DE3789561D1 - Hemmer von "Reverse Transkriptase" zur Vorbeugung und Behandlung von Retrovirus-Infektionen bei Säugern. - Google Patents

Hemmer von "Reverse Transkriptase" zur Vorbeugung und Behandlung von Retrovirus-Infektionen bei Säugern.

Info

Publication number
DE3789561D1
DE3789561D1 DE3789561T DE3789561T DE3789561D1 DE 3789561 D1 DE3789561 D1 DE 3789561D1 DE 3789561 T DE3789561 T DE 3789561T DE 3789561 T DE3789561 T DE 3789561T DE 3789561 D1 DE3789561 D1 DE 3789561D1
Authority
DE
Germany
Prior art keywords
mammals
reverse transcriptase
prevention
treatment
retrovirus infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3789561T
Other languages
English (en)
Other versions
DE3789561T2 (de
Inventor
Heino Dr Diringer
Karin Dr Moelling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to DE3789561T priority Critical patent/DE3789561T2/de
Application granted granted Critical
Publication of DE3789561D1 publication Critical patent/DE3789561D1/de
Publication of DE3789561T2 publication Critical patent/DE3789561T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3789561T 1986-01-16 1987-01-15 Hemmer von "Reverse Transkriptase" zur Vorbeugung und Behandlung von Retrovirus-Infektionen bei Säugern. Expired - Fee Related DE3789561T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3789561T DE3789561T2 (de) 1986-01-16 1987-01-15 Hemmer von "Reverse Transkriptase" zur Vorbeugung und Behandlung von Retrovirus-Infektionen bei Säugern.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863601136 DE3601136A1 (de) 1986-01-16 1986-01-16 Hemmstoffe der reversen transkriptase fuer prophylaxe und therapie von retrovirus-infektionen in saeugetieren
DE3789561T DE3789561T2 (de) 1986-01-16 1987-01-15 Hemmer von "Reverse Transkriptase" zur Vorbeugung und Behandlung von Retrovirus-Infektionen bei Säugern.

Publications (2)

Publication Number Publication Date
DE3789561D1 true DE3789561D1 (de) 1994-05-19
DE3789561T2 DE3789561T2 (de) 1994-07-21

Family

ID=6291973

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19863601136 Granted DE3601136A1 (de) 1986-01-16 1986-01-16 Hemmstoffe der reversen transkriptase fuer prophylaxe und therapie von retrovirus-infektionen in saeugetieren
DE3789561T Expired - Fee Related DE3789561T2 (de) 1986-01-16 1987-01-15 Hemmer von "Reverse Transkriptase" zur Vorbeugung und Behandlung von Retrovirus-Infektionen bei Säugern.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19863601136 Granted DE3601136A1 (de) 1986-01-16 1986-01-16 Hemmstoffe der reversen transkriptase fuer prophylaxe und therapie von retrovirus-infektionen in saeugetieren

Country Status (6)

Country Link
US (1) US5153181A (de)
EP (1) EP0232744B1 (de)
JP (1) JPS62215529A (de)
AT (1) ATE104148T1 (de)
DE (2) DE3601136A1 (de)
ES (1) ES2054622T3 (de)

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EP0240098A3 (de) * 1986-04-04 1989-05-10 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Oligo und Polysaccharide zur Behandlung von Krankheiten verursacht durch Retroviren
JPS6345223A (ja) * 1986-04-04 1988-02-26 Ueno Seiyaku Oyo Kenkyusho:Kk ひと免疫不全ウイルス性疾患処置剤
EP0285357A3 (de) * 1987-03-31 1989-10-25 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Bekämpfung von Retroviren
EP0293826A3 (de) * 1987-06-02 1989-05-10 Stichting REGA V.Z.W. Therapeutische und prophylaktische Gabe von sulfatierten Polysacchariden gegen AIDS
JPH0825896B2 (ja) * 1987-06-18 1996-03-13 呉羽化学工業株式会社 抗レトロウィルス剤
JPS6413026A (en) * 1987-07-07 1989-01-17 Ajinomoto Kk Antiviral agent
DE3734962C1 (de) * 1987-10-15 1989-01-05 Luitpold Werk Chem Pharm Verwendung von Chondroitinpolysulfat zur vorbeugenden,lindernden oder heilenden Behandlung von AIDS und ARC
WO1989003684A1 (en) * 1987-10-30 1989-05-05 Chugai Seiyaku Kabushiki Kaisha Anti-hiv agent
DE3744119A1 (de) * 1987-12-24 1989-07-06 Basf Ag Verwendung von polysulfatierten heparinen
DE3812181A1 (de) * 1988-04-13 1989-10-26 Werner E G Prof Dr Mueller Arzneimittel, enthaltend natuerliche und/oder chemisch modifizierte mono- oder polysaccharide und deren verwendung
US5512672A (en) * 1988-07-07 1996-04-30 Ajinomoto Co., Inc. Curdlan sulfate
JPH0725802B2 (ja) * 1988-11-28 1995-03-22 味の素株式会社 カードランまたはレンチナンの硫酸エステルまたはその塩の製造方法
US5272261A (en) * 1989-01-11 1993-12-21 Merrell Dow Pharmaceuticals Inc. Preparation of sulfated polysaccharide fractions
DE3917982A1 (de) * 1989-06-02 1990-12-06 Behringwerke Ag Verwendung von xylanpolyhydrogensulfaten zur therapie von zellproliferations-bedingten erkrankungen
DE3919644A1 (de) * 1989-06-16 1990-12-20 Diagen Inst Molekularbio Mittel zur prophylaktischen und therapeutischen behandlung von viralen infektionen
FR2655267B1 (fr) * 1989-12-04 1992-04-03 Roussel Uclaf Nouveau derive sulfate du galactanne extrait de klebsiella, procede de preparation, application a titre de medicaments et compositions pharmaceutiques le renfermant.
DE4021066A1 (de) * 1990-07-03 1992-01-09 Hoechst Ag Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
CA2071915A1 (en) 1990-08-23 1992-02-24 Tadao Shoji Antiviral agent
GB9020861D0 (en) * 1990-09-25 1990-11-07 Ml Lab Plc Pharmaceutical compositions
US5514667A (en) * 1990-11-05 1996-05-07 Arthropharm Pty. Limited Method for topical treatment of herpes infections
DE4103904C2 (de) * 1991-02-08 1995-06-14 Analyticon Ges Fuer Chemische Neue Arzneimittel aus Gamma-Pyronen, Gamma-Pyridonen sowie Gamma-Thiopyronen
JPH05213982A (ja) * 1991-03-26 1993-08-24 Dainippon Ink & Chem Inc オリゴ糖トコフェロール配糖体及び硫酸化オリゴ糖トコフェロール配糖体並びにこれを有効成分とする抗ウイルス剤
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
DE69422496T2 (de) * 1993-09-20 2002-07-11 Ajinomoto Kk Mittel gegen malaria
IL112174A (en) * 1994-01-03 1999-05-09 Merrell Dow Pharma Oligomers of polythioureas pharmaceutical compositions containing them and a process for their preparation
AU2963195A (en) * 1994-07-05 1996-01-25 Baltech, Inc. Prevention and treatment of human herpesvirus-6 infection with quaternary ammonium compounds and/or ganglionic blocking agents
ZA965962B (en) * 1995-07-13 1997-01-31 Ajinomoto Kk Anti-piroplasmotic agent
EP2116600B1 (de) * 1998-04-23 2013-09-18 Takara Bio Inc. Methode für DNA Synthese
US6667165B2 (en) * 2001-11-13 2003-12-23 Eppendorf Ag Method and compositions for reversible inhibition of thermostable polymerases
US20040009953A1 (en) * 2002-01-10 2004-01-15 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
US20030181416A1 (en) * 2002-01-10 2003-09-25 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
US20040180852A1 (en) * 2003-03-10 2004-09-16 Cara-Lynne Schengrund Use of multivalent glycodendrimers to inhibit the activity of human immunodeficiency virus
US20050009782A1 (en) * 2003-07-09 2005-01-13 Comper Wayne D. Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof
JP4686756B2 (ja) * 2004-03-31 2011-05-25 独立行政法人産業技術総合研究所 動物臓器から抽出した水溶性画分、その製造方法、逆転写反応阻害剤、逆転写酵素阻害剤、ウイルス増殖阻害剤及び医薬組成物
ES2526264B1 (es) * 2013-06-05 2015-12-02 Consejo Superior De Investigaciones Cientificas (Csic) Secuencia de nucleótidos codificante de una enzima con actividad dextransacarasa, células que la expresan y su uso para la obtención de exopolisacáridos con actividad antiviral y composiciones que los contienen

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US4066829A (en) * 1976-07-12 1978-01-03 American Cyanamid Company Malto-dextrin poly(H-)sulfates
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DE3124384C2 (de) * 1981-06-22 1985-05-15 Herbert Prof. Dr. 1000 Berlin Voß Dermatanpolysulfat, Verfahren zu dessen Herstellung und dieses enthaltendes virushemmendes Mittel
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US4640912A (en) * 1983-06-09 1987-02-03 Hausman Marvin S Administration of "active" chondroitin sulfate A and "active" chondroitin sulfate C or mixtures thereof to mammals including humans
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Also Published As

Publication number Publication date
ES2054622T3 (es) 1994-08-16
DE3601136C2 (de) 1990-10-18
EP0232744A2 (de) 1987-08-19
ATE104148T1 (de) 1994-04-15
US5153181A (en) 1992-10-06
DE3601136A1 (de) 1987-07-23
DE3789561T2 (de) 1994-07-21
EP0232744A3 (en) 1989-05-10
JPH0234926B2 (de) 1990-08-07
EP0232744B1 (de) 1994-04-13
JPS62215529A (ja) 1987-09-22

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