DE3853910T2 - Molekulare köder und deren verwendung. - Google Patents
Molekulare köder und deren verwendung.Info
- Publication number
- DE3853910T2 DE3853910T2 DE3853910T DE3853910T DE3853910T2 DE 3853910 T2 DE3853910 T2 DE 3853910T2 DE 3853910 T DE3853910 T DE 3853910T DE 3853910 T DE3853910 T DE 3853910T DE 3853910 T2 DE3853910 T2 DE 3853910T2
- Authority
- DE
- Germany
- Prior art keywords
- receptor
- substance
- binding
- pharmaceutical composition
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
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- 229940093471 ethyl oleate Drugs 0.000 description 1
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- 229910052740 iodine Inorganic materials 0.000 description 1
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- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- YFVGRULMIQXYNE-UHFFFAOYSA-M lithium;dodecyl sulfate Chemical compound [Li+].CCCCCCCCCCCCOS([O-])(=O)=O YFVGRULMIQXYNE-UHFFFAOYSA-M 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 229960005453 strychnine Drugs 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Polyamides (AREA)
- Developing Agents For Electrophotography (AREA)
- Paper (AREA)
- Battery Electrode And Active Subsutance (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL8368787A IL83687A (en) | 1987-08-30 | 1987-08-30 | Pharmaceutical compositions comprising molecular decays and their use in the manufacture of said compositions |
| PCT/US1988/002991 WO1989001779A1 (en) | 1987-08-30 | 1988-08-30 | Molecular decoyants and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3853910D1 DE3853910D1 (de) | 1995-07-06 |
| DE3853910T2 true DE3853910T2 (de) | 1995-10-12 |
Family
ID=11058121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3853910T Expired - Fee Related DE3853910T2 (de) | 1987-08-30 | 1988-08-30 | Molekulare köder und deren verwendung. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5770572A (https=) |
| EP (1) | EP0329778B1 (https=) |
| JP (1) | JP2791074B2 (https=) |
| AT (1) | ATE123224T1 (https=) |
| AU (1) | AU2383988A (https=) |
| CA (1) | CA1336489C (https=) |
| DE (1) | DE3853910T2 (https=) |
| DK (1) | DK175596B1 (https=) |
| FI (1) | FI100169B (https=) |
| IL (1) | IL83687A (https=) |
| NO (1) | NO891787L (https=) |
| WO (1) | WO1989001779A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02501192A (ja) * | 1987-09-04 | 1990-04-26 | バイオジェン インコーポレイテッド | 可溶性ｔ４蛋白を製造するためのｄｎａ配列、組換ｄｎａ分子および方法 |
| US5132402A (en) * | 1987-11-25 | 1992-07-21 | Agency Of Industrial Science And Technology | Adsorbent, method for production thereof, and method for use thereof |
| EP0318240A3 (en) * | 1987-11-25 | 1990-08-16 | AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY MINISTRY OF INTERNATIONAL TRADE & INDUSTRY | Peptide, adsorbent, method for production thereof, and method for use thereof |
| US6919076B1 (en) * | 1998-01-20 | 2005-07-19 | Pericor Science, Inc. | Conjugates of agents and transglutaminase substrate linking molecules |
| US7311920B1 (en) | 1999-10-08 | 2007-12-25 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
| US6908612B2 (en) | 1999-10-08 | 2005-06-21 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
| ITRM20010563A1 (it) * | 2001-09-14 | 2003-03-14 | Univ Siena | Peptidi antigenici multipli come antidoti nell'intossicazione da veleno di serpente. |
| US8535672B2 (en) * | 2002-04-04 | 2013-09-17 | Yissum Research Development Of The Hebrew University Of Jerusalem | Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between CD28 and the superantigen and uses thereof |
| RU2005102604A (ru) * | 2002-07-03 | 2005-09-10 | Перикор Сайенс, Инк. (Us) | Композиция гиалуроновой кислоты и способы применения |
| JP4495776B1 (ja) * | 2009-07-30 | 2010-07-07 | 日本製薬株式会社 | 融合蛋白質 |
| AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
| CA2789539A1 (en) | 2011-09-12 | 2013-03-12 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| WO2015153647A1 (en) * | 2014-03-31 | 2015-10-08 | Mice With Horns, Llc | Method of preventing or reducing virus transmission in animals |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570278B1 (fr) * | 1984-09-14 | 1987-02-13 | Pasteur Institut | Compositions et procede pour proteger les lymphocytes t contre l'agent etiologique des lymphadenopathies et du syndrome d'immunodepression acquise |
| US4761371A (en) * | 1985-02-12 | 1988-08-02 | Genentech, Inc. | Insulin receptor |
| US5126433A (en) * | 1986-08-21 | 1992-06-30 | The Trustees Of Columbia University In The City Of New York | Soluble forms of the t cell surface protein cd4 |
| DE3751751T2 (de) * | 1986-08-21 | 1996-10-17 | Univ Columbia | Für das t-zell oberflächenprotein t4 kodierende dna und verwendung von t4-fragmenten bei der behandlung von aids |
-
1987
- 1987-08-30 IL IL8368787A patent/IL83687A/en not_active IP Right Cessation
-
1988
- 1988-08-30 DE DE3853910T patent/DE3853910T2/de not_active Expired - Fee Related
- 1988-08-30 EP EP88908569A patent/EP0329778B1/en not_active Expired - Lifetime
- 1988-08-30 AU AU23839/88A patent/AU2383988A/en not_active Abandoned
- 1988-08-30 AT AT88908569T patent/ATE123224T1/de not_active IP Right Cessation
- 1988-08-30 US US07/410,778 patent/US5770572A/en not_active Expired - Lifetime
- 1988-08-30 WO PCT/US1988/002991 patent/WO1989001779A1/en not_active Ceased
- 1988-08-30 CA CA000576111A patent/CA1336489C/en not_active Expired - Fee Related
- 1988-08-30 JP JP63507516A patent/JP2791074B2/ja not_active Expired - Fee Related
-
1989
- 1989-04-27 FI FI892005A patent/FI100169B/fi not_active IP Right Cessation
- 1989-04-28 NO NO89891787A patent/NO891787L/no unknown
- 1989-05-01 DK DK198902119A patent/DK175596B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2791074B2 (ja) | 1998-08-27 |
| DK175596B1 (da) | 2004-12-13 |
| EP0329778B1 (en) | 1995-05-31 |
| IL83687A0 (https=) | 1988-01-31 |
| FI100169B (fi) | 1997-10-15 |
| US5770572A (en) | 1998-06-23 |
| IL83687A (en) | 1995-03-30 |
| WO1989001779A1 (en) | 1989-03-09 |
| EP0329778A1 (en) | 1989-08-30 |
| JPH02502538A (ja) | 1990-08-16 |
| FI892005A0 (fi) | 1989-04-27 |
| CA1336489C (en) | 1995-08-01 |
| DK211989D0 (da) | 1989-05-01 |
| NO891787L (no) | 1989-06-06 |
| DE3853910D1 (de) | 1995-07-06 |
| AU2383988A (en) | 1989-03-31 |
| EP0329778A4 (en) | 1990-12-27 |
| FI892005L (fi) | 1989-04-27 |
| DK211989A (da) | 1989-06-28 |
| ATE123224T1 (de) | 1995-06-15 |
| NO891787D0 (no) | 1989-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |