DE3881217T2 - Extraktionsverfahren reiner fraktionen von laktoperoxidase und laktoferrin aus milchserum. - Google Patents
Extraktionsverfahren reiner fraktionen von laktoperoxidase und laktoferrin aus milchserum.Info
- Publication number
- DE3881217T2 DE3881217T2 DE88910417T DE3881217T DE3881217T2 DE 3881217 T2 DE3881217 T2 DE 3881217T2 DE 88910417 T DE88910417 T DE 88910417T DE 3881217 T DE3881217 T DE 3881217T DE 3881217 T2 DE3881217 T2 DE 3881217T2
- Authority
- DE
- Germany
- Prior art keywords
- lactoperoxidase
- pct
- milk serum
- pure fractions
- lactotrine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108010023244 Lactoperoxidase Proteins 0.000 title abstract 4
- 102000045576 Lactoperoxidases Human genes 0.000 title abstract 4
- 229940057428 lactoperoxidase Drugs 0.000 title abstract 4
- 235000013336 milk Nutrition 0.000 title abstract 3
- 239000008267 milk Substances 0.000 title abstract 3
- 210000004080 milk Anatomy 0.000 title abstract 3
- 210000002966 serum Anatomy 0.000 title abstract 3
- 238000000605 extraction Methods 0.000 title 1
- 102000010445 Lactoferrin Human genes 0.000 abstract 3
- 108010063045 Lactoferrin Proteins 0.000 abstract 3
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 abstract 3
- 229940078795 lactoferrin Drugs 0.000 abstract 3
- 235000021242 lactoferrin Nutrition 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
- A23C9/146—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by ion-exchange
- A23C9/1465—Chromatographic separation of protein or lactose fraction; Adsorption of protein or lactose fraction followed by elution
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
- A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
- A23C9/1425—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of whey, e.g. treatment of the UF permeate
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Water Supply & Treatment (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Dairy Products (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8704719A SE458818B (sv) | 1987-11-27 | 1987-11-27 | Foerfarande foer utvinning av rena fraktioner av laktoperoxidas och laktoferrin ur mjoelkserum |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3881217D1 DE3881217D1 (de) | 1993-06-24 |
DE3881217T2 true DE3881217T2 (de) | 1994-01-05 |
Family
ID=20370415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE88910417T Expired - Fee Related DE3881217T2 (de) | 1987-11-27 | 1988-11-25 | Extraktionsverfahren reiner fraktionen von laktoperoxidase und laktoferrin aus milchserum. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5149647A (de) |
EP (1) | EP0390821B1 (de) |
JP (1) | JP2553180B2 (de) |
AT (1) | ATE89454T1 (de) |
AU (1) | AU613688B2 (de) |
DE (1) | DE3881217T2 (de) |
DK (1) | DK173642B1 (de) |
FI (1) | FI91032C (de) |
NO (1) | NO177268C (de) |
NZ (1) | NZ227097A (de) |
SE (1) | SE458818B (de) |
WO (1) | WO1989004608A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4879110A (en) * | 1983-10-27 | 1989-11-07 | Stolle Research And Development Corporation | Antihypertensive hyperimmune milk, production, composition, and use |
US5756333A (en) * | 1989-11-03 | 1998-05-26 | Incyte Pharmaceuticals, Inc. | Recombinant production of lactoperoxidase |
WO1991006639A1 (en) * | 1989-11-03 | 1991-05-16 | Ideon Corporation | Recombinant production of lactoperoxidase |
JP3035833B2 (ja) * | 1991-01-21 | 2000-04-24 | 雪印乳業株式会社 | シアル酸類含有組成物の製造方法 |
JP3110078B2 (ja) * | 1991-06-21 | 2000-11-20 | 森永乳業株式会社 | 高純度抗菌性ペプチドの大量製造法 |
