ATE113654T1 - Follistatin und verfahren zur reinigung desselben. - Google Patents

Follistatin und verfahren zur reinigung desselben.

Info

Publication number
ATE113654T1
ATE113654T1 AT88908558T AT88908558T ATE113654T1 AT E113654 T1 ATE113654 T1 AT E113654T1 AT 88908558 T AT88908558 T AT 88908558T AT 88908558 T AT88908558 T AT 88908558T AT E113654 T1 ATE113654 T1 AT E113654T1
Authority
AT
Austria
Prior art keywords
porcine
rat
protein
residues
gln
Prior art date
Application number
AT88908558T
Other languages
English (en)
Inventor
Nicholas Chai-Kwan Ling
Naoto Assistant Professor Ueno
Of Tsukuba University
Shunichi Shimasaki
Frederick Steven Esch
Shao-Yao Ying
Roger Charles Louis Guillemin
Original Assignee
Salk Inst For Biological Studi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Application granted granted Critical
Publication of ATE113654T1 publication Critical patent/ATE113654T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT88908558T 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben. ATE113654T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9063587A 1987-08-28 1987-08-28
US07/224,432 US5041538A (en) 1987-08-28 1988-07-26 Mammalian follistatin

Publications (1)

Publication Number Publication Date
ATE113654T1 true ATE113654T1 (de) 1994-11-15

Family

ID=26782471

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88908558T ATE113654T1 (de) 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben.

Country Status (8)

Country Link
US (1) US5041538A (de)
EP (1) EP0377659B1 (de)
JP (1) JP2709113B2 (de)
AT (1) ATE113654T1 (de)
AU (1) AU620346B2 (de)
CA (1) CA1340972C (de)
DE (1) DE3852033T2 (de)
WO (1) WO1989001945A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
DE3853383T2 (de) * 1987-01-29 1995-07-27 Biotech Australia Pty Ltd Isolierung von einkettigen proteinen mit fsh unter- drückender aktivität aus follikularflüssigkeit.
US5942220A (en) * 1990-03-16 1999-08-24 Chiron Corporation Inhibitor of cytokine activity and applications thereof
AU674500B2 (en) 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3681069B2 (ja) * 1993-05-12 2005-08-10 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｂｍｐ−１１組成物
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6686198B1 (en) * 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
ATE355369T1 (de) * 1993-10-14 2006-03-15 Harvard College Verfahren zur induzierung und zur erhaltung neuronalen zellen
PT733109E (pt) 1993-12-07 2006-07-31 Genetics Inst Llc Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao
US5658876A (en) * 1994-04-28 1997-08-19 The General Hospital Corporation Activin antagonists as novel contraceptives
AU5902398A (en) * 1996-12-31 1998-07-31 Human Genome Sciences, Inc. Cortistatin polypeptides
US5942420A (en) * 1997-11-17 1999-08-24 Millennium Biotherapeutics, Inc. Molecules of the follistatin-related protein family and uses therefor
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2001009368A1 (en) * 1999-07-30 2001-02-08 The General Hospital Corporation Follistatin antagonists
WO2001028602A1 (en) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations of hyaluronic acid for delivery of osteogenic proteins
TWI329129B (en) * 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
ATE476654T1 (de) * 2001-03-02 2010-08-15 Activx Biosciences Inc Plattform für protein-profiling
NZ530045A (en) 2001-06-01 2007-07-27 Wyeth Corp Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
MXPA03011386A (es) * 2001-06-08 2004-05-27 Smith & Dephew Plc Proteina de union para su uso en la regeneracion de hueso o cartilago.
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
AUPR638101A0 (en) * 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
ATE349554T1 (de) * 2001-10-31 2007-01-15 Alcon Inc Knochen-morphogene proteine (bmp), bmp-rezeptoren und bmp-bindungsproteine und ihre verwendung bei der diagnose und behandlung des glaukoms
ATE357244T1 (de) 2003-09-12 2007-04-15 Wyeth Corp Injizierbare feste calciumphosphat-stäbe zur abgabe von osteogenen proteinen
ES2468516T3 (es) * 2003-10-06 2014-06-16 Paranta Biosciences Limited Folistatina para usar en la regulaci�n negativa de una respuesta inflamatoria
WO2008067480A2 (en) * 2006-11-29 2008-06-05 Nationwide Children's Hospital Myostatin inhibition for enhancing muscle and/or improving muscle function
US20100008918A1 (en) 2008-06-26 2010-01-14 Acceleron Pharma Inc. Methods for dosing an actriib antagonist and monitoring of treated patients
CN108744262A (zh) 2010-11-23 2018-11-06 普莱萨格生命科学公司 用于实体递送的治疗方法和组合物
MX366864B (es) 2012-02-27 2019-07-26 Amunix Operating Inc Composiciones de conjugados de xten y métodos para realizarlas.
EP2674033A1 (de) * 2012-06-11 2013-12-18 Deutsches Institut für Lebensmitteltechnik e.V. Prozess zur Herstellung einer Zusammensetzung mit aktivem Follistatin
EP2883461B1 (de) * 2013-12-11 2017-11-08 Deutsches Institut für Lebensmitteltechnik e.V. Verfahren zur Herstellung von aktivem Follistatin
MA51074A (fr) 2014-06-04 2020-10-14 Acceleron Pharma Inc Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
KR20170129233A (ko) 2015-03-26 2017-11-24 악셀레론 파마 인코포레이티드 폴리스타틴-관련된 융합 단백질 및 이들의 용도
IL294072A (en) 2019-12-20 2022-08-01 Res Inst Nationwide Childrens Hospital Gene therapy is efficient for targeting muscle in muscle diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624944A (en) * 1985-06-14 1986-11-25 The Regents Of The University Of California Human seminal alpha-inhibins

Also Published As

Publication number Publication date
AU620346B2 (en) 1992-02-20
JPH04504105A (ja) 1992-07-23
DE3852033T2 (de) 1995-04-27
EP0377659A1 (de) 1990-07-18
EP0377659A4 (en) 1990-12-27
AU2420088A (en) 1989-03-31
CA1340972C (en) 2000-04-25
JP2709113B2 (ja) 1998-02-04
US5041538A (en) 1991-08-20
WO1989001945A1 (en) 1989-03-09
EP0377659B1 (de) 1994-11-02
DE3852033D1 (de) 1994-12-08

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee