DE3671244D1 - Fusionspolypeptid mit antigener wirkung. - Google Patents

Fusionspolypeptid mit antigener wirkung.

Info

Publication number
DE3671244D1
DE3671244D1 DE8686111884T DE3671244T DE3671244D1 DE 3671244 D1 DE3671244 D1 DE 3671244D1 DE 8686111884 T DE8686111884 T DE 8686111884T DE 3671244 T DE3671244 T DE 3671244T DE 3671244 D1 DE3671244 D1 DE 3671244D1
Authority
DE
Germany
Prior art keywords
antigent
effect
fusion polypeptide
polypeptide
fusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686111884T
Other languages
English (en)
Inventor
Tetsuro Kuga
Susumu Sekine
Seiga Itoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE3671244D1 publication Critical patent/DE3671244D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • AIDS & HIV (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DE8686111884T 1985-08-28 1986-08-27 Fusionspolypeptid mit antigener wirkung. Expired - Lifetime DE3671244D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60188868A JP2564268B2 (ja) 1985-08-28 1985-08-28 融合抗原ポリペプチド

Publications (1)

Publication Number Publication Date
DE3671244D1 true DE3671244D1 (de) 1990-06-21

Family

ID=16231274

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198686111884T Pending DE214555T1 (de) 1985-08-28 1986-08-27 Fusionspolypeptid mit antigener wirkung.
DE8686111884T Expired - Lifetime DE3671244D1 (de) 1985-08-28 1986-08-27 Fusionspolypeptid mit antigener wirkung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198686111884T Pending DE214555T1 (de) 1985-08-28 1986-08-27 Fusionspolypeptid mit antigener wirkung.

Country Status (5)

Country Link
US (2) US4939094A (de)
EP (1) EP0214555B1 (de)
JP (1) JP2564268B2 (de)
CA (1) CA1306209C (de)
DE (2) DE214555T1 (de)

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JP2501569B2 (ja) * 1986-11-14 1996-05-29 協和醗酵工業株式会社 抗成人ｔ細胞白血病ウイルス抗体の検出法
US5614366A (en) * 1986-12-31 1997-03-25 Genelabs Technologies, Inc. HTLV-I peptide antigens and kit
US5643714A (en) * 1986-12-31 1997-07-01 Genelabs Technologies, Inc. Method and assay for HTLV
EP0307149B1 (de) * 1987-09-04 1993-01-07 International Murex Technologies Corporation Festphasenimmunoassay für einen Antikörper und hierbei verwendete biologische Produkte
US5017687A (en) * 1988-03-10 1991-05-21 Virovahl, S.A. Peptides for the detection of HTLV-1 infection
AU611784B2 (en) * 1988-04-22 1991-06-20 Pharmacia & Upjohn Company Chimeric glycoproteins containing immunogenic segments of human parainfluenza virus type 3
EP0345792A3 (de) * 1988-06-10 1991-05-02 F. Hoffmann-La Roche Ag HTLV-1/HIV-1-Fusionsproteine
CA2003383A1 (en) 1988-11-23 1990-05-23 Sushil G. Devare Synthetic dna derived recombinant hiv antigens
AU5827590A (en) * 1989-06-01 1991-01-07 E.I. Du Pont De Nemours And Company Htlv-1 env gene products expressed in (e. coli)
EP0424748B1 (de) * 1989-10-23 1995-05-10 F. Hoffmann-La Roche Ag Synthetische HTLV-I Hüll-Peptide
IE904083A1 (en) * 1989-11-13 1991-05-22 Cambridge Biotech Corp Diagnostic proteins to test for more than one antibody
DE4420742A1 (de) * 1993-10-20 1995-04-27 Boehringer Mannheim Gmbh Synthetischer Standard für Immunoassays
US6982323B1 (en) * 1997-12-23 2006-01-03 Alexion Pharmaceuticals, Inc. Chimeric proteins for diagnosis and treatment of diabetes
WO1999032136A1 (en) * 1997-12-23 1999-07-01 Alexion Pharmaceuticals, Inc. Chimeric proteins for the treatment of diabetes
CA2736981A1 (en) 1998-04-14 1999-10-21 Kyowa Hakko Bio Co., Ltd. Process for producing isoprenoid compounds by microorganisms
AU3956399A (en) 1998-06-02 1999-12-20 Kyowa Hakko Kogyo Co. Ltd. Iga nephropathy-associated dna
EP1295939A4 (de) 2000-06-15 2005-02-02 Kyowa Hakko Kogyo Kk Insulin-ähnliches wachstumsfaktor bindendes protein
EP1371727A4 (de) * 2001-02-22 2004-07-28 Gencom Corp Rekombinantes gen, welches eine umgekehrte repeat-sequenz enthält und verwendung derselben
AU2002251533B2 (en) * 2001-04-25 2006-09-28 Institut National De La Recherche Agronomique Protein involved in restoration of cytoplasmic male sterility to fertility and gene encoding the protein and gene
US20040117868A1 (en) * 2002-01-29 2004-06-17 Jun Imamura Protein participating in restoration from cytoplasmic male sterility to fertility and gene encoding the same
US6995236B2 (en) * 2001-05-08 2006-02-07 Riken Sphingomyelin detecting probe
WO2003027296A1 (fr) * 2001-09-20 2003-04-03 Plantech Research Institute Genes intervenant dans la synthese d'acide gras presentant une liaison double conjuguee trans-11-, cis-13-, et utilisation desdits genes
JP2003144141A (ja) * 2001-11-14 2003-05-20 Gencom Co ＲＮＡｉ効果が増強したＥＳ細胞
WO2003095660A1 (en) 2002-05-08 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Process for producing cytidine 5’-diphocphate choline
JP4171256B2 (ja) * 2002-07-18 2008-10-22 三菱化学株式会社 パピローマウイルスベクターを用いたＲＮＡｉ表現型を有する非ヒト哺乳動物の作製方法
CA2497338A1 (en) 2002-08-30 2004-03-18 Japan Science And Technology Corporation Method of targeted gene disruption, genome of hyperthermostable bacterium and genome chip using the same
JP2004180641A (ja) * 2002-12-06 2004-07-02 Gencom Co ＲＮＡｉ表現型を有する非ヒト哺乳動物の作製方法
US20090270314A1 (en) 2005-09-29 2009-10-29 Tohoku University Polypeptide having anti-angiogenic activity
US8093362B2 (en) 2005-12-06 2012-01-10 Kyowa Hakko Kirin Co., Ltd. Anti-PERP recombinant antibody
JP5592059B2 (ja) 2005-12-27 2014-09-17 協和発酵バイオ株式会社 Ｌ−グルタミンの製造法
KR20090029227A (ko) 2006-06-06 2009-03-20 교와 핫꼬 기린 가부시키가이샤 헤파린 결합 상피세포 증식 인자 유사 증식 인자에 결합하는 모노클로날 항체
EP2138576A4 (de) 2007-03-16 2011-02-23 Kyowa Hakko Kirin Co Ltd Anti-claudin-4-antikörper
WO2008123308A1 (ja) 2007-03-29 2008-10-16 National University Corporation Okayama University バソヒビン含有治療剤
JP5550041B2 (ja) 2007-09-27 2014-07-16 塩野義製薬株式会社 チトクロームｐ４５０を用いたアダマンタン水酸化体の製造方法
WO2009072628A1 (ja) 2007-12-05 2009-06-11 Kyowa Hakko Kirin Co., Ltd. ヘパリン結合上皮細胞増殖因子様増殖因子に結合するモノクローナル抗体
CA2729567C (en) 2008-06-30 2018-04-24 Kyowa Hakko Kirin Co., Ltd. Anti-cd27 antibody
EP2311946B1 (de) 2008-07-17 2016-04-06 Kyowa Hakko Kirin Co., Ltd. Antikörper gegen system-asc-aminosäuretransporter 2 (asct2)
PL2374883T3 (pl) 2008-12-26 2017-05-31 Kyowa Hakko Kirin Co., Ltd. Przeciwciało anty-CD4
PL2423228T3 (pl) 2009-04-20 2016-06-30 Kyowa Hakko Kirin Co Ltd Przeciwciało zawierające IGG2 mającą wprowadzoną do niej mutację aminokwasową
PL2581113T3 (pl) 2010-06-11 2018-11-30 Kyowa Hakko Kirin Co., Ltd. Przeciwciało anty-tim-3
AU2012274461A1 (en) 2011-06-20 2014-01-16 Kyowa Hakko Kirin Co., Ltd. Anti-erbB3 antibody
CA2874117C (en) 2012-07-02 2021-10-12 Kyowa Hakko Kirin Co., Ltd. Pharmaceutical agent comprising anti-bmp9 antibody as active ingredient for treatment of anemia such as renal anemia and cancer anemia
AU2013355931B2 (en) 2012-12-07 2019-03-14 Kyowa Kirin Co., Ltd. Anti-FOLR1 antibody
EP2913338A1 (de) * 2014-02-28 2015-09-02 Roche Diagniostics GmbH Lösliche und immunoreaktive Varianten von HTLV-Antigen-Kapsid P24
CN115011572A (zh) 2016-03-04 2022-09-06 国立大学法人新潟大学 变异型四异戊烯基-β-姜黄烯环化酶及龙涎香醇的制备方法
EP3492591A4 (de) 2016-07-26 2020-04-01 Shizuoka Prefecture Anti-b7-h4-antikörper
EP3498856A4 (de) 2016-08-10 2020-05-06 Spiber Inc. Verfahren zur herstellung eines unlöslichen rekombinanten proteinaggregats
US20190225646A1 (en) 2016-10-03 2019-07-25 Spiber Inc. Method for Purifying Recombinant Protein
JP6577691B2 (ja) 2017-07-13 2019-09-18 協和キリン株式会社 抗ｂｒｉｌ抗体及び該抗体を用いたｂｒｉｌ融合タンパク質の安定化方法
WO2019017401A1 (ja) 2017-07-18 2019-01-24 協和発酵キリン株式会社 抗ヒトｃｃｒ１モノクローナル抗体
WO2019022163A1 (ja) 2017-07-26 2019-01-31 Ｓｐｉｂｅｒ株式会社 改変フィブロイン
EP3677683A4 (de) 2017-09-01 2021-08-04 Niigata University Effizientes verfahren zur herstellung von ambrein
EP3708589A4 (de) 2017-11-08 2021-08-11 Kyowa Kirin Co., Ltd. Bispezifischer antikörper, der an cd40 und epcam bindet
AU2018384239A1 (en) 2017-12-12 2020-07-02 Kyowa Kirin Co., Ltd. Anti-BMP10 antibody, and therapeutic agent for hypertension and hypertensive diseases comprising said antibody as active ingredient
CN112424357A (zh) 2018-06-26 2021-02-26 协和麒麟株式会社 与硫酸软骨素蛋白聚糖5结合的抗体
JP7397445B2 (ja) 2018-06-26 2023-12-13 協和キリン株式会社 Ｃｅｌｌ Ａｄｈｅｓｉｏｎ Ｍｏｌｅｃｕｌｅ３に結合する抗体
EP3903816A4 (de) 2018-12-28 2022-09-07 Kyowa Kirin Co., Ltd. An tfr bindende bispezifische antikörperbindung
WO2020145363A1 (ja) 2019-01-09 2020-07-16 Ｓｐｉｂｅｒ株式会社 改変フィブロイン
BR112021014805A2 (pt) 2019-01-31 2022-01-04 Spiber Inc Métodos de produção para uma proteína recombinante e para aumentar o volume de produção
TW202108625A (zh) 2019-05-15 2021-03-01 日商協和麒麟股份有限公司 與cd40及gpc3結合之雙專一性抗體
JPWO2020230899A1 (de) 2019-05-15 2020-11-19
TW202140561A (zh) 2020-02-14 2021-11-01 日商協和麒麟股份有限公司 與cd3結合之雙特異性抗體
JPWO2021187502A1 (de) 2020-03-16 2021-09-23
JPWO2023027177A1 (de) 2021-08-26 2023-03-02

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Also Published As

Publication number Publication date
JP2564268B2 (ja) 1996-12-18
US5082776A (en) 1992-01-21
DE214555T1 (de) 1987-09-24
US4939094A (en) 1990-07-03
JPS6248699A (ja) 1987-03-03
EP0214555B1 (de) 1990-05-16
EP0214555A1 (de) 1987-03-18
CA1306209C (en) 1992-08-11

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