DE3543021A1 - Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte - Google Patents

Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte

Info

Publication number
DE3543021A1
DE3543021A1 DE19853543021 DE3543021A DE3543021A1 DE 3543021 A1 DE3543021 A1 DE 3543021A1 DE 19853543021 DE19853543021 DE 19853543021 DE 3543021 A DE3543021 A DE 3543021A DE 3543021 A1 DE3543021 A1 DE 3543021A1
Authority
DE
Germany
Prior art keywords
threo
aminodiol
hcl
thiamphenicol
hydrochloric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19853543021
Other languages
German (de)
English (en)
Other versions
DE3543021C2 (cg-RX-API-DMAC10.html
Inventor
Helmut Dr Rer Nat Dick
Wolf-Dietrich Dr Rer Na Gradel
Mathias Dr Rer Nat Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6287716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3543021(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19853543021 priority Critical patent/DE3543021A1/de
Priority to ES86116667T priority patent/ES2008668B3/es
Priority to US06/936,173 priority patent/US4945181A/en
Priority to EP86116667A priority patent/EP0224902B1/de
Priority to AT86116667T priority patent/ATE42094T1/de
Priority to DE8686116667T priority patent/DE3662786D1/de
Priority to JP61287879A priority patent/JPS62132852A/ja
Publication of DE3543021A1 publication Critical patent/DE3543021A1/de
Publication of DE3543021C2 publication Critical patent/DE3543021C2/de
Application granted granted Critical
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19853543021 1985-12-05 1985-12-05 Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte Granted DE3543021A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19853543021 DE3543021A1 (de) 1985-12-05 1985-12-05 Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte
AT86116667T ATE42094T1 (de) 1985-12-05 1986-12-01 Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl)-2-dichlorace amido- propandiol-1,3-(thiamphenicol)sowie verwendung geeigneter zwischenprodukte.
US06/936,173 US4945181A (en) 1985-12-05 1986-12-01 Method for resolution of racemic thiamphenicol precursors and intermediates therefor
EP86116667A EP0224902B1 (de) 1985-12-05 1986-12-01 Verbesserte Verfahren zur Herstellung von D-threo-1-(p-Methylsulfonylphenyl)-2-dichloracetamido-propandiol-1,3-(Thiamphenicol)sowie Verwendung geeigneter Zwischenprodukte
ES86116667T ES2008668B3 (es) 1985-12-05 1986-12-01 Procedimiento perfeccionado para la obtencion de d - treo - 1(p - metilsulfonilfenil) - 2 - dicloroacetamida - propandiol - 1,3 (tiamfenicol), asi como la utilizacion de los productos intermedios adecuados.
DE8686116667T DE3662786D1 (en) 1985-12-05 1986-12-01 Process for the preparation of d-threo-1(p-methylsulfonylphenyl)-2-dichloracetamido-propandiol-1,3-(thiamphenicol)and use of suitable intermediate products
JP61287879A JPS62132852A (ja) 1985-12-05 1986-12-04 チアムフエニコ−ル（１）の製法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853543021 DE3543021A1 (de) 1985-12-05 1985-12-05 Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte

Publications (2)

Publication Number Publication Date
DE3543021A1 true DE3543021A1 (de) 1987-06-11
DE3543021C2 DE3543021C2 (cg-RX-API-DMAC10.html) 1988-04-14

Family

ID=6287716

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19853543021 Granted DE3543021A1 (de) 1985-12-05 1985-12-05 Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte
DE8686116667T Expired DE3662786D1 (en) 1985-12-05 1986-12-01 Process for the preparation of d-threo-1(p-methylsulfonylphenyl)-2-dichloracetamido-propandiol-1,3-(thiamphenicol)and use of suitable intermediate products

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8686116667T Expired DE3662786D1 (en) 1985-12-05 1986-12-01 Process for the preparation of d-threo-1(p-methylsulfonylphenyl)-2-dichloracetamido-propandiol-1,3-(thiamphenicol)and use of suitable intermediate products

Country Status (6)

Country Link
US (1) US4945181A (cg-RX-API-DMAC10.html)
EP (1) EP0224902B1 (cg-RX-API-DMAC10.html)
JP (1) JPS62132852A (cg-RX-API-DMAC10.html)
AT (1) ATE42094T1 (cg-RX-API-DMAC10.html)
DE (2) DE3543021A1 (cg-RX-API-DMAC10.html)
ES (1) ES2008668B3 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02771A (ja) * 1988-01-08 1990-01-05 Nippon Zeon Co Ltd チアンフェニコールの製造法
US5346828A (en) * 1991-03-27 1994-09-13 Celgene Corporation Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
IT1318459B1 (it) * 2000-04-11 2003-08-25 Zambon Spa Uso del tiamfenicolo e di suoi derivati per la preparazione dicomposizioni farmaceutiche utili per il trattamento di infezioni da
EP1785414A1 (en) * 2005-11-09 2007-05-16 KRKA, tovarna zdravil, d.d., Novo mesto Process for the synthesis of intermediates of chloramphenicol or its analogues

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB745900A (en) * 1951-10-01 1956-03-07 Sterling Drug Inc Acylaminodiols and method for preparing same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA526865A (en) * 1956-06-26 A. Gregory Walter Substituted sulfonylphenyl-amido-1,3-propanediols and process for preparing them
GB770277A (en) * 1952-08-23 1957-03-20 Parke Davis & Co Amino-propanediols and their derivatives
US2791595A (en) * 1953-01-14 1957-05-07 Parke Davis & Co Long chain esters of nitrophenylaminopropanediols and preparation thereof
US2742500A (en) * 1953-12-22 1956-04-17 Du Pont Resolution of phenylaminopropanediols and intermediates
US2726266A (en) * 1954-05-10 1955-12-06 Du Pont Antibacterial composition containing diastereoisomers of 1-(p-methylsul-fonylphenyl)-2-(alpha, alpha-dichlo-roacetamido)-1, 3-propanediol
CH589617A5 (cg-RX-API-DMAC10.html) * 1973-11-22 1977-07-15 Hoffmann La Roche
US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
US4582918A (en) * 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB745900A (en) * 1951-10-01 1956-03-07 Sterling Drug Inc Acylaminodiols and method for preparing same

Also Published As

Publication number Publication date
EP0224902A1 (de) 1987-06-10
DE3662786D1 (en) 1989-05-18
JPS62132852A (ja) 1987-06-16
EP0224902B1 (de) 1989-04-12
DE3543021C2 (cg-RX-API-DMAC10.html) 1988-04-14
US4945181A (en) 1990-07-31
ATE42094T1 (de) 1989-04-15
ES2008668B3 (es) 1989-08-01

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee