DE3853718T2 - Menschliche gamma, delta-t-zellen-antigen-rezeptor-polypeptide und nukleinsäuren. - Google Patents

Menschliche gamma, delta-t-zellen-antigen-rezeptor-polypeptide und nukleinsäuren.

Info

Publication number
DE3853718T2
DE3853718T2 DE3853718T DE3853718T DE3853718T2 DE 3853718 T2 DE3853718 T2 DE 3853718T2 DE 3853718 T DE3853718 T DE 3853718T DE 3853718 T DE3853718 T DE 3853718T DE 3853718 T2 DE3853718 T2 DE 3853718T2
Authority
DE
Germany
Prior art keywords
delta
gamma
nucleic acids
antigen receptor
cell antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3853718T
Other languages
English (en)
Other versions
DE3853718D1 (de
Inventor
Michael Brenner
Stephen Ip
Jonathan Seidman
Hamid Band
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Harvard College
Dana Farber Cancer Institute Inc
T Cell Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/115,256 external-priority patent/US5024940A/en
Application filed by Harvard College, Dana Farber Cancer Institute Inc, T Cell Sciences Inc filed Critical Harvard College
Publication of DE3853718D1 publication Critical patent/DE3853718D1/de
Application granted granted Critical
Publication of DE3853718T2 publication Critical patent/DE3853718T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE3853718T 1987-10-29 1988-10-28 Menschliche gamma, delta-t-zellen-antigen-rezeptor-polypeptide und nukleinsäuren. Expired - Fee Related DE3853718T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/115,256 US5024940A (en) 1987-02-19 1987-10-29 Nucleic acids encoding the delta chain of the T cell antigen receptor
US07/187,698 US5260223A (en) 1986-07-03 1988-04-29 Methods for detection of human gamma, γ T cell receptor
PCT/US1988/003869 WO1989003996A1 (en) 1987-10-29 1988-10-28 Human gamma, delta t cell antigen receptor polypeptides and nucleic acids

Publications (2)

Publication Number Publication Date
DE3853718D1 DE3853718D1 (de) 1995-06-08
DE3853718T2 true DE3853718T2 (de) 1995-09-07

Family

ID=26813001

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3853718T Expired - Fee Related DE3853718T2 (de) 1987-10-29 1988-10-28 Menschliche gamma, delta-t-zellen-antigen-rezeptor-polypeptide und nukleinsäuren.

Country Status (10)

Country Link
US (1) US5260223A (de)
EP (1) EP0345318B1 (de)
JP (2) JP3176049B2 (de)
KR (1) KR0132680B1 (de)
AT (1) ATE122148T1 (de)
AU (1) AU631780B2 (de)
CA (1) CA1340140C (de)
DE (1) DE3853718T2 (de)
HK (1) HK1005893A1 (de)
WO (1) WO1989003996A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5426029A (en) * 1986-03-31 1995-06-20 T Cell Diagnostics, Inc. Therapeutic and diagnostic methods using leukocyte surface antigens
US6416971B1 (en) 1990-05-15 2002-07-09 E.R. Squibb & Sons, Inc. Soluble single chain T cell receptors
FR2698880B1 (fr) * 1992-11-25 1995-02-24 Inst Nat Sante Rech Med Procédé de production de récepteurs T solubles, produits ainsi obtenus et leur utilisation dans des compositions diagnostiques ou thérapeutiques.
US5552300A (en) * 1994-01-13 1996-09-03 T Cell Sciences, Inc. T cell antigen receptor V region proteins and methods of preparation thereof
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US6451571B1 (en) 1994-05-02 2002-09-17 University Of Washington Thymidine kinase mutants
US5708156A (en) * 1996-05-31 1998-01-13 Ilekis; John V. Epidermal growth factor receptor-like gene product and its uses
DK2331701T3 (da) * 2008-08-08 2013-06-24 Vib Vzw Celler, der danner glycoproteiner med ændrede glycosyleringsmønstre og fremgangsmåder dermed og anvendelse deraf
EP3333186B9 (de) 2012-03-28 2023-10-04 Gadeta B.V. Kombinatorischer gamma-9-delta-2-t-zellen-rezeptorkettenaustausch
IL252131B2 (en) 2014-11-17 2023-04-01 Adicet Bio Inc Transgenic gamma delta T cells
MX2018013864A (es) 2016-05-12 2019-06-10 Adicet Bio Inc Métodos para la expansión selectiva de poblaciones de células t gama y composicicones de estas.
CA3027124A1 (en) * 2016-06-10 2017-12-14 Umc Utrecht Holding B.V. Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response
US11845796B2 (en) * 2017-09-22 2023-12-19 WuXi Biologics Ireland Limited Bispecific polypeptide complexes
GB201719169D0 (en) * 2017-11-20 2018-01-03 Univ College Cardiff Consultants Ltd Novel T-cell receptor and ligand
WO2020156405A1 (en) * 2019-01-28 2020-08-06 Wuxi Biologics (Shanghai) Co. Ltd. Novel bispecific cd3/cd20 polypeptide complexes
CN111333709B (zh) * 2020-03-17 2023-09-08 吉林大学 旋毛虫肌幼虫期丝氨酸蛋白酶抑制剂的b细胞表位多肽、杂交瘤细胞株、单克隆抗体及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444744A (en) * 1980-03-03 1984-04-24 Goldenberg Milton David Tumor localization and therapy with labeled antibodies to cell surface antigens
US4550086A (en) * 1983-02-16 1985-10-29 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that recognize human T cells
US4713332A (en) * 1984-01-13 1987-12-15 The Ontario Cancer Institute T cell specific CDNA clone
EP0200350A3 (de) * 1985-04-15 1987-05-13 The Ontario Cancer Institute Nukleinsäure mit Code für ein T-Zellen-Antigenrezeptor-Polypeptid
DE3650184T2 (de) * 1985-12-03 1995-05-11 T Cell Sciences Inc Zellenfreier t-zellenantigenrezeptor und klinische verwendung.
US4845026A (en) * 1985-12-03 1989-07-04 T Cell Sciences, Inc. Assay systems for detecting cell-free T cell antigen receptor related molecules and the clinical utilities of the assays
US5185250A (en) * 1986-07-03 1993-02-09 T Cell Sciences, Inc. Human γ, δT cell antigen receptor polypeptides and nucleic acids
US5340921A (en) * 1986-07-03 1994-08-23 T Cell Sciences, Inc. Γ, δT cell receptor and methods and detection
GB8626412D0 (en) * 1986-11-05 1986-12-03 Clark M R Antibodies

Also Published As

Publication number Publication date
HK1005893A1 (en) 1999-01-29
JPH1169975A (ja) 1999-03-16
KR0132680B1 (ko) 1998-04-11
JP3176049B2 (ja) 2001-06-11
KR890702031A (ko) 1989-12-22
CA1340140C (en) 1998-11-24
DE3853718D1 (de) 1995-06-08
JPH03503956A (ja) 1991-09-05
EP0345318A4 (en) 1990-09-05
ATE122148T1 (de) 1995-05-15
WO1989003996A1 (en) 1989-05-05
EP0345318B1 (de) 1995-05-03
US5260223A (en) 1993-11-09
JP3176338B2 (ja) 2001-06-18
AU2712288A (en) 1989-05-23
AU631780B2 (en) 1992-12-10
EP0345318A1 (de) 1989-12-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTRA AB, SOEDERTAELJE, SE DANA-FARBER CANCER INST

8339 Ceased/non-payment of the annual fee