date
AU3343395A (en) 1996-03-07
PL318503A1 (en) 1997-06-23
HUT77532A (hu) 1998-05-28
IL114858A0 (en) 1995-12-08
NO970602D0 (no) 1997-02-10
DE59505856D1 (de) 1999-06-10
AU695878B2 (en) 1998-08-27
JPH10503777A (ja) 1998-04-07
GR3030827T3 (en) 1999-11-30
ATE179696T1 (de) 1999-05-15
CZ40597A3 (en) 1997-07-16
FI970535A0 (fi) 1997-02-07
EP0775104B1 (de) 1999-05-06
FI970535A (fi) 1997-02-07
ES2134487T3 (es) 1999-10-01
NO970602L (no) 1997-02-10
MX9701080A (es) 1997-05-31
DK0775104T3 (da) 2000-01-03
US5695737A (en) 1997-12-09
ZA956650B (en) 1996-03-19
WO1996005167A1 (de) 1996-02-22
EP0775104A1 (de) 1997-05-28
KR970704668A (ko) 1997-09-06
SK17397A3 (en) 1997-11-05
CA2197074A1 (en) 1996-02-22

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