EP0595993A4 (en) * | 1991-07-25 | 1994-08-17 | Commw Scient Ind Res Org | Isolation of charged particles from fluids |
CA2128111C (en) * | 1992-01-15 | 1998-06-16 | Klaas Daniel Kussendrager | Process for isolating lactoferrin and lactoperoxidase from milk and milk products, and products obtained by such process |
JPH05202098A (ja) * | 1992-01-29 | 1993-08-10 | Snow Brand Milk Prod Co Ltd | 乳質原料から生理活性物質の製造法 |
SE470375B (sv) * | 1992-05-07 | 1994-02-07 | Alfa Laval Food Eng Ab | Sätt att erhålla högvärdiga proteinprodukter ur vassle |
US5756680A (en) * | 1994-01-05 | 1998-05-26 | Sepragen Corporation | Sequential separation of whey proteins and formulations thereof |
US5468844A (en) * | 1994-01-07 | 1995-11-21 | Protose Technologies Inc. | Process for the membrane-filtering of protein solutions |
WO1995022258A2 (en) * | 1994-02-16 | 1995-08-24 | Pharming Bv | Isolation of lactoferrin from milk |
WO1996008155A1 (en) * | 1994-09-16 | 1996-03-21 | New Zealand Dairy Board | Physical separation of casein and whey proteins |
JP3112637B2 (ja) * | 1994-09-30 | 2000-11-27 | 雪印乳業株式会社 | 骨強化剤 |
JP2974604B2 (ja) * | 1996-01-23 | 1999-11-10 | 雪印乳業株式会社 | 塩基性タンパク質組成物、塩基性ペプチド組成物及びその利用 |
JP3073439B2 (ja) * | 1996-02-08 | 2000-08-07 | 雪印乳業株式会社 | 骨形成促進及び骨吸収防止剤 |
CA2197515A1 (en) * | 1996-07-15 | 1998-01-16 | Reyad Mahmoud | Methods of treating milk products |
EP0926499A4 (de) * | 1996-07-30 | 2000-08-16 | Shionogi & Co | Methode um die adsorption von lactoferrin zu verhindern |
DE69737030T2 (de) | 1996-09-06 | 2007-06-28 | Pall Corp. | Scherkraft trennverfahren und vorrichtung |
JP4082782B2 (ja) * | 1998-04-30 | 2008-04-30 | 雪印乳業株式会社 | 歯周病予防及び改善剤 |
US20030040475A1 (en) † | 2001-01-16 | 2003-02-27 | Yasuhiro Toba | Agents for improving lipid metabolism and reducing high blood pressure |
US6875459B2 (en) * | 2001-09-10 | 2005-04-05 | Henry B. Kopf | Method and apparatus for separation of milk, colostrum, and whey |
FR2841747B1 (fr) | 2002-07-02 | 2004-08-20 | Cie Laitiere Europeenne | Isolat de proteines de lait et procede pour sa preparation |
EP1585965A4 (de) * | 2002-08-29 | 2009-05-13 | Univ Massachusetts | BENUTZUNG DER EMULSIONSGRENZFLûCHENTECHNIK ZUR ERZEUGUNG OXIDATIV STABILER LIPIDABLIEFERUNGSSYSTEME |
CN1703421B (zh) * | 2002-09-20 | 2010-06-23 | 法玛西亚公司 | 降低peg化蛋白的聚集体水平的方法 |
JP4263932B2 (ja) * | 2003-04-01 | 2009-05-13 | 雪印乳業株式会社 | ラクトフェリンの製造方法 |
US20040259770A1 (en) * | 2003-06-19 | 2004-12-23 | Rush University Medical Center | Method for determining leukocyte activation |
US7547770B2 (en) * | 2003-11-03 | 2009-06-16 | Advanced Protein Systems | Colostral fractionation process |
WO2005078078A1 (ja) * | 2004-02-17 | 2005-08-25 | Morinaga Milk Industry Co., Ltd. | ラクトパーオキシダーゼの製造方法 |
US7125963B2 (en) * | 2004-03-03 | 2006-10-24 | En N Tech Inc | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions |
US20070142629A1 (en) * | 2004-06-16 | 2007-06-21 | Ciphergen Biosystems, Inc. | Multichemistry fractionation |
TW200716664A (en) | 2005-05-10 | 2007-05-01 | Murray Goulburn Coop Co Ltd | Immunoglobulin fraction and process therefor |
FR2889068B1 (fr) * | 2005-07-29 | 2012-03-02 | Cie Laitiere Europeenne | Nouvelles fractions proteiques laitieres et leur utilisation pour la prevention ou le traitement des maladies inflammatoires chroniques |
US20070212367A1 (en) * | 2006-03-13 | 2007-09-13 | Keech Andrew M | Novel immunologically active peptide fragments of a proline-rich polypeptide isolated from colostral mammalian fluids for treatment of viral and non-viral diseases or diseased conditions |
NZ583234A (en) | 2007-07-10 | 2012-06-29 | Glanbia Nutritionals | Method for removing endotoxin from proteins |
JPWO2009057281A1 (ja) * | 2007-11-01 | 2011-03-10 | 雪印乳業株式会社 | 骨芽細胞分化促進及び破骨細胞分化抑制用食品素材 |
US9055752B2 (en) * | 2008-11-06 | 2015-06-16 | Intercontinental Great Brands Llc | Shelf-stable concentrated dairy liquids and methods of forming thereof |
UA112972C2 (uk) | 2010-09-08 | 2016-11-25 | Інтерконтінентал Грейт Брендс ЛЛС | Рідкий молочний концентрат з високим вмістом сухих речовин |
PL2732707T3 (pl) | 2012-11-15 | 2016-08-31 | Arla Foods Amba | Sposób wytwarzania kompozycji zawierającej kazeinomakropeptyd |
CZ305371B6 (cs) * | 2013-11-15 | 2015-08-19 | Univerzita PalackĂ©ho | Způsob separace syrovátkových proteinů z mléčného média a zařízení k provádění tohoto způsobu |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896241A (en) * | 1971-09-01 | 1975-07-22 | Coca Cola Co | Preparation of a whey protein concentrate |
FR2505615A1 (fr) * | 1981-05-15 | 1982-11-19 | Elf Aquitaine | Procede d'extraction de lactoferrine et d'immunoglobulines du lait |
JPS61145200A (ja) * | 1984-12-19 | 1986-07-02 | Snow Brand Milk Prod Co Ltd | ウシラクトフェリンの分離精製法 |
FR2584727B1 (fr) * | 1985-07-11 | 1988-06-17 | Roussel Uclaf | Procede d'extraction de proteines du lait, produits, application du procede, et compositions pharmaceutiques |
IE61701B1 (en) * | 1986-07-17 | 1994-11-30 | Morinaga Milk Industry Co Ltd | Process for producing bovine lactoferrin in high purity |
FR2616628B1 (fr) * | 1987-06-19 | 1989-09-29 | Entremont Sa | Procede pour extraire des proteines du lactoserum par adsorption et elution |
-
1987
- 1987-11-27 SE SE8704719A patent/SE458818B/sv not_active IP Right Cessation
-
1988
- 1988-11-25 AU AU27180/88A patent/AU613688B2/en not_active Ceased
- 1988-11-25 WO PCT/SE1988/000643 patent/WO1989004608A1/en active IP Right Grant
- 1988-11-25 EP EP88910417A patent/EP0390821B1/de not_active Expired - Lifetime
- 1988-11-25 US US07/488,040 patent/US5149647A/en not_active Expired - Lifetime
- 1988-11-25 DE DE88910417T patent/DE3881217T2/de not_active Expired - Fee Related
- 1988-11-25 AT AT88910417T patent/ATE89454T1/de not_active IP Right Cessation
- 1988-11-25 JP JP63509492A patent/JP2553180B2/ja not_active Expired - Fee Related
- 1988-11-28 NZ NZ227097A patent/NZ227097A/xx unknown
-
1990
- 1990-05-18 DK DK199001245A patent/DK173642B1/da not_active IP Right Cessation
- 1990-05-23 FI FI902562A patent/FI91032C/fi not_active IP Right Cessation
- 1990-05-25 NO NO902328A patent/NO177268C/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ227097A (en) | 1991-01-29 |
EP0390821A1 (de) | 1990-10-10 |
NO177268B (no) | 1995-05-08 |
DK173642B1 (da) | 2001-05-14 |
FI91032C (fi) | 1994-05-10 |
NO902328D0 (no) | 1990-05-25 |
SE458818B (sv) | 1989-05-16 |
JPH03502921A (ja) | 1991-07-04 |
ATE89454T1 (de) | 1993-06-15 |
FI902562A0 (fi) | 1990-05-23 |
AU613688B2 (en) | 1991-08-08 |
JP2553180B2 (ja) | 1996-11-13 |
NO902328L (no) | 1990-05-25 |
EP0390821B1 (de) | 1993-05-19 |
AU2718088A (en) | 1989-06-14 |
NO177268C (no) | 1995-08-16 |
SE8704719D0 (sv) | 1987-11-27 |
DE3881217D1 (de) | 1993-06-24 |
DK124590D0 (da) | 1990-05-18 |
US5149647A (en) | 1992-09-22 |
DK124590A (da) | 1990-05-25 |
WO1989004608A1 (en) | 1989-06-01 |
FI91032B (fi) | 1994-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: CAMPINA MELKUNIE B.V., ZALTBOMMEL, NL |
|
8339 | Ceased/non-payment of the annual fee |