ATE112573T1 - Inhibin und dessen reinigung. - Google Patents
Inhibin und dessen reinigung.Info
- Publication number
- ATE112573T1 ATE112573T1 AT86904699T AT86904699T ATE112573T1 AT E112573 T1 ATE112573 T1 AT E112573T1 AT 86904699 T AT86904699 T AT 86904699T AT 86904699 T AT86904699 T AT 86904699T AT E112573 T1 ATE112573 T1 AT E112573T1
- Authority
- AT
- Austria
- Prior art keywords
- leu
- pro
- cys
- phe
- gly
- Prior art date
Links
- 239000000893 inhibin Substances 0.000 title abstract 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 230000006334 disulfide bridging Effects 0.000 abstract 2
- 102000002746 Inhibins Human genes 0.000 abstract 1
- 108010004250 Inhibins Proteins 0.000 abstract 1
- 239000012506 Sephacryl® Substances 0.000 abstract 1
- 229920002684 Sepharose Polymers 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000001733 follicular fluid Anatomy 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 238000004264 monolayer culture Methods 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 238000004007 reversed phase HPLC Methods 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75686685A | 1985-07-18 | 1985-07-18 | |
| US06/784,436 US4740587A (en) | 1985-07-18 | 1985-10-03 | Inhibin and method of purifying same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE112573T1 true ATE112573T1 (de) | 1994-10-15 |
Family
ID=27116303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86904699T ATE112573T1 (de) | 1985-07-18 | 1986-07-17 | Inhibin und dessen reinigung. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4740587A (de) |
| EP (1) | EP0232326B1 (de) |
| JP (1) | JPH07108916B2 (de) |
| AT (1) | ATE112573T1 (de) |
| AU (1) | AU605105B2 (de) |
| DE (1) | DE3650088T2 (de) |
| WO (1) | WO1987000528A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341617C (en) * | 1984-06-08 | 2011-06-28 | Henry George Burger | Inhibin isolated from ovarian follicular fluid |
| DE3650689T2 (de) | 1985-04-18 | 1999-04-08 | Biotechnology Australia Pty. Ltd., East Roseville, Neussuedwales | Rekombinantes inhibin |
| AU610821B2 (en) * | 1985-04-18 | 1991-05-30 | Inhibin Pty Limited | Recombinant inhibin |
| JPH0637520B2 (ja) * | 1985-07-03 | 1994-05-18 | 味の素株式会社 | ポリペプチド |
| US5089396A (en) * | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| ZA867569B (en) * | 1985-10-03 | 1988-06-29 | Genentech Inc | Nucleic acid encoding the alpha or beta chains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US5047336A (en) * | 1985-10-30 | 1991-09-10 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing mullerian inhibiting substance-like polypeptides |
| US5427780A (en) * | 1985-10-30 | 1995-06-27 | Biogen, Inc. | Composition comprising Mullerian inhibiting substance-like polypeptides |
| US4864019A (en) * | 1985-11-08 | 1989-09-05 | The Salk Institute For Biological Studies | Antibodies to inhibin and conjugates produced therefrom |
| ZA871844B (en) * | 1986-03-13 | 1988-05-25 | Biotechnology Pty Ltd | Method of assay of inhibin |
| US5015729A (en) * | 1986-06-24 | 1991-05-14 | The Salk Institute For Biological Studies | Ovine inhibin |
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| JP2653125B2 (ja) * | 1988-09-22 | 1997-09-10 | 味の素株式会社 | 血糖低下剤 |
| US5200395A (en) * | 1988-10-18 | 1993-04-06 | Ajinomoto Company, Inc. | Pharmaceutical composition of BUF-5 for treating anemia |
| US4997815A (en) * | 1988-11-01 | 1991-03-05 | Children's Hospital Medical Center Of Northern California | Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin |
| US5942220A (en) * | 1990-03-16 | 1999-08-24 | Chiron Corporation | Inhibitor of cytokine activity and applications thereof |
| DK0698094T3 (da) * | 1993-05-12 | 2004-05-03 | Inst Genetics Llc | BMP-11-sammensætninger |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US5658876A (en) * | 1994-04-28 | 1997-08-19 | The General Hospital Corporation | Activin antagonists as novel contraceptives |
| JPH07238097A (ja) * | 1994-09-07 | 1995-09-12 | Masao Igarashi | インヒビンを抗原とするＩｇＧ抗体 |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| ATE271886T1 (de) | 1999-10-15 | 2004-08-15 | Inst Genetics Llc | Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine |
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| WO2002099037A2 (en) | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| CA2490409A1 (en) | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0730114B2 (ja) * | 1985-04-03 | 1995-04-05 | 正雄 五十嵐 | インヒビン |
| AU610821B2 (en) * | 1985-04-18 | 1991-05-30 | Inhibin Pty Limited | Recombinant inhibin |
| AU5903986A (en) * | 1985-04-18 | 1986-11-05 | Biotechnology Australia Proprietary Limited | Recombinant inhibin |
| NZ231899A (en) * | 1985-10-03 | 1991-07-26 | Genentech Inc | Human or porcine inhibin peptide compositions and dna encoding them |
-
1985
- 1985-10-03 US US06/784,436 patent/US4740587A/en not_active Expired - Lifetime
-
1986
- 1986-07-17 AT AT86904699T patent/ATE112573T1/de not_active IP Right Cessation
- 1986-07-17 JP JP61504032A patent/JPH07108916B2/ja not_active Expired - Lifetime
- 1986-07-17 AU AU61498/86A patent/AU605105B2/en not_active Expired
- 1986-07-17 EP EP86904699A patent/EP0232326B1/de not_active Expired - Lifetime
- 1986-07-17 DE DE3650088T patent/DE3650088T2/de not_active Expired - Lifetime
- 1986-07-17 WO PCT/US1986/001505 patent/WO1987000528A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0232326B1 (de) | 1994-10-05 |
| US4740587A (en) | 1988-04-26 |
| AU6149886A (en) | 1987-02-10 |
| EP0232326A4 (de) | 1988-06-14 |
| EP0232326A1 (de) | 1987-08-19 |
| JPH07108916B2 (ja) | 1995-11-22 |
| JPS63500309A (ja) | 1988-02-04 |
| DE3650088T2 (de) | 1995-01-26 |
| DE3650088D1 (de) | 1994-11-10 |
| WO1987000528A1 (en) | 1987-01-29 |
| AU605105B2 (en) | 1991-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |