DE3376978D1 - Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids - Google Patents
Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acidsInfo
- Publication number
- DE3376978D1 DE3376978D1 DE8383305895T DE3376978T DE3376978D1 DE 3376978 D1 DE3376978 D1 DE 3376978D1 DE 8383305895 T DE8383305895 T DE 8383305895T DE 3376978 T DE3376978 T DE 3376978T DE 3376978 D1 DE3376978 D1 DE 3376978D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- salts
- quinazolinone
- lower alkyl
- alkanoic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Manufacture Of Tobacco Products (AREA)
Abstract
Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3376978D1 true DE3376978D1 (en) | 1988-07-14 |
Family
ID=23708017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686201912T Expired - Lifetime DE3382013D1 (en) | 1982-09-30 | 1983-09-29 | SUBSTITUTED CHINAZOLINONES. |
| DE8383305895T Expired DE3376978D1 (en) | 1982-09-30 | 1983-09-29 | Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686201912T Expired - Lifetime DE3382013D1 (en) | 1982-09-30 | 1983-09-29 | SUBSTITUTED CHINAZOLINONES. |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (en) |
| AT (2) | ATE34979T1 (en) |
| DE (2) | DE3382013D1 (en) |
| ES (4) | ES526133A0 (en) |
| HU (1) | HU192242B (en) |
| IL (1) | IL69849A (en) |
| NO (1) | NO833541L (en) |
| NZ (1) | NZ205685A (en) |
| PH (2) | PH19508A (en) |
| RO (2) | RO87466B (en) |
| SG (1) | SG31887G (en) |
| YU (2) | YU196983A (en) |
| ZW (1) | ZW20883A1 (en) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-29 HU HU833392A patent/HU192242B/en unknown
- 1983-09-29 RO RO112200A patent/RO87466B/en unknown
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/en not_active Expired - Lifetime
- 1983-09-29 AT AT83305895T patent/ATE34979T1/en active
- 1983-09-29 AT AT86201912T patent/ATE58531T1/en not_active IP Right Cessation
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/en unknown
- 1983-09-29 ES ES526133A patent/ES526133A0/en active Granted
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/en not_active Expired
- 1983-09-29 RO RO83116473A patent/RO89787A/en unknown
- 1983-09-29 NO NO833541A patent/NO833541L/en unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/en not_active Application Discontinuation
- 1983-09-30 YU YU01969/83A patent/YU196983A/en unknown
-
1984
- 1984-05-29 ES ES532920A patent/ES532920A0/en active Granted
- 1984-05-29 ES ES532919A patent/ES532919A0/en active Granted
- 1984-05-29 ES ES532918A patent/ES532918A0/en active Granted
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/en unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZW20883A1 (en) | 1985-05-01 |
| DE3382013D1 (en) | 1991-01-03 |
| HU192242B (en) | 1988-10-28 |
| ATE58531T1 (en) | 1990-12-15 |
| PH21757A (en) | 1988-02-18 |
| RO87466A (en) | 1985-08-31 |
| NO833541L (en) | 1984-04-02 |
| ATE34979T1 (en) | 1988-06-15 |
| YU196983A (en) | 1987-02-28 |
| ES8507510A1 (en) | 1985-09-01 |
| RO89787A (en) | 1986-07-30 |
| ES8507512A1 (en) | 1985-09-01 |
| ES532920A0 (en) | 1985-09-01 |
| NZ205685A (en) | 1987-03-31 |
| ES8503671A1 (en) | 1985-03-16 |
| ES532918A0 (en) | 1985-09-01 |
| ES8507511A1 (en) | 1985-09-01 |
| ES532919A0 (en) | 1985-09-01 |
| PH19508A (en) | 1986-05-14 |
| IL69849A0 (en) | 1983-12-30 |
| ES526133A0 (en) | 1985-03-16 |
| SG31887G (en) | 1987-07-17 |
| IL69849A (en) | 1987-11-30 |
| RO87466B (en) | 1985-08-31 |
| YU192285A (en) | 1987-12-31 |
| KR840006218A (en) | 1984-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |