CA1340972C - Follistatin and method of purifying same - Google Patents

Follistatin and method of purifying same

Info

Publication number
CA1340972C
CA1340972C CA000575768A CA575768A CA1340972C CA 1340972 C CA1340972 C CA 1340972C CA 000575768 A CA000575768 A CA 000575768A CA 575768 A CA575768 A CA 575768A CA 1340972 C CA1340972 C CA 1340972C
Authority
CA
Canada
Prior art keywords
cys
glu
lys
ser
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000575768A
Other languages
English (en)
French (fr)
Inventor
Nicholas Chai-Kwan Ling
Naoto Ueno
Shunichi Shimasaki
Frederick Steven Esch
Shao-Yao Ying
Roger Charles Louis Guillemin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of CA1340972C publication Critical patent/CA1340972C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000575768A 1987-08-28 1988-08-26 Follistatin and method of purifying same Expired - Fee Related CA1340972C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9063587A 1987-08-28 1987-08-28
US90,635 1987-08-28
US07/224,432 US5041538A (en) 1987-08-28 1988-07-26 Mammalian follistatin
US224,432 1988-07-26

Publications (1)

Publication Number Publication Date
CA1340972C true CA1340972C (en) 2000-04-25

Family

ID=26782471

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000575768A Expired - Fee Related CA1340972C (en) 1987-08-28 1988-08-26 Follistatin and method of purifying same

Country Status (8)

Country Link
US (1) US5041538A (de)
EP (1) EP0377659B1 (de)
JP (1) JP2709113B2 (de)
AT (1) ATE113654T1 (de)
AU (1) AU620346B2 (de)
CA (1) CA1340972C (de)
DE (1) DE3852033T2 (de)
WO (1) WO1989001945A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
WO1988005789A1 (en) * 1987-01-29 1988-08-11 Biotechnology Australia Pty. Ltd. Isolation of single chain proteins with fsh suppressing activity from follicular fluid
US5942220A (en) * 1990-03-16 1999-08-24 Chiron Corporation Inhibitor of cytokine activity and applications thereof
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
EP2272959A1 (de) * 1993-05-12 2011-01-12 Genetics Institute, LLC BMP-11 Zusammenstellungen
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6686198B1 (en) * 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
JPH09503673A (ja) * 1993-10-14 1997-04-15 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ ニューロン細胞の誘導および維持法
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US5658876A (en) * 1994-04-28 1997-08-19 The General Hospital Corporation Activin antagonists as novel contraceptives
AU5902398A (en) * 1996-12-31 1998-07-31 Human Genome Sciences, Inc. Cortistatin polypeptides
US5942420A (en) * 1997-11-17 1999-08-24 Millennium Biotherapeutics, Inc. Molecules of the follistatin-related protein family and uses therefor
US6004937A (en) * 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2001009368A1 (en) * 1999-07-30 2001-02-08 The General Hospital Corporation Follistatin antagonists
ES2225241T3 (es) 1999-10-15 2005-03-16 Genetics Institute, Llc Formulaciones de acido hialuronico para suministrar proteinas osteogenicas.
TW200526779A (en) * 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
WO2002071066A1 (en) * 2001-03-02 2002-09-12 Activx Biosciences, Inc. Protein profiling platform
JP2005500280A (ja) 2001-06-01 2005-01-06 ワイエス 骨形成タンパク質（ｂｍｐ）をコードする配列の全身投与のための組成物および方法
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
CA2449573A1 (en) * 2001-06-08 2002-12-19 Smith & Nephew Plc Bmp binding proteins for use in bone or cartilage regeneration
AUPR638101A0 (en) 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
DE60217152T2 (de) * 2001-10-31 2007-10-31 Alcon Inc. Knochen-morphogene proteine (bmp), bmp-rezeptoren und bmp-bindungsproteine und ihre verwendung bei der diagnose und behandlung des glaukoms
SI1675608T1 (sl) 2003-09-12 2007-08-31 Wyeth Corp Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov
US8920806B2 (en) * 2003-10-06 2014-12-30 Paranta Biosciences Limited Method of modulating inflammatory response by downregulation of activin
US8895309B2 (en) * 2006-11-29 2014-11-25 Nationwide Children's Hospital Myostatin inhibition for enhancing muscle and/or improving muscle function
CA2729100C (en) 2008-06-26 2018-01-02 Acceleron Pharma Inc. Methods for dosing an activin-actriia antagonist and monitoring of treated patients
EP2643045A4 (de) 2010-11-23 2016-01-13 Presage Biosciences Inc Therapeutische verfahren und zusammensetzungen zur abgabe in fester form
EP3406347A3 (de) 2012-02-27 2019-02-13 Amunix Operating Inc. Xten-konjugat-zusammensetzungen und verfahren zur herstellung davon
EP2674033A1 (de) * 2012-06-11 2013-12-18 Deutsches Institut für Lebensmitteltechnik e.V. Prozess zur Herstellung einer Zusammensetzung mit aktivem Follistatin
ES2658189T3 (es) * 2013-12-11 2018-03-08 Deutsches Institut Für Lebensmitteltechnik E.V. Proceso para producir folistatina activa
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
BR112016028520A2 (pt) 2014-06-04 2017-10-24 Acceleron Pharma Inc métodos e composições para o tratamento de transtornos com polipeptídeos de folistatina
JP2018510637A (ja) 2015-03-26 2018-04-19 アクセルロン ファーマ， インコーポレイテッド フォリスタチン関連融合タンパク質およびその使用
EP4077687A1 (de) 2019-12-20 2022-10-26 Research Institute at Nationwide Children's Hospital Optimierte gentherapie zum targeting von muskeln bei muskelerkrankungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624944A (en) * 1985-06-14 1986-11-25 The Regents Of The University Of California Human seminal alpha-inhibins

Also Published As

Publication number Publication date
DE3852033D1 (de) 1994-12-08
AU2420088A (en) 1989-03-31
DE3852033T2 (de) 1995-04-27
EP0377659A1 (de) 1990-07-18
AU620346B2 (en) 1992-02-20
WO1989001945A1 (en) 1989-03-09
ATE113654T1 (de) 1994-11-15
US5041538A (en) 1991-08-20
JP2709113B2 (ja) 1998-02-04
EP0377659B1 (de) 1994-11-02
EP0377659A4 (en) 1990-12-27
JPH04504105A (ja) 1992-07-23

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