DE3852033D1 - Follistatin und verfahren zur reinigung desselben. - Google Patents

Follistatin und verfahren zur reinigung desselben.

Info

Publication number
DE3852033D1
DE3852033D1 DE3852033T DE3852033T DE3852033D1 DE 3852033 D1 DE3852033 D1 DE 3852033D1 DE 3852033 T DE3852033 T DE 3852033T DE 3852033 T DE3852033 T DE 3852033T DE 3852033 D1 DE3852033 D1 DE 3852033D1
Authority
DE
Germany
Prior art keywords
porcine
rat
protein
residues
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3852033T
Other languages
English (en)
Other versions
DE3852033T2 (de
Inventor
Nicholas Ling
Naoto Ueno
Shunichi Shimasaki
Frederick Esch
Shao-Yao Ying
Roger Guillemin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of DE3852033D1 publication Critical patent/DE3852033D1/de
Publication of DE3852033T2 publication Critical patent/DE3852033T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE3852033T 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben. Expired - Fee Related DE3852033T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9063587A 1987-08-28 1987-08-28
US07/224,432 US5041538A (en) 1987-08-28 1988-07-26 Mammalian follistatin
PCT/US1988/002971 WO1989001945A1 (en) 1987-08-28 1988-08-26 Follistatin and method of purifying same

Publications (2)

Publication Number Publication Date
DE3852033D1 true DE3852033D1 (de) 1994-12-08
DE3852033T2 DE3852033T2 (de) 1995-04-27

Family

ID=26782471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852033T Expired - Fee Related DE3852033T2 (de) 1987-08-28 1988-08-26 Follistatin und verfahren zur reinigung desselben.

Country Status (8)

Country Link
US (1) US5041538A (de)
EP (1) EP0377659B1 (de)
JP (1) JP2709113B2 (de)
AT (1) ATE113654T1 (de)
AU (1) AU620346B2 (de)
CA (1) CA1340972C (de)
DE (1) DE3852033T2 (de)
WO (1) WO1989001945A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
AU610858B2 (en) * 1987-01-29 1991-05-30 Inhibin Pty Limited Isolation of single chain proteins with fsh suppressing activity from follicular fluid
US5942220A (en) * 1990-03-16 1999-08-24 Chiron Corporation Inhibitor of cytokine activity and applications thereof
EP0612348B1 (de) 1991-11-04 2003-04-23 Genetics Institute, LLC Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
EP2272959A1 (de) * 1993-05-12 2011-01-12 Genetics Institute, LLC BMP-11 Zusammenstellungen
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
ATE355369T1 (de) * 1993-10-14 2006-03-15 Harvard College Verfahren zur induzierung und zur erhaltung neuronalen zellen
US6686198B1 (en) * 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
ES2255059T3 (es) 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
US5658876A (en) * 1994-04-28 1997-08-19 The General Hospital Corporation Activin antagonists as novel contraceptives
AU5902398A (en) 1996-12-31 1998-07-31 Human Genome Sciences, Inc. Cortistatin polypeptides
US5942420A (en) 1997-11-17 1999-08-24 Millennium Biotherapeutics, Inc. Molecules of the follistatin-related protein family and uses therefor
US6004937A (en) * 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
WO2001009368A1 (en) * 1999-07-30 2001-02-08 The General Hospital Corporation Follistatin antagonists
EP2286847A1 (de) 1999-10-15 2011-02-23 Genetics Institute, LLC Hyaluronsäure enthaltende Zusammensetzungen zur Abgabe osteogener Proteine
TW200526779A (en) * 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
ATE476654T1 (de) * 2001-03-02 2010-08-15 Activx Biosciences Inc Plattform für protein-profiling
ES2305246T3 (es) 2001-06-01 2008-11-01 Wyeth Composiciones para la administracion sistemica de secuencias que codifican proteinas oseas morfogeneticas.
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
CN1538850A (zh) * 2001-06-08 2004-10-20 ʷ 用于骨或软骨再生的bmp结合蛋白
AUPR638101A0 (en) * 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
BR0213738A (pt) * 2001-10-31 2006-11-21 Alcon Inc proteìnas morfogênicas ósseas (bmp), receptores de bmp e proteìnas de ligação de bmp e seu uso no diagnóstico e no tratamento de glaucoma
EP2374471A1 (de) 2003-09-12 2011-10-12 Wyeth LLC Injizierbare härtbare Calciumphosphat-Pasten zur Abgabe osteogener Proteine
ES2468516T3 (es) * 2003-10-06 2014-06-16 Paranta Biosciences Limited Folistatina para usar en la regulaci�n negativa de una respuesta inflamatoria
ES2569365T3 (es) 2006-11-29 2016-05-10 Nationwide Children's Hospital Inhibición de miostatina para la potenciación de músculo y/o la mejora de la función muscular
US20100015144A1 (en) 2008-06-26 2010-01-21 Acceleron Pharma Inc. Methods for dosing an activin-actriia antagonist and monitoring of treated patients
CN108744262A (zh) 2010-11-23 2018-11-06 普莱萨格生命科学公司 用于实体递送的治疗方法和组合物
MX366864B (es) 2012-02-27 2019-07-26 Amunix Operating Inc Composiciones de conjugados de xten y métodos para realizarlas.
EP2674033A1 (de) * 2012-06-11 2013-12-18 Deutsches Institut für Lebensmitteltechnik e.V. Prozess zur Herstellung einer Zusammensetzung mit aktivem Follistatin
PL2883461T3 (pl) * 2013-12-11 2018-04-30 Deutsches Institut Für Lebensmitteltechnik E.V. Sposób wytwarzania aktywnej folistatyny
WO2015187977A1 (en) 2014-06-04 2015-12-10 Acceleron Pharma, Inc. Methods and compositions for treatment of disorders with follistatin polypeptides
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
WO2016154601A1 (en) 2015-03-26 2016-09-29 Acceleron Pharma Inc. Follistatin-related fusion proteins and uses thereof
AU2020408225A1 (en) 2019-12-20 2022-07-14 Research Institute At Nationwide Children's Hospital Optimized gene therapy for targeting muscle in muscle diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4624944A (en) * 1985-06-14 1986-11-25 The Regents Of The University Of California Human seminal alpha-inhibins

Also Published As

Publication number Publication date
DE3852033T2 (de) 1995-04-27
WO1989001945A1 (en) 1989-03-09
US5041538A (en) 1991-08-20
CA1340972C (en) 2000-04-25
EP0377659A4 (en) 1990-12-27
EP0377659A1 (de) 1990-07-18
AU620346B2 (en) 1992-02-20
JP2709113B2 (ja) 1998-02-04
ATE113654T1 (de) 1994-11-15
JPH04504105A (ja) 1992-07-23
AU2420088A (en) 1989-03-31
EP0377659B1 (de) 1994-11-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee