DE3750669D1 - Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit. - Google Patents
Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit.Info
- Publication number
- DE3750669D1 DE3750669D1 DE3750669T DE3750669T DE3750669D1 DE 3750669 D1 DE3750669 D1 DE 3750669D1 DE 3750669 T DE3750669 T DE 3750669T DE 3750669 T DE3750669 T DE 3750669T DE 3750669 D1 DE3750669 D1 DE 3750669D1
- Authority
- DE
- Germany
- Prior art keywords
- aspartyl
- alpha
- preparation
- methyl ester
- improved solubility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61187757A JPH07103152B2 (ja) | 1986-08-12 | 1986-08-12 | 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3750669D1 true DE3750669D1 (de) | 1994-11-24 |
| DE3750669T2 DE3750669T2 (de) | 1995-05-11 |
Family
ID=16211668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3750669T Expired - Fee Related DE3750669T2 (de) | 1986-08-12 | 1987-08-12 | Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalaninmethylester mit verbesserter Löslichkeit. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4831180A (de) |
| EP (1) | EP0256513B1 (de) |
| JP (1) | JPH07103152B2 (de) |
| AU (1) | AU590439B2 (de) |
| CA (1) | CA1319787C (de) |
| DE (1) | DE3750669T2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5543554A (en) * | 1982-04-12 | 1996-08-06 | Ajinomoto Co., Inc. | Process for preparing dry crystals of the methyl ester of α-L-aspartyl-L-phenylalanine, having improved solubility |
| US4835303A (en) * | 1986-08-12 | 1989-05-30 | Toyo Soda Manufacturing Company, Ltd. | Process for producing dry α-L-aspartyl-L-phenylalanine methyl ester |
| JPH07103154B2 (ja) * | 1986-08-13 | 1995-11-08 | 東ソー株式会社 | 安定なα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法 |
| EP0362706B1 (de) * | 1988-10-03 | 1996-01-17 | Ajinomoto Co., Inc. | Verfahren zur Herstellung von trockenen IB Kristallen des alpha-L-Aspartyl-L-phenylalaninmethylesters, die eine verbesserte Löslichkeit besitzen |
| JP2946853B2 (ja) * | 1991-05-09 | 1999-09-06 | 味の素株式会社 | アスパルテームの晶析法 |
| US5473097A (en) * | 1991-05-24 | 1995-12-05 | Ajinomoto Company, Inc. | Granules of α-L-aspartyl-L-phenylalanine methyl ester |
| JP2000026496A (ja) * | 1998-05-08 | 2000-01-25 | Ajinomoto Co Inc | 新規アスパルテーム誘導体結晶及びその製造法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5742623A (en) * | 1980-08-29 | 1982-03-10 | Sawai Seiyaku Kk | Antialcoholic adipohepatic agent |
| JPS5995862A (ja) * | 1982-11-25 | 1984-06-02 | Ajinomoto Co Inc | ジペプチド甘味料顆粒の製造法 |
| JPH0631312B2 (ja) * | 1983-03-18 | 1994-04-27 | 味の素株式会社 | ジペプチド結晶及びその製造方法 |
| JPH0710878B2 (ja) * | 1986-07-28 | 1995-02-08 | 東ソー株式会社 | 溶解性の改善されたα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法 |
| US4835303A (en) * | 1986-08-12 | 1989-05-30 | Toyo Soda Manufacturing Company, Ltd. | Process for producing dry α-L-aspartyl-L-phenylalanine methyl ester |
| JPH07103154B2 (ja) * | 1986-08-13 | 1995-11-08 | 東ソー株式会社 | 安定なα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法 |
| JPH0637949A (ja) * | 1992-07-17 | 1994-02-10 | Ricoh Co Ltd | ファクシミリ装置 |
-
1986
- 1986-08-12 JP JP61187757A patent/JPH07103152B2/ja not_active Expired - Lifetime
-
1987
- 1987-08-11 US US07/084,090 patent/US4831180A/en not_active Expired - Lifetime
- 1987-08-11 CA CA000544246A patent/CA1319787C/en not_active Expired - Fee Related
- 1987-08-12 DE DE3750669T patent/DE3750669T2/de not_active Expired - Fee Related
- 1987-08-12 AU AU76819/87A patent/AU590439B2/en not_active Ceased
- 1987-08-12 EP EP87111695A patent/EP0256513B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4831180A (en) | 1989-05-16 |
| EP0256513A2 (de) | 1988-02-24 |
| JPS6344592A (ja) | 1988-02-25 |
| DE3750669T2 (de) | 1995-05-11 |
| EP0256513A3 (en) | 1989-04-26 |
| JPH07103152B2 (ja) | 1995-11-08 |
| AU7681987A (en) | 1988-02-18 |
| AU590439B2 (en) | 1989-11-02 |
| EP0256513B1 (de) | 1994-10-19 |
| CA1319787C (en) | 1993-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |