ATE312079T1 - Nichtnukleoside reverse transkriptase-hemmer zur behandlung von hiv-infektion - Google Patents
Nichtnukleoside reverse transkriptase-hemmer zur behandlung von hiv-infektionInfo
- Publication number
- ATE312079T1 ATE312079T1 AT99913888T AT99913888T ATE312079T1 AT E312079 T1 ATE312079 T1 AT E312079T1 AT 99913888 T AT99913888 T AT 99913888T AT 99913888 T AT99913888 T AT 99913888T AT E312079 T1 ATE312079 T1 AT E312079T1
- Authority
- AT
- Austria
- Prior art keywords
- nonnucleosides
- treatment
- reverse transcriptase
- hiv infection
- transcriptase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/040,538 US5998411A (en) | 1998-03-17 | 1998-03-17 | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
| PCT/US1999/005602 WO1999047501A2 (en) | 1998-03-17 | 1999-03-16 | Nonnucleoside inhibitors of reverse transcriptase for the treatment of hiv-infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312079T1 true ATE312079T1 (de) | 2005-12-15 |
Family
ID=21911533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99913888T ATE312079T1 (de) | 1998-03-17 | 1999-03-16 | Nichtnukleoside reverse transkriptase-hemmer zur behandlung von hiv-infektion |
Country Status (11)
| Country | Link |
|---|---|
| US (8) | US5998411A (de) |
| EP (2) | EP1528057A1 (de) |
| JP (1) | JP2002506854A (de) |
| CN (1) | CN1301254A (de) |
| AP (1) | AP2000001944A0 (de) |
| AT (1) | ATE312079T1 (de) |
| AU (1) | AU752010B2 (de) |
| CA (1) | CA2323418A1 (de) |
| DE (1) | DE69928779T2 (de) |
| EA (1) | EA200000958A1 (de) |
| WO (1) | WO1999047501A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998411A (en) | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
| IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
| US6136335A (en) * | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
| US7186736B1 (en) * | 1999-03-20 | 2007-03-06 | Parker Hughes Institute | NNI for treatment of multi-drug resistant HIV |
| US6207688B1 (en) * | 1999-06-23 | 2001-03-27 | Parker Hughes Institute | Phenethyl-thiourea compounds and use |
| US6545152B1 (en) * | 2000-07-18 | 2003-04-08 | Parker Hughes Institute | R-isomers of nonnucleoside inhibitors |
| US6960606B2 (en) * | 2000-10-19 | 2005-11-01 | Parker Hughes Institute | Adamantyl Thiazole Thioureas |
| US6689793B2 (en) * | 2000-12-06 | 2004-02-10 | Parker Hughes Institute | Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity |
| SE0100733D0 (sv) | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| US7642277B2 (en) * | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| TW200600492A (en) | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| US7892618B2 (en) | 2005-03-21 | 2011-02-22 | Sony Corporation | Deterring theft of optical media |
| US7702625B2 (en) * | 2006-03-03 | 2010-04-20 | International Business Machines Corporation | Building a unified query that spans heterogeneous environments |
| EP2044037A2 (de) * | 2006-07-24 | 2009-04-08 | Gilead Sciences, Inc. | Hemmer reverser hiv-transkriptase |
| AR067181A1 (es) * | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Inhibidores de transcriptasa inversa de hiv, composicion farmaceutica, uso del compuesto para preparar un medicamento, agente de combinacion farmaceutica y metodo de inhibicion de la replicacion de un retrovirus |
| US8354421B2 (en) * | 2007-06-29 | 2013-01-15 | Korea Research Insitute Of Chemical Technology | HIV reverse transcriptase inhibitors |
| US8119800B2 (en) * | 2007-12-21 | 2012-02-21 | Korea Research Institute Of Chemical Technology | Processes for preparing HIV reverse transcriptase inhibitors |
| CN103288719A (zh) * | 2012-03-05 | 2013-09-11 | 苏州欧凯医药技术有限公司 | 非核甘艾滋病毒抑制物-吡啶酮类先导体的合成 |
| US9471130B2 (en) * | 2013-10-25 | 2016-10-18 | Advanced Micro Devices, Inc. | Configuring idle states for entities in a computing device based on predictions of durations of idle periods |
| CN107301327A (zh) * | 2017-05-17 | 2017-10-27 | 华南理工大学 | 一种使用计算机模拟金属配合物与dna相互作用的方法 |
| CN108010101A (zh) * | 2017-12-18 | 2018-05-08 | 重庆大学 | 一种绘制分子片段2d投影图的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD283613A5 (de) * | 1988-03-31 | 1990-10-17 | ��@���������@�������k�� | Verfahren zur herstellung von in 6-stellung substituierte acyclopyrimidin-nucleosid-derivaten |
| US5686428A (en) * | 1989-04-07 | 1997-11-11 | Aktiebolaget Astra | Pharmaceutical composition |
| HU205917B (en) | 1989-09-29 | 1992-07-28 | Mitsubishi Chem Ind | Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components |
| EP0449726B1 (de) * | 1990-03-29 | 1997-06-11 | Mitsubishi Chemical Corporation | Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten |
| US5503978A (en) * | 1990-06-11 | 1996-04-02 | University Research Corporation | Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase |
| IL102548A (en) | 1991-08-02 | 1998-08-16 | Medivir Ab | Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds |
| US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
| JPH0725770A (ja) | 1993-07-09 | 1995-01-27 | Mitsubishi Chem Corp | 経皮吸収性抗ウイルス剤 |
| DK0706514T3 (da) | 1993-08-24 | 1999-08-02 | Medivir Ab | Forbindelser og fremgangsmåder til inhibering af HIV og relaterede vira |
| US5998411A (en) | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
-
1998
- 1998-03-17 US US09/040,538 patent/US5998411A/en not_active Expired - Fee Related
- 1998-12-04 US US09/205,167 patent/US6180654B1/en not_active Expired - Fee Related
- 1998-12-04 US US09/205,469 patent/US6124307A/en not_active Expired - Fee Related
- 1998-12-04 US US09/205,253 patent/US6156759A/en not_active Expired - Fee Related
- 1998-12-04 US US09/205,785 patent/US6925388B1/en not_active Expired - Fee Related
-
1999
- 1999-03-16 EP EP05000683A patent/EP1528057A1/de not_active Withdrawn
- 1999-03-16 AU AU31864/99A patent/AU752010B2/en not_active Ceased
- 1999-03-16 JP JP2000536698A patent/JP2002506854A/ja active Pending
- 1999-03-16 EP EP99913888A patent/EP1064263B1/de not_active Expired - Lifetime
- 1999-03-16 AT AT99913888T patent/ATE312079T1/de not_active IP Right Cessation
- 1999-03-16 CN CN99806293A patent/CN1301254A/zh active Pending
- 1999-03-16 AP APAP/P/2000/001944A patent/AP2000001944A0/en unknown
- 1999-03-16 CA CA002323418A patent/CA2323418A1/en not_active Abandoned
- 1999-03-16 WO PCT/US1999/005602 patent/WO1999047501A2/en active IP Right Grant
- 1999-03-16 EA EA200000958A patent/EA200000958A1/ru unknown
- 1999-03-16 DE DE69928779T patent/DE69928779T2/de not_active Expired - Fee Related
-
2000
- 2000-10-17 US US09/690,265 patent/US6300351B1/en not_active Expired - Fee Related
-
2001
- 2001-07-13 US US09/904,979 patent/US6380190B1/en not_active Expired - Fee Related
-
2004
- 2004-10-12 US US10/964,976 patent/US20050153995A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US5998411A (en) | 1999-12-07 |
| US6180654B1 (en) | 2001-01-30 |
| EA200000958A1 (ru) | 2001-06-25 |
| DE69928779D1 (de) | 2006-01-12 |
| DE69928779T2 (de) | 2006-11-02 |
| JP2002506854A (ja) | 2002-03-05 |
| CN1301254A (zh) | 2001-06-27 |
| US6156759A (en) | 2000-12-05 |
| US6925388B1 (en) | 2005-08-02 |
| EP1528057A1 (de) | 2005-05-04 |
| AP2000001944A0 (en) | 2000-12-31 |
| US6380190B1 (en) | 2002-04-30 |
| EP1064263A2 (de) | 2001-01-03 |
| WO1999047501A3 (en) | 1999-12-02 |
| US6124307A (en) | 2000-09-26 |
| WO1999047501A2 (en) | 1999-09-23 |
| AU752010B2 (en) | 2002-09-05 |
| US20050153995A1 (en) | 2005-07-14 |
| EP1064263B1 (de) | 2005-12-07 |
| US6300351B1 (en) | 2001-10-09 |
| CA2323418A1 (en) | 1999-09-23 |
| AU3186499A (en) | 1999-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |