DE3852033T2 - Follistatin und verfahren zur reinigung desselben. - Google Patents

Follistatin und verfahren zur reinigung desselben.

Info

Publication number
DE3852033T2
DE3852033T2 DE3852033T DE3852033T DE3852033T2 DE 3852033 T2 DE3852033 T2 DE 3852033T2 DE 3852033 T DE3852033 T DE 3852033T DE 3852033 T DE3852033 T DE 3852033T DE 3852033 T2 DE3852033 T2 DE 3852033T2
Authority
DE
Germany
Prior art keywords
porcine
rat
protein
residues
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3852033T
Other languages
English (en)
Other versions
DE3852033D1 (de
Inventor
Nicholas Ling
Naoto Ueno
Shunichi Shimasaki
Frederick Esch
Shao-Yao Ying
Roger Guillemin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of DE3852033D1 publication Critical patent/DE3852033D1/de
Application granted granted Critical
Publication of DE3852033T2 publication Critical patent/DE3852033T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
DE3852033T 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben. Expired - Fee Related DE3852033T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9063587A 1987-08-28 1987-08-28
US07/224,432 US5041538A (en) 1987-08-28 1988-07-26 Mammalian follistatin
PCT/US1988/002971 WO1989001945A1 (en) 1987-08-28 1988-08-26 Follistatin and method of purifying same

Publications (2)

Publication Number Publication Date
DE3852033D1 DE3852033D1 (de) 1994-12-08
DE3852033T2 true DE3852033T2 (de) 1995-04-27

Family

ID=26782471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852033T Expired - Fee Related DE3852033T2 (de) 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben.

Country Status (8)

Country Link
US (1) US5041538A (de)
EP (1) EP0377659B1 (de)
JP (1) JP2709113B2 (de)
AT (1) ATE113654T1 (de)
AU (1) AU620346B2 (de)
CA (1) CA1340972C (de)
DE (1) DE3852033T2 (de)
WO (1) WO1989001945A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
AU610858B2 (en) * 1987-01-29 1991-05-30 Inhibin Pty Limited Isolation of single chain proteins with fsh suppressing activity from follicular fluid
US5942220A (en) * 1990-03-16 1999-08-24 Chiron Corporation Inhibitor of cytokine activity and applications thereof
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
PT1378572E (pt) * 1993-05-12 2007-01-31 Genetics Inst Composições de bmp-11
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6686198B1 (en) 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
DE69434934D1 (de) * 1993-10-14 2007-04-12 Harvard College Verfahren zur induzierung und zur erhaltung neuronalen zellen
PT733109E (pt) 1993-12-07 2006-07-31 Genetics Inst Llc Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao
US5658876A (en) * 1994-04-28 1997-08-19 The General Hospital Corporation Activin antagonists as novel contraceptives
AU5902398A (en) * 1996-12-31 1998-07-31 Human Genome Sciences, Inc. Cortistatin polypeptides
US5942420A (en) * 1997-11-17 1999-08-24 Millennium Biotherapeutics, Inc. Molecules of the follistatin-related protein family and uses therefor
US6004937A (en) * 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2001009368A1 (en) * 1999-07-30 2001-02-08 The General Hospital Corporation Follistatin antagonists
PT1223990E (pt) 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
TWI329129B (en) * 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
DE60237194D1 (de) * 2001-03-02 2010-09-16 Activx Biosciences Inc Plattform für protein-profiling
ES2305246T3 (es) 2001-06-01 2008-11-01 Wyeth Composiciones para la administracion sistemica de secuencias que codifican proteinas oseas morfogeneticas.
IL159240A0 (en) * 2001-06-08 2004-06-01 Smith & Nephew Bmp binding proteins for use in bone or cartilage regeneration
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
AUPR638101A0 (en) * 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
DE60217152T2 (de) * 2001-10-31 2007-10-31 Alcon Inc. Knochen-morphogene proteine (bmp), bmp-rezeptoren und bmp-bindungsproteine und ihre verwendung bei der diagnose und behandlung des glaukoms
WO2005025595A2 (en) 2003-09-12 2005-03-24 Wyeth Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
WO2005032578A1 (en) * 2003-10-06 2005-04-14 Monash University Therapeutic method
EP2097095B1 (de) * 2006-11-29 2016-01-27 Nationwide Children's Hospital Myostatin-hemmung für erhöhte und/oder verbesserte muskelfunktion
KR101871510B1 (ko) 2008-06-26 2018-06-26 악셀레론 파마 인코포레이티드 액티빈-ａｃｔｒｉｉａ 길항물질을 투약하는 방법 및 치료된 환자의 모니터링
CA2816883A1 (en) 2010-11-23 2012-05-31 Presage Biosciences, Inc. Therapeutic methods and compositions for solid delivery
US10172953B2 (en) 2012-02-27 2019-01-08 Amunix Operating Inc. XTEN conjugate compositions and methods of making same
EP2674033A1 (de) * 2012-06-11 2013-12-18 Deutsches Institut für Lebensmitteltechnik e.V. Prozess zur Herstellung einer Zusammensetzung mit aktivem Follistatin
EP2883461B1 (de) * 2013-12-11 2017-11-08 Deutsches Institut für Lebensmitteltechnik e.V. Verfahren zur Herstellung von aktivem Follistatin
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
CN106795224B (zh) 2014-06-04 2021-05-18 阿塞勒隆制药公司 用促滤泡素抑制素多肽治疗病症的方法和组合物
US9975934B2 (en) 2015-03-26 2018-05-22 Acceleron Pharma Inc. Follistatin-related fusion proteins
CA3165469A1 (en) 2019-12-20 2021-06-24 Research Institute At Nationwide Children's Hospital Optimized gene therapy for targeting muscle in muscle diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624944A (en) * 1985-06-14 1986-11-25 The Regents Of The University Of California Human seminal alpha-inhibins

Also Published As

Publication number Publication date
EP0377659B1 (de) 1994-11-02
CA1340972C (en) 2000-04-25
JPH04504105A (ja) 1992-07-23
JP2709113B2 (ja) 1998-02-04
DE3852033D1 (de) 1994-12-08
ATE113654T1 (de) 1994-11-15
EP0377659A4 (en) 1990-12-27
AU620346B2 (en) 1992-02-20
US5041538A (en) 1991-08-20
EP0377659A1 (de) 1990-07-18
WO1989001945A1 (en) 1989-03-09
AU2420088A (en) 1989-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee