DE3751193D1 - Verfahren zur Herstellung von trockenem alpha-L-Aspartyl-L-phenylalaninmethylester. - Google Patents

Verfahren zur Herstellung von trockenem alpha-L-Aspartyl-L-phenylalaninmethylester.

Info

Publication number
DE3751193D1
DE3751193D1 DE3751193T DE3751193T DE3751193D1 DE 3751193 D1 DE3751193 D1 DE 3751193D1 DE 3751193 T DE3751193 T DE 3751193T DE 3751193 T DE3751193 T DE 3751193T DE 3751193 D1 DE3751193 D1 DE 3751193D1
Authority
DE
Germany
Prior art keywords
aspartyl
preparation
methyl ester
phenylalanine methyl
dry alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3751193T
Other languages
English (en)
Other versions
DE3751193T2 (de
Inventor
Hidetoshi Wakamatsu
Shigeaki Irino
Tsuneo Harada
Akira Tokuda
Kiyotaka Oyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Holland Sweetener Co VOF
Original Assignee
Holland Sweetener Co VOF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61187758A external-priority patent/JPH07103153B2/ja
Priority claimed from JP61188662A external-priority patent/JPH07103155B2/ja
Application filed by Holland Sweetener Co VOF filed Critical Holland Sweetener Co VOF
Publication of DE3751193D1 publication Critical patent/DE3751193D1/de
Application granted granted Critical
Publication of DE3751193T2 publication Critical patent/DE3751193T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
DE3751193T 1986-08-12 1987-08-12 Verfahren zur Herstellung von trockenem alpha-L-Aspartyl-L-phenylalaninmethylester. Expired - Fee Related DE3751193T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61187758A JPH07103153B2 (ja) 1986-08-12 1986-08-12 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
JP61188662A JPH07103155B2 (ja) 1986-08-13 1986-08-13 安定なα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法

Publications (2)

Publication Number Publication Date
DE3751193D1 true DE3751193D1 (de) 1995-05-04
DE3751193T2 DE3751193T2 (de) 1995-11-09

Family

ID=26504540

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751193T Expired - Fee Related DE3751193T2 (de) 1986-08-12 1987-08-12 Verfahren zur Herstellung von trockenem alpha-L-Aspartyl-L-phenylalaninmethylester.

Country Status (4)

Country Link
US (1) US4835303A (de)
EP (1) EP0256515B1 (de)
AU (1) AU606071B2 (de)
DE (1) DE3751193T2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543554A (en) * 1982-04-12 1996-08-06 Ajinomoto Co., Inc. Process for preparing dry crystals of the methyl ester of α-L-aspartyl-L-phenylalanine, having improved solubility
JPH07103152B2 (ja) * 1986-08-12 1995-11-08 東ソー株式会社 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
JPH0832719B2 (ja) * 1986-12-19 1996-03-29 三井東圧化学株式会社 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
JPH05194587A (ja) * 1992-01-14 1993-08-03 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの精製法
JP3409396B2 (ja) * 1993-11-19 2003-05-26 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造法
US6844465B2 (en) * 1998-10-30 2005-01-18 Ajinomoto Co., Inc. Method for preparing highly stable crystals of aspartame derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5742623A (en) * 1980-08-29 1982-03-10 Sawai Seiyaku Kk Antialcoholic adipohepatic agent
JPS5995862A (ja) * 1982-11-25 1984-06-02 Ajinomoto Co Inc ジペプチド甘味料顆粒の製造法
JPH0631312B2 (ja) * 1983-03-18 1994-04-27 味の素株式会社 ジペプチド結晶及びその製造方法
JPH0622457B2 (ja) * 1983-08-10 1994-03-30 味の素株式会社 ジペプチド甘味料含有錠剤又は顆粒及びその製造法
JPH0710878B2 (ja) * 1986-07-28 1995-02-08 東ソー株式会社 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
JPH07103152B2 (ja) * 1986-08-12 1995-11-08 東ソー株式会社 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
JPH07103154B2 (ja) * 1986-08-13 1995-11-08 東ソー株式会社 安定なα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法

Also Published As

Publication number Publication date
AU7681887A (en) 1988-02-18
US4835303A (en) 1989-05-30
EP0256515A3 (en) 1989-05-03
EP0256515B1 (de) 1995-03-29
EP0256515A2 (de) 1988-02-24
AU606071B2 (en) 1991-01-31
DE3751193T2 (de) 1995-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee