DE3689684T2 - Cephemverbindungen und Verfahren zu ihrer Herstellung. - Google Patents

Cephemverbindungen und Verfahren zu ihrer Herstellung.

Info

Publication number
DE3689684T2
DE3689684T2 DE3689684T DE3689684T DE3689684T2 DE 3689684 T2 DE3689684 T2 DE 3689684T2 DE 3689684 T DE3689684 T DE 3689684T DE 3689684 T DE3689684 T DE 3689684T DE 3689684 T2 DE3689684 T2 DE 3689684T2
Authority
DE
Germany
Prior art keywords
processes
preparation
cephem compounds
cephem
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3689684T
Other languages
English (en)
Other versions
DE3689684D1 (de
Inventor
Takao Takaya
Kazuo Sakane
Kenzi Miyai
Kohji Kawabata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858528803A external-priority patent/GB8528803D0/en
Priority claimed from GB868610720A external-priority patent/GB8610720D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE3689684D1 publication Critical patent/DE3689684D1/de
Application granted granted Critical
Publication of DE3689684T2 publication Critical patent/DE3689684T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3689684T 1985-11-22 1986-11-19 Cephemverbindungen und Verfahren zu ihrer Herstellung. Expired - Fee Related DE3689684T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858528803A GB8528803D0 (en) 1985-11-22 1985-11-22 Cephem compounds
GB868610720A GB8610720D0 (en) 1986-05-01 1986-05-01 Cephem compounds

Publications (2)

Publication Number Publication Date
DE3689684D1 DE3689684D1 (de) 1994-04-07
DE3689684T2 true DE3689684T2 (de) 1994-06-23

Family

ID=26290033

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3689684T Expired - Fee Related DE3689684T2 (de) 1985-11-22 1986-11-19 Cephemverbindungen und Verfahren zu ihrer Herstellung.

Country Status (14)

Country Link
US (1) US4960766A (de)
EP (1) EP0223246B1 (de)
JP (1) JPH07116201B2 (de)
KR (1) KR940000111B1 (de)
CN (1) CN86107947A (de)
AU (1) AU6556186A (de)
DE (1) DE3689684T2 (de)
DK (1) DK560486A (de)
FI (1) FI864658A (de)
HU (1) HUT43079A (de)
IL (1) IL80669A0 (de)
NO (1) NO864674L (de)
OA (1) OA08444A (de)
PT (1) PT83794B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194432A (en) * 1985-11-22 1993-03-16 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
IL86941A (en) * 1987-07-10 1993-07-08 Gist Brocades Nv Process for the preparation of cephem compounds and some new cephalosporin derivatives prepared by this process
US5663163A (en) * 1987-09-07 1997-09-02 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
US5210080A (en) * 1987-09-07 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
IE63094B1 (en) * 1987-09-14 1995-03-22 Fujisawa Pharmaceutical Co Cephem compound and a process for preparation thereof
GB8905301D0 (en) * 1989-03-08 1989-04-19 Fujisawa Pharmaceutical Co New cephem compound and a process for preparation thereof
EP0517041A1 (de) * 1991-06-07 1992-12-09 Fujisawa Pharmaceutical Co., Ltd. Cephemverbindungen
AUPN955596A0 (en) * 1996-04-30 1996-05-23 Fujisawa Pharmaceutical Co., Ltd. New compound
US7847093B2 (en) * 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
EP1618114B1 (de) 2003-04-16 2010-07-14 Sandoz AG Verfahren zur herstellung von cefepim
WO2005019227A1 (en) * 2003-08-22 2005-03-03 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cephalosporin antibiotic
CN102336771A (zh) * 2011-07-11 2012-02-01 珠海联邦制药股份有限公司 一种硫酸头孢噻利中间体的制备方法
JP6151257B2 (ja) 2011-09-09 2017-06-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 肺内感染症の治療方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
EP3100732A1 (de) 2013-03-15 2016-12-07 Merck Sharp & Dohme Corp. Antibiotische ceftolozanzusammensetzungen
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
ES485439A1 (es) * 1978-10-27 1980-07-01 Glaxo Group Ltd Un procedimiento para la preparacion de antibioticos de ce- falosporina
ZA796130B (en) * 1978-11-15 1981-06-24 Glaxo Group Ltd Cephalosporin antibiotics
SE7909401L (sv) * 1978-11-15 1980-05-16 Glaxo Group Ltd Cefalosporinantibiotika
ES8103104A1 (es) * 1979-02-23 1981-02-16 Glaxo Group Ltd Un procedimiento para la preparacion de un antibiotico de cefalosporina.
GR78245B (de) * 1980-09-12 1984-09-26 Ciba Geigy Ag
EP0062321B1 (de) * 1981-04-03 1989-03-01 Fujisawa Pharmaceutical Co., Ltd. Cephalosporinderivate, Verfahren zu ihrer Herstellung, sie enthaltende pharmazeutische Präparate und ihre Ausgangsprodukte
JPS584789A (ja) * 1981-04-03 1983-01-11 Fujisawa Pharmaceut Co Ltd 新規セフエム化合物およびその製造法
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
GB2125033B (en) * 1982-07-23 1985-08-29 Servipharm Ltd Cephalosporins
DE3330605A1 (de) * 1983-08-25 1985-03-14 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
JPS6067483A (ja) * 1983-09-24 1985-04-17 Sankyo Co Ltd チアゾリオメチル置換基を有するセフアロスポリン誘導体
JPS6067484A (ja) * 1983-09-26 1985-04-17 Sankyo Co Ltd ピリダジニウムメチル置換基を有するセフアロスポリン誘導体
DE3336755A1 (de) * 1983-10-08 1985-04-25 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3336757A1 (de) * 1983-10-08 1985-04-25 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPH07116201B2 (ja) 1995-12-13
DE3689684D1 (de) 1994-04-07
JPS62174085A (ja) 1987-07-30
DK560486D0 (da) 1986-11-21
NO864674D0 (no) 1986-11-21
OA08444A (fr) 1988-06-30
FI864658A0 (fi) 1986-11-17
CN86107947A (zh) 1987-05-27
KR940000111B1 (ko) 1994-01-05
KR870004995A (ko) 1987-06-04
IL80669A0 (en) 1987-02-27
FI864658A (fi) 1987-05-23
EP0223246A2 (de) 1987-05-27
PT83794A (en) 1986-12-01
AU6556186A (en) 1987-05-28
EP0223246B1 (de) 1994-03-02
EP0223246A3 (en) 1988-11-23
HUT43079A (en) 1987-09-28
US4960766A (en) 1990-10-02
DK560486A (da) 1987-05-23
NO864674L (no) 1987-05-25
PT83794B (en) 1988-10-19

Similar Documents

Publication Publication Date Title
DE3885688T2 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung.
DE3780263T2 (de) Imidazopyridinverbindungen und verfahren zu ihrer herstellung.
DE3682874D1 (de) Pyranoindolizinderivate und verfahren zu ihrer herstellung.
DE3689684T2 (de) Cephemverbindungen und Verfahren zu ihrer Herstellung.
DE3650120D1 (de) Vermiculit-Dispersionen und Verfahren zu ihrer Herstellung.
DE3789243T2 (de) Naphthalocyaninverbindungen und Verfahren zu ihrer Herstellung.
DE3588039T2 (de) Azetidinonderivate und Verfahren zu ihrer Herstellung.
PT86826A (pt) Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE68923993T2 (de) Polymaleimid-Verbindungen und Verfahren zu ihrer Herstellung.
DE3786452T2 (de) Benzylether-Verbindungen und Verfahren zu ihrer Herstellung.
DE3685013D1 (de) Amino-trifluormethylpyridinverbindung und verfahren zu ihrer herstellung.
DE3673515D1 (de) Gonatrien-derivate und verfahren zu ihrer herstellung.
DE3677259D1 (de) Chinazolinonverbindungen und verfahren zu ihrer herstellung.
DE3788489T2 (de) Fe7C3-enthaltende Partikel und Verfahren zu ihrer Herstellung.
DE3880490T2 (de) Perfluoramino-oxaziridine und Verfahren zu ihrer Herstellung.
DE3688287T4 (de) Spirodiphosphoamidatverbindungen und Verfahren zu ihrer Herstellung.
DE68914500T2 (de) Alkylarylsulfone und Verfahren zu ihrer Herstellung.
ATE102209T1 (de) Cephemverbindungen und verfahren zu ihrer herstellung.
ATE60606T1 (de) Chinazolinonverbindungen und verfahren zu ihrer herstellung.
ATE78035T1 (de) Imidazopyridinverbindungen und verfahren zu ihrer herstellung.
PT86889A (pt) Cephalosporinderivate und verfahren zu ihrer herstellung
DE3678018D1 (de) 5-thiaprostaglandine-e1 und verfahren zu ihrer herstellung.
ATE79120T1 (de) Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
ATE97416T1 (de) Cephemverbindungen und verfahren zu ihrer herstellung.
DE3667173D1 (de) Ascorbinsaeure- oder erythorbinsaeurederivate und verfahren zu ihrer herstellung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee