CA2097801A1 - Method of producing collagen particles, and the use of such particles as substrates for active substances - Google Patents
Method of producing collagen particles, and the use of such particles as substrates for active substancesInfo
- Publication number
- CA2097801A1 CA2097801A1 CA002097801A CA2097801A CA2097801A1 CA 2097801 A1 CA2097801 A1 CA 2097801A1 CA 002097801 A CA002097801 A CA 002097801A CA 2097801 A CA2097801 A CA 2097801A CA 2097801 A1 CA2097801 A1 CA 2097801A1
- Authority
- CA
- Canada
- Prior art keywords
- particles
- collagen
- cross
- substrates
- active substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
Abstract
The invention concerns a process for the production of cross-linked collagen particles whose size lies in the micro and nanometer range, in which a solution or disper-sion of collagen in water is distributed finely in discrete droplets in a waterimmiscible organic phase, whereby emul-sifying agents are added, a water-in-oil emulsion thereby being formed, the collagen being subsequently cross-linked in the interface of the droplets, using a cross-linking agent, and the collagen particles produced in this manner being purified and isolated by separating the organic phase and washing.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4038887.5 | 1990-12-06 | ||
DE4038887A DE4038887A1 (en) | 1990-12-06 | 1990-12-06 | METHOD FOR THE PRODUCTION OF COLLAGEN PARTICLES AND THEIR USE AS AN ACTIVE SUBSTANCE |
PCT/EP1991/002195 WO1992010287A1 (en) | 1990-12-06 | 1991-11-21 | Method of producing collagen particles, and the use of such particles as substrates for active substances |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2097801A1 true CA2097801A1 (en) | 1992-06-07 |
CA2097801C CA2097801C (en) | 2002-01-22 |
Family
ID=6419700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002097801A Expired - Lifetime CA2097801C (en) | 1990-12-06 | 1991-11-21 | Method of producing collagen particles, and the use of such particles as substrates for active substances |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0561821B1 (en) |
JP (1) | JP3233631B2 (en) |
AT (1) | ATE116158T1 (en) |
CA (1) | CA2097801C (en) |
DE (2) | DE4038887A1 (en) |
DK (1) | DK0561821T3 (en) |
ES (1) | ES2069316T3 (en) |
GR (1) | GR3015518T3 (en) |
WO (1) | WO1992010287A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10201506B2 (en) | 2013-03-12 | 2019-02-12 | Cephalon, Inc. | Nanoparticulate and macroparticulate formulations |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4414755C2 (en) * | 1994-04-27 | 2000-11-16 | Lohmann Therapie Syst Lts | Collagen preparation for the controlled delivery of active ingredients, processes and use |
DE19624332B4 (en) * | 1996-06-19 | 2009-12-24 | Namos Gmbh | Metallic nanostructure based on highly ordered proteins and methods for their production |
DE19739031A1 (en) * | 1997-09-05 | 1999-03-11 | Suwelack Nachf Dr Otto | Oral administration agent, its preparation and use |
DE19839515B4 (en) * | 1998-08-29 | 2012-02-02 | Nanohale Gmbh | New pharmaceutical preparation containing colloidal polymer-drug associations, especially for mucosal drug administration |
DE19934894A1 (en) * | 1999-07-24 | 2001-02-01 | Pharma Concepts Gmbh & Co Kg | Collagen particles for use as drug carriers, e.g. for administration of proteins or peptides by injection, prepared from emulsion containing collagen solution or dispersion without using crosslinking agents |
DE10010113B4 (en) * | 2000-03-03 | 2009-05-07 | Wolfgang Dr. Schatton | Native sponge collagen, process for its isolation and its use, as well as native nanoparticulate sponge collagen, process for its preparation and its use |
WO2002060486A2 (en) * | 2001-01-29 | 2002-08-08 | Fresco Bernard B | Controlled release microsphere system for administration of drug to the eye |
JP2009510168A (en) * | 2005-10-03 | 2009-03-12 | マーク エー. ピンスカイ | Compositions and methods for improved skin care |
US20080175807A1 (en) | 2007-01-24 | 2008-07-24 | Fujifilm Corporation | Composition for hair |
JP2008201767A (en) * | 2007-01-24 | 2008-09-04 | Fujifilm Corp | Composition for hair |
JP2008255020A (en) * | 2007-04-02 | 2008-10-23 | Fujifilm Corp | Antiaging skin care preparation |
DE102008036576A1 (en) | 2008-07-31 | 2010-02-04 | Gelita Ag | Particles of collagen material and method of manufacture |
CN115252898B (en) * | 2022-08-19 | 2023-08-18 | 江苏西宏生物医药有限公司 | Long-acting microparticle type I and type V collagen composite implant |
CN115350329A (en) * | 2022-08-19 | 2022-11-18 | 江苏西宏生物医药有限公司 | Long-acting particle type I and type III collagen composite implant |
CN115350328A (en) * | 2022-08-19 | 2022-11-18 | 江苏西宏生物医药有限公司 | Long-acting particle III type collagen implant |
CN115317668B (en) * | 2022-08-19 | 2023-12-29 | 北京西宏润美医药科技有限公司 | Long-acting microparticle type I collagen implant |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
JPS60174725A (en) * | 1984-02-22 | 1985-09-09 | Koken:Kk | Substrate containing regenerated collagen fibril and its preparation |
SE459005B (en) * | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | SET TO MANUFACTURE SPHERICAL POLYMER PARTICLES |
-
1990
- 1990-12-06 DE DE4038887A patent/DE4038887A1/en active Granted
-
1991
- 1991-11-21 AT AT91920426T patent/ATE116158T1/en not_active IP Right Cessation
- 1991-11-21 DK DK91920426.3T patent/DK0561821T3/en active
- 1991-11-21 EP EP91920426A patent/EP0561821B1/en not_active Expired - Lifetime
- 1991-11-21 WO PCT/EP1991/002195 patent/WO1992010287A1/en active IP Right Grant
- 1991-11-21 CA CA002097801A patent/CA2097801C/en not_active Expired - Lifetime
- 1991-11-21 ES ES91920426T patent/ES2069316T3/en not_active Expired - Lifetime
- 1991-11-21 DE DE59104102T patent/DE59104102D1/en not_active Expired - Lifetime
- 1991-11-21 JP JP51866791A patent/JP3233631B2/en not_active Expired - Lifetime
-
1995
- 1995-03-22 GR GR950400651T patent/GR3015518T3/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10201506B2 (en) | 2013-03-12 | 2019-02-12 | Cephalon, Inc. | Nanoparticulate and macroparticulate formulations |
Also Published As
Publication number | Publication date |
---|---|
EP0561821B1 (en) | 1994-12-28 |
WO1992010287A1 (en) | 1992-06-25 |
EP0561821A1 (en) | 1993-09-29 |
GR3015518T3 (en) | 1995-06-30 |
DE59104102D1 (en) | 1995-02-09 |
ATE116158T1 (en) | 1995-01-15 |
JPH06503259A (en) | 1994-04-14 |
ES2069316T3 (en) | 1995-05-01 |
CA2097801C (en) | 2002-01-22 |
DK0561821T3 (en) | 1995-06-12 |
DE4038887A1 (en) | 1992-07-02 |
DE4038887C2 (en) | 1992-10-08 |
JP3233631B2 (en) | 2001-11-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |