DE3910084A1 - Polypeptide mit wachstumsfaktor-aktivitaet und nukleinsaeuresequenzen - Google Patents
Polypeptide mit wachstumsfaktor-aktivitaet und nukleinsaeuresequenzenInfo
- Publication number
- DE3910084A1 DE3910084A1 DE3910084A DE3910084A DE3910084A1 DE 3910084 A1 DE3910084 A1 DE 3910084A1 DE 3910084 A DE3910084 A DE 3910084A DE 3910084 A DE3910084 A DE 3910084A DE 3910084 A1 DE3910084 A1 DE 3910084A1
- Authority
- DE
- Germany
- Prior art keywords
- sequence
- amino acid
- amino acids
- egf
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17265388A | 1988-03-24 | 1988-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3910084A1 true DE3910084A1 (de) | 1989-11-16 |
Family
ID=22628611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3910084A Withdrawn DE3910084A1 (de) | 1988-03-24 | 1989-03-28 | Polypeptide mit wachstumsfaktor-aktivitaet und nukleinsaeuresequenzen |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPH0279981A (fi) |
| KR (1) | KR890014743A (fi) |
| AU (2) | AU3169589A (fi) |
| BE (1) | BE1004202A5 (fi) |
| CH (1) | CH681081A5 (fi) |
| DE (1) | DE3910084A1 (fi) |
| DK (1) | DK146789A (fi) |
| ES (1) | ES2013408A6 (fi) |
| FI (1) | FI891308A (fi) |
| FR (1) | FR2632321A1 (fi) |
| GB (1) | GB2219799B (fi) |
| GR (1) | GR1000876B (fi) |
| HU (1) | HUT50501A (fi) |
| IE (1) | IE890950L (fi) |
| IL (1) | IL89673A0 (fi) |
| IT (1) | IT1234961B (fi) |
| LU (1) | LU87489A1 (fi) |
| NL (1) | NL8900724A (fi) |
| NO (1) | NO891273D0 (fi) |
| NZ (1) | NZ228427A (fi) |
| PT (1) | PT90118B (fi) |
| SE (1) | SE8901031L (fi) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0444961A1 (en) * | 1990-03-02 | 1991-09-04 | Bristol-Myers Squibb Company | Her3: A novel EGF receptor homolog |
| EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
| EP0910569A1 (en) * | 1996-04-10 | 1999-04-28 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
| US6852506B1 (en) | 1996-04-10 | 2005-02-08 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0293785A3 (en) * | 1987-05-29 | 1990-05-02 | Oncogen Limited Partnership | Cloning and expression of simian transforming growth factor-ss1 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0108132A1 (en) * | 1982-05-06 | 1984-05-16 | Applied Molecular Genetics Inc. | The manufacture and expression of genes for urogastrone and polypeptide analogs thereof |
| JPS6028994A (ja) * | 1983-07-08 | 1985-02-14 | Wakunaga Seiyaku Kk | 〔２１―ロイシン〕ヒトウロガストロン |
| WO1985002198A1 (en) * | 1983-11-01 | 1985-05-23 | Amgen | Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides |
| JP2554459B2 (ja) * | 1984-07-02 | 1996-11-13 | アース製薬 株式会社 | β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体 |
| JPS62501071A (ja) * | 1984-10-30 | 1987-04-30 | オンコゲン | 成長因子活性を有する新規なポリペプチド及び該ポリペプチドをコ−ドする核酸配列 |
| GB8507666D0 (en) * | 1985-03-25 | 1985-05-01 | Wellcome Found | Epidermal growth factor production |
| US4743679A (en) * | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
| GB2210618B (en) * | 1987-10-08 | 1991-10-16 | British Bio Technology | Synthetic egf gene |
| EP0372005A4 (en) * | 1987-10-30 | 1990-06-26 | Oncogen | EXPRESSION SYSTEMS FOR THE PREPARATION OF POLYPEPTIDES IN PROKARYOTIC CELLS. |
| EP0314184B1 (en) * | 1987-10-30 | 1995-12-13 | Bristol-Myers Squibb Company | Expression plasmids |
-
1989
- 1989-03-20 IL IL89673A patent/IL89673A0/xx unknown
- 1989-03-20 FI FI891308A patent/FI891308A/fi not_active IP Right Cessation
- 1989-03-21 NZ NZ228427A patent/NZ228427A/xx unknown
- 1989-03-22 NO NO891273A patent/NO891273D0/no unknown
- 1989-03-22 DK DK146789A patent/DK146789A/da not_active Application Discontinuation
- 1989-03-22 ES ES8901049A patent/ES2013408A6/es not_active Expired - Lifetime
- 1989-03-22 SE SE8901031A patent/SE8901031L/xx not_active Application Discontinuation
- 1989-03-23 IE IE890950A patent/IE890950L/xx unknown
- 1989-03-23 AU AU31695/89A patent/AU3169589A/en not_active Abandoned
- 1989-03-23 NL NL8900724A patent/NL8900724A/nl not_active Application Discontinuation
- 1989-03-23 GR GR890100185A patent/GR1000876B/el unknown
- 1989-03-23 GB GB8906758A patent/GB2219799B/en not_active Expired - Fee Related
- 1989-03-24 IT IT8919917A patent/IT1234961B/it active
- 1989-03-24 HU HU891515A patent/HUT50501A/hu unknown
- 1989-03-24 JP JP1073723A patent/JPH0279981A/ja active Pending
- 1989-03-24 BE BE8900329A patent/BE1004202A5/fr not_active IP Right Cessation
- 1989-03-24 KR KR1019890003761A patent/KR890014743A/ko not_active Application Discontinuation
- 1989-03-24 LU LU87489A patent/LU87489A1/xx unknown
- 1989-03-24 FR FR8903952A patent/FR2632321A1/fr not_active Withdrawn
- 1989-03-27 PT PT90118A patent/PT90118B/pt active IP Right Grant
- 1989-03-28 DE DE3910084A patent/DE3910084A1/de not_active Withdrawn
- 1989-03-28 CH CH1114/89A patent/CH681081A5/de not_active IP Right Cessation
-
1992
- 1992-12-04 AU AU29904/92A patent/AU2990492A/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0444961A1 (en) * | 1990-03-02 | 1991-09-04 | Bristol-Myers Squibb Company | Her3: A novel EGF receptor homolog |
| EP0739984A1 (en) * | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalent polypeptides containing at least two domains |
| EP0910569A1 (en) * | 1996-04-10 | 1999-04-28 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
| EP0910569A4 (en) * | 1996-04-10 | 2002-05-08 | Human Genome Sciences Inc | EXTRA-CELLULAR PROTEINS OR EPIDERMAL GROWTH FACTORS LIKE THE PROTEIN |
| US6852506B1 (en) | 1996-04-10 | 2005-02-08 | Human Genome Sciences, Inc. | Extracellular/epidermal growth factor-like protein |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2013408A6 (es) | 1990-05-01 |
| NO891273D0 (no) | 1989-03-22 |
| NL8900724A (nl) | 1989-10-16 |
| PT90118B (pt) | 1994-07-29 |
| FI891308A0 (fi) | 1989-03-20 |
| LU87489A1 (fr) | 1989-10-26 |
| HUT50501A (en) | 1990-02-28 |
| SE8901031L (sv) | 1989-09-25 |
| GB2219799B (en) | 1992-10-14 |
| GB8906758D0 (en) | 1989-05-10 |
| GR890100185A (en) | 1990-01-19 |
| SE8901031D0 (sv) | 1989-03-22 |
| DK146789D0 (da) | 1989-03-22 |
| NZ228427A (en) | 1993-03-26 |
| AU3169589A (en) | 1989-09-28 |
| JPH0279981A (ja) | 1990-03-20 |
| GB2219799A (en) | 1989-12-20 |
| IE890950L (en) | 1989-09-24 |
| GR1000876B (el) | 1993-03-16 |
| FI891308A (fi) | 1989-09-25 |
| IL89673A0 (en) | 1989-09-28 |
| DK146789A (da) | 1989-09-25 |
| AU2990492A (en) | 1993-03-04 |
| CH681081A5 (fi) | 1993-01-15 |
| IT8919917A0 (it) | 1989-03-24 |
| FR2632321A1 (fr) | 1989-12-08 |
| IT1234961B (it) | 1992-06-09 |
| BE1004202A5 (fr) | 1992-10-13 |
| PT90118A (pt) | 1989-11-10 |
| KR890014743A (ko) | 1989-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8181 | Inventor (new situation) |
Free format text: BROWN, JOSEPH P., SEATTLE, WASH., US TWARDZIK, DANIEL R., BAINBRIDGE ISLAND, WASH., US MARQUARDT, HANS, MERCER ISLAND, WASH., US TODARO, GEORGE J. BRUCE, A. GREGORY ROSE, TIMOTHY M. PURCHIO, ANTHONY F., SEATTLE, WASH., US MU, SHIU-LOK, REDMOND, WASH., US CHANG, WEN, CAMBRIDGE, MASS., US LIU, SUO WIN, DEWITT, N.Y., US FRANCESCHINI, THOMAS J., EAST SYRACUSE, N.Y., US SHOYAB, MOHAMMED PLOWMAN, GREG, SEATTLE, WASH., US |
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| 8139 | Disposal/non-payment of the annual fee |