DE3681185D1 - Methode zur aufloesung und naturation von somatotropin. - Google Patents

Methode zur aufloesung und naturation von somatotropin.

Info

Publication number
DE3681185D1
DE3681185D1 DE8686870023T DE3681185T DE3681185D1 DE 3681185 D1 DE3681185 D1 DE 3681185D1 DE 8686870023 T DE8686870023 T DE 8686870023T DE 3681185 T DE3681185 T DE 3681185T DE 3681185 D1 DE3681185 D1 DE 3681185D1
Authority
DE
Germany
Prior art keywords
naturation
somatotropin
solution
protein
dimethylsulfone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686870023T
Other languages
English (en)
Inventor
Larry Andrew Bentle
James William Mitchell
Stephen Bradley Storrs
Grant Tsuyoshi Shimamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Technology LLC
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107301&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3681185(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/704,677 external-priority patent/US4652630A/en
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of DE3681185D1 publication Critical patent/DE3681185D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
DE8686870023T 1985-02-22 1986-02-21 Methode zur aufloesung und naturation von somatotropin. Expired - Fee Related DE3681185D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70434185A 1985-02-22 1985-02-22
US06/704,677 US4652630A (en) 1985-02-22 1985-02-22 Method of somatotropin naturation

Publications (1)

Publication Number Publication Date
DE3681185D1 true DE3681185D1 (de) 1991-10-10

Family

ID=27107301

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686870023T Expired - Fee Related DE3681185D1 (de) 1985-02-22 1986-02-21 Methode zur aufloesung und naturation von somatotropin.

Country Status (14)

Country Link
EP (1) EP0192629B2 (de)
JP (1) JP2572963B2 (de)
KR (1) KR890003082B1 (de)
CN (1) CN1010097B (de)
AT (1) ATE66930T1 (de)
AU (3) AU587423B2 (de)
CA (1) CA1268300A (de)
DE (1) DE3681185D1 (de)
DK (1) DK172526B1 (de)
ES (1) ES8800957A1 (de)
IE (1) IE58871B1 (de)
IL (1) IL77951A (de)
NZ (1) NZ215259A (de)
SU (1) SU1542402A3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
US4985544A (en) * 1987-08-04 1991-01-15 Kyowa Hakko Kogyo Co., Ltd. Process for renaturing fish growth hormone
JP2669859B2 (ja) * 1987-08-04 1997-10-29 協和醗酵工業株式会社 タンパク質の再活性化法
JPH01132598A (ja) * 1987-10-14 1989-05-25 Pitman Moore Inc 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法
JPH01257491A (ja) * 1988-04-08 1989-10-13 Tosoh Corp 不溶性融合異種蛋白質の処理方法
US5089473A (en) 1988-08-29 1992-02-18 Monsanto Company Somatotropin variants and their use
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US5064943A (en) * 1988-12-16 1991-11-12 American Cyanamid Company Method for solubilization and naturation of somatotropin
JP2517100B2 (ja) * 1989-03-08 1996-07-24 協和醗酵工業株式会社 ヒト顆粒球コロニ―刺激因子活性を有する蛋白質の精製法
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
US5023323A (en) * 1990-09-12 1991-06-11 Monsanto Company Method of somatotropin naturation
WO1995032222A1 (en) * 1994-05-19 1995-11-30 Monsanto Company Method for purifying somatotropin monomers
JPH11505507A (ja) * 1994-07-25 1999-05-21 ノバルティス アクチェンゲゼルシャフト 組換えヒルジンまたは表皮増殖因子のようなタンパク質の折りたたみ方法
ZA9711733B (en) 1996-12-31 1998-07-01 Monsanto Co Method for solubilization and naturation of somatotropins
EP0984789A2 (de) * 1997-06-27 2000-03-15 Monsanto Company Somatotropin zur beschleunigung des wachstums eines tierischen hufs
WO2007014170A2 (en) * 2005-07-25 2007-02-01 Trubion Pharmaceuticals, Inc. Compositions and methods for protein deaggregation
JP4766052B2 (ja) 2005-11-24 2011-09-07 株式会社村田製作所 電気音響変換器
RU2385877C1 (ru) 2005-12-22 2010-04-10 Дженентек, Инк. Рекомбинантное получение связывающих гепарин белков
EP2041154B1 (de) * 2006-07-14 2018-12-12 Genentech, Inc. Rückfaltung rekombinanter proteine
US11959125B2 (en) 2016-09-15 2024-04-16 Sun Genomics, Inc. Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample
CN110249048A (zh) * 2016-09-15 2019-09-17 太阳基因组学公司 用于从样品中的一种或多种类型的微生物的多样性群体中提取核酸分子的通用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59500996A (ja) * 1982-06-07 1984-06-07 セルテク　リミテツド キモシンの生産方法
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
JPH06102034B2 (ja) * 1983-03-25 1994-12-14 セルテク リミテツド タンパク質の生産方法

Also Published As

Publication number Publication date
ES552233A0 (es) 1987-12-01
AU5385386A (en) 1986-08-28
KR890003082B1 (ko) 1989-08-21
KR860006541A (ko) 1986-09-13
EP0192629A3 (en) 1988-07-27
NZ215259A (en) 1989-11-28
JPS61195698A (ja) 1986-08-29
IL77951A (en) 1990-11-05
JP2572963B2 (ja) 1997-01-16
AU618386B2 (en) 1991-12-19
ES8800957A1 (es) 1987-12-01
CN1010097B (zh) 1990-10-24
EP0192629A2 (de) 1986-08-27
CA1268300C (en) 1990-04-24
AU621111B2 (en) 1992-03-05
CN86100915A (zh) 1986-08-20
ATE66930T1 (de) 1991-09-15
IE860466L (en) 1986-08-22
EP0192629B1 (de) 1991-09-04
AU3925889A (en) 1990-04-05
AU587423B2 (en) 1989-08-17
CA1268300A (en) 1990-04-24
IE58871B1 (en) 1993-11-17
DK172526B1 (da) 1998-11-16
SU1542402A3 (ru) 1990-02-07
DK80986D0 (da) 1986-02-21
DK80986A (da) 1986-08-23
AU3498089A (en) 1989-09-14
EP0192629B2 (de) 1997-03-05

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: MONSANTO TECHNOLOGY LLC, ST. LOUIS, MO., US

8339 Ceased/non-payment of the annual fee