DE4038887C2 - - Google Patents
Info
- Publication number
- DE4038887C2 DE4038887C2 DE4038887A DE4038887A DE4038887C2 DE 4038887 C2 DE4038887 C2 DE 4038887C2 DE 4038887 A DE4038887 A DE 4038887A DE 4038887 A DE4038887 A DE 4038887A DE 4038887 C2 DE4038887 C2 DE 4038887C2
- Authority
- DE
- Germany
- Prior art keywords
- collagen
- particles
- organic phase
- water
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 claims abstract description 64
- 102000008186 Collagen Human genes 0.000 claims abstract description 47
- 108010035532 Collagen Proteins 0.000 claims abstract description 47
- 229920001436 collagen Polymers 0.000 claims abstract description 47
- 238000000034 method Methods 0.000 claims abstract description 27
- 239000000839 emulsion Substances 0.000 claims abstract description 15
- 239000012074 organic phase Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 8
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 3
- 239000004480 active ingredient Substances 0.000 claims description 16
- 239000011859 microparticle Substances 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 7
- 229930195729 fatty acid Natural products 0.000 claims description 7
- 239000000194 fatty acid Substances 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- -1 fatty acid ester Chemical class 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- 230000001588 bifunctional effect Effects 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 3
- 239000002537 cosmetic Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000003925 fat Substances 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 150000001299 aldehydes Chemical class 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 239000012948 isocyanate Substances 0.000 claims description 2
- 150000002513 isocyanates Chemical class 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- 239000001993 wax Substances 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims 1
- 239000006185 dispersion Substances 0.000 abstract description 12
- 239000000243 solution Substances 0.000 description 12
- 238000011068 loading method Methods 0.000 description 11
- 238000009826 distribution Methods 0.000 description 9
- 239000000835 fiber Substances 0.000 description 6
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 244000309466 calf Species 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 239000002775 capsule Substances 0.000 description 3
- 235000012343 cottonseed oil Nutrition 0.000 description 3
- 239000002385 cottonseed oil Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
- 229930002875 chlorophyll Natural products 0.000 description 2
- 235000019804 chlorophyll Nutrition 0.000 description 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 description 2
- 229960004189 ethacridine lactate Drugs 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 244000001582 Canarium odontophyllum Species 0.000 description 1
- 229920002085 Dialdehyde starch Polymers 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 238000012695 Interfacial polymerization Methods 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000005100 correlation spectroscopy Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000010512 hydrogenated peanut oil Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011257 shell material Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 201000009482 yaws Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Colloid Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4038887A DE4038887A1 (de) | 1990-12-06 | 1990-12-06 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstofftraeger |
| DK91920426.3T DK0561821T3 (da) | 1990-12-06 | 1991-11-21 | Fremgangsmåde til fremstilling af kollagenpartikler og deres anvendelse som bærerstof for aktive stoffer |
| EP91920426A EP0561821B1 (de) | 1990-12-06 | 1991-11-21 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstoffträger |
| DE59104102T DE59104102D1 (de) | 1990-12-06 | 1991-11-21 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstoffträger. |
| PCT/EP1991/002195 WO1992010287A1 (de) | 1990-12-06 | 1991-11-21 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstoffträger |
| ES91920426T ES2069316T3 (es) | 1990-12-06 | 1991-11-21 | Un procedimiento para la obtencion de particulas colagenas, y su utilizacion como soportes de sustancia activa. |
| AT91920426T ATE116158T1 (de) | 1990-12-06 | 1991-11-21 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstoffträger. |
| CA002097801A CA2097801C (en) | 1990-12-06 | 1991-11-21 | Method of producing collagen particles, and the use of such particles as substrates for active substances |
| JP51866791A JP3233631B2 (ja) | 1990-12-06 | 1991-11-21 | コラーゲン粒子の製造法及びその活性基質に対する担体としての使用法 |
| GR950400651T GR3015518T3 (en) | 1990-12-06 | 1995-03-22 | Method of producing collagen particles, and the use of such particles as substrates for active substances. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4038887A DE4038887A1 (de) | 1990-12-06 | 1990-12-06 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstofftraeger |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE4038887A1 DE4038887A1 (de) | 1992-07-02 |
| DE4038887C2 true DE4038887C2 (forum.php) | 1992-10-08 |
Family
ID=6419700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4038887A Granted DE4038887A1 (de) | 1990-12-06 | 1990-12-06 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstofftraeger |
| DE59104102T Expired - Lifetime DE59104102D1 (de) | 1990-12-06 | 1991-11-21 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstoffträger. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59104102T Expired - Lifetime DE59104102D1 (de) | 1990-12-06 | 1991-11-21 | Verfahren zur herstellung von kollagenpartikeln und ihre verwendung als wirkstoffträger. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0561821B1 (forum.php) |
| JP (1) | JP3233631B2 (forum.php) |
| AT (1) | ATE116158T1 (forum.php) |
| CA (1) | CA2097801C (forum.php) |
| DE (2) | DE4038887A1 (forum.php) |
| DK (1) | DK0561821T3 (forum.php) |
| ES (1) | ES2069316T3 (forum.php) |
| GR (1) | GR3015518T3 (forum.php) |
| WO (1) | WO1992010287A1 (forum.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19934894A1 (de) * | 1999-07-24 | 2001-02-01 | Pharma Concepts Gmbh & Co Kg | Verfahren zur Herstellung von Kollagenpartikeln |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4414755C2 (de) * | 1994-04-27 | 2000-11-16 | Lohmann Therapie Syst Lts | Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung |
| DE19624332B4 (de) * | 1996-06-19 | 2009-12-24 | Namos Gmbh | Metallische Nanostruktur auf der Basis hochgeordneter Proteine sowie Verfahren zu deren Herstellung |
| DE19739031A1 (de) * | 1997-09-05 | 1999-03-11 | Suwelack Nachf Dr Otto | Mittel zur peroralen Verabreichung, seine Herstellung und Verwendung |
| DE19839515B4 (de) * | 1998-08-29 | 2012-02-02 | Nanohale Gmbh | Neue pharmazeutische Zubereitung, enthaltend kolloidale Polymer-Wirkstoff-Assoziate, insbesondere auch für mucosale Wirkstoffverabreichung |
| DE10010113B4 (de) * | 2000-03-03 | 2009-05-07 | Wolfgang Dr. Schatton | Natives Schwammkollagen, Verfahren zu seiner Isolierung und seine Verwendung, sowie natives nanopartikuläres Schwammkollagen, Verfahren zu seiner Herstellung und seine Verwendung |
| WO2002060486A2 (en) * | 2001-01-29 | 2002-08-08 | Fresco Bernard B | Controlled release microsphere system for administration of drug to the eye |
| EP3015101B1 (en) | 2005-10-03 | 2019-08-21 | PINSKY, Mark A. | Non-phospholipid liposomes comprising hyaluronic acid |
| US20080175807A1 (en) | 2007-01-24 | 2008-07-24 | Fujifilm Corporation | Composition for hair |
| JP2008201767A (ja) * | 2007-01-24 | 2008-09-04 | Fujifilm Corp | 頭髪用組成物 |
| JP2008255020A (ja) * | 2007-04-02 | 2008-10-23 | Fujifilm Corp | 抗老化皮膚外用剤 |
| DE102008036576A1 (de) | 2008-07-31 | 2010-02-04 | Gelita Ag | Partikel aus Kollagenmaterial und Verfahren zur Herstellung |
| CA2904143A1 (en) | 2013-03-12 | 2014-10-09 | Cephalon, Inc. | Nanoparticulate and macroparticulate formulations |
| CN115317668B (zh) * | 2022-08-19 | 2023-12-29 | 北京西宏润美医药科技有限公司 | 一种长效微粒ⅰ型胶原蛋白植入剂 |
| CN115252898B (zh) * | 2022-08-19 | 2023-08-18 | 江苏西宏生物医药有限公司 | 一种长效微粒ⅰ型与ⅴ型胶原蛋白复合植入剂 |
| CN115340597A (zh) * | 2022-08-19 | 2022-11-15 | 江苏东方妍美生物技术发展有限公司 | 一种长效植入级ⅱ型胶原蛋白的制备方法 |
| CN115300614A (zh) * | 2022-08-19 | 2022-11-08 | 江苏东方妍美生物技术发展有限公司 | 一种长效微粒胶原蛋白植入剂 |
| CN115350329A (zh) * | 2022-08-19 | 2022-11-18 | 江苏西宏生物医药有限公司 | 一种长效微粒ⅰ型与iii型胶原蛋白复合植入剂 |
| CN115350328A (zh) * | 2022-08-19 | 2022-11-18 | 江苏西宏生物医药有限公司 | 一种长效微粒iii型胶原蛋白植入剂 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60174725A (ja) * | 1984-02-22 | 1985-09-09 | Koken:Kk | 再生コラ−ゲンフイプリルを含有する基質及びその製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL58965A (en) | 1978-12-19 | 1982-08-31 | Mars Inc | Production of microcapsules |
| US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
| SE459005B (sv) * | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
-
1990
- 1990-12-06 DE DE4038887A patent/DE4038887A1/de active Granted
-
1991
- 1991-11-21 JP JP51866791A patent/JP3233631B2/ja not_active Expired - Lifetime
- 1991-11-21 AT AT91920426T patent/ATE116158T1/de not_active IP Right Cessation
- 1991-11-21 ES ES91920426T patent/ES2069316T3/es not_active Expired - Lifetime
- 1991-11-21 CA CA002097801A patent/CA2097801C/en not_active Expired - Lifetime
- 1991-11-21 WO PCT/EP1991/002195 patent/WO1992010287A1/de not_active Ceased
- 1991-11-21 DK DK91920426.3T patent/DK0561821T3/da active
- 1991-11-21 EP EP91920426A patent/EP0561821B1/de not_active Expired - Lifetime
- 1991-11-21 DE DE59104102T patent/DE59104102D1/de not_active Expired - Lifetime
-
1995
- 1995-03-22 GR GR950400651T patent/GR3015518T3/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60174725A (ja) * | 1984-02-22 | 1985-09-09 | Koken:Kk | 再生コラ−ゲンフイプリルを含有する基質及びその製造方法 |
Non-Patent Citations (1)
| Title |
|---|
| Derwent Publications LTD London, GB, Database WPIL, Nr. 85-260393 [42], & JP,A,60174725 (KOKEN K.K.) 9. September 1985 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19934894A1 (de) * | 1999-07-24 | 2001-02-01 | Pharma Concepts Gmbh & Co Kg | Verfahren zur Herstellung von Kollagenpartikeln |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2097801A1 (en) | 1992-06-07 |
| DE4038887A1 (de) | 1992-07-02 |
| EP0561821A1 (de) | 1993-09-29 |
| JP3233631B2 (ja) | 2001-11-26 |
| GR3015518T3 (en) | 1995-06-30 |
| JPH06503259A (ja) | 1994-04-14 |
| ATE116158T1 (de) | 1995-01-15 |
| WO1992010287A1 (de) | 1992-06-25 |
| DK0561821T3 (da) | 1995-06-12 |
| CA2097801C (en) | 2002-01-22 |
| EP0561821B1 (de) | 1994-12-28 |
| ES2069316T3 (es) | 1995-05-01 |
| DE59104102D1 (de) | 1995-02-09 |
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Owner name: LTS LOHMANN THERAPIE-SYSTEME AG, 56269 DIERDORF, D |