LTIP262A - Chromatographic separation of plasma protein and concentrates obtained by this method - Google Patents

Chromatographic separation of plasma protein and concentrates obtained by this method

Info

Publication number
LTIP262A
LTIP262A LTIP262A LTIP262A LTIP262A LT IP262 A LTIP262 A LT IP262A LT IP262 A LTIP262 A LT IP262A LT IP262 A LTIP262 A LT IP262A LT IP262 A LTIP262 A LT IP262A
Authority
LT
Lithuania
Prior art keywords
pct
sec
date
fraction
chromatographic separation
Prior art date
Application number
LTIP262A
Inventor
Thierry Burnouf
Miryana Burnouf
Original Assignee
Centre Regional De Transfusion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9367001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LTIP262(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centre Regional De Transfusion filed Critical Centre Regional De Transfusion
Publication of LTIP262A publication Critical patent/LTIP262A/en
Publication of LT3333B publication Critical patent/LT3333B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PCT No. PCT/FR89/00050 Sec. 371 Date Apr. 6, 1990 Sec. 102(e) Date Apr. 6, 1990 PCT Filed Feb. 8, 1989 PCT Pub. No. WO89/12065 PCT Pub. Date Dec. 14, 1989.The invention relates to a process for separating proteins from a fraction of human or animal plasma. According to this process, a solubilized fraction of cryoprecipitated plasma is subjected to a single stage of chromatography on a moderately ionic anion exchange resin permitting hydrophobic interactions to take place, which does not adsorb certain proteins and fixes others, which are then eluted by increasing the ionic strength of the buffer by the addition of NaCl. The process according to the invention makes it possible, in particular, to obtain a Factor VIII concentrate of high purity that can be used for the treatment of haemophilia A. The process also makes it possible to obtain concentrates of fibrinogen, Von Willebrand's factor and fibronectin.
LTIP262A 1988-06-07 1992-12-29 Chromatographic separation of plasma protein and concentrates obtained by this method LT3333B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8807530A FR2632309B1 (en) 1988-06-07 1988-06-07 PROCESS FOR THE CHROMATOGRAPHIC PURIFICATION OF PROTEINS, PARTICULARLY FACTOR VIII, AND THE PRODUCTS OBTAINED

Publications (2)

Publication Number Publication Date
LTIP262A true LTIP262A (en) 1994-10-25
LT3333B LT3333B (en) 1995-07-25

Family

ID=9367001

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP262A LT3333B (en) 1988-06-07 1992-12-29 Chromatographic separation of plasma protein and concentrates obtained by this method

Country Status (17)

Country Link
US (1) US5252709A (en)
EP (1) EP0359593B2 (en)
JP (1) JP2805364B2 (en)
KR (1) KR970010923B1 (en)
AT (1) ATE121750T1 (en)
AU (2) AU622436B2 (en)
CA (1) CA1340742C (en)
DE (2) DE359593T1 (en)
DK (1) DK175322B1 (en)
ES (1) ES2070919T5 (en)
FI (1) FI96210C (en)
FR (1) FR2632309B1 (en)
LT (1) LT3333B (en)
NO (1) NO177188C (en)
RU (1) RU1837880C (en)
UA (1) UA11061A (en)
WO (1) WO1989012065A1 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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GB8729822D0 (en) * 1987-12-22 1988-02-03 Central Blood Lab Authority Chemical process
DE3904354A1 (en) * 1989-02-14 1990-08-16 Behringwerke Ag PASTEURIZED, PURIFIED OF WILLEBRAND FACTOR CONCENTRATE AND METHOD FOR THE PRODUCTION THEREOF
FR2665449B1 (en) * 1990-08-02 1995-04-14 Aquitaine Developp Transf Sang METHOD FOR MANUFACTURING A VON WILLEBRAND FACTOR HAVING VERY HIGH PURITY, MAINLY LACKING AN ANTIHEMOPHILIC FACTOR (FVIIIC), AND VON WILLEBRAND FACTOR THUS OBTAINED, AS WELL AS A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME.
US5760183A (en) * 1989-02-17 1998-06-02 Association D'aquitaine Pour De Developpment De La Transfusion Sanguine Et Des Recherches Hematologiques Process for the manufacture of very high-purity antithaemophilic factor (FVIIIC), and von Willebrand factor, and pharmaceutical compositions containing same
FR2644064B1 (en) * 1989-02-17 1994-05-27 Aquitaine Dev Transf Sanguine PROCESS FOR THE MANUFACTURE OF THE FVIIIC ANTIHEMOPHILIC FACTOR HAVING VERY HIGH PURITY AND THE FVIIIC ANTIHEMOPHILIC FACTOR THUS OBTAINED, AS WELL AS THE PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
DE3926034C3 (en) * 1989-08-07 1996-11-21 Behringwerke Ag Process for the preparation of a stable factor VIII
FR2651437A1 (en) * 1989-09-05 1991-03-08 Lille Transfusion Sanguine PROCESS FOR PREPARING A CONCENTRATE OF THE VON WILLEBRAND FACTOR VIII-FACTOR COMPLEX OF BLOOD COAGULATION FROM TOTAL PLASMA.
NL9000090A (en) * 1990-01-15 1991-08-01 Harimex Ligos Bv METHOD FOR PREPARING A FIBRINOGEN CONCENTRATE FROM BLOOD PLASMA, APPARATUS FOR CARRYING OUT THIS PROCESS AND METHOD FOR PREPARING FIBRINOGEN FROM THE CONCENTRATE
FR2673632A1 (en) 1991-03-08 1992-09-11 Lille Transfusion Sanguine PROCESS FOR THE PREPARATION OF HUMAN VON WILLEBRAND FACTOR CONCENTRATE OF HIGH PURITY, SUITABLE FOR THERAPEUTIC USE
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
FR2681867B1 (en) 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins FACTOR VIII PURIFICATION PROCESS AND PREPARATIONS OBTAINED.
DE4202667C1 (en) * 1992-01-29 1993-05-13 Behringwerke Ag, 3550 Marburg, De
DE4204694C3 (en) * 1992-02-01 1995-10-12 Octapharma Ag Method for obtaining highly pure, virus-inactivated factor VIII by means of anion exchange chromatography
FR2686883B1 (en) * 1992-02-04 1994-05-13 Aquitaine Develop Transf Sanguin PROCESS FOR THE MANUFACTURE OF VERY HIGH PURITY FIBRINOGEN, VERY HIGH PURITY FIBRINOGENE, OBTAINED AS WELL AS A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME.
AT399818B (en) * 1992-04-24 1995-07-25 Immuno Ag METHOD FOR PRODUCING A HIGH PURIFIED VIRUS-SAFE FACTOR VIII PREPARATION
ES2139227T5 (en) * 1994-07-14 2011-05-04 Caf-Dcf Département Central De Fractionnement De La Croix Rouge S.C.R.L. FIBRINOGEN CONCENTRATE OBTAINED FROM BLOOD PLASMA, PROCEDURE AND INSTALLATION FOR PREPARATION.
DE4435485C1 (en) * 1994-10-04 1996-03-21 Immuno Ag Process for obtaining high-purity von Willebrand factor
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
AT403764B (en) 1996-03-15 1998-05-25 Immuno Ag STABLE FACTOR VIII / VWF COMPLEX
ES2145466T3 (en) * 1996-06-24 2000-07-01 Max Planck Inst Fur Physiologi PROCEDURE FOR THE PURIFICATION OF FACTOR VIII BY AFFINITY CHROMATOGRAPHY.
US6037457A (en) * 1997-01-31 2000-03-14 The University Of North Carolina At Chapel Hill Method for recombinant fibrinogen production
AT405403B (en) 1997-02-27 1999-08-25 Immuno Ag CLEANING OF WILLEBRAND FACTOR BY CATION EXCHANGER CHROMATOGRAPHY
DK2193809T3 (en) 1999-02-22 2015-05-26 Univ Connecticut The albumin-free Factor VIII formulation
EP1148063A1 (en) * 2000-04-18 2001-10-24 Octapharma AG Composition containing hemostatic activ vWF and process for its preparation
FR2857267B1 (en) 2003-07-09 2006-03-10 Lab Francais Du Fractionnement STABILIZING AND SOLUBILIZING FORMULATION FOR CRYOPRECIPITABLE PROTEINS.
SG150501A1 (en) * 2004-02-05 2009-03-30 Millipore Corp Porous adsorptive or chromatographic media
DE102004009400A1 (en) 2004-02-24 2005-09-08 Zlb Behring Gmbh Fibrinogen purification
FR2874216B1 (en) 2004-08-16 2006-11-03 Lab Francais Du Fractionnement PROCESS FOR THE PREPARATION OF A VON WILLEBRAND FACTOR CONCENTRATE (FVW) BY CHROMATOGRAPHIC AND CONCENTRATED FVW SO LIKELY TO BE OBTAINED
FR2885369B1 (en) * 2005-05-04 2010-11-12 Lab Francais Du Fractionnement PRION TYPE SYNTHETIC AND STANDARDIZED INFECTIOUS MATERIAL AND USES THEREOF AS INFECTING INOCULUM.
FR2887883B1 (en) 2005-06-29 2007-08-31 Lab Francais Du Fractionnement PROCESS FOR SEPARATING FIBRINOGEN PROTEINS, FACTOR XIII AND BIOLOGICAL GLUE OF SOLUBILIZED PLASMA FRONTION AND PREPARATION OF LYOPHILIZED CONCENTRATES OF SAID PROTEINS
US9433922B2 (en) 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
FR2920429B1 (en) * 2007-08-30 2012-10-05 Lfb Biotechnologies PROCESS FOR PURIFYING FACTOR VIII AND VON WILLEBRAND FACTOR
US20090130738A1 (en) * 2007-11-19 2009-05-21 Mikhail Kozlov Media for membrane ion exchange chromatography
WO2009145722A1 (en) * 2008-05-30 2009-12-03 Ge Healthcare Bio-Sciences Ab Separation method utilizing polyallylamine ligands
HUE028626T2 (en) 2008-06-23 2016-12-28 Bio-Products & Bio-Engineering Ag Fibrinogen being funtionally intact , storage stable and virus-inactivated
MX339060B (en) 2008-11-07 2016-05-09 Baxter Int Factor viii formulations.
IT1396528B1 (en) * 2009-01-19 2012-12-14 Kedrion Spa NEW HIGHLY SELECTIVE PURIFICATION PROCESS OF TWO PLASMATIC PROTEINS: VON WILLEBRAND FACTOR (VWF) AND FIBRONECTIN (FN).
MX2012005527A (en) 2009-11-13 2012-08-08 Grifols Therapeutics Inc Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto.
FR2952641B1 (en) 2009-11-18 2012-01-13 Lfb Biomedicaments PROCESS FOR TREATING BLOOD PLASMA COMPRISING A DISPERSION WASH STEP
BR112012017696A2 (en) 2010-01-18 2017-10-03 Novo Nordisk Healthcare Ag PURIFICATION OF BLOOD CLOTHING FACTORS
RU2445974C2 (en) * 2010-04-26 2012-03-27 Учреждение Российской академии медицинских наук Гематологический научный центр ГНЦ РАМН Method for producing concentrated factor viii of human blood plasma
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
US10188965B2 (en) 2012-12-05 2019-01-29 Csl Behring Gmbh Hydrophobic charge induction chromatographic depletion of a protein from a solution
US20140154233A1 (en) * 2012-12-05 2014-06-05 Csl Limited Method of purifying therapeutic proteins
FR3034669B1 (en) 2015-04-07 2020-02-14 Laboratoire Francais Du Fractionnement Et Des Biotechnologies NEW USE OF THE VON WILLEBRAND FACTOR
WO2019050321A1 (en) * 2017-09-07 2019-03-14 (주)프로테옴텍 Chromatographic strip comprising multiple test lines, diagnostic kit comprising same, and qualitative, semi-quantitative or quantitative analysis method comprising multiple competitive reaction measurement steps
EP3488858A1 (en) 2017-11-27 2019-05-29 Laboratoire Français du Fractionnement et des Biotechnologies A von willebrand factor composition for use in treating a pathology mediated by angiogenesis

Family Cites Families (21)

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US4278594A (en) * 1979-06-19 1981-07-14 David Amrani Process for separation and isolation of AHF, von Willebrand's ristocetin cofactor (VWF:RCF) and fibronectin from blood plasma
EP0022053A1 (en) * 1979-06-25 1981-01-07 Rexnord Inc. Shear bar having notched edge configuration
US4341764A (en) * 1980-03-05 1982-07-27 Cutter Laboratories, Inc. Method of preparing fibronectin and antihemophilic factor
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4764369A (en) * 1983-07-14 1988-08-16 New York Blood Center Inc. Undenatured virus-free biologically active protein derivatives
US4508709A (en) * 1983-12-05 1985-04-02 Armour Pharmaceutical Company Process for purifying factor VIII:C
GB8403473D0 (en) * 1984-02-09 1984-03-14 Special Trustees For St Thomas Purification of factor viii
FR2570276B1 (en) * 1984-09-18 1987-09-04 Immunotech Sa PROCESS FOR OBTAINING FVIII / VWF COMPLEX FOR THERAPEUTIC USE AND PRODUCTS THEREOF
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
JPS61189228A (en) * 1985-02-19 1986-08-22 Nippon Sekijiyuujishiya Production of blood coagulation factor viii
EP0235526A3 (en) * 1986-01-29 1988-03-23 Leipziger Arzneimittelwerk GmbH Activated polymer solids and process for their manufacture
DE3609431A1 (en) * 1986-03-20 1987-09-24 Biotest Pharma Gmbh METHOD FOR PRODUCING A STERILE PRESERVATIVE CONTAINING THE BLOOD coagulation factor VIII
DE3707213A1 (en) * 1987-03-06 1988-09-15 Behringwerke Ag METHOD FOR PRODUCING FACTOR VIII: C-DEFECTIVE PLASMA AND A DEFECTIVE PLASMA OBTAINED THEREOF
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor
US5097018A (en) * 1988-05-12 1992-03-17 University Of Southern California Sequential heat treatment of blood-clotting factor products
NL8701915A (en) * 1987-08-14 1989-03-01 Waander Riethorst ADSORBENS MATERIAL AND USE THEREOF FOR INSULATING CLOTHING FACTORS.
DE3904354A1 (en) * 1989-02-14 1990-08-16 Behringwerke Ag PASTEURIZED, PURIFIED OF WILLEBRAND FACTOR CONCENTRATE AND METHOD FOR THE PRODUCTION THEREOF
US5110907A (en) * 1989-08-01 1992-05-05 Alpha Therapeutic Corporation Factor viii complex purification using heparin affinity chromatography
IT1306645B1 (en) 1999-04-08 2001-10-02 Challenger Gestao E Consultado STRUCTURE OF CHAIR, ARMCHAIR OR SIMILAR WITH EASY ASSEMBLY.

Also Published As

Publication number Publication date
ES2070919T3 (en) 1995-06-16
DE68922358T3 (en) 2004-08-19
KR970010923B1 (en) 1997-07-02
DK175322B1 (en) 2004-08-23
FR2632309A1 (en) 1989-12-08
NO177188B (en) 1995-04-24
FR2632309B1 (en) 1990-08-24
UA11061A (en) 1996-12-25
EP0359593B1 (en) 1995-04-26
AU622436B2 (en) 1992-04-09
DK29990D0 (en) 1990-02-06
ES2070919T5 (en) 2004-07-16
FI96210B (en) 1996-02-15
EP0359593B2 (en) 2004-01-07
NO177188C (en) 1995-08-02
DK29990A (en) 1990-03-28
FI96210C (en) 1996-05-27
DE359593T1 (en) 1990-09-27
LT3333B (en) 1995-07-25
WO1989012065A1 (en) 1989-12-14
KR900701823A (en) 1990-12-04
CA1340742C (en) 1999-09-14
ATE121750T1 (en) 1995-05-15
NO900529L (en) 1990-04-06
EP0359593A1 (en) 1990-03-21
AU3068289A (en) 1990-01-05
NO900529D0 (en) 1990-02-05
RU1837880C (en) 1993-08-30
US5252709A (en) 1993-10-12
FI900397A0 (en) 1990-01-25
DE68922358T2 (en) 1995-10-12
JP2805364B2 (en) 1998-09-30
JPH03501974A (en) 1991-05-09
DE68922358D1 (en) 1995-06-01
AU1138392A (en) 1992-05-14

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Legal Events

Date Code Title Description
PC9A Transfer of patents

Owner name: THE LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES

Effective date: 20090511

TC9A Change of representative

Representative=s name: ZABOLIENE, REDA, LT

MM9A Lapsed patents

Effective date: 20091229