RO89787A - PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES - Google Patents
PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONESInfo
- Publication number
- RO89787A RO89787A RO83116473A RO11647383A RO89787A RO 89787 A RO89787 A RO 89787A RO 83116473 A RO83116473 A RO 83116473A RO 11647383 A RO11647383 A RO 11647383A RO 89787 A RO89787 A RO 89787A
- Authority
- RO
- Romania
- Prior art keywords
- alkyl
- salts
- lower alkyl
- substd
- quat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Manufacture Of Tobacco Products (AREA)
Abstract
Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO89787A true RO89787A (en) | 1986-07-30 |
Family
ID=23708017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO112200A RO87466B (en) | 1982-09-30 | 1983-09-29 | Process for preparing substituted quinazolinones |
| RO83116473A RO89787A (en) | 1982-09-30 | 1983-09-29 | PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO112200A RO87466B (en) | 1982-09-30 | 1983-09-29 | Process for preparing substituted quinazolinones |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (en) |
| AT (2) | ATE34979T1 (en) |
| DE (2) | DE3376978D1 (en) |
| ES (4) | ES8503671A1 (en) |
| HU (1) | HU192242B (en) |
| IL (1) | IL69849A (en) |
| NO (1) | NO833541L (en) |
| NZ (1) | NZ205685A (en) |
| PH (2) | PH19508A (en) |
| RO (2) | RO87466B (en) |
| SG (1) | SG31887G (en) |
| YU (2) | YU196983A (en) |
| ZW (1) | ZW20883A1 (en) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/en unknown
- 1983-09-29 AT AT83305895T patent/ATE34979T1/en active
- 1983-09-29 ES ES526133A patent/ES8503671A1/en not_active Expired
- 1983-09-29 RO RO112200A patent/RO87466B/en unknown
- 1983-09-29 RO RO83116473A patent/RO89787A/en unknown
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/en not_active Expired
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/en not_active Expired - Lifetime
- 1983-09-29 NO NO833541A patent/NO833541L/en unknown
- 1983-09-29 AT AT86201912T patent/ATE58531T1/en not_active IP Right Cessation
- 1983-09-29 HU HU833392A patent/HU192242B/en unknown
- 1983-09-30 YU YU01969/83A patent/YU196983A/en unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/en not_active Application Discontinuation
-
1984
- 1984-05-29 ES ES532920A patent/ES8507512A1/en not_active Expired
- 1984-05-29 ES ES532918A patent/ES532918A0/en active Granted
- 1984-05-29 ES ES532919A patent/ES532919A0/en active Granted
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/en unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES532920A0 (en) | 1985-09-01 |
| ES8507510A1 (en) | 1985-09-01 |
| IL69849A (en) | 1987-11-30 |
| YU196983A (en) | 1987-02-28 |
| KR840006218A (en) | 1984-11-22 |
| ES526133A0 (en) | 1985-03-16 |
| ES8507512A1 (en) | 1985-09-01 |
| ES8507511A1 (en) | 1985-09-01 |
| PH19508A (en) | 1986-05-14 |
| IL69849A0 (en) | 1983-12-30 |
| RO87466A (en) | 1985-08-31 |
| NO833541L (en) | 1984-04-02 |
| ES8503671A1 (en) | 1985-03-16 |
| YU192285A (en) | 1987-12-31 |
| NZ205685A (en) | 1987-03-31 |
| ES532918A0 (en) | 1985-09-01 |
| DE3382013D1 (en) | 1991-01-03 |
| RO87466B (en) | 1985-08-31 |
| ATE58531T1 (en) | 1990-12-15 |
| DE3376978D1 (en) | 1988-07-14 |
| SG31887G (en) | 1987-07-17 |
| ATE34979T1 (en) | 1988-06-15 |
| ZW20883A1 (en) | 1985-05-01 |
| HU192242B (en) | 1988-10-28 |
| ES532919A0 (en) | 1985-09-01 |
| PH21757A (en) | 1988-02-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8507129A1 (en) | Acrylic-acid amides, their preparation and use. | |
| EP0148623A3 (en) | Quinolone inotropic agents | |
| ES8801787A1 (en) | Heterocyclic amide derivatives. | |
| ES8503666A1 (en) | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments. | |
| GB1054833A (en) | ||
| ES8403466A1 (en) | Hydroxyalkynyl-azolyl derivatives, process for their preparation and their use as fungicides. | |
| GB1435755A (en) | 2-phenoxy alkyl sulphonalides | |
| ES369802A1 (en) | N-phenylsuccinimide derivatives | |
| RO89787A (en) | PROCESS FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES | |
| Verhé et al. | Reactions of N-1 (2, 2-dichloroalkylidene) amines with potassium cyanide: synthesis of β-chloro-α-cyanoenamines, α-chloroimidates and 2-amino-5-cyan | |
| MY103910A (en) | 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof | |
| GB1208195A (en) | Process for producing benzodiazepine derivatives | |
| ES8500908A1 (en) | N-sulphenylized hydantoins, process for their preparation and their microbicidal use. | |
| US4111941A (en) | Thienyl pyrazole thioamides | |
| ES2170802T3 (en) | BICYCLE CARBOXAMIDS AS LIGANDS OF THE 5-HT1A RECEPTORS. | |
| ES8103082A1 (en) | Pyrido[3,4-e]-as-triazines | |
| GB1082571A (en) | New heterocyclic amino compounds, their salts and a process for the preparation thereof | |
| ES554887A0 (en) | PROCEDURE FOR PREPARING PIRAZOL-1,5-A-PYRIMIDINES | |
| GB1135947A (en) | Novel biologically active derivatives of phenanthridone | |
| ATE28628T1 (en) | PHENYLETHYLAMIN DERIVATIVES AND THEIR INTERMEDIATE PRODUCTS. | |
| GB1447738A (en) | Antifogging agents for silver halide photographic emulsions | |
| ES8701716A1 (en) | New N,N'-di:phenyl-malon-bis:amide derivs. | |
| ES8101636A1 (en) | Monoazo-dyes |