DE4001655A1 - 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel - Google Patents

6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Info

Publication number
DE4001655A1
DE4001655A1 DE4001655A DE4001655A DE4001655A1 DE 4001655 A1 DE4001655 A1 DE 4001655A1 DE 4001655 A DE4001655 A DE 4001655A DE 4001655 A DE4001655 A DE 4001655A DE 4001655 A1 DE4001655 A1 DE 4001655A1
Authority
DE
Germany
Prior art keywords
meaning
group
groups
hydrogen atom
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4001655A
Other languages
German (de)
English (en)
Inventor
Heinz Dr Gries
Bernd Dr Raduechel
Johannes Dr Platzek
Hanns-Joachim Dr Weinmann
Wolf-Ruediger Press
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE4001655A priority Critical patent/DE4001655A1/de
Priority to IL96840A priority patent/IL96840A0/xx
Priority to JP3002602A priority patent/JPH05112567A/ja
Priority to EP91250008A priority patent/EP0438206B1/de
Priority to DE59108091T priority patent/DE59108091D1/de
Priority to DK91250008.9T priority patent/DK0438206T3/da
Priority to ES91250008T priority patent/ES2091865T3/es
Priority to AT91250008T priority patent/ATE141602T1/de
Priority to CA002034242A priority patent/CA2034242A1/en
Priority to NZ236803A priority patent/NZ236803A/xx
Priority to HU91156A priority patent/HUT56569A/hu
Priority to NO91910191A priority patent/NO910191L/no
Priority to PT96505A priority patent/PT96505B/pt
Priority to KR1019910000816A priority patent/KR910014377A/ko
Priority to IE16291A priority patent/IE75898B1/en
Priority to FI910276A priority patent/FI94758C/fi
Priority to AU69812/91A priority patent/AU6981291A/en
Priority to ZA91389A priority patent/ZA91389B/xx
Publication of DE4001655A1 publication Critical patent/DE4001655A1/de
Priority to TW080108935A priority patent/TW233298B/zh
Priority to US07/907,929 priority patent/US5334371A/en
Priority to US08/213,431 priority patent/US5403572A/en
Priority to GR960402335T priority patent/GR3020973T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
DE4001655A 1988-07-20 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel Withdrawn DE4001655A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE4001655A DE4001655A1 (de) 1990-01-18 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IL96840A IL96840A0 (en) 1990-01-18 1990-12-31 Macrocyclic tetraaza compounds containing a six-membered ring,process for their production,and pharmaceutical agents containing the same
JP3002602A JPH05112567A (ja) 1990-01-18 1991-01-14 ６員環を有する巨大環式テトラアザ化合物、その製法及びこれを含有する薬剤
EP91250008A EP0438206B1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE59108091T DE59108091D1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DK91250008.9T DK0438206T3 (zh-CN) 1990-01-18 1991-01-16
ES91250008T ES2091865T3 (es) 1990-01-18 1991-01-16 Tetraaza-compuestos macrociclicos que contienen 6 anillos, procedimiento para su preparacion y agentes farmaceuticos que los contienen.
AT91250008T ATE141602T1 (de) 1990-01-18 1991-01-16 6-ring enthaltende makrocyclische tetraaza- verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
CA002034242A CA2034242A1 (en) 1990-01-18 1991-01-16 Macrocyclic tetraaza compounds containing a six-membered ring, processes for their production, and pharmaceutical agents containing same
NO91910191A NO910191L (no) 1990-01-18 1991-01-17 Makrocykliske tetraazaforbindelser som inneholder en seksring, fremgangsmaate for fremstilling derav, samt farmasoeytiske midler som inneholder slike.
HU91156A HUT56569A (en) 1990-01-18 1991-01-17 Process for producing macrocyclic tetraaza compounds, their metal complexes and pharmaceutical compositions comprising such compounds
NZ236803A NZ236803A (en) 1990-01-18 1991-01-17 Tetra-aza macrocyclic complexing agents for metal ions, optionally attached to another macromolecule; therapeutic and diagnostic uses
PT96505A PT96505B (pt) 1990-01-18 1991-01-17 Processo para preparacao de compostos tetra-aza macrociclicos contendo um anel de 6 elementos e de composicoes farmaceuticas que os contem
AU69812/91A AU6981291A (en) 1990-01-18 1991-01-18 Macrocyclic tetraaza compounds containing a six-membered ring, processes for their production, and pharmaceutical agents containing them
IE16291A IE75898B1 (en) 1990-01-18 1991-01-18 Macrocyclic tetraaza compounds containing a six-membered ring processes for their production and pharmaceutical agents containing the same
FI910276A FI94758C (fi) 1990-01-18 1991-01-18 Makrosyklisiä yhdisteitä, joissa on 3,6,9,15-tetra-atsabisyklo/9.3.1/pentadekaanirakenne, niiden käyttö NMR-, röntgen- tai radiodiagnostiikkaan käytettävissä koostumuksissa ja tällaiset koostumukset
KR1019910000816A KR910014377A (ko) 1990-01-18 1991-01-18 6-원 환을 함유하는 마크로사이클릭 테트라아자 화합물, 이의 제조방법 및 이를 함유하는 약제
ZA91389A ZA91389B (en) 1990-01-18 1991-01-18 Macrocyclic tetraaza compounds containing a six-membered ring,processes for their production,and pharmaceutical agents containing same
TW080108935A TW233298B (zh-CN) 1990-01-18 1991-08-06
US07/907,929 US5334371A (en) 1988-07-20 1992-07-06 Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
US08/213,431 US5403572A (en) 1988-07-20 1994-03-15 Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them
GR960402335T GR3020973T3 (en) 1990-01-18 1996-09-06 6-Ring-containing macrocyclic tetraaza compounds, processes for their preparation, and pharmaceutical agents containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4001655A DE4001655A1 (de) 1990-01-18 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
DE4001655A1 true DE4001655A1 (de) 1991-07-25

Family

ID=6398485

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4001655A Withdrawn DE4001655A1 (de) 1988-07-20 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE59108091T Expired - Lifetime DE59108091D1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59108091T Expired - Lifetime DE59108091D1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel

Country Status (19)

Country Link
EP (1) EP0438206B1 (zh-CN)
JP (1) JPH05112567A (zh-CN)
KR (1) KR910014377A (zh-CN)
AT (1) ATE141602T1 (zh-CN)
AU (1) AU6981291A (zh-CN)
CA (1) CA2034242A1 (zh-CN)
DE (2) DE4001655A1 (zh-CN)
DK (1) DK0438206T3 (zh-CN)
ES (1) ES2091865T3 (zh-CN)
FI (1) FI94758C (zh-CN)
GR (1) GR3020973T3 (zh-CN)
HU (1) HUT56569A (zh-CN)
IE (1) IE75898B1 (zh-CN)
IL (1) IL96840A0 (zh-CN)
NO (1) NO910191L (zh-CN)
NZ (1) NZ236803A (zh-CN)
PT (1) PT96505B (zh-CN)
TW (1) TW233298B (zh-CN)
ZA (1) ZA91389B (zh-CN)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
AU3246893A (en) * 1991-12-10 1993-07-19 Dow Chemical Company, The Bicycloazamacrocyclophosphonic acid, conjugates, contrast agents and preparation
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
MX9207165A (es) * 1991-12-10 1993-06-01 Dow Chemical Co Complejos de acido biciclopoliazamacrociclocarboxilico, sus conjugados, procedimientos para su preparacion y su uso como radiofarmaceuticos.
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
DE69230970T2 (de) * 1991-12-10 2001-01-04 Dow Chemical Co Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
AU4237493A (en) * 1993-05-06 1994-12-12 Dow Chemical Company, The Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
DE69504220T2 (de) * 1994-02-21 1999-04-29 Pliva Pharm & Chem Works Sulfonamidodioxepane mit hypoglykämischen Eigenschaften, Methoden zu ihrer Herstellung, ihre Zwischenprodukte und Salze
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
WO1996030377A1 (en) 1995-03-27 1996-10-03 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
AU719002B2 (en) * 1996-04-19 2000-05-04 Dow Chemical Company, The Fluorescent chelates as visual tissue specific imaging agents
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
WO1998047539A1 (en) * 1997-04-22 1998-10-29 Nycomed Imaging As Nmr image compounds
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
EP2004642B1 (en) 2006-03-10 2017-07-26 Nordion (Canada) Inc. Bifunctional polyazamacrocyclic chelating agents
JP6608805B2 (ja) 2013-04-26 2019-11-20 ゲルベ 造影製剤および関連する調製方法
EP3544964B1 (en) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
JOP20210114A1 (ar) 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
US20230339945A1 (en) 2020-07-17 2023-10-26 Guerbet Method for preparing a chelating ligand derived from pcta
CN114105983B (zh) * 2021-11-09 2023-08-11 国科温州研究院(温州生物材料与工程研究所) 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071564A1 (de) * 1981-07-24 1983-02-09 Schering Aktiengesellschaft Paramagnetische Komplexsalze, deren Herstellung und Verwendung bei der NMR-Diagnostik
DE3401052A1 (de) * 1983-01-21 1984-07-26 Schering AG, 1000 Berlin und 4709 Bergkamen Diagnostische mittel
EP0130934A1 (de) * 1983-07-01 1985-01-09 Schering Aktiengesellschaft Neue Komplexbildner, Komplexe und Komplexsalze
EP0203047A1 (en) * 1985-05-23 1986-11-26 Jouko Kankare Fluorescent lanthanide chelates
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036945A (en) 1976-05-03 1977-07-19 The Massachusetts General Hospital Composition and method for determining the size and location of myocardial infarcts
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
DE3150917A1 (de) 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
DE3417413A1 (de) 1984-05-11 1985-11-14 Dr. Karl Thomae Gmbh, 7950 Biberach Dicarbonsaeure-monohydrazid-derivate, ihre herstellung und ihre verwendung als kopplungskomponenten
EP0232751B1 (en) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
IT1224416B (it) 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
DE3713842A1 (de) 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
WO1989000557A1 (en) 1987-07-16 1989-01-26 Cockbain, Julian, Roderick, Michaelson Aminopolycarboxylic acids and derivatives thereof
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071564A1 (de) * 1981-07-24 1983-02-09 Schering Aktiengesellschaft Paramagnetische Komplexsalze, deren Herstellung und Verwendung bei der NMR-Diagnostik
DE3401052A1 (de) * 1983-01-21 1984-07-26 Schering AG, 1000 Berlin und 4709 Bergkamen Diagnostische mittel
EP0130934A1 (de) * 1983-07-01 1985-01-09 Schering Aktiengesellschaft Neue Komplexbildner, Komplexe und Komplexsalze
EP0203047A1 (en) * 1985-05-23 1986-11-26 Jouko Kankare Fluorescent lanthanide chelates
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DE-Z.: Angew. Chemie 98 (1986), S.1119-21 *
GB-Z.: Tetrahedron 37 (1981), 767-72 *

Also Published As

Publication number Publication date
JPH05112567A (ja) 1993-05-07
NO910191L (no) 1991-07-19
EP0438206B1 (de) 1996-08-21
FI94758B (fi) 1995-07-14
GR3020973T3 (en) 1996-12-31
DE59108091D1 (de) 1996-09-26
NZ236803A (en) 1993-08-26
HU910156D0 (en) 1991-08-28
IE75898B1 (en) 1997-09-24
KR910014377A (ko) 1991-08-31
IL96840A0 (en) 1991-09-16
ATE141602T1 (de) 1996-09-15
HUT56569A (en) 1991-09-30
CA2034242A1 (en) 1991-07-19
ZA91389B (en) 1991-10-30
FI94758C (fi) 1995-10-25
FI910276A (fi) 1991-07-19
PT96505B (pt) 1998-07-31
AU6981291A (en) 1991-08-22
FI910276A0 (fi) 1991-01-18
EP0438206A1 (de) 1991-07-24
DK0438206T3 (zh-CN) 1997-01-20
NO910191D0 (no) 1991-01-17
TW233298B (zh-CN) 1994-11-01
ES2091865T3 (es) 1996-11-16
PT96505A (pt) 1991-10-15
IE910162A1 (en) 1991-07-31

Similar Documents

Publication Publication Date Title
EP0438206B1 (de) 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP0430863B1 (de) Kaskadenpolymer-gebundene Komplexbildner, deren Komplexe und Konjugate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5403572A (en) Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them
EP0255471B1 (de) 1,4,7,10-Tetraazacyclododecan-Derivate
EP0305320B1 (de) Mehrkernige substituierte Komplexbildner, Komplexe und Komplexsalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel
EP0662972B1 (de) 3-,8-substituierte deuteroporphyrinderivate, diese enthaltende pharmazeutische mittel und verfahren zu ihrer herstellung
EP0355097A1 (de) Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
EP0352218B1 (de) 5- oder 6-Ring-enthaltende makrocyclische Polyaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE4035760A1 (de) Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
EP0331616A2 (de) Polymer-gebundene Komplexbildner, deren Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE4115789A1 (de) Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19744003B4 (de) Kontrastmittel für das Infarkt- und Nekroseimaging
EP1904462A2 (de) Perfluoralkylhaltige komplexe, verfahren zu deren herstellung, sowie deren verwendung
DE10040381C1 (de) Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE3701665A1 (de) Polymer-komplexe, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
DE102005033902B3 (de) Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE3710730A1 (de) Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
EP1307237B9 (de) Perfluoralkylhaltige komplexe mit polaren resten, verfahren zu deren herstellung und ihre verwendung
DE102006049821A1 (de) Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102005033903B4 (de) Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel

Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: SCHERING AG, 13353 BERLIN, DE

8141 Disposal/no request for examination
8110 Request for examination paragraph 44
8170 Reinstatement of the former position
8130 Withdrawal