ATE183775T1 - Cysteinfreie il-6 mutanten - Google Patents

Cysteinfreie il-6 mutanten

Info

Publication number
ATE183775T1
ATE183775T1 AT92915014T AT92915014T ATE183775T1 AT E183775 T1 ATE183775 T1 AT E183775T1 AT 92915014 T AT92915014 T AT 92915014T AT 92915014 T AT92915014 T AT 92915014T AT E183775 T1 ATE183775 T1 AT E183775T1
Authority
AT
Austria
Prior art keywords
positions
cystein
mutants
free
muteins
Prior art date
Application number
AT92915014T
Other languages
English (en)
Inventor
Susan M Skelly
Charles T Tackney
John N Snouwaert
Dana M Fowlkes
Original Assignee
Imclone Systems Inc
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imclone Systems Inc, Univ North Carolina filed Critical Imclone Systems Inc
Application granted granted Critical
Publication of ATE183775T1 publication Critical patent/ATE183775T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin
AT92915014T 1991-07-02 1992-07-02 Cysteinfreie il-6 mutanten ATE183775T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72469891A 1991-07-02 1991-07-02

Publications (1)

Publication Number Publication Date
ATE183775T1 true ATE183775T1 (de) 1999-09-15

Family

ID=24911511

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92915014T ATE183775T1 (de) 1991-07-02 1992-07-02 Cysteinfreie il-6 mutanten

Country Status (18)

Country Link
US (2) US5359034A (de)
EP (1) EP0592566B1 (de)
JP (1) JPH07502162A (de)
AT (1) ATE183775T1 (de)
AU (1) AU2308992A (de)
CA (1) CA2111327A1 (de)
DE (1) DE69229862T2 (de)
DK (1) DK0592566T3 (de)
ES (1) ES2138973T3 (de)
GR (1) GR3031927T3 (de)
IE (1) IE922153A1 (de)
IL (1) IL102346A0 (de)
MX (1) MX9203879A (de)
NZ (1) NZ243290A (de)
PT (1) PT100651A (de)
TW (1) TW275066B (de)
WO (1) WO1993001212A1 (de)
ZA (1) ZA924674B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003492A1 (en) * 1992-08-06 1994-02-17 The University Of Melbourne Interleukin-6 variants and uses therefor
EP0672144A1 (de) * 1992-10-20 1995-09-20 Chiron Corporation Interleukin-6-receptor-antagonisten
US5641657A (en) * 1994-05-19 1997-06-24 Human Genome Sciences, Inc. DNA encoding an interleukin-6 splice variant
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
WO1996040912A1 (en) * 1995-06-07 1996-12-19 Amgen Inc. Ob protein compositions and method
US5861500A (en) * 1996-07-25 1999-01-19 The Trustees Of Columbia University In The City Of New York Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and uses thereof
US5854398A (en) * 1996-07-25 1998-12-29 The Trustees Of Columbia University In The City Of New York Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and uses thereof
US6558671B1 (en) 1997-01-30 2003-05-06 The University Of Virginia Patent Foundation Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor
WO2005072340A2 (en) * 2004-01-27 2005-08-11 Compugen Ltd. Novel polynucleotides encoding polypeptides and methods using same
WO2006072954A2 (en) * 2005-01-05 2006-07-13 Compugen Ltd. Novel il-6 polynucleotides encoding variant il-6 polypeptides and methods using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4853332A (en) * 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
EP0257406B2 (de) * 1986-08-06 1998-08-12 Ajinomoto Co., Inc. Rekombinanter B-Zell-Differenzierungsfaktor
PT92479A (pt) * 1988-12-01 1990-06-29 Univ North Carolina Processo de preparacao de genes recombinantes e suas proteinas de codificacao

Also Published As

Publication number Publication date
AU2308992A (en) 1993-02-11
EP0592566B1 (de) 1999-08-25
CA2111327A1 (en) 1993-01-21
PT100651A (pt) 1993-09-30
WO1993001212A1 (en) 1993-01-21
DK0592566T3 (da) 1999-12-13
TW275066B (de) 1996-05-01
EP0592566A4 (de) 1995-05-24
ZA924674B (en) 1993-04-28
ES2138973T3 (es) 2000-02-01
IE922153A1 (en) 1993-01-13
DE69229862D1 (de) 1999-09-30
DE69229862T2 (de) 2000-01-13
NZ243290A (en) 1995-04-27
US5359034A (en) 1994-10-25
US5545537A (en) 1996-08-13
EP0592566A1 (de) 1994-04-20
GR3031927T3 (en) 2000-03-31
IL102346A0 (en) 1993-01-14
JPH07502162A (ja) 1995-03-09
MX9203879A (es) 1994-01-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee