ATE34979T1 - ORTHOSUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS. - Google Patents
ORTHOSUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS.Info
- Publication number
- ATE34979T1 ATE34979T1 AT83305895T AT83305895T ATE34979T1 AT E34979 T1 ATE34979 T1 AT E34979T1 AT 83305895 T AT83305895 T AT 83305895T AT 83305895 T AT83305895 T AT 83305895T AT E34979 T1 ATE34979 T1 AT E34979T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- salts
- lower alkyl
- orthosubstituted
- quinazolinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Manufacture Of Tobacco Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
| EP83305895A EP0107398B1 (en) | 1982-09-30 | 1983-09-29 | Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE34979T1 true ATE34979T1 (en) | 1988-06-15 |
Family
ID=23708017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86201912T ATE58531T1 (en) | 1982-09-30 | 1983-09-29 | SUBSTITUTED CHINAZOLINONES. |
| AT83305895T ATE34979T1 (en) | 1982-09-30 | 1983-09-29 | ORTHOSUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86201912T ATE58531T1 (en) | 1982-09-30 | 1983-09-29 | SUBSTITUTED CHINAZOLINONES. |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (en) |
| AT (2) | ATE58531T1 (en) |
| DE (2) | DE3382013D1 (en) |
| ES (4) | ES8503671A1 (en) |
| HU (1) | HU192242B (en) |
| IL (1) | IL69849A (en) |
| NO (1) | NO833541L (en) |
| NZ (1) | NZ205685A (en) |
| PH (2) | PH19508A (en) |
| RO (2) | RO87466B (en) |
| SG (1) | SG31887G (en) |
| YU (2) | YU196983A (en) |
| ZW (1) | ZW20883A1 (en) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/en unknown
- 1983-09-29 ES ES526133A patent/ES8503671A1/en not_active Expired
- 1983-09-29 RO RO112200A patent/RO87466B/en unknown
- 1983-09-29 AT AT86201912T patent/ATE58531T1/en not_active IP Right Cessation
- 1983-09-29 RO RO83116473A patent/RO89787A/en unknown
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/en not_active Expired - Lifetime
- 1983-09-29 AT AT83305895T patent/ATE34979T1/en active
- 1983-09-29 NO NO833541A patent/NO833541L/en unknown
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/en not_active Expired
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/en unknown
- 1983-09-29 HU HU833392A patent/HU192242B/en unknown
- 1983-09-30 YU YU01969/83A patent/YU196983A/en unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/en not_active Application Discontinuation
-
1984
- 1984-05-29 ES ES532918A patent/ES8507510A1/en not_active Expired
- 1984-05-29 ES ES532919A patent/ES532919A0/en active Granted
- 1984-05-29 ES ES532920A patent/ES532920A0/en active Granted
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/en unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ205685A (en) | 1987-03-31 |
| HU192242B (en) | 1988-10-28 |
| SG31887G (en) | 1987-07-17 |
| RO89787A (en) | 1986-07-30 |
| ES8507511A1 (en) | 1985-09-01 |
| ES526133A0 (en) | 1985-03-16 |
| YU196983A (en) | 1987-02-28 |
| PH19508A (en) | 1986-05-14 |
| DE3376978D1 (en) | 1988-07-14 |
| KR840006218A (en) | 1984-11-22 |
| IL69849A0 (en) | 1983-12-30 |
| ES532918A0 (en) | 1985-09-01 |
| ES8503671A1 (en) | 1985-03-16 |
| ES8507512A1 (en) | 1985-09-01 |
| ZW20883A1 (en) | 1985-05-01 |
| ES8507510A1 (en) | 1985-09-01 |
| PH21757A (en) | 1988-02-18 |
| ES532920A0 (en) | 1985-09-01 |
| NO833541L (en) | 1984-04-02 |
| RO87466A (en) | 1985-08-31 |
| IL69849A (en) | 1987-11-30 |
| ES532919A0 (en) | 1985-09-01 |
| RO87466B (en) | 1985-08-31 |
| YU192285A (en) | 1987-12-31 |
| DE3382013D1 (en) | 1991-01-03 |
| ATE58531T1 (en) | 1990-12-15 |
